{"id":26179,"date":"2022-10-12T13:31:29","date_gmt":"2022-10-12T13:31:29","guid":{"rendered":"https:\/\/zeepedia.com\/?p=26179"},"modified":"2022-10-13T08:17:55","modified_gmt":"2022-10-13T08:17:55","slug":"valganciclovir-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/valganciclovir-accord\/","title":{"rendered":"Valganciclovir Accord &#8211; Valganciclovir uses, dose and side effects"},"content":{"rendered":"\n<p>450 mg&nbsp;film-coated tablets<br>valganciclovir<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Valganciclovir Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Valganciclovir Accord<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to valganciclovir, ganciclovir, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are breastfeeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Valganciclovir Accord:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to aciclovir, penciclovir, valaciclovir or famciclovir.\u00a0Other drugs are used in viral infections.<\/li><\/ul>\n\n\n\n<p>Take special care with Valganciclovir Accord:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have a low number of\u00a0white blood cells,\u00a0red blood cells,\u00a0or\u00a0platelets\u00a0(small cells involved in blood\u00a0clotting\u00a0) in your blood.\u00a0The doctor will carry out blood tests before you start taking Valganciclovir Accord tablets and more samples will be taken while you are taking the tablets.<\/li><li>if you are undergoing radiation therapy or\u00a0hemodialysis.<\/li><li>if you have kidney problems.\u00a0The doctor may need to prescribe you a lower\u00a0dose\u00a0and your blood levels may need to be checked frequently during treatment.<\/li><li>if you are currently