{"id":27048,"date":"2022-10-18T12:01:18","date_gmt":"2022-10-18T12:01:18","guid":{"rendered":"https:\/\/zeepedia.com\/?p=27048"},"modified":"2022-10-19T07:24:00","modified_gmt":"2022-10-19T07:24:00","slug":"vargatef","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vargatef\/","title":{"rendered":"Vargatef &#8211; Nintedanib uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg&nbsp;soft capsules<br>nintedanib<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Vargatef is and what it is used for<\/h2>\n\n\n\n<p>Vargatef capsules contain the active substance nintedanib.\u00a0Nintedanib blocks the activity of a group of\u00a0proteins\u00a0involved in the formation of new blood vessels, which cancer cells need to get blood and oxygen.\u00a0By blocking the activity of the\u00a0proteins, nintedanib can stop the growth and spread of the cancer tumor.<\/p>\n\n\n\n<p>This medicine is used in combination with another cancer medicine (docetaxel) to treat a type of cancer in the lungs called non-small cell lung cancer\u00a0(NSCLC).\u00a0It is intended for adult patients who have a certain type of NSCLC (&#8221;\u00a0<em>adenocarcinoma<\/em>\u00a0&#8220;), and who have already received a treatment cycle with another medicine against this cancer, but where the\u00a0tumor\u00a0has started to grow again.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Vargatef<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Vargatef:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to nintedanib, peanuts or soya, or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Vargatef<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have or have had liver problems if you have or have had bleeding problems, especially if you have recently had a lung bleed<\/li><li>if you have or have had kidney problems or if an increased amount of\u00a0protein\u00a0has been detected in the urine (\u00a0proteinuria\u00a0)<\/li><li>if you take blood-thinning medicines (eg\u00a0warfarin, phenprocoumon,\u00a0heparin,\u00a0or\u00a0aspirin\u00a0) to prevent blood clots.\u00a0Treatment with Vargatef may lead to an increased risk of bleeding<\/li><li>if you have recently had surgery or are about to undergo surgery.\u00a0Nintedanib may affect wound healing.\u00a0Therefore, a break-in treatment with Vargatef is usually done before an operation.\u00a0Your doctor will decide when to resume treatment with this medicine.<\/li><li>if you have cancer that has spread to the brain<\/li><li>if you have high\u00a0blood pressure<\/li><li>if you have or have had an\u00a0aneurysm\u00a0(enlargement and weakening of a vessel wall) or a rupture in a vessel wall<\/li><\/ul>\n\n\n\n<p>When your doctor receives this information, he\/she may take blood samples, for example, to check your liver function and to determine how quickly your blood can clot.\u00a0The doctor will discuss the results of the tests with you and decide whether you can receive Vargatef.<\/p>\n\n\n\n<p>When you take the medicine, tell your doctor immediately about<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you get diarrhea.\u00a0Treatment must be started at the first sign of diarrhea (see section 4)<\/li><li>you vomit or feel sick (nausea)<\/li><li>if you have unexplained symptoms such as yellowing of the skin or the whites of the eyes (jaundice), dark or brown (tea-colored) urine, right-sided pain in the upper part of the stomach (abdomen), increased tendency to bleed or bruise, or feeling tired.\u00a0This could be a sign of serious liver problems<\/li><li>if you develop a fever, chills, fast heartbeat, or feel short of breath.\u00a0These may be signs of\u00a0infection\u00a0or blood poisoning (\u00a0sepsis\u00a0) (see section 4)<\/li><li>if you experience severe pain in the stomach, fever, chills, nausea, vomiting, hard abdominal wall, or feeling of bloating, as these may be symptoms of a hole in the intestinal wall (&#8220;gastrointestinal perforation&#8221;)<\/li><li>if you experience pain, swelling,\u00a0redness, warmth in an arm or leg or if you experience chest pain and difficulty breathing, as these may be symptoms of a blood clot in a vein<\/li><li>if you have a major bleed<\/li><li>if you feel pressure or pain in the chest, usually on the left side of the body, pain in the neck, jaw, shoulder, or arm, fast heartbeat, shortness of breath, nausea, or vomiting, as these may be symptoms of a heart attack<\/li><li>if any of the\u00a0side effects\u00a0you may get (see section 4) become serious<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine has not been studied in children and adolescents and is therefore not intended for use by children and adolescents under the age of 18.