{"id":27316,"date":"2022-10-19T12:27:17","date_gmt":"2022-10-19T12:27:17","guid":{"rendered":"https:\/\/zeepedia.com\/?p=27316"},"modified":"2022-10-20T07:04:06","modified_gmt":"2022-10-20T07:04:06","slug":"veklury","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/veklury\/","title":{"rendered":"Veklury &#8211; Remdesivir uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg&nbsp;powder for concentrate for&nbsp;infusion&nbsp;solution,<br>remdesivir solution<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Veklury is and what it is used for<\/h2>\n\n\n\n<p>The active substance in Veklury is remdesivir.&nbsp;It is an antiviral drug used to treat COVID\u201119.<\/p>\n\n\n\n<p>COVID\u201119 is caused by a\u00a0virus\u00a0called coronavirus.\u00a0Veklury stops the\u00a0virus\u00a0et from multiplying in cells and this prevents the\u00a0virus\u00a0et from multiplying in the body.\u00a0It can help the body overcome the viral infection and can help you recover faster.<\/p>\n\n\n\n<p>Very will be given to treat COVID-19 in:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>adults and children, who are at least 4 weeks old and weigh at least 3 kg, who has\u00a0pneumonia\u00a0and need extra oxygen to help them breathe, but who are not being treated with artificial ventilation (where mechanical aids are used to supplement or replace spontaneous breathing at the start of treatment).<\/li><li>adults and children (weighing at least 40 kg), who do not need supplemental oxygen to help them breathe and who are at increased risk of developing severe COVID-19.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you receive Veklury<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Veklury<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic<\/strong>&nbsp;to remdesivir or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p><strong>\u2192 Talk to a doctor or nurse as soon as possible,<\/strong>&nbsp;if this applies to you.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before you receive Veklury:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you have liver problems.\u00a0<\/strong>Some people get elevated liver enzymes after taking Veklury.\u00a0Your doctor will take blood samples before starting the treatment to check that you can receive them safely.<\/li><li>if you have kidney problems.\u00a0Some people with severe kidney problems cannot receive this medicine.\u00a0Your doctor will do blood tests to check if you can get it safely.<\/li><li>if you have a weakened immune system.\u00a0The doctor may monitor you more closely if your immune system is weakened to make sure the treatment is working.<\/li><\/ul>\n\n\n\n<p><strong>Reactions after&nbsp;infusion&nbsp;a<\/strong><\/p>\n\n\n\n<p>Very can cause allergic reactions after and during\u00a0infusion, including anaphylactic reactions (sudden life-threatening allergic reactions).\u00a0Allergic reactions have been observed in rare cases.\u00a0The frequency of anaphylactic reactions cannot be calculated from the available data.<\/p>\n\n\n\n<p>Symptoms may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Changes in\u00a0blood pressure\u00a0or heart rate.<\/li><li>Low oxygen content in the blood<\/li><li>High body temperature<\/li><li>Shortness of breath, wheezing<\/li><li>Swelling of the face, lips, tongue, or throat (\u00a0angioedema\u00a0)<\/li><li>Rash<\/li><li>Nausea<\/li><li>Vomiting<\/li><li>Sweating<\/li><li>Overindulge.<\/li><\/ul>\n\n\n\n<p><strong>\u2192 Tell your doctor or nurse immediately<\/strong>&nbsp;if you notice any of these symptoms.<\/p>\n\n\n\n<p><strong>Blood samples before and during treatment<\/strong><\/p>\n\n\n\n<p>If you are prescribed Veklury, blood samples will be taken from you before treatment begins.\u00a0Patients treated with Veklury will have blood samples taken during their treatment as instructed by their healthcare professional.\u00a0These samples are taken to check if you have kidney or liver problems and how quickly your blood clots.\u00a0Very treatment will be stopped if your kidneys or liver show signs of damage during treatment.\u00a0See section 4 (\u00a0<em>Possible\u00a0side effects\u00a0).<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Very should not be given to children younger than 4 weeks of age or children weighing less than 3 kg.\u00a0Not enough is known about the drug for it to be given to these children.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Veklury<\/h2>\n\n\n\n<p><strong>Tell your doctor or nurse<\/strong>&nbsp;if you are taking or have recently taken any other medicines.