{"id":26543,"date":"2022-10-14T14:17:51","date_gmt":"2022-10-14T14:17:51","guid":{"rendered":"https:\/\/zeepedia.com\/?p=26543"},"modified":"2022-10-18T07:43:45","modified_gmt":"2022-10-18T07:43:45","slug":"vancomycin-orion","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vancomycin-orion\/","title":{"rendered":"Vancomycin Orion &#8211; Glycopeptides uses, dose and side effects"},"content":{"rendered":"\n<p>glycopeptides<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Vancomycin Orion is and what it is used for<\/h2>\n\n\n\n<p>Vancomycin is an\u00a0antibiotic\u00a0that belongs to a group of\u00a0antibiotics\u00a0called &#8220;glycopeptides&#8221;.\u00a0Vancomycin works by killing certain bacteria that cause your\u00a0infection.<\/p>\n\n\n\n<p>Vancomycin powder is made into an\u00a0infusion solution.<\/p>\n\n\n\n<p>Vancomycin is used in all age groups as&nbsp;an infusion&nbsp;to treat the following serious infections:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Infection\u00a0in the skin and\u00a0tissue\u00a0under the skin.<\/li><li>Infection\u00a0in bones and joints.<\/li><li>Pneumonia.<\/li><li>Infection\u00a0of the inside of the heart (\u00a0endocarditis\u00a0) and to prevent\u00a0endocarditis\u00a0in patients at risk of\u00a0endocarditis\u00a0when undergoing major surgery.<\/li><li>Central nervous\u00a0system\u00a0infection.<\/li><li>Infection\u00a0in the blood is linked to the\u00a0infections\u00a0listed above.<\/li><\/ul>\n\n\n\n<p>The vancomycin contained in Vancomycin Orion may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Vancomycin Orion<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Vancomycin Orion<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to vancomycin or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Serious\u00a0side effects\u00a0that may lead to loss of vision have been reported following\u00a0the injection\u00a0of vancomycin into the eyes.<\/p>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Vancomycin Orion if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>You have\u00a0<\/strong><strong>signs of increasing skin rash, often\u00a0<\/strong><strong>with\u00a0<\/strong><strong>blisters\u00a0<\/strong><strong>or\u00a0<\/strong><strong>damage to the mucous membranes (Stevens-Johnson syndrome).\u00a0Contact\u00a0<\/strong><strong>your doctor<\/strong>.\u00a0Treatment with vancomycin should be stopped\u00a0immediately.<\/li><li>You have ever had a severe skin rash or scaly skin, blisters, and\/or sores in your mouth after taking vancomycin? Serious skin reactions including\u00a0Stevens-Johnson syndrome,\u00a0toxic epidermal necrolysis, drug reaction with\u00a0eosinophilia\u00a0and systemic symptoms (DRESS), and\u00a0acute\u00a0generalized exanthematous\u00a0pustulosis\u00a0(AGEP) have been reported in association with vancomycin treatment.\u00a0Stop using vancomycin and contact your doctor immediately if you notice any of the symptoms described in section 4.<\/li><li>You have kidney disease (you will need to provide blood and kidney samples during treatment).<\/li><li>You have a hearing impairment, especially if you are elderly (you may need hearing tests during treatment).<\/li><li>You also use medicines that can damage the ears (e.g.\u00a0aminoglycosides, a certain type of\u00a0antibiotic\u00a0).<\/li><li>You have previously suffered from an\u00a0allergic reaction\u00a0to teicoplanin, as this may mean that you are also allergic to vancomycin.<\/li><li>You receive vancomycin by\u00a0infusion\u00a0to treat diarrhea associated with\u00a0Clostridium\u00a0<em>difficile<\/em>\u00a0infection\u00a0instead of by mouth.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse during treatment with Vancomycin Orion if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You receive vancomycin for a long time (you may need to provide blood, liver, and kidney samples during treatment).<\/li><li>You get a skin reaction during the treatment.<\/li><li>If you get severe or prolonged diarrhea during or after using vancomycin;\u00a0contact a doctor immediately.\u00a0This can be a sign of intestinal inflammation (pseudomembranous\u00a0colitis\u00a0) which can occur after treatment with\u00a0antibiotics.\u00a0Do not take any anti-diarrhea medicine without consulting a doctor first.