{"id":26534,"date":"2022-10-14T14:08:03","date_gmt":"2022-10-14T14:08:03","guid":{"rendered":"https:\/\/zeepedia.com\/?p=26534"},"modified":"2022-10-18T07:44:13","modified_gmt":"2022-10-18T07:44:13","slug":"valtsu-comp","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/valtsu-comp\/","title":{"rendered":"Valtsu comp &#8211; Valsartan\/hydrochlorothiazide uses, dose and side effects"},"content":{"rendered":"\n<p>80 mg\/12.5 mg, 160 mg\/12.5 mg and 160 mg\/25 mg&nbsp;film-coated tablets<br>valsartan\/hydrochlorothiazide<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Valtsu comp is and what it is used for<\/h2>\n\n\n\n<p>Valtsu comp film-coated tablets contain two active substances, valsartan and\u00a0hydrochlorothiazide.\u00a0Both substances help to control high\u00a0blood pressure\u00a0(\u00a0hypertension\u00a0).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Valsartan<\/strong>\u00a0belongs to a group of drugs called &#8220;angiotensin II receptor blockers&#8221; and is used to lower high\u00a0blood pressure.\u00a0Angiotensin\u00a0II is a substance found in the body that constricts the blood vessels, which increases\u00a0blood pressure\u00a0et.\u00a0Valsartan works by\u00a0inhibiting\u00a0the effect of\u00a0angiotensin\u00a0II.\u00a0This leads to\u00a0vessels\u00a0dilating and\u00a0blood pressure\u00a0falling.<br><\/li><li><strong>Hydrochlorothiazide<\/strong>\u00a0belongs to a group of drugs called thiazide diuretics (also called diuretics).\u00a0Hydrochlorothiazide\u00a0increases urine production, which also lowers\u00a0blood pressure\u00a0et.<\/li><\/ul>\n\n\n\n<p>Valtsu comp is used to treat high&nbsp;blood pressure&nbsp;that cannot be lowered sufficiently with just one of the substances.<\/p>\n\n\n\n<p>High\u00a0blood pressure\u00a0increases the load on the heart and blood\u00a0vessels.\u00a0If left untreated, it can damage the blood vessels in the brain, heart, and kidneys and lead to stroke,\u00a0heart\u00a0failure,\u00a0or\u00a0kidney failure.\u00a0High\u00a0blood pressure\u00a0increases the risk of a heart attack.\u00a0A lowering of\u00a0blood pressure\u00a0et to a normal level reduces the risk of these diseases.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Valtsu comp<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Valtsu comp:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to valsartan,\u00a0hydrochlorothiazide, sulphonamide derivatives (substances chemically related to\u00a0hydrochlorothiazide\u00a0), or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you\u00a0have been pregnant for more than 3 months\u00a0(it is also good to avoid Valtsu comp earlier in pregnancy, see the section &#8220;Pregnancy and breast-feeding&#8221;)<\/li><li>if you have\u00a0severe\u00a0liver disease, destruction of the small bile ducts in the liver (\u00a0biliary cirrhosis\u00a0) leads to bile accumulating in the liver (cholestasis)<\/li><li>if you have\u00a0<strong>severe<\/strong>\u00a0kidney disease<\/li><li>if you cannot produce urine (\u00a0anuria\u00a0)<\/li><li>if you are being treated with an artificial kidney<\/li><li>if your\u00a0potassium\u00a0or sodium level in the blood is lower than normal or if the calcium level in the blood is higher than normal despite treatment<\/li><li>if you have\u00a0gout<\/li><li>if you have\u00a0diabetes\u00a0or impaired kidney function and you are being treated with an antihypertensive medicine containing aliskiren<\/li><\/ul>\n\n\n\n<p><strong>If any of the above apply to you, talk to your doctor, and do not take Valtsu comp.<\/strong><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Valtsu comp<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are taking potassium-sparing medicines, potassium supplements, salt substitutes containing\u00a0potassium,\u00a0or other medicines that increase the amount of\u00a0potassium\u00a0in the blood, for example,\u00a0heparin.\u00a0Your doctor may need to check the amount of\u00a0potassium\u00a0in your blood regularly<\/li><li>if you have low levels of potassium in your blood<\/li><li>if you have diarrhea or severe vomiting<\/li><li>if you take high\u00a0doses\u00a0of water-reducing tablets (\u00a0diuretics\u00a0)<\/li><li>if you have a serious heart condition<\/li><li>if you have\u00a0heart failure\u00a0or have had a heart attack.\u00a0Follow your doctor&#8217;s instructions for the starting dose carefully.