{"id":27308,"date":"2022-10-19T12:22:42","date_gmt":"2022-10-19T12:22:42","guid":{"rendered":"https:\/\/zeepedia.com\/?p=27308"},"modified":"2022-10-20T07:04:25","modified_gmt":"2022-10-20T07:04:25","slug":"vectibix","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vectibix\/","title":{"rendered":"Vectibix &#8211; Panitumumab uses, dose and side effects"},"content":{"rendered":"\n<p>20 mg\/ml&nbsp;Concentrate for&nbsp;infusion solution&nbsp;, solution.<br>panitumumab<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Vectibix is \u200b\u200band what it is used for<\/h2>\n\n\n\n<p>Vectibix is \u200b\u200bused to treat metastatic colorectal cancer (cancer of the colon) in adult patients with a particular type of&nbsp;tumor&nbsp;called &#8220;tumors with wild-type&nbsp;<em>RAS<\/em>&nbsp;&#8220;.&nbsp;Vectibix is \u200b\u200bused alone or in combination with other cancer medicines.<\/p>\n\n\n\n<p>Vectibix contains the active substance panitumumab, which belongs to a group of medicines called monoclonal\u00a0antibodies.\u00a0Monoclonal\u00a0antibodies\u00a0are\u00a0proteins\u00a0that specifically recognize and attach to (bind to) other unique\u00a0proteins\u00a0in the body.<\/p>\n\n\n\n<p>Panitumumab recognizes and binds specifically to a&nbsp;protein&nbsp;called&nbsp;epidermal&nbsp;growth&nbsp;factor&nbsp;receptor&nbsp;(EGFR&nbsp;), which is found on the surface of some cancer cells.&nbsp;When growth factors (other body proteins) bind to EGFR, the cancer cell is stimulated to grow and divide.&nbsp;Panitumumab binds to EGFR and thus prevents the cancer cell from receiving the information it needs to grow and divide.<br><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Vectibix<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Vectibix<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to panitumumab or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have previously had or had interstitial\u00a0pneumonitis\u00a0(swelling of the lungs leading to coughing and difficulty breathing) or\u00a0pulmonary fibrosis\u00a0(scarring and thickening of the lungs with shortness of breath).<\/li><li>in combination with oxaliplatin-based\u00a0chemotherapy\u00a0(medicine to treat cancer), if your\u00a0<em>RAS<\/em>\u00a0test shows that you have a\u00a0tumor\u00a0with mutated\u00a0<em>RAS<\/em>\u00a0or if your\u00a0<em>RAS<\/em>\u00a0mutation status is not known.\u00a0Consult your doctor if you are unsure of your\u00a0<em>RAS<\/em>\u00a0mutation status.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>You may develop skin reactions or severe swelling and tissue damage.&nbsp;If these symptoms worsen or become unbearable, tell the doctor or nurse immediately.&nbsp;If you get a serious skin reaction, your doctor may recommend that the&nbsp;dose&nbsp;of Vectibix be changed.&nbsp;If you develop a serious&nbsp;infection&nbsp;or fever due to skin reactions, your doctor may decide to stop treatment with Vectibix.<\/p>\n\n\n\n<p>You should limit your exposure to the sun while being treated with Vectibix and if you experience skin reactions, as sunlight may worsen these.\u00a0Use sunscreen and protective headgear if you are going to be in the sun.\u00a0Your doctor may tell you to use a moisturizing\u00a0cream, sunscreen (sun protection factor (SPF) > 15),\u00a0topical\u00a0(\u00a0external\u00a0) steroid cream (cortisone cream), and\/or oral\u00a0antibiotics\u00a0to manage skin reactions that may occur when using Vectibix.<\/p>\n\n\n\n<p>Before you start treatment with Vectibix, the doctor will check the level of various substances in the blood, e.g.\u00a0magnesium,\u00a0calcium,\u00a0and\u00a0potassium.\u00a0The doctor will also check the level of\u00a0magnesium\u00a0and\u00a0calcium\u00a0in the blood regularly during the treatment and for up to 8 weeks after the end of the treatment.\u00a0If these levels are too low, the doctor can prescribe appropriate supplements.<\/p>\n\n\n\n<p>Tell your doctor or nurse if you have severe diarrhea, as you may lose a lot of fluid from your body (be dehydrated) and this may damage your kidneys.