{"id":26407,"date":"2022-10-13T09:20:53","date_gmt":"2022-10-13T09:20:53","guid":{"rendered":"https:\/\/zeepedia.com\/?p=26407"},"modified":"2022-10-14T12:18:50","modified_gmt":"2022-10-14T12:18:50","slug":"valsartan-hydrochlorothiazide-krka","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/valsartan-hydrochlorothiazide-krka\/","title":{"rendered":"Vfalsartan\/Hydrochlorothiazide Krka &#8211; Hydrochlorothiazide uses, dose and side effects"},"content":{"rendered":"\n<p>80 mg\/12.5 mg, 160 mg\/12.5 mg, 160 mg\/25 mg, 320 mg\/12.5 mg and 320 mg\/25 mg&nbsp;film-coated tablets<br>valsartan \/&nbsp;hydrochlorothiazide<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Valsartan\/Hydrochlorothiazide Krka is and what it is used for<\/h2>\n\n\n\n<p>Valsartan\/Hydrochlorothiazide Krka film-coated tablets contain two active substances, valsartan and\u00a0hydrochlorothiazide\u00a0.\u00a0Both substances help control high\u00a0blood pressure.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Valsartan<\/strong>\u00a0belongs to a group of drugs called &#8220;angiotensin-II receptor blockers&#8221; and is used to lower high\u00a0blood pressure.\u00a0Angiotensin\u00a0II is a substance found in the body that constricts the blood vessels, which increases\u00a0blood pressure\u00a0et.\u00a0Valsartan works by\u00a0inhibiting\u00a0the effect of\u00a0angiotensin\u00a0II.\u00a0This leads to\u00a0vessels\u00a0dilating and\u00a0blood pressure\u00a0falling.<\/li><li>Hydrochlorothiazide\u00a0belongs to a group of drugs called thiazide diuretics (also called diuretics).\u00a0Hydrochlorothiazide\u00a0increases urine production, which also lowers\u00a0blood pressure, etc.<\/li><\/ul>\n\n\n\n<p>Valsartan\/Hydrochlorothiazide Krka is used to treat high&nbsp;blood pressure&nbsp;that cannot be lowered sufficiently with just one of the substances.<\/p>\n\n\n\n<p>High\u00a0blood pressure\u00a0increases the load on the heart and blood\u00a0vessels.\u00a0If left untreated, it can damage the blood vessels in the brain, heart, and kidneys, and lead to stroke,\u00a0heart\u00a0failure,\u00a0or\u00a0kidney failure.\u00a0High\u00a0blood pressure\u00a0increases the risk of a heart attack.\u00a0A lowering of\u00a0blood pressure\u00a0et to a normal level reduces the risk of these diseases.<\/p>\n\n\n\n<p>Valsartan and\u00a0hydrochlorothiazide\u00a0contained in Valsartan\/Hydrochlorothiazide Krka may also be approved to treat other conditions not mentioned in this leaflet.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Valsartan\/Hydrochlorothiazide Krka<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Valsartan\/Hydrochlorothiazide Krka<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to valsartan,\u00a0hydrochlorothiazide, sulfonamide derivatives (substances chemically related to\u00a0hydrochlorothiazide\u00a0), or any other ingredient in this medicine (listed in section 6).<\/li><li>during the last 6 months of pregnancy\u00a0(even earlier during pregnancy it is good to avoid Valsartan\/Hydrochlorothiazide Krka, see section &#8220;Pregnancy and breast-feeding&#8221;).<\/li><li>if you have\u00a0severe\u00a0liver disease;\u00a0the destruction of the small bile ducts in the liver (\u00a0biliary cirrhosis\u00a0) leads to a build-up of bile in the liver (cholestasis).<\/li><li>if you have\u00a0severe\u00a0kidney disease<\/li><li>if you cannot produce urine (anuria).<\/li><li>if you are being treated with an artificial kidney.<\/li><li>if your\u00a0potassium\u00a0or sodium level in the blood is lower than normal or if the calcium level in the blood is higher than normal despite treatment.<\/li><li>if you have\u00a0gout.<\/li><li>if you have\u00a0diabetes\u00a0or impaired kidney function and are being treated with an antihypertensive medicine containing aliskiren.<\/li><\/ul>\n\n\n\n<p><strong>If any of the above applies to you, you should not take this medicine.&nbsp;Talk to your doctor.