\u00a0Your doctor may also check your kidney function<\/li><li>if you have narrowing of the renal arteries<\/li><li>if you have recently had a kidney transplant (received a new kidney)<\/li><li>if you have hyperaldosteronism.\u00a0This is a disease in which your adrenal glands produce too much of\u00a0the\u00a0hormone\u00a0aldosterone.\u00a0If this applies to you, Valtsu comp should not be used<\/li><li>if you have liver or kidney disease<\/li><li>if you have ever experienced swelling of the tongue and face caused by an\u00a0allergic reaction\u00a0called\u00a0angioedema\u00a0while taking another medicine (including\u00a0ACE inhibitors\u00a0), talk to your doctor.\u00a0If these symptoms occur while taking Valtsu comp, stop taking Valtsu comp immediately and never take it again.\u00a0See also section 4, &#8220;Potential side effects&#8221;<\/li><li>if you have a fever, rash, and joint pain, which may be signs of systemic lupus erythematosus (\u00a0SLE, a so-called\u00a0autoimmune\u00a0disease)<\/li><li>if you have\u00a0diabetes,\u00a0gout, high\u00a0cholesterol\u00a0or triglyceride levels in the blood<\/li><li>if you have had an\u00a0allergic reaction\u00a0when using other blood pressure-lowering agents belonging to this drug group (\u00a0angiotensin\u00a0II receptor blockers) or if you have\u00a0allergies\u00a0or\u00a0asthma<\/li><li>if your vision deteriorates or your eyes hurt.\u00a0These may be symptoms of fluid accumulation in the eye (between the choroid and sclera) or increased pressure in the eye and may occur within hours to weeks of taking Valtsu comp.\u00a0It can lead to permanent vision loss if left untreated.\u00a0If you have previously had an\u00a0allergic reaction\u00a0to\u00a0penicillin\u00a0or sulfonamides, the risk of this\u00a0side effect\u00a0may be higher<\/li><li>if you are taking any of the following medicines used to treat high blood pressure:- an\u00a0ACE inhibitor\u00a0(for example\u00a0enalapril, lisinopril, ramipril), especially if you have diabetes-related kidney problems.- the aliskiren<\/li><li>if you have had skin cancer or if you get an unexpected skin change during treatment.\u00a0Treatment with hydrochlorothiazide, especially long-term use at high\u00a0doses, may increase the risk of certain types of skin and lip cancer (non-melanoma\u00a0skin cancer).\u00a0Protect your skin from exposure to sunlight and UV rays while taking Valtsu comp.<\/li><li>if you have previously had breathing or lung problems (including\u00a0inflammation\u00a0or fluid in the lungs) after taking hydrochlorothiazide.\u00a0If you experience severe shortness of breath or severe breathing problems after taking Valtsu comp, seek medical attention immediately.<\/li><\/ul>\n\n\n\n<p>Your doctor may need to check your kidney function,\u00a0blood pressure,\u00a0and the number of\u00a0electrolytes\u00a0(eg\u00a0potassium\u00a0) in your blood at regular intervals.<\/p>\n\n\n\n<p>See also the information under the heading &#8220;Don&#8217;t take Valtsu comp&#8221;.<\/p>\n\n\n\n<p>Valtsu comp can increase the skin&#8217;s sensitivity to the sun.<\/p>\n\n\n\n<p>You must tell your doctor if you think you are (&nbsp;<strong>or may become<\/strong>&nbsp;) pregnant.&nbsp;Valtsu comp is not recommended in early pregnancy and must not be used if you are more than 3 months pregnant, as the medicine may cause birth defects if used at this stage (see section &#8220;Pregnancy and breast-feeding&#8221;)<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Use of Valtsu comp in children and adolescents (younger than 18 years) is not recommended.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Valtsu comp<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>The treatment effect can be affected if Valtsu comp is taken together with certain other medicines.\u00a0It may be necessary to change the\u00a0dose, take other precautions or, in some cases, stop treatment with one of the drugs.\u00a0This applies in particular to the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lithium, a medicine used to treat certain types of mental illness<\/li><li>medicines or substances that can increase the amount of\u00a0potassium\u00a0in the blood.\u00a0These are potassium supplements or, salt substitutes containing\u00a0potassium, potassium-sparing drugs, and\u00a0heparin<\/li><li>medicines that can reduce the amount of\u00a0potassium\u00a0in the blood, e.g.