<\/p>\n\n\n\n<p>Do not take chloroquine or hydroxychloroquine at the same time as Veklury.<\/p>\n\n\n\n<p>Certain medicines such as&nbsp;midazolam or pitavastatin should be taken at least 2 hours after Veklury as Veklury may affect how they work.<\/p>\n\n\n\n<p>Very can affect the way some medicines (eg theophylline or midazolam) work.<\/p>\n\n\n\n<p>Some medicines (eg rifampicin) can affect how Veklury works.<\/p>\n\n\n\n<p><strong>\u2192 Tell your doctor if you are taking any of these medicines<\/strong><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p><strong>Tell your doctor or nurse if you are pregnant<\/strong>\u00a0or might be pregnant.\u00a0There is not enough information to determine whether Veklury is safe to use during pregnancy.\u00a0Very is given only if the possible benefits of the treatment outweigh the possible risks to the mother and the unborn child.\u00a0<strong>You must use effective contraception while being treated with Veklury.<\/strong><\/p>\n\n\n\n<p><strong>Tell your doctor or nurse if you are breastfeeding.\u00a0<\/strong>It is not yet known whether Veklury or the COVID-19\u00a0virus\u00a0is transmitted to human breast milk or what effects it may have on the baby or milk production.\u00a0The doctor will help you decide whether to continue breastfeeding or start treatment with Veklury.\u00a0You must consider the possible benefits of treatment against the health benefits and risks of breastfeeding for your baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Very is not expected to have any effect on your ability to drive.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Veklury contains cyclodextrin<\/h2>\n\n\n\n<p>This medicine contains 3 g of sulfobutylbetadex sodium in each 100 mg dose of Veklury (6 g starting dose).&nbsp;This ingredient is a&nbsp;<em>cyclodextrin emulsifier<\/em>&nbsp;that helps the medicine spread in the body.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Veklury is given to you<\/h2>\n\n\n\n<p>Very will be given to you by a nurse or doctor, as a drip into a vein (\u00a0<em>an\u00a0intravenous\u00a0infusion<\/em>\u00a0) lasting 30 to 120 minutes, once a day.\u00a0You will be closely monitored during your treatment.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><\/th><th scope=\"col\">Adults<\/th><th scope=\"col\">Children (weighing at least 40 kg)<\/th><th scope=\"col\">Children who are at least 4 weeks old (weighing at least 3 kg but less than 40 kg)<\/th><\/tr><\/thead><tbody><tr><td><strong>Day 1<\/strong>(single starting dose)<\/td><td>200 mg<\/td><td>200 mg<\/td><td>5 mg per kg of body weight<\/td><\/tr><tr><td><strong>Day 2 onwards<\/strong>(Once a day)<\/td><td>100 mg<\/td><td>100 mg<\/td><td>2.5 mg per kg of body weight<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>How long the treatment lasts:<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><\/th><th scope=\"col\">Adults<\/th><th scope=\"col\">Children (weighing at least 40 kg)<\/th><th scope=\"col\">Children who are at least 4 weeks old (weighing at least 3 kg but less than 40 kg)<\/th><\/tr><\/thead><tbody><tr><td>Patients with&nbsp;<strong>pneumonia&nbsp;who need extra oxygen<\/strong><\/td><td>Daily for\u00a0<strong>at least 5 days<\/strong>.\u00a0Can be extended up to\u00a0a total of 10 days.<\/td><td>Daily for\u00a0<strong>at least 5 days<\/strong>.\u00a0Can be extended up to\u00a0a total of 10 days.<\/td><td>Daily for up to\u00a0<strong>a total of 10 days<\/strong>.<\/td><\/tr><tr><td>Patients who&nbsp;<strong>do not need supplemental oxygen<\/strong>&nbsp;and who are at increased risk of developing severe COVID-19<\/td><td>Daily for\u00a0<strong>3 days<\/strong>, starting within 7 days of the onset of COVID-19 symptoms.<\/td><td>Daily for\u00a0<strong>3 days<\/strong>, starting within 7 days of the onset of COVID-19 symptoms.<\/td><td>not applicable<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>See\u00a0<em>Instructions for Healthcare Professionals<\/em>\u00a0for detailed information on how\u00a0to administer a Veklury infusion.<\/p>\n\n\n\n<p><strong>If you get more or less Veklury then you should<\/strong><\/p>\n\n\n\n<p>Because Veklury is only given to you by a healthcare professional, it is unlikely that you will be given too much or too little.&nbsp;If you have had an extra&nbsp;dose&nbsp;or missed one,&nbsp;<strong>tell the nurse or doctor immediately.