<\/strong><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Valsartan\/Hydrochlorothiazide Krka:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are taking potassium-sparing medicines, potassium supplements, salt substitutes containing\u00a0potassium,\u00a0or other medicines that increase the amount of\u00a0potassium\u00a0in the blood, for example,\u00a0heparin.\u00a0Your doctor may need to check the amount of\u00a0potassium\u00a0in your blood regularly.<\/li><li>if you have low levels of potassium in your blood.<\/li><li>if you have diarrhea or severe vomiting.<\/li><li>if you take high\u00a0doses\u00a0of water-reducing tablets (\u00a0diuretics\u00a0).<\/li><li>if you have a serious heart condition.<\/li><li>if you have\u00a0heart failure\u00a0or have had a heart attack.\u00a0Follow your doctor&#8217;s instructions for the starting dose carefully.\u00a0Your doctor may also check your kidney function.<\/li><li>if you have a narrowing of the renal arteries.<\/li><li>if you have recently had a kidney transplant (received a new kidney).<\/li><li>if you have hyperaldosteronism.\u00a0This is a disease in which your adrenal glands produce too much of\u00a0the\u00a0hormone\u00a0aldosterone.\u00a0If this applies to you, Valsartan\/Hydrochlorothiazide Krka should not be used.<\/li><li>if you have liver or kidney disease.<\/li><li>if you have ever experienced swelling of the tongue and face caused by an\u00a0allergic reaction\u00a0called\u00a0angioedema\u00a0while taking another medicine (including\u00a0ACE inhibitors\u00a0), talk to your doctor.\u00a0If these symptoms occur while taking Valsartan\/Hydrochlorothiazide Krka, stop taking Valsartan\/Hydrochlorothiazide Krka immediately and never take it again.\u00a0See also section 4, &#8220;Possible side effects&#8221;.<\/li><li>if you have a fever, rash, and joint pain, which may be signs of systemic lupus erythematosus (\u00a0SLE, a so-called\u00a0autoimmune\u00a0disease).<\/li><li>if you have\u00a0diabetes,\u00a0gout, high cholesterol levels, or high blood lipids.<\/li><li>if you have had an\u00a0allergic reaction\u00a0when using other blood pressure-lowering agents belonging to this drug group (\u00a0angiotensin\u00a0II receptor blockers) or if you have\u00a0allergies\u00a0or\u00a0asthma.<\/li><li>if you experience impaired vision or eye pain.\u00a0These may be symptoms of fluid accumulation in the eye (between the choroid and sclera) or an increase in pressure in the eye and may occur within hours to weeks of taking Valsartan\/Hydrochlorothiazide Krka.\u00a0This can lead to permanent vision loss if left untreated.\u00a0If you have previously had a\u00a0penicillin\u00a0or sulfonamide allergy, you may be at greater risk of developing this.<\/li><li>it can increase the skin&#8217;s sensitivity to the sun.<\/li><li>if you have had skin cancer or if you get an unexpected skin change during treatment.\u00a0Treatment with\u00a0hydrochlorothiazide, especially long-term use at high\u00a0doses, may increase the risk of certain types of skin and lip cancer (non-melanoma\u00a0skin cancer).\u00a0Protect your skin from exposure to sunlight and UV rays while using Valsartan\/Hydrochlorothiazide Krka.<\/li><li>if you have previously had breathing or lung problems (including\u00a0inflammation\u00a0or fluid in the lungs) after taking\u00a0hydrochlorothiazide.\u00a0If you experience severe shortness of breath or severe breathing problems after taking Valsartan\/Hydrochlorothiazide Krka, seek medical attention immediately.<\/li><li>if you are taking any of the following medicines used to treat high blood pressure:<ul><li>an\u00a0ACE inhibitor\u00a0(eg\u00a0enalapril, lisinopril, ramipril), especially if you have diabetes-related kidney problems.<\/li><li>the aliskiren<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Your doctor may need to check your kidney function,\u00a0blood pressure,\u00a0and the number of\u00a0electrolytes\u00a0(eg\u00a0potassium\u00a0) in your blood at regular intervals.<\/p>\n\n\n\n<p>See also the information under the heading &#8220;Do not take Valsartan\/Hydrochlorothiazide Krka&#8221;.