\u00a0diuretics,\u00a0corticosteroids,\u00a0laxatives, ACTH (a\u00a0hormone\u00a0), carbenoxolone, amphotericin,\u00a0penicillin\u00a0G, salicylic acid, and\u00a0derivatives<\/li><li>certain\u00a0antibiotics\u00a0(rifamycin group), a medicine used to protect against transplant rejection (cyclosporin), or an antiretroviral medicine for\u00a0HIV\u00a0\/AIDS\u00a0infection\u00a0(ritonavir).\u00a0These medicines can enhance the effect of Valtsu comp<\/li><li>medicines that can cause &#8220;torsades de pointes&#8221; (irregular heartbeats) such as\u00a0antiarrhythmics\u00a0(medicines for heart problems) and some antipsychotics (for mental illnesses)<\/li><li>medicines that can reduce the amount of\u00a0sodium\u00a0in the blood, e.g.\u00a0antidepressants, antipsychotics, and\u00a0antiepileptics<\/li><li>medicines for\u00a0gout, e.g.\u00a0allopurinol, probenecid, sulfinpyrazone<\/li><li>Vitamin D\u00a0and\u00a0calcium supplements<\/li><li>diabetes medication (oral agents e.g.\u00a0metformin, or\u00a0insulin\u00a0er)<\/li><li>other antihypertensive drugs, including methyldopa,\u00a0ACE inhibitors\u00a0(for example,\u00a0enalapril, lisinopril, ramipril, etc.), or aliskiren (see also the information under the headings &#8220;Do not take Valtsu comp&#8221; and &#8220;Warnings and precautions&#8221;)<\/li><li>medicines that raise\u00a0blood pressure, etc., e.g.\u00a0norepinephrine\u00a0or\u00a0adrenaline<\/li><li>digoxin\u00a0or other\u00a0digitalis glycosides\u00a0(medicines to treat heart problems)<\/li><li>medicines that can raise blood sugar, e.g.\u00a0diazoxide or\u00a0beta-blockers<\/li><li>cytostatics\u00a0(drugs against cancer), e.g.\u00a0methotrexate or cyclophosphamide<\/li><li>pain relievers, e.g.\u00a0non-steroidal anti-inflammatory agents (\u00a0NSAID\u00a0), which include e.g.\u00a0selective\u00a0cyclooxygenase\u00a02 inhibitors (Cox 2 inhibitors) and\u00a0aspirin in\u00a0doses\u00a0higher\u00a0than 3 grams per day<\/li><li>muscle relaxants, e.g.\u00a0tubocurarine<\/li><li>anticholinergic drugs (used to treat several different diseases, e.g. spasmodic pain in the gastrointestinal tract, bladder spasm,\u00a0asthma, motion sickness, muscle spasms, and\u00a0Parkinson&#8217;s disease, as well as to facilitate\u00a0anesthesia), such as atropine or biperiden<\/li><li>amantadine (used in\u00a0Parkinson&#8217;s disease\u00a0and also to treat or prevent certain diseases caused by viruses)<\/li><li>cholestyramine and colestipol (medicines used for high blood lipid levels)<\/li><li>ciclosporin, a medicine used in organ transplants to prevent rejection<\/li><li>alcohol, sleeping pills, and\u00a0anesthetics\u00a0(drugs with a sleep-inducing or anesthetic effect, such as those used in operations)<\/li><li>iodine contrast agent (used in imaging)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Valtsu comp with food, drink, and alcohol<\/h2>\n\n\n\n<p>You can take Valtsu comp with or without food.<br>Avoid drinking alcohol until you have spoken to your doctor.&nbsp;Alcohol can lower&nbsp;blood pressure&nbsp;further and\/or increase the risk of you becoming dizzy or fainting.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>You must talk to your doctor if you think you are (or may become) pregnant.&nbsp;<\/strong>Usually, your doctor will suggest that you stop taking Valtsu comp before pregnancy or as soon as you know you are pregnant and will recommend another medicine for you instead.&nbsp;Valtsu comp should not be used in early pregnancy and should not be used during the last 6 months of pregnancy as it can cause serious birth defects.<\/li><\/ul>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor if you are breastfeeding<\/strong> or intend to start breastfeeding.<br>Valtsu comp is not recommended during breastfeeding and your doctor may choose another treatment for you if you wish to breastfeed your baby, especially if your baby is a newborn or was born prematurely.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Before you drive a vehicle, use tools or machines, or perform activities that require concentration, make sure you know how Valtsu comp affects you.\u00a0Like many other medicines for the treatment of high\u00a0blood pressure, Valtsu comp can rarely cause dizziness and affect the ability to concentrate.