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Vancomycin should be used with particular caution in premature infants and newborns, as their kidneys are not fully developed and they may accumulate vancomycin in the blood.&nbsp;This age group may need to provide blood samples to check the vancomycin levels in the blood.<\/p>\n\n\n\n<p>Concomitant use of vancomycin and&nbsp;anesthetics&nbsp;(numbing agents) has been associated with skin flushing (&nbsp;erythema&nbsp;) and allergic reactions in children.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Vancomycin Orion<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Medicines that can damage the kidneys<\/strong>\u00a0(eg aminoglycoside antibiotics, piperacillin\/tazobactam, iodine contrast agents, non-steroidal anti-inflammatory drugs (\u00a0NSAIDs, eg\u00a0ibuprofen\u00a0) or amphotericin B (antifungal medicine), platinum-based\u00a0chemotherapy\u00a0(cancer medicine), methotrexate at high\u00a0doses, and certain medicines against viral infections such as pentamidine, foscarnet, aciclovir, ganciclovir, famciclovir, valaciclovir, valganciclovir, ciclosporin or tacrolimus).\u00a0If these medicines are given at the same time as vancomycin, the risk of kidney damage may increase and therefore it may be necessary to take blood tests and check kidney function more often.<\/li><li>Medicines that can damage hearing\u00a0(eg\u00a0aminoglycosides, platinum-based\u00a0chemotherapy,\u00a0and some diuretics).\u00a0If these drugs are given at the same time as vancomycin, the harmful effect on hearing may be increased.\u00a0In such cases, a careful and regular check of the hearing function is necessary.<\/li><li>Anesthetics:\u00a0The use of anesthetics increases the risk of certain\u00a0side effects\u00a0of vancomycin such as blood pressure drop, skin redness,\u00a0hives, impaired heart function, and\u00a0itching.<\/li><li><strong>Muscle relaxants<\/strong>\u00a0(eg succinylcholine).\u00a0If these drugs are given at the same time as vancomycin, the effect of the muscle relaxant may be enhanced or prolonged.<\/li><li><strong>Medicines that prevent the blood from clotting<\/strong>\u00a0(eg\u00a0warfarin\u00a0).\u00a0If these drugs are given at the same time as vancomycin, the effect of\u00a0warfarin\u00a0may be increased.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>If you are pregnant, your doctor should only give you vancomycin if necessary after carefully weighing the benefits and risks.\u00a0Vancomycin can affect the ears and kidneys of the fetus.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Vancomycin passes into breast milk and may affect the baby.\u00a0Your doctor should only give you vancomycin if necessary and after carefully weighing the benefits and risks.\u00a0If you receive vancomycin, you should stop breastfeeding.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Vancomycin Orion has no or negligible effect on the ability to drive and use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Vancomycin Orion<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Administration<\/h2>\n\n\n\n<p>You will be given Vancomycin Orion by healthcare professionals while you are in the hospital.\u00a0Your doctor will decide how much of this medicine you should receive each day and how long the treatment should last.<\/p>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>The dose&nbsp;given&nbsp;to you depends on:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>your age,<\/li><li>your weight,<\/li><li>what&nbsp;infection&nbsp;you have,<\/li><li>how well your kidneys are working,<\/li><li>your hearing,<\/li><li>other medicines you take.<\/li><\/ul>\n\n\n\n<p><strong>Intravenous&nbsp;use<\/strong><\/p>\n\n\n\n<p><strong>Adults and adolescents (from 12 years and older)<\/strong><\/p>\n\n\n\n<p>Will one be calculated based on your body weight?\u00a0The usual infusion dose is 15 to 20 mg per kg of body weight.\u00a0It is usually given every 8 to 12 hours.\u00a0In some cases, the doctor may decide to give an initial\u00a0dose\u00a0of up to 30 mg per kg of body weight.\u00a0The maximum daily\u00a0dose\u00a0should not exceed 2 g.<\/p>\n\n\n\n<p><strong>Use in children<\/strong><\/p>\n\n\n\n<p><em>Children from the age of one month to less than 12 years<\/em><\/p>\n\n\n\n<p>Will one be calculated based on your child&#8217;s body weight?