<\/p>\n\n\n\n<p><strong>If any of these apply to you, talk to your doctor.<\/strong><\/p>\n\n\n\n<p>If you think you are pregnant or become pregnant during treatment, contact your doctor.<\/p>\n\n\n\n<p>Valsartan\/Hydrochlorothiazide Krka is not recommended during pregnancy and should not be used during the last 6 months of pregnancy as it may then cause birth defects (see &#8220;Pregnancy and breast-feeding&#8221;).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Use of Valsartan\/Hydrochlorothiazide Krka in children or adolescents (younger than 18 years) is not recommended.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Valsartan\/Hydrochlorothiazide Krka<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>The treatment effect can be affected if Valsartan\/Hydrochlorothiazide Krka is taken together with certain other medicines.\u00a0It may be necessary to change the\u00a0dose, take other precautions or, in some cases, stop treatment with one of the drugs.\u00a0This applies in particular to the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lithium, a medicine used to treat certain types of mental illness<\/li><li>medicines or substances that can increase the amount of\u00a0potassium\u00a0in the blood.\u00a0These include potassium supplements or salt substitutes containing\u00a0potassium, potassium-sparing drugs, and\u00a0heparin<\/li><li>medicines that can reduce the amount of\u00a0potassium\u00a0in the blood, e.g.\u00a0diuretics\u00a0(water tablets),\u00a0corticosteroids,\u00a0laxatives, carbenoxolone, amphotericin, or\u00a0penicillin\u00a0G<\/li><li>certain\u00a0antibiotics\u00a0(rifamycin group), a medicine used to protect against transplant rejection (ciclosporin), or an antiretroviral medicine for\u00a0HIV\u00a0\/AIDS\u00a0infection\u00a0(ritonavir).\u00a0These medicines can increase the effect of Valsartan\/Hydrochlorothiazide Krka<\/li><li>medicines that can cause &#8220;torsades de pointes&#8221; (irregular heart rhythm), e.g.\u00a0antiarrhythmics\u00a0(medicines used to treat heart problems) and some antipsychotics<\/li><li>medicines that can reduce the amount of\u00a0sodium\u00a0in the blood, e.g.\u00a0antidepressants, antipsychotics,\u00a0antiepileptics<\/li><li>medicines for\u00a0gout, e.g.\u00a0allopurinol, probenecid, sulfinpyrazone<\/li><li>therapeutic\u00a0vitamin D\u00a0and calcium supplements\u00a0<\/li><li>diabetes medications (oral agents, eg\u00a0metformin\u00a0or\u00a0insulin\u00a0er)<\/li><li>other antihypertensive drugs including methyldopa<\/li><li>medicines to increase\u00a0blood pressure\u00a0et, e.g.\u00a0norepinephrine\u00a0or\u00a0adrenaline<\/li><li>digoxin\u00a0or other\u00a0digitalis glycosides\u00a0(medicines used to treat heart problems)<\/li><li>medicines that increase blood sugar, e.g.\u00a0diazoxide or\u00a0beta-blockers<\/li><li>cytotoxic drugs (used to treat cancer), e.g.\u00a0methotrexate or cyclophosphamide<\/li><li>pain relievers such as non-steroidal anti-inflammatory drugs (\u00a0NSAIDs\u00a0), including selective\u00a0cyclooxygenase\u00a02 inhibitors (COX 2 inhibitors) and\u00a0aspirin\u00a0more than 3 grams<\/li><li>muscle relaxants, e.g.\u00a0tubocurarine<\/li><li>anticholinergic drugs (agents for the treatment of a variety of disorders, such as gastrointestinal spasms, bladder spasms,\u00a0asthma, motion sickness, muscle spasms,\u00a0Parkinson&#8217;s disease,\u00a0and as an aid to\u00a0anesthesia\u00a0)<\/li><li>amantadine (an agent used to treat\u00a0Parkinson&#8217;s disease\u00a0and also to treat or prevent certain diseases caused by\u00a0viruses\u00a0)<\/li><li>cholestyramine and colestipol (medicines usually used for high levels of\u00a0lipids\u00a0(fats) in the blood)<\/li><li>ciclosporin, a medicine used in organ transplants to prevent rejection<\/li><li>alcohol, sleeping pills, and anesthetics (drugs with a sleeping or pain-relieving effect used, for example, during surgery)<\/li><li>iodinated contrast agent (agent used in imaging studies)<\/li><li>if you are taking an\u00a0ACE inhibitor\u00a0or aliskiren (see also the information under the headings &#8220;Do not take Valsartan\/Hydrochlorothiazide Krka&#8221; and &#8220;Warnings and precautions&#8221;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Valsartan\/Hydrochlorothiazide Krka with food, drink, and alcohol<\/h2>\n\n\n\n<p>You can take Valsartan\/Hydrochlorothiazide Krka regardless of meals.