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Valtsu comp contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per tablet, i.e. it is almost &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Valtsu comp<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor, so that you get the best results and reduce the risk of\u00a0side effects.\u00a0Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>People with high&nbsp;blood pressure&nbsp;often do not experience any symptoms of this.&nbsp;Many feel as usual.&nbsp;It is therefore important that you go to your doctor&#8217;s appointments as planned, even if you feel well.<\/p>\n\n\n\n<p>Your doctor will tell you how many Valtsu comp tablets to take.\u00a0Depending on the treatment result, the doctor can raise or lower the\u00a0dose.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended\u00a0dose\u00a0of Valtsu comp is one tablet per day.<\/li><li>Do not change the\u00a0dose\u00a0or stop the treatment without consulting the doctor.<\/li><li>The medicine should be taken at the same time every day, usually in the morning.<\/li><li>You can take Valtsu comp regardless of a meal.<\/li><li>Swallow Valtsu comp with a glass of water.<\/li><li>The 160 mg\/25 mg tablet can be divided into two equal\u00a0doses.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Valtsu comp<\/h2>\n\n\n\n<p>If you experience severe dizziness and\/or fainting, seek medical attention immediately and lie down.<\/p>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has accidentally ingested the medicine, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Valtsu comp<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose, take it as soon as you remember.\u00a0If it is almost time for the next\u00a0dose, then skip the missed\u00a0dose.<br>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Valtsu comp<\/h2>\n\n\n\n<p>If you stop your treatment with Valtsu comp, your high&nbsp;blood pressure&nbsp;may get worse.&nbsp;Do not stop taking your medicine unless your doctor tells you to stop.<\/p>\n\n\n\n<p><strong>If you have further questions about this medicine, contact your doctor or pharmacist.<\/strong><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;can be serious and require immediate medical attention:<\/strong><\/p>\n\n\n\n<p>You should contact your doctor immediately if you experience symptoms of\u00a0angioedema, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swollen face, tongue, or throat<\/li><li>difficulty swallowing<\/li><li>hives, difficulty breathing<\/li><li>serious skin disease causing rash,\u00a0reddened\u00a0skin, blisters on lips, eyes, or mouth, scaly skin, fever (\u00a0toxic epidermal necrolysis\u00a0)<\/li><li>impaired vision or pain in the eyes due to high pressure (may be a sign of fluid accumulation in the eye (between the choroid and sclera) or\u00a0acute\u00a0narrow-angle glaucoma\u00a0)<\/li><li>fever, sore throat, or frequent\u00a0infections\u00a0(\u00a0agranulocytosis\u00a0)<\/li><li>acute\u00a0respiratory distress syndrome (signs of this are severe shortness of breath, fever, weakness, and confusion) (frequency: very rare).<\/li><\/ul>\n\n\n\n<p>These&nbsp;side effects&nbsp;are very rare or occur in an unknown number of users.<\/p>\n\n\n\n<p><strong>If you experience any of these symptoms, stop taking Valtsu comp and contact your doctor immediately (see also section 2 &#8220;Warnings and precautions&#8221;).<\/strong><\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are:<\/strong><\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cough<\/li><li>low\u00a0blood pressure<\/li><li>dizziness<\/li><li>dehydration (with symptoms such as thirst, dry mouth, and tongue, decreased urination, dark-colored urine, and dry skin)<\/li><li>pain in the muscles<\/li><li>fatigue<\/li><li>tingling and numbness<\/li><li>blurred vision<\/li><li>roaring and buzzing in the ears<\/li><\/ul>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness<\/li><li>diarrhea<\/li><li>pain in the joints<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty breathing<\/li><li>significantly reduced urine output<\/li><li>low sodium levels in the blood (can trigger tiredness, confusion, muscle twitching, and\/or seizures in severe cases)<\/li><li>low level of potassium in the blood (sometimes associated with muscle weakness, muscle cramps, and abnormal heart rhythm)<\/li><li>low level of\u00a0white blood cells\u00a0in the blood (with symptoms