<\/p>\n\n\n\n<p>Tell the doctor if you wear contact lenses and\/or if you have had eye problems in the past, e.g.\u00a0very dry eyes,\u00a0inflammation\u00a0of the cornea (front part of the eye), or corneal ulcers.<\/p>\n\n\n\n<p>If you develop&nbsp;acute&nbsp;or worsening eye&nbsp;redness&nbsp;and pain, increased tearing, blurred vision, and\/or sensitivity to light, tell your doctor or nurse immediately as you may need immediate treatment (see \u201cPossible side effects\u201d below).<\/p>\n\n\n\n<p>Depending on your age (over 65 years) or general health, your doctor will talk to you about your ability to tolerate Vectibix together with your\u00a0chemotherapy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Vectibix<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines.&nbsp;This also applies to over-the-counter medicines and herbal remedies.<\/p>\n\n\n\n<p>Vectibix should not be used in combination with bevacizumab (another monoclonal&nbsp;antibody&nbsp;used in the treatment of bowel cancer) or with a chemotherapy combination called &#8216;IFL&#8217;.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Vectibix has not been tested on pregnant women.\u00a0It is important that you tell your doctor if you are pregnant, think you are pregnant, or plan to become pregnant.\u00a0Vectibix can affect the unborn baby or your ability to maintain a pregnancy.<\/p>\n\n\n\n<p>If you are a woman of\u00a0childbearing\u00a0age, you must use effective contraceptive methods while you are receiving treatment with Vectibix and for 2 months after the last\u00a0dose.<\/p>\n\n\n\n<p>It is not recommended that you breastfeed during treatment with Vectibix and 2 months after the last\u00a0dose.\u00a0It is important to tell the doctor if you plan to breastfeed.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Talk to your doctor before driving or using machines as some&nbsp;side effects&nbsp;may affect your ability to do so safely.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vectibix contains sodium<\/h2>\n\n\n\n<p>This medicine contains 3.45 mg of&nbsp;sodium&nbsp;(the main ingredient in common\/table salt) per ml.&nbsp;This corresponds to 0.17% of the maximum recommended daily intake of&nbsp;sodium&nbsp;for adults.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Vectibix<\/h2>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;of Vectibix is \u200b\u200b6 mg\/kg (milligrams per kilogram of body weight) once every two weeks.&nbsp;The treatment generally takes about 60 minutes.<\/p>\n\n\n\n<p>Vectibix is \u200b\u200badministered in a ward under the supervision of a doctor experienced in treatment with cancer drugs.<\/p>\n\n\n\n<p>Vectibix is \u200b\u200badministered&nbsp;intravenously&nbsp;(into a vein) using an infusion pump (an instrument that gives a slow&nbsp;injection&nbsp;).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The most serious&nbsp;side effects&nbsp;and the main&nbsp;side effects&nbsp;with Vectibix are described below:<\/p>\n\n\n\n<p><strong>Infusion reactions<\/strong><\/p>\n\n\n\n<p>During or after treatment, you may experience an infusion reaction.\u00a0Such reactions may be mild or moderate (likely to affect about 5 in 100 people who use Vectibix), or serious (likely to affect 1 in 100 people who use Vectibix).\u00a0Symptoms may include headache, rash,\u00a0itching\u00a0or\u00a0hives, hot flushes, swelling (face, lips, mouth, around the eyes and throat), fast and irregular heartbeat, fast\u00a0pulse, sweating, nausea, vomiting, dizziness, difficulty breathing or swallowing, or a drop in blood pressure that can be serious or life-threatening and, in very rare cases, lead to death.\u00a0If you experience any of these symptoms, talk to your doctor immediately.\u00a0The doctor may decide to reduce the infusion rate or stop treatment with Vectibix.