<\/strong><\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Some&nbsp;side effects&nbsp;may be or may become serious.<\/p>\n\n\n\n<p><strong>Rare<\/strong><\/p>\n\n\n\n<p>(these may occur in up to 1 in 1,000 patients)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic or post-infusion\u00a0reactions\u00a0a.\u00a0Symptoms may include:<ul><li>Changes in\u00a0blood pressure\u00a0or heart rate<\/li><li>Low oxygen level in the blood<\/li><li>High body temperature<\/li><li>Shortness of breath, wheezing<\/li><li>Swelling of the face, lips, tongue, or throat (\u00a0angioedema\u00a0)<\/li><li>Rash<\/li><li>Nausea<\/li><li>Vomiting<\/li><li>Sweating<\/li><li>Overindulge<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Not known<\/strong><\/p>\n\n\n\n<p>(frequency cannot be calculated from available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anaphylactic reactions, anaphylactic&nbsp;shock&nbsp;(sudden life-threatening allergic reactions)<\/li><\/ul>\n\n\n\n<p>The symptoms are the same as for allergic reactions, however, the reaction is more severe and requires immediate medical attention.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sinus bradycardia&nbsp;(heart beats more slowly than normal)<\/li><\/ul>\n\n\n\n<p><strong>\u2192&nbsp;<\/strong><strong>Tell your doctor or nurse immediately<\/strong>&nbsp;if you experience any of these symptoms.<\/p>\n\n\n\n<p><strong>Other side effects:<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>(these may affect more than 1 in 10 patients)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blood tests can show elevated values \u200b\u200bof certain liver enzymes, so-called\u00a0transaminases<\/li><li>Blood tests may show that it takes longer for the blood to clot.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>(these may occur in up to 1 in 10 patients)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Nausea<\/li><li>Rash<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Veklury<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Before use<\/strong>, this medicine does not need to be stored specially.<\/li><li>Once Veklury has been reconstituted, it should be diluted immediately.<\/li><li>After dilution, Veklury should be used immediately.\u00a0If necessary, bags of diluted solution can be stored for up to 24 hours at room temperatures up to 25 \u00b0C, or for up to 48 hours in a refrigerator.\u00a0The time between dilution and\u00a0administration\u00a0must not be longer than 48 hours.<\/li><\/ul>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacy staff how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>The active substance<\/strong>\u00a0is remdesivir.\u00a0Each\u00a0vial\u00a0contains 100 mg.<\/li><li><strong>Other ingredients<\/strong>\u00a0are: sulfobutylbetadex sodium,\u00a0hydrochloric acid,\u00a0and sodium hydroxide<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Very 100 mg powder for concentrate for solution for\u00a0infusion\u00a0is a white, off-white to yellow powder, which must be reconstituted and then diluted in saline (sodium chloride) before\u00a0administration\u00a0by\u00a0intravenous\u00a0infusion.\u00a0It is supplied in a clear glass\u00a0vial\u00a0for single use.<\/p>\n\n\n\n<p>Very is supplied in cartons containing 1\u00a0vial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>County Cork, T45 DP77<\/p>\n\n\n\n<p>Ireland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The active substance in Veklury is remdesivir.\u00a0It is an antiviral drug used to treat COVID\u201119.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[27091,27096,27087,27090,27092,27095,27088,27093,27089,27094],"class_list":["post-27316","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-benefits-of-remdesivir","tag-benefits-of-veklury","tag-remdesivir","tag-remdesivir-side-effects","tag-veklury","tag-veklury-side-effects","tag-what-is-remdesivir","tag-what-is-veklury","tag-what-remdesivir-is-used-for","tag-what-veklury-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27316","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=27316"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27316\/revisions"}],"predecessor-version":[{"id":27359,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27316\/revisions\/27359"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=27316"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=27316"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=27316"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}