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Vargatef<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including herbal and non-prescription medicines.<\/p>\n\n\n\n<p>This medicine may interfere, or be interfered with, with some other medicines.\u00a0The following medicines may increase the blood levels of nintedanib, the active substance in Vargatef, and thus increase the risk of\u00a0side effects\u00a0(see section 4):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ketoconazole&nbsp;(used for fungal infections)<\/li><li>Erythromycin (used against bacterial infections)<\/li><\/ul>\n\n\n\n<p>The following medicines can lower the blood levels of nintedanib and thus cause Vargatef to be less effective:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rifampicin (an&nbsp;antibiotic&nbsp;used for&nbsp;tuberculosis&nbsp;)<\/li><li>Carbamazepine,&nbsp;phenytoin&nbsp;(used for seizures)<\/li><li>John&#8217;s wort&nbsp;(a (traditional) herbal remedy for mild depression)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>Do not take this medicine during pregnancy, as it may harm the unborn baby and cause birth defects.<\/p>\n\n\n\n<p><strong>Contraceptive<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Women who could become pregnant must use highly effective contraception to prevent pregnancy when they start taking Vargatef, while they are taking Vargatef, and for at least 3 months after they stop treatment.<\/li><li>You should discuss with your doctor which contraceptives are best for you.<\/li><li>Vomiting and\/or diarrhea or other gastrointestinal complaints can affect the absorption of hormonal contraceptives taken by mouth, e.g.\u00a0birth\u00a0control pills, and can reduce their effect.\u00a0If you experience these conditions, you should therefore speak to your doctor to discuss an alternative, more suitable method of contraception.<\/li><li>Tell your doctor or pharmacist immediately if you become pregnant or think you may be pregnant during treatment with Vargatef.<\/li><\/ul>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>It is not known whether the drug passes into breast milk and could harm a nursing baby.\u00a0Therefore, women must not breastfeed while being treated with Vargatef.<\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>The effect of this medicine on human&nbsp;fertility&nbsp;has not been studied.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Vargatef may have a minor effect on the ability to drive and use machines.&nbsp;You should not drive or operate machinery if you feel ill.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vargatef contains soy<\/h2>\n\n\n\n<p>The capsules contain soy lecithin.&nbsp;If you are allergic to peanuts or soya, you should not use this medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Vargatef<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Do not take Vargatef on the same day as your docetaxel chemotherapy treatment.<\/p>\n\n\n\n<p>Swallow the capsules whole with water.&nbsp;You must not chew them.&nbsp;The recommendation is that you take the capsules with food, that is, during or immediately before or after a meal.<\/p>\n\n\n\n<p>The capsule must not be opened or crushed (see section 5).<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0is four capsules per day (that is, a total of 400 mg of nintedanib per day).\u00a0Do not take more than that one\u00a0dose.<\/p>\n\n\n\n<p>This daily dose should be divided into two\u00a0doses\u00a0of two capsules approximately 12 hours apart, for example, two capsules in the morning and two capsules in the evening.\u00a0Take both of these\u00a0doses\u00a0at about the same time each day.\u00a0By taking the medicine in this way, you are sure to always have an even amount of nintedanib in your body.<\/p>\n\n\n\n<p><strong>Dose reduction<\/strong><\/p>\n\n\n\n<p>If you cannot tolerate the recommended&nbsp;dose&nbsp;of 400 mg per day due to&nbsp;side effects&nbsp;(see section 4), your doctor may reduce the daily&nbsp;dose&nbsp;of Vargatef.