<\/p>\n\n\n\n<p>Avoid drinking alcohol until you have spoken to your doctor.&nbsp;Alcohol can lower&nbsp;blood pressure&nbsp;further and\/or increase the risk of you becoming dizzy or fainting.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Consult a doctor or pharmacist before using this medicine.<\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>If you think you are pregnant or become pregnant during treatment, contact your doctor.<\/p>\n\n\n\n<p>Your doctor will usually suggest that you stop taking Valsartan\/Hydrochlorothiazide Krka before pregnancy or as soon as you know you are pregnant and will recommend another medicine for you instead.&nbsp;Valsartan\/Hydrochlorothiazide Krka should not be used in early pregnancy and should not be used during the last 6 months of pregnancy as it may cause birth defects.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Tell your doctor if you are breastfeeding or intend to start breastfeeding.<\/p>\n\n\n\n<p>Valsartan\/Hydrochlorothiazide Krka is not recommended during breastfeeding and your doctor may choose a different treatment for you if you wish to breastfeed your baby, especially if your baby is a newborn or was born prematurely.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Before you drive, use tools or machines or perform activities that require concentration, make sure you know how Valsartan\/Hydrochlorothiazide Krka affects you.\u00a0Like many other medicines for the treatment of high\u00a0blood pressure, Valsartan\/Hydrochlorothiazide Krka can rarely cause dizziness and affect concentration.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Valsartan\/Hydrochlorothiazide Krka contains&nbsp;lactose<\/strong>&nbsp;<strong>and&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, you should contact your doctor before taking this medicine.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e.&nbsp;is next to &#8220;sodium-free&#8221;.<a><\/a><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Valsartan\/Hydrochlorothiazide Krka<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.\u00a0It will give the best result and reduce the risk of\u00a0side effects.\u00a0Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>People with high&nbsp;blood pressure&nbsp;often do not experience any symptoms of this.&nbsp;Many feel as usual.&nbsp;It is therefore important that you go to your doctor&#8217;s appointments as planned, even if you feel well.<\/p>\n\n\n\n<p>Your doctor will tell you how many Valsartan\/Hydrochlorothiazide Krka tablets to take.\u00a0Depending on the treatment result, the doctor can raise or lower the\u00a0dose.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual&nbsp;dose&nbsp;of Valsartan\/Hydrochlorothiazide Krka is one tablet per day<\/li><li>Do not change the&nbsp;dose&nbsp;or stop treatment without consulting a doctor<\/li><li>The medicine should be taken at the same time every day, usually in the morning<\/li><li>You can take Valsartan\/Hydrochlorothiazide Krka regardless of meals<\/li><li>Swallow the tablet with a glass of water<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Valsartan\/Hydrochlorothiazide Krka&nbsp;<\/h2>\n\n\n\n<p>If you experience severe dizziness and\/or fainting, lie down and contact a doctor immediately.<\/p>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the drug by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Valsartan\/Hydrochlorothiazide Krka<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose, take it as soon as you remember.\u00a0If it is almost time for the next\u00a0dose, then skip the missed\u00a0dose.