<\/p>\n\n\n\n<p><strong>Allergic reactions<\/strong><\/p>\n\n\n\n<p>In very rare cases, serious allergic reactions (&nbsp;hypersensitivity reactions&nbsp;), with symptoms similar to those of an infusion reaction (see \u201cInfusion reactions\u201d), have occurred more than 24 hours after treatment and have resulted in death.&nbsp;Seek immediate medical attention if you experience symptoms of an&nbsp;allergic reaction&nbsp;to Vectibix, including difficulty breathing, tightness in the chest, feeling of choking, dizziness, or fainting.<\/p>\n\n\n\n<p><strong>Skin reactions<\/strong><\/p>\n\n\n\n<p>Skin reactions are likely to affect about 94 out of 100 people who use Vectibix.\u00a0They are usually mild or moderate.\u00a0The rash generally resembles\u00a0acne\u00a0and often affects the face, upper chest, and back, but can appear anywhere on the body.\u00a0Some rashes are red, itchy, and scaly and can become serious.\u00a0In some cases, they can cause infected wounds that require drug treatment and\/or surgery, and they can also cause severe skin reactions that are rarely fatal.\u00a0In rare cases, patients may experience blisters on the skin, mouth, eyes, and genitals.\u00a0This may indicate a serious skin reaction called &#8220;Stevens-Johnson syndrome&#8221;.\u00a0Blisters on the skin can also indicate a serious skin reaction called \u201ctoxic\u00a0epidermal necrolysis\u201d.\u00a0If you get blisters, contact a doctor immediately.\u00a0Prolonged exposure to sunlight can worsen the rash.\u00a0Dry skin, skin cracks on fingers and toes,\u00a0and infection\u00a0or\u00a0inflammation\u00a0of the\u00a0nail bed\u00a0on fingers or toes (\u00a0paronychia\u00a0) have also been reported.\u00a0Skin reactions generally reverse when treatment is temporarily interrupted or discontinued.\u00a0The doctor can decide to treat the rash, adjust the\u00a0dose\u00a0or stop the treatment with Vectibix.<\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;are:<\/p>\n\n\n\n<p><strong>Very common:<\/strong>&nbsp;may affect more than 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the low number of\u00a0red blood cells\u00a0(\u00a0anemia\u00a0), low potassium in the blood (\u00a0hypokalemia\u00a0), low magnesium in the blood (\u00a0hypomagnesemia\u00a0)<\/li><li>eye inflammation (\u00a0conjunctivitis\u00a0)<\/li><li>localized or widespread rash that may be bumpy (with or without spots), itchy, red, or scaly<\/li><li>hair loss (\u00a0alopecia\u00a0), mouth sores and mouth ulcers (\u00a0stomatitis\u00a0),\u00a0inflammation\u00a0of the mouth (mucositis)<\/li><li>diarrhea, nausea, vomiting, abdominal pain, constipation, decreased appetite, weight loss<\/li><li>extreme tiredness (fatigue), fever or elevated temperature (\u00a0pyrexia\u00a0), weakness (\u00a0asthenia\u00a0), accumulation of fluid in the arms and legs (peripheral\u00a0edema)<\/li><li>back pain<\/li><li>difficulty sleeping (insomnia)<\/li><li>cough,\u00a0dyspnoea\u00a0(difficulty breathing).<\/li><\/ul>\n\n\n\n<p><strong>Common side effects:<\/strong>&nbsp;may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the low number of\u00a0white blood cells\u00a0(\u00a0leukopenia\u00a0), low calcium in the blood (\u00a0hypocalcemia\u00a0), low phosphate in the blood (\u00a0hypophosphatemia\u00a0), high glucose in the blood (\u00a0hyperglycemia\u00a0)<\/li><li>eyelash growth,\u00a0increased lacrimation, eye redness (\u00a0ocular\u00a0hyperemia\u00a0), dry eyes, itchy eyes (ocular pruritus), eye irritation, eyelid inflammation (\u00a0blepharitis\u00a0)<\/li><li>skin wounds, scabs, excessive hair growth (hypertrichosis),\u00a0redness\u00a0and swelling of the palms of the hands and soles of the feet (hand-foot syndrome), excessive sweating (\u00a0hyperhidrosis\u00a0), skin reaction (\u00a0dermatitis\u00a0)<\/li><li>infection\u00a0that spreads under the skin (\u00a0cellulitis\u00a0),\u00a0inflammation\u00a0of hair follicles (\u00a0folliculitis\u00a0), localized\u00a0infection, a rash with blisters (pustular rash), urinary tract infection<\/li><li>nail problems, brittle nails (onycholysis)<\/li><li>dehydration\u00a0_\u00a0_<\/li><li>dry mouth, indigestion (\u00a0dyspepsia\u00a0), rectal bleeding, lip inflammation (cheilitis), heartburn (\u00a0gastroesophageal reflux\u00a0)<\/li><li>chest pain, pain, chills, pain in arms and legs, immune reaction (hypersensitivity), fast heartbeat (\u00a0tachycardia\u00a0)<\/li><li>blood clots in the lungs (pulmonary embolism), with symptoms such as sudden shortness of breath or chest pain, nosebleeds (\u00a0epistaxis\u00a0), blood clots in blood vessels (deep\u00a0vein thrombosis\u00a0), high\u00a0blood pressure\u00a0(\u00a0hypertension\u00a0), hot flashes<\/li><li>headache, dizziness, and anxiety.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;may affect up to 1 in 100 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>bluish discoloration of the skin and mucous membranes (cyanosis)<\/li><li>cell death in the skin (skin necrosis)<\/li><li>severe skin reaction with blisters on the skin, mouth, eyes, and genitals (Stevens-Johnson syndrome)<\/li><li>severe skin reaction with blisters on the skin (\u00a0toxic epidermal necrolysis\u00a0)<\/li><li>a serious condition with ulcers in the cornea (front part of the eye) that requires immediate treatment (ulcerative\u00a0keratitis\u00a0)<\/li><li>inflammation\u00a0of the cornea (front part of the eye) (\u00a0keratitis\u00a0)<\/li><li>eyelid irritation, chapped lips and\/or dry lips,\u00a0eye infection, eyelid infection, dry nose, loosening of nails (\u00a0onycholysis\u00a0), ingrown nails, excessive hair growth (\u00a0hirsutism\u00a0)<\/li><li>inflammation\u00a0of the lungs (interstitial lung disease).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How Vectibix should be stored<\/h2>\n\n\n\n<p>Vectibix must be stored in the ward where it is used.<\/p>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store in a refrigerator (2\u00b0C\u20138\u00b0C).<\/p>\n\n\n\n<p>Do not freeze.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Each ml of concentrate contains 20 mg of panitumumab.\u00a0Each\u00a0vial\u00a0contains either 100 mg panitumumab in 5 ml or 400 mg panitumumab in 20 ml.<\/li><li>The active substance is panitumumab 20 mg\/ml.\u00a0Other ingredients are sodium chloride, sodium acetate trihydrate, acetic acid (concentrated), and water for injections.\u00a0See section 2, \u201cVectibix contains sodium\u201d.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Vectibix is \u200b\u200ba colorless liquid that may contain visible particles and is supplied in a\u00a0glass\u00a0vial.\u00a0Each pack contains one\u00a0vial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Amgen Europe BV<\/p>\n\n\n\n<p>Minervum 7061<\/p>\n\n\n\n<p>4817 ZK Breda<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vectibix is \u200b\u200bused to treat metastatic colorectal cancer (cancer of the colon) in adult patients with a particular type of\u00a0tumor\u00a0called &#8220;tumors with wild-type\u00a0RAS\u00a0&#8220;.\u00a0Vectibix is \u200b\u200bused alone or in combination with other cancer medicines.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[27110,27116,27107,27111,27112,27115,27108,27113,27109,27114],"class_list":["post-27308","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-benefits-of-panitumumab","tag-benefits-of-vectibix","tag-panitumumab","tag-panitumumab-side-effects","tag-vectibix","tag-vectibix-side-effects","tag-what-is-panitumumab","tag-what-is-vectibix","tag-what-panitumumab-is-used-for","tag-what-vectibix-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27308","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=27308"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27308\/revisions"}],"predecessor-version":[{"id":27361,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27308\/revisions\/27361"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=27308"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=27308"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=27308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}