&nbsp;Do not reduce the&nbsp;dose&nbsp;or stop the treatment yourself without first consulting your doctor!<\/p>\n\n\n\n<p>Your doctor may reduce your recommended&nbsp;dose&nbsp;to 300 mg per day (two 150 mg capsules).&nbsp;In that case, the doctor prescribes Vargatef 150 mg soft capsules for your treatment.<\/p>\n\n\n\n<p>If necessary, your doctor may further reduce your daily\u00a0dose\u00a0to 200 mg per day (two capsules of 100 mg each).\u00a0If that happens, the doctor will prescribe the correct capsule strength.<\/p>\n\n\n\n<p>In either case, take one capsule of the correct strength twice daily, approximately 12 hours apart, with food (for example, in the morning and the evening) at approximately the same time each day.<\/p>\n\n\n\n<p>If your doctor has stopped your&nbsp;chemotherapy&nbsp;with docetaxel, you should continue to take Vargatef twice a day.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Vargatef<\/h2>\n\n\n\n<p>Contact a doctor or pharmacist immediately.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Vargatef<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.\u00a0Take the next\u00a0dose\u00a0of Vargatef as planned at the next regular time and in the\u00a0dose\u00a0recommended by the doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Vargatef<\/h2>\n\n\n\n<p>Do not stop taking Vargatef without first talking to your doctor.\u00a0You must take this medicine every day, as long as your doctor prescribes it.\u00a0If you do not take this medicine as directed by your doctor, this cancer treatment may not work as it should.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>You must pay particular attention if you experience the following&nbsp;side effects&nbsp;during treatment with Vargatef:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong><em>Diarrhea<\/em>&nbsp;<\/strong><em>(very common, may affect more than 1 in 10 users):<\/em><\/li><\/ul>\n\n\n\n<p>Diarrhea can cause the body to lose fluids and important salts (\u00a0electrolytes, such as\u00a0sodium\u00a0or\u00a0potassium\u00a0).\u00a0At the first sign of diarrhea, drink plenty of fluids and contact your doctor immediately.\u00a0Start appropriate anti-diarrheal therapy, e.g.\u00a0with loperamide, as soon as possible after you have contacted the doctor.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em><strong>Febrile&nbsp;neutropenia&nbsp;<\/strong>and&nbsp;<strong>sepsis<\/strong><\/em>&nbsp;<em>(common, may affect up to 1 in 10&nbsp;<\/em><em>people&nbsp;<\/em><em>):<\/em><\/li><\/ul>\n\n\n\n<p>Treatment with Vargatef can lead to a reduced number of a certain type of white blood cells\u00a0<em>(\u00a0neutropenia\u00a0)<\/em>.\u00a0These are cells that are important for the body&#8217;s defense against\u00a0bacterial\u00a0and fungal infections.\u00a0As a result of neutropenia, one can get a fever (\u00a0<em>febrile\u00a0neutropenia<\/em>\u00a0) and blood poisoning (\u00a0<em>sepsis<\/em>\u00a0).\u00a0Tell your doctor immediately if you develop a fever, chills, fast heartbeat, or feel short of breath.<\/p>\n\n\n\n<p>During treatment with Vargatef, your doctor will regularly check your blood and examine you to see if you have any signs of\u00a0infection, such as\u00a0inflammation, fever, or fatigue.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;were observed during treatment with this medicine:<\/p>\n\n\n\n<p><em>Very common&nbsp;side effects&nbsp;(may affect more than 1 in 10&nbsp;<\/em><em>users&nbsp;<\/em><em>)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea &#8211; see above<\/li><li>Painful numbness and\/or tingling in fingers and toes (\u00a0<em>peripheral\u00a0neuropathy<\/em>\u00a0)<\/li><li>Nausea<\/li><li>Vomiting<\/li><li>Pain in the abdomen<\/li><li>Bleeding<\/li><li>Decrease in the number of\u00a0white blood cells\u00a0(\u00a0<em>neutropenia<\/em>\u00a0)<\/li><li>Inflammation\u00a0of the mucous membranes of the digestive tract, including various types of ulcers in the mouth (\u00a0<em>mucositis, including\u00a0stomatitis<\/em>\u00a0)<\/li><li>Rash<\/li><li>Decreased appetite<\/li><li>Electrolyte imbalance (impaired salt levels)<\/li><li>Elevated liver enzyme levels (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase in the blood) in the blood, which can be seen in blood tests<\/li><li>Hair loss (alopecia)<\/li><\/ul>\n\n\n\n<p><em>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10&nbsp;<\/em><em>users&nbsp;<\/em><em>)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blood poisoning (\u00a0<em>sepsis<\/em><em>\u00a0)<\/em>\u00a0\u2013 see above<\/li><li>Decrease in the number of\u00a0white blood cells\u00a0combined with fever (\u00a0<em>febrile\u00a0neutropenia<\/em>\u00a0)<\/li><li>Blood clots in the veins (\u00a0<em>venous\u00a0thromboembolism<\/em>\u00a0), especially in the legs (symptoms include pain,\u00a0redness, swelling, and warmth in an arm or leg), can travel via blood vessels to the lungs and cause chest pain and difficulty breathing (see a doctor immediately if you notice any of these symptoms)<\/li><li>High\u00a0blood pressure\u00a0(\u00a0hypertension\u00a0)<\/li><li>Fluid loss (\u00a0dehydration\u00a0)<\/li><li>Abscesses\u00a0_<\/li><li>Low\u00a0platelet count\u00a0(\u00a0thrombocytopenia\u00a0)<\/li><li>Jaundice (\u00a0hyperbilirubinemia\u00a0)\u00a0<\/li><li>Elevated liver enzyme levels (gamma-glutamyltransferase) in the blood, which can be seen in blood tests<\/li><li>Weight loss<\/li><li>Itching<\/li><li>Headache<\/li><li>The increased amount of\u00a0protein\u00a0in the urine\u00a0<em>(\u00a0proteinuria<\/em>\u00a0)<\/li><\/ul>\n\n\n\n<p><em>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>That a hole occurs in the intestinal wall (&nbsp;<em>gastrointestinal&nbsp;perforation<\/em>&nbsp;)<\/li><li>Severe liver problems<\/li><li>Inflammation&nbsp;of the pancreas (&nbsp;<em>pancreatitis<\/em>&nbsp;)<\/li><li>Myocardial infarction<\/li><li>Kidney failure<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation&nbsp;of the colon<\/li><li>An enlargement and weakening of a vessel wall or a rupture in a vessel wall (&nbsp;aneurysms&nbsp;and arterial dissections)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How Vargatef should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton, outer cover, and blister.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 25 \u00b0C.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Do not use this medicine if you notice that the blister containing the capsules has been opened or that a capsule is broken.<\/p>\n\n\n\n<p>If you come into contact with the contents of the capsule, wash your hands immediately with plenty of water (see section 3).<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is nintedanib.\u00a0Each soft capsule contains 100 mg of nintedanib (as besylate).<\/p>\n\n\n\n<p>The auxiliary substances are:<\/p>\n\n\n\n<p><em>Capsule content:&nbsp;<\/em>Triglyceride&nbsp;er, medium chains;&nbsp;hard fat, soy lecithin (E322)<\/p>\n\n\n\n<p><em>Capsule shell:<\/em>&nbsp;Gelatin,&nbsp;glycerol&nbsp;(85%), titanium dioxide (E171), red iron oxide (E172),<\/p>\n\n\n\n<p>yellow iron oxide (E172)<\/p>\n\n\n\n<p><em>Printing ink:<\/em>&nbsp;Shellac, black iron oxide (E172), propylene glycol (E1520)<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Vargatef 100 mg soft capsules (capsules) are peach-colored, opaque, oblong capsules with the Boehringer Ingelheim corporate symbol and \u201c100\u201d printed in black on one side.<\/p>\n\n\n\n<p>There are three different pack sizes of Vargatef 100 mg soft capsules:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A carton containing 60 capsules (6 aluminum blisters each containing 10 capsules).<\/li><li>A carton containing 120 capsules (12 aluminum blisters each containing 10 capsules).<\/li><li>A multipack containing 120 capsules (2 cartons of 60 capsules each held together by a wrapper).<\/li><\/ul>\n\n\n\n<p>Not all pack sizes of Vargatef 100 mg soft capsules may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Boehringer Ingelheim International GmbH<\/p>\n\n\n\n<p>Binger Strasse 173<\/p>\n\n\n\n<p>55216 Ingelheim am Rhein<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Boehringer Ingelheim Pharma GmbH &amp; Co.&nbsp;KG<\/p>\n\n\n\n<p>Binger Strasse 173<\/p>\n\n\n\n<p>55216 Ingelheim am Rhein<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Boehringer Ingelheim France<\/p>\n\n\n\n<p>100-104 Avenue de France<\/p>\n\n\n\n<p>75013 Paris<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>SCS Boehringer Ingelheim Comm.VT\u00e9l\/Tel: +32 2 773 33 11<\/td><td><strong>Lithuania<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGLietuvos filialasPhone: +370 5 2595942<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Bj\u00f6ringer Ingelheim \u0420\u0426\u0412 \u0413\u043c\u0431\u0425 \u0438 \u041a\u043e.