<\/p>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a missed tablet.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Valsartan\/Hydrochlorothiazide Krka<\/h2>\n\n\n\n<p>If you stop your treatment with Valsartan\/Hydrochlorothiazide Krka, your high&nbsp;blood pressure&nbsp;may get worse.&nbsp;Do not stop taking your medicine unless your doctor tells you to stop.<\/p>\n\n\n\n<p><strong>If you have further questions about this medicine, contact your doctor or pharmacist.<\/strong><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, but not everybody gets them.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;can be serious and require immediate medical attention:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Contact a doctor immediately if you experience symptoms of\u00a0angioedema, such as:<ul><li>swollen face, tongue, or throat<\/li><li>difficulty swallowing<\/li><li>hives\u00a0and difficulty breathing<\/li><\/ul><\/li><li>Severe skin disease causing rash,\u00a0redness, blisters on the lips, eyes, or mouth, peeling, fever (\u00a0toxic epidermal necrolysis\u00a0)<\/li><li>Decreased vision or pain in the eyes due to high pressure (possible sign of fluid accumulation in the eye (between the choroid and the sclera) or\u00a0acute\u00a0narrow-angle glaucoma\u00a0)<\/li><li>Fever, sore throat, more frequent\u00a0infections\u00a0(\u00a0agranulocytosis\u00a0)<\/li><li>Acute\u00a0respiratory distress syndrome (signs of this are severe shortness of breath, fever, weakness, and confusion)<\/li><\/ul>\n\n\n\n<p>These&nbsp;side effects&nbsp;are very rare or occur in an unknown number of users.<\/p>\n\n\n\n<p><strong>If you get any of these symptoms, stop taking Valsartan\/Hydrochlorothiazide Krka and contact your doctor immediately (see section 2 \u201cWarnings and precautions\u201d).<\/strong><\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;include:<\/strong><\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cough<\/li><li>low\u00a0blood pressure<\/li><li>dizzy<\/li><li>dehydration (with symptoms such as thirst, dry mouth, and tongue, rarely needing to empty the bladder, dark-colored urine, and dry skin)<\/li><li>pain in the muscles<\/li><li>fatigue<\/li><li>tingling and numbness<\/li><li>blurred vision<\/li><li>buzzing or buzzing in the ears<\/li><\/ul>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness<\/li><li>diarrhea<\/li><li>pain in the joints<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty breathing<\/li><li>significantly reduced urine output<\/li><li>low blood sodium (which can trigger tiredness, confusion, muscle twitching, and\/or seizures in severe cases)<\/li><li>low level of potassium in the blood (sometimes with muscle weakness, muscle cramps, and abnormal heart rhythm)<\/li><li>low level of\u00a0white blood cells\u00a0in the blood (with symptoms such as fever, skin infections, sore throat or mouth ulcers due to\u00a0infection, weakness)<\/li><li>increased level of bilirubin in the blood (which in severe cases can cause yellow skin and yellow eyes)<\/li><li>increased values \u200b\u200bof urea nitrogen and\u00a0creatinine\u00a0in the blood (which may indicate impaired kidney function)<\/li><li>the increased uric acid level in the blood (which in severe cases can trigger\u00a0gout\u00a0)<\/li><li>syncope\u00a0(fainting)<\/li><\/ul>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;have been reported for products containing valsartan or hydrochlorothiazide:<\/strong><\/p>\n\n\n\n<p><strong>Valsartan<\/strong><\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sensation of spinning<\/li><li>pain in the abdomen<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>skin rash with or without\u00a0itching\u00a0along with any of the following symptoms: fever, joint pain, muscle pain, swollen\u00a0lymph nodes,\u00a0and\/or\u00a0flu-like symptoms<\/li><li>rash, purple-red spots, fever,\u00a0itching\u00a0(symptoms of\u00a0inflammation\u00a0of the blood vessels)<\/li><li>low\u00a0platelet counts\u00a0(sometimes with unusual bleeding or bruising)<\/li><li>high level of potassium in the blood (sometimes with muscle cramps, abnormal heart rhythm)<\/li><li>allergic reactions (with symptoms such as rash,\u00a0itching, hives, difficulty breathing or difficulty swallowing, and dizziness)<\/li><li>swelling, especially in the face and throat, rash,\u00a0itching<\/li><li>elevated liver function values<\/li><li>reduced hemoglobin value and reduced proportion of\u00a0red blood cells\u00a0in the blood (\u00a0both can cause\u00a0anemia in\u00a0severe\u00a0cases ).