\u00a0The usual infusion dose is 10 to 15 mg per kg of body weight.\u00a0It is usually given every 6 hours.<\/p>\n\n\n\n<p><em>Premature\u00a0<\/em><em>and full-term<\/em><em>\u00a0<\/em><em>infants\u00a0<\/em><em>(from 0 to 27 days)<\/em><\/p>\n\n\n\n<p>Will one be calculated based on postmenstrual age (the time between the first day of the last menstrual period and delivery (gestational age) plus the time elapsed after birth (\u00a0postnatal\u00a0age))?<\/p>\n\n\n\n<p>Elderly people, pregnant women, and patients with kidney disease, including those receiving\u00a0dialysis, may need a different\u00a0dose.<\/p>\n\n\n\n<p><strong>Mode of administration<\/strong><\/p>\n\n\n\n<p>Intravenous\u00a0infusion\u00a0means that the medicine flows from an\u00a0infusion bottle\u00a0or bag through a tube into one of your blood vessels and your body.\u00a0The doctor or nurse will always give vancomycin into the blood and not into a muscle.<\/p>\n\n\n\n<p>Vancomycin is given into a vein over at least 60 minutes.<\/p>\n\n\n\n<p><strong>If someone forgets to give you Vancomycin Orion<\/strong><\/p>\n\n\n\n<p>A double\u00a0dose\u00a0should not be given to compensate for a missed\u00a0dose.\u00a0A missed\u00a0dose\u00a0should only be given if there is enough time left until the next regular\u00a0dose.<\/p>\n\n\n\n<p><strong>If treatment with Vancomycin Orion is interrupted or stopped prematurely<\/strong><\/p>\n\n\n\n<p>Too low a\u00a0dosage, irregular\u00a0administration,\u00a0or premature discontinuation of the treatment can affect the results of the treatment or lead to relapse, which is more difficult to treat.\u00a0Follow the doctor&#8217;s instructions.<\/p>\n\n\n\n<p><strong>If you have received too much Vancomycin Orion<\/strong><br>If you have taken too much medicine or if e.g.\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Vancomycin Orion can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Vancomycin can cause allergic\u00a0<\/strong><strong>reactions<\/strong>, although serious allergic reactions (anaphylactic\u00a0shock\u00a0) are rare.\u00a0Contact a doctor\u00a0immediately if you suddenly experience wheezing, difficulty breathing,\u00a0redness\u00a0of the\u00a0upper body,\u00a0skin rash,\u00a0or\u00a0itching<strong>.<\/strong><\/p>\n\n\n\n<p><strong>Stop using vancomycin and contact your doctor immediately if you notice any of the following symptoms:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Red, non-raised, target-like, or round spots on the trunk, often with blisters in the center, scaly skin, and sores in the mouth, throat, nose, genitals, and eyes.\u00a0These severe skin rashes may be preceded by fever and\u00a0flu-like symptoms\u00a0(\u00a0Stevens-Johnson syndrome\u00a0and\u00a0toxic epidermal necrolysis\u00a0).<\/li><li>Widespread rash, fever, and enlarged\u00a0lymph nodes\u00a0(DRESS syndrome or drug hypersensitivity syndrome).<\/li><li>Red, widespread, and scaly rash with nodules under the skin and blisters along with fever that occurs at the beginning of treatment (\u00a0Acute\u00a0generalized exanthematous\u00a0pustulosis\u00a0).<\/li><\/ul>\n\n\n\n<p><em>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drop in blood pressure<\/li><li>Shortness of breath, noisy breathing (a raspy sound that occurs due to obstructed airflow in the upper airways)<\/li><li>Rash and\u00a0inflammation\u00a0of the mucous membrane of the mouth,\u00a0itching, itchy rash,\u00a0hives<\/li><li>Kidney problems that can be seen mainly through blood tests<\/li><li>Redness\u00a0on the upper body and face,\u00a0inflammation\u00a0of a vein<\/li><\/ul>\n\n\n\n<p><em>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Temporary or permanent hearing loss<\/li><\/ul>\n\n\n\n<p><em>Rare&nbsp;side effects&nbsp;(may affect up to 1 in 1,000 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decrease in\u00a0white blood cells,\u00a0red blood cells,\u00a0and\u00a0platelets\u00a0(blood cells responsible for blood clotting)<\/li><li>Increase in certain\u00a0white blood cells\u00a0in the blood<\/li><li>Loss of balance, ringing in the ears, dizziness<\/li><li>Vascular inflammation<\/li><li>Nausea<\/li><li>Inflammation\u00a0of the kidneys and\u00a0kidney failure<\/li><li>Fever, chills<\/li><li>Pain in chest and back muscles<\/li><\/ul>\n\n\n\n<p><em>Very rare&nbsp;side effects&nbsp;(may affect up to 1 in 10,000 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sudden onset severe allergic skin reaction with peeling skin, blisters, or peeling.