\u00a0KG &#8211; clone Bulgaria phone: +359 2 958 79 98<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>SCS Boehringer Ingelheim Comm.VT\u00e9l\/Tel: +32 2 773 33 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Boehringer Ingelheim coil.\u00a0s iPhone: +420 234 655 111<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGMagyarorsz\u00e1gi Fi\u00f3ktelepePhone: +36 1 299 8900<\/td><\/tr><tr><td><strong>Denmark<\/strong>Boehringer Ingelheim Danmark A\/SPhone: +45 39 15 88 88<\/td><td><strong>Malta<\/strong>Boehringer Ingelheim Ireland Ltd.Phone: +353 1 295 9620<\/td><\/tr><tr><td><strong>Deutschland<\/strong>Boehringer Ingelheim Pharma GmbH &amp; Co.&nbsp;KGPhone: +49 (0) 800 77 90 900<\/td><td><strong>The Netherlands<\/strong>Boehringer Ingelheim bvPhone: +31 (0) 800 22 55 889<\/td><\/tr><tr><td><strong>Estonia<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGEstonian branchPhone: +372 612 8000<\/td><td><strong>Norway<\/strong>Boehringer Ingelheim Norway KSPhone: +47 66 76 13 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Boehringer Ingelheim\u0395\u03bb\u03bb\u03ac\u03c2 \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b7 AETel: +30 2 10 89 06 300<\/td><td><strong>Austria<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGPhone: +43 1 80 105-7870<\/td><\/tr><tr><td><strong>Spain<\/strong>Boehringer Ingelheim Espa\u00f1a, SAPhone: +34 93 404 51 00<\/td><td><strong>Polish<\/strong>Boehringer Ingelheim Sp.\u00a0z o. iPhone: +48 22 699 0 699<\/td><\/tr><tr><td><strong>France<\/strong>Boehringer Ingelheim France SASTel: +33 3 26 50 45 33<\/td><td><strong>Portugal<\/strong>Boehringer Ingelheim Portugal, Lda.Phone: +351 21 313 53 00<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Boehringer Ingelheim Zagreb dooPhone: +385 1 2444 600<\/td><td><strong>Romania<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGViena &#8211; Sucursala BucurestiPhone: +40 21 302 2800<\/td><\/tr><tr><td><strong>Ireland<\/strong>Boehringer Ingelheim Ireland Ltd.Phone: +353 1 295 9620<\/td><td><strong>Slovenija<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGPodru\u017enica LjubljanaPhone: +386 1 586 40 00<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGorganiza\u010dn\u00e1 zlo\u017ekaPhone: +421 2 5810 1211<\/td><\/tr><tr><td><strong>Italy<\/strong>Boehringer Ingelheim Italia SpAPhone: +39 02 5355 1<\/td><td><strong>Finland\/Finland<\/strong>Boehringer Ingelheim Finland KyPhone\/Tel: +358 10 3102 800<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Boehringer Ingelheim\u0395\u03bb\u03bb\u03ac\u03c2 \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b7 AETel: +30 2 10 89 06 300<\/td><td><strong>Sweden<\/strong>Boehringer Ingelheim ABPhone: +46 8 721 21 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGLatvijas filialePhone: +371 67 240 011<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Boehringer Ingelheim Ireland Ltd.Phone: +353 1 295 9620<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Vargatef capsules contain the active substance nintedanib.\u00a0Nintedanib blocks the activity of a group of\u00a0proteins\u00a0involved in the formation of new blood vessels, which cancer cells need to get blood and oxygen.\u00a0By blocking the activity of the\u00a0proteins\u00a0, nintedanib can stop the growth and spread of the cancer tumor.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[19743,19747,19746,27072,27076,27075,19744,27073,19745,27074],"class_list":["post-27048","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-nintedanib","tag-nintedanib-capsule","tag-nintedanib-side-effects","tag-vargatef","tag-vargatef-capsule","tag-vargatef-side-effects","tag-what-is-nintedanib","tag-what-is-vargatef","tag-what-nintedanib-is-used-for","tag-what-vargatef-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27048","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=27048"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27048\/revisions"}],"predecessor-version":[{"id":27253,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/27048\/revisions\/27253"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=27048"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=27048"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=27048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}