<\/li><li>kidney failure<\/li><li>low level of\u00a0sodium\u00a0in the blood (which can trigger tiredness, confusion, muscle twitching, and\/or seizures in severe cases)<\/li><\/ul>\n\n\n\n<p><strong>Hydrochlorothiazide<\/strong><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 in 10 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low level of&nbsp;potassium&nbsp;in the blood<\/li><li>elevated lipid values \u200b\u200bin the blood<\/li><li>Common (may affect up to 1 in 10 users)<\/li><li>low level of&nbsp;sodium&nbsp;in the blood<\/li><li>low level of&nbsp;magnesium&nbsp;in the blood<\/li><li>high level of&nbsp;uric acid&nbsp;in the blood<\/li><li>itchy rashes and other types of rashes<\/li><li>decreased appetite<\/li><li>slight nausea and vomiting<\/li><li>dizziness, fainting when standing up<\/li><li>inability to get or maintain&nbsp;an erection<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling and blistering of the skin (due to increased sensitivity to the sun)<\/li><li>high level of\u00a0calcium\u00a0in the blood<\/li><li>high blood sugar level<\/li><li>sugar in the urine<\/li><li>deterioration of metabolic diabetes condition<\/li><li>constipation, diarrhea, discomfort in the stomach and intestines, and liver disorders which can occur together with yellow skin and yellow eyes<\/li><li>irregular heartbeats<\/li><li>headache<\/li><li>sleep disorders<\/li><li>low mood (depression)<\/li><li>low\u00a0platelet counts\u00a0(sometimes with bleeding or bruising under the skin)<\/li><li>dizziness<\/li><li>tingling or numbness<\/li><li>visual disturbances<\/li><\/ul>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation\u00a0of the blood vessels with symptoms such as rash, red-purple-red spots, fever (\u00a0vasculitis\u00a0)<\/li><li>rash,\u00a0itching, hives, difficulty breathing or swallowing, dizziness (\u00a0hypersensitivity reaction\u00a0)<\/li><li>rash on the face, joint pain, muscle disease, fever (lupus erythematosus)<\/li><li>severe pain in the upper part of the stomach (\u00a0pancreatitis\u00a0)<\/li><li>difficulty breathing with fever, cough, wheezing, and shortness of breath (shortness of breath including\u00a0pneumonitis\u00a0and\u00a0pulmonary edema)<\/li><li>pale skin, tiredness, shortness of breath, dark urine (\u00a0hemolytic anemia\u00a0)<\/li><li>fever, sore throat, or mouth sores due to\u00a0infection\u00a0(\u00a0leukopenia\u00a0)<\/li><li>confusion, fatigue, muscle twitching and\u00a0spasms, rapid breathing (hypochloraemic\u00a0alkalosis\u00a0)<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>skin and lip cancer (Non-\u00a0melanoma\u00a0skin cancer)<\/li><li>weakness, bruising and frequent\u00a0infections\u00a0(\u00a0aplastic anemia\u00a0)<\/li><li>severely reduced urine output (possible signs of kidney disease or\u00a0kidney failure\u00a0)<\/li><li>skin rash,\u00a0redness, blisters on the lips, eyes, or mouth, peeling of the skin, fever (possible signs of erythema multiforme)<\/li><li>muscle cramp<\/li><li>fever (\u00a0pyrexia\u00a0)<\/li><li>weakness (\u00a0asthenia\u00a0)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Valsartan\/Hydrochlorothiazide Krka<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the packaging after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 30\u00b0C.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Light sensitive.