\u00a0This may be associated with high fever and joint pain<\/li><li>Inflammation\u00a0of the intestine causes abdominal pain and diarrhea, which may contain blood<\/li><li>Cardiac arrest<\/li><\/ul>\n\n\n\n<p><em>Frequency not known (frequency cannot be estimated from available data):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rash with blisters and fever<\/li><li>Vomiting, diarrhea<\/li><li>Confusion, drowsiness, lack of energy, swelling,\u00a0fluid retention, decreased urine<\/li><li>Rash with swelling or pain behind the ears, in the neck, groin, under the chin, and armpits (swollen\u00a0lymph nodes\u00a0), abnormal blood, and liver function tests.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Vancomycin Orion<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p><strong>Store&nbsp;<\/strong><strong>at a maximum of&nbsp;<\/strong><strong>25 \u00b0C.&nbsp;<\/strong>Store the vial in the outer packaging.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Instructions for storage after&nbsp;preparation&nbsp;and dilution are given at the end of this leaflet.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment<\/p>\n\n\n\n<p><strong>Contents of the packaging and other information<\/strong><\/p>\n\n\n\n<p><strong>Contents declaration<\/strong><\/p>\n\n\n\n<p>The active substance is vancomycin hydrochloride.<\/p>\n\n\n\n<p>1\u00a0vial\u00a0of Vancomycin Orion 500 mg powder for concentrate for\u00a0infusion solution, solution,<\/p>\n\n\n\n<p>contains 500 mg vancomycin hydrochloride equivalent to 500,000 IU vancomycin).<\/p>\n\n\n\n<p>1\u00a0vial\u00a0of Vancomycin Orion 1000 mg powder to concentrate for\u00a0infusion solution, solution, contains 1000 mg vancomycin hydrochloride equivalent to 1,000,000 IU vancomycin).<\/p>\n\n\n\n<p>This medicine does not contain any other ingredients.<\/p>\n\n\n\n<p><strong>Appearance and package sizes of the medicine<\/strong><\/p>\n\n\n\n<p>This medicine is a homogeneous, white to light brown freeze-dried powder concentrated into\u00a0an infusion liquid, solution.<\/p>\n\n\n\n<p>Vancomycin Orion is supplied in colorless glass vials closed with a chlorobutyl rubber stopper and sealed with an aluminum plastic flip cap.<\/p>\n\n\n\n<p>Package sizes<\/p>\n\n\n\n<p><em>Vancomycin Orion 500 mg powder for concentrate for\u00a0infusion<\/em>, solution: powder in 10 ml glass bottle, cartons with 1 or 10 vials.<\/p>\n\n\n\n<p><em>Vancomycin Orion 1,000 mg powder for concentrate for\u00a0infusion<\/em>, solution: powder in 20 ml glass bottle, cartons with 1 or 10 injection bottles.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<p><strong>Marketing authorization holder and manufacturer<\/strong><\/p>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Orion Corporation<\/p>\n\n\n\n<p>Orion Indie 1<\/p>\n\n\n\n<p>02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Orion Corporation Orion Pharma<\/p>\n\n\n\n<p>Orion Indie 1<\/p>\n\n\n\n<p>02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vancomycin is an\u00a0antibiotic\u00a0that belongs to a group of\u00a0antibiotics\u00a0called &#8220;glycopeptides&#8221;.\u00a0Vancomycin works by killing certain bacteria that cause your\u00a0infection\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[26991,26997,26989,26998,26992,26994,26990,26993,26995,26996],"class_list":["post-26543","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-benefits-of-glycopeptides","tag-benefits-of-vancomycin-orion","tag-glycopeptides","tag-glycopeptides-side-effects","tag-vancomycin-orion","tag-vancomycin-orion-side-effects","tag-what-glycopeptides-is-used-for","tag-what-is-glycopeptides","tag-what-is-vancomycin-orion","tag-what-vancomycin-orion-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26543","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=26543"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26543\/revisions"}],"predecessor-version":[{"id":27033,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26543\/revisions\/27033"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=26543"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=26543"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=26543"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}