such as fever, skin infections, sore throat or mouth ulcers due to\u00a0infection, weakness)<\/li><li>increased level of bilirubin in the blood (which in severe cases can cause yellow skin and yellow eyes)<\/li><li>increased values \u200b\u200bof urea nitrogen and\u00a0creatinine\u00a0in the blood (which may indicate impaired kidney function)<\/li><li>the increased uric acid level in the blood (which in severe cases can trigger\u00a0gout\u00a0)<\/li><li>syncope\u00a0(fainting)<\/li><\/ul>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;have been reported for products containing valsartan or hydrochlorothiazide:<\/strong><\/p>\n\n\n\n<p><strong>Valsartan<\/strong><\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sensation of spinning<\/li><li>pain in the abdomen<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blistering of the skin (a sign of bullous\u00a0dermatitis\u00a0)<\/li><li>skin rash with or without\u00a0itching\u00a0along with any of the following symptoms: fever, joint pain, muscle pain, swollen\u00a0lymph nodes,\u00a0and\/or\u00a0flu-like symptoms<\/li><li>rash, purple-red spots, fever,\u00a0itching\u00a0(symptoms of\u00a0inflammation\u00a0of the blood vessels)<\/li><li>low\u00a0platelet counts\u00a0(sometimes with unusual bleeding or bruising)<\/li><li>high level of potassium in the blood (sometimes with muscle cramps, abnormal heart rhythm)<\/li><li>allergic reactions (with symptoms such as rash,\u00a0itching, hives, difficulty breathing or difficulty swallowing, and dizziness)<\/li><li>swelling especially in the face and throat, rash,\u00a0itching<\/li><li>elevated liver function values<\/li><li>reduced hemoglobin value and reduced proportion of\u00a0red blood cells\u00a0in the blood (\u00a0both can cause\u00a0anemia in\u00a0severe\u00a0cases )<\/li><li>kidney failure<\/li><li>low level of sodium in the blood (sometimes associated with nausea, tiredness, confusion, feeling unwell, and convulsions)<\/li><\/ul>\n\n\n\n<p><strong>Hydrochlorothiazide<\/strong><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 in 10 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low level of potassium in the blood<\/li><li>increased lipid content in the blood<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low blood sodium<\/li><li>low level of magnesium in the blood<\/li><li>high levels of uric acid in the blood<\/li><li>itchy rashes and other types of rashes<\/li><li>loss of appetite<\/li><li>slight nausea and vomiting<\/li><li>dizziness, fainting when standing up<\/li><li>inability to get and maintain an&nbsp;erection<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling and blistering of the skin (due to increased sensitivity to the sun)<\/li><li>high blood calcium levels<\/li><li>high blood sugar<\/li><li>sugar in the urine<\/li><li>impaired metabolic status in\u00a0diabetes<\/li><li>constipation, diarrhea, stomach, and intestinal discomfort, liver disorders (which may appear as yellow skin and yellow eyes)<\/li><li>irregular heartbeats<\/li><li>headache<\/li><li>sleep disorders<\/li><li>low mood (depression)<\/li><li>low\u00a0platelet counts\u00a0(sometimes with bleeding or bruising under the skin)<\/li><li>dizziness<\/li><li>tingling and numbness<\/li><li>visual disturbances<\/li><\/ul>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation\u00a0of the blood vessels with symptoms such as rash, red-purple-red spots, fever (\u00a0vasculitis\u00a0)<\/li><li>rash,\u00a0itching,\u00a0hives, trouble breathing or swallowing, dizziness (\u00a0hypersensitivity reaction\u00a0)<\/li><li>rash on the face, pain in the joints<\/li><li>muscle disease<\/li><li>fever (lupus erythematosus)<\/li><li>severe pain in the upper part of the stomach;\u00a0(\u00a0pancreatitis\u00a0)<\/li><li>breathing difficulties with fever, cough, wheezing\/wheezing, and shortness of breath (\u00a0respiratory\u00a0distress with\u00a0pneumonitis\u00a0and\u00a0pulmonary edema\u00a0)<\/li><li>pale skin, tiredness, shortness of breath, dark urine (\u00a0hemolytic anemia\u00a0)<\/li><li>fever, sore throat, or mouth ulcers due to\u00a0infection\u00a0(\u00a0leukopenia\u00a0)<\/li><li>confusion, fatigue, muscle twitching and\u00a0spasms, rapid breathing (hypochloraemic\u00a0alkalosis\u00a0)<\/li><li>lack of or low levels of various\u00a0blood\u00a0cells<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>weakness, bruising