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are valsartan and\u00a0hydrochlorothiazide\u00a0.Each Valsartan\/Hydrochlorothiazide Krka 80 mg\/12.5 mg film-coated tablet contains 80 mg valsartan and 12.5 mg\u00a0hydrochlorothiazide\u00a0.Each Valsartan\/Hydrochlorothiazide Krka 160 mg\/12.5 mg film-coated tablet contains 160 mg of valsartan and 12.5 mg\u00a0of hydrochlorothiazide\u00a0.Each Valsartan\/Hydrochlorothiazide Krka 160 mg\/25 mg film-coated tablet contains 160 mg valsartan and 25 mg\u00a0hydrochlorothiazide\u00a0.Each Valsartan\/Hydrochlorothiazide Krka 320 mg\/12.5 mg film-coated tablet contains 320 mg valsartan and 12.5 mg\u00a0hydrochlorothiazide\u00a0.Each Valsartan\/Hydrochlorothiazide Krka 320 mg\/25 mg film-coated tablet contains 320 mg valsartan and 25 mg\u00a0hydrochlorothiazide\u00a0.<\/li><li>Other ingredients in the tablet are microcrystalline cellulose,\u00a0lactose monohydrate, magnesium stearate (E470b), croscarmellose sodium, povidone K25, and anhydrous\u00a0colloidal\u00a0silicon dioxide in the tablet core as well as hypromellose, titanium dioxide (E171), macrogol 4000, red iron oxide (E172) &#8211; only in 80 mg\/12.5 mg, 160 mg\/12.5 mg, 160 mg\/25 mg, and 320 mg\/12.5 mg tablets, yellow iron oxide (E172) \u2013 only in 80 mg\/12.5 mg, 160 mg\/25 mg and 320 mg\/ 25 mg tablets \u2013 in the film coating.\u00a0See section 2 &#8220;Valsartan\/Hydrochlorothiazide Krka contains\u00a0lactose\u00a0and sodium&#8221;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Valsartan\/Hydrochlorothiazide Krka 80 mg\/12.5 mg film-coated tablets are pink, oval, and biconvex tablets.<br>Valsartan\/Hydrochlorothiazide Krka 160 mg\/12.5 mg film-coated tablets are red-brown, oval, and biconvex tablets.<br>Valsartan\/Hydrochlorothiazide Krka 160 mg\/25 mg film-coated tablets are light brown, oval, and biconvex tablets.<br>Valsartan\/Hydrochlorothiazide Krka 320 mg\/12.5 mg film-coated tablets are pink, oval, and biconvex tablets.<br>Valsartan\/Hydrochlorothiazide Krka 320 mg\/25 mg film-coated tablets are pale yellow, oval, biconvex tablets.<br>The tablet can be divided into two equal parts.<\/p>\n\n\n\n<p>Valsartan\/Hydrochlorothiazide Krka 80 mg\/12.5 mg, 160 mg\/12.5 mg and 160 mg\/25 mg film-coated tablets are supplied in packs of 14, 28, 30, 56, 60, 84, 90, 98, 280, 56 x 1, 98 x 1 and 280 x 1 film-coated tablets in blisters.<\/p>\n\n\n\n<p>Valsartan\/Hydrochlorothiazide Krka 320 mg\/12.5 mg and 320 mg\/25 mg film-coated tablets are supplied in packs of 10, 14, 28, 30, 56, 60, 84, 90, 98, 100, 280, 56&#215;1, 98&#215;1 and 280&#215;1 film-coated tablets in blisters.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>KRKA, dd, Novo mesto, \u0160marje\u0161ka cesta 6, 8501 Novo mesto, Slovenia.<\/p>\n\n\n\n<p>TAD Pharma GmbH, Heinz-Lohmann-Stra\u00dfe 5, 27472 Cuxhaven, Germany.<\/p>\n\n\n\n<p>KRKA-POLSKA Sp.&nbsp;z o. o., ul.&nbsp;R\u00f3wnoleg\u0142a 5, 02-235 Warsaw, Poland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Valsartan\/Hydrochlorothiazide Krka film-coated tablets contain two active substances, valsartan and\u00a0hydrochlorothiazide\u00a0.\u00a0Both substances help control high\u00a0blood pressure\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[3664,7937,3666,4301,4124,4126,5514,7947,4300,4125,10570],"class_list":["post-26407","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-hydrochlorothiazide","tag-hydrochlorothiazide-krka","tag-hydrochlorothiazide-side-effects","tag-hydrochlorothiazide-tablet","tag-valsartan","tag-valsartan-side-effects","tag-valsartan-tablet","tag-what-hydrochlorothiazide-is-used-for","tag-what-is-hydrochlorothiazide","tag-what-is-valsartan","tag-what-valsartan-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=26407"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26407\/revisions"}],"predecessor-version":[{"id":26531,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26407\/revisions\/26531"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=26407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=26407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=26407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}