and frequent\u00a0infections\u00a0(\u00a0aplastic anemia\u00a0)<\/li><li>drastically reduced urine output (may be a sign of kidney disease or\u00a0kidney failure\u00a0)<\/li><li>rash,\u00a0reddened\u00a0skin, blisters on the lips, eyes, or mouth, scaly skin, fever (may be signs of erythema multiforme)<\/li><li>muscle cramps<\/li><li>fever (\u00a0pyrexia\u00a0)<\/li><li>weakness (\u00a0asthenia\u00a0)<\/li><li>skin and lip cancer (non-melanoma\u00a0skin cancer)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Valtsu comp<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br>Use before the expiry date which is stated on the carton, can, or blister pack after EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><em>Cans<\/em><\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p><em>Blister packs:<\/em><br>Store at a maximum of 30 \u00b0C<br>Store in the original packaging.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Do not use this medicine if the packaging is damaged or shows signs of tampering.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substances are valsartan and\u00a0hydrochlorothiazide.<br>Valtsu comp 80 mg\/12.5 mg: each tablet contains 80 mg valsartan and 12.5 mg\u00a0hydrochlorothiazide\u00a0.<br>Valtsu comp 160 mg\/12.5 mg: each tablet contains 160 mg valsartan and 12.5 mg\u00a0hydrochlorothiazide\u00a0.<\/p>\n\n\n\n<p>Valtsu comp 160 mg\/25 mg: each tablet contains 160 mg valsartan and 25 mg&nbsp;hydrochlorothiazide&nbsp;.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p><em>Tablet core:<\/em><br>Microcrystalline cellulose, croscarmellose sodium, povidone (K-30), magnesium stearate<\/p>\n\n\n\n<p><em>Film coating:<\/em><\/p>\n\n\n\n<p>80 mg\/12.5 mg: polyvinyl alcohol (partially hydrolyzed), macrogol, talc, titanium dioxide (E171), red iron oxide (E172), yellow iron oxide (E172), black iron oxide (E172)<\/p>\n\n\n\n<p>160 mg\/12.5 mg: polyvinyl alcohol (partially hydrolyzed), macrogol, talc, titanium dioxide (E171), red iron oxide (E172), yellow iron oxide (E172)<\/p>\n\n\n\n<p>160 mg\/25 mg: polyvinyl alcohol (partially hydrolyzed), macrogol, talc, titanium dioxide (E171), red iron oxide (E172), yellow iron oxide (E172), black iron oxide (E172)<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Valtsu comp 80 mg\/12.5 mg is a light orange, oval film-coated tablet (size approx. 5.3 x 10.2 mm).<\/p>\n\n\n\n<p>Valtsu comp 160 mg\/12.5 mg is a dark red, oval film-coated tablet (size approx. 6.1 x 15.2 mm).<\/p>\n\n\n\n<p>Valtsu comp 160 mg\/25 mg is a brown, oval film-coated tablet, scored on one side (size approx. 5.6 x 14.2 mm).\u00a0The tablet can be divided into two equal\u00a0doses.<\/p>\n\n\n\n<p><em>Blisters:<\/em><\/p>\n\n\n\n<p>Packs of 14, 20, 28, 30, 56, 60, 98, 100 film-coated tablets.<\/p>\n\n\n\n<p><em>Cans:<\/em><\/p>\n\n\n\n<p>100, 500 film-coated tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>HBM Pharma sro, Sklabinska 30, 03680 Martin, Slovakia<\/p>\n\n\n\n<p>Merckle GmbH, Ludwig-Merckle-Str.&nbsp;3, Weiler, 89143 Blaubeuren, Germany<\/p>\n\n\n\n<p>Teva Pharmaceutical Works, 13 Pallagi Street, 4042 Debrecen, Hungary<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Valtsu comp film-coated tablets contain two active substances, valsartan and\u00a0hydrochlorothiazide\u00a0.\u00a0Both substances help to control high\u00a0blood pressure\u00a0(\u00a0hypertension\u00a0).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[3664,4301,4124,5514,27028,27030,7947,4300,4125,27027,10570,27029],"class_list":["post-26534","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-hydrochlorothiazide","tag-hydrochlorothiazide-tablet","tag-valsartan","tag-valsartan-tablet","tag-valtsu-comp","tag-valtsu-comp-tablet","tag-what-hydrochlorothiazide-is-used-for","tag-what-is-hydrochlorothiazide","tag-what-is-valsartan","tag-what-is-valtsu-comp","tag-what-valsartan-is-used-for","tag-what-valtsu-comp-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=26534"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26534\/revisions"}],"predecessor-version":[{"id":27038,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26534\/revisions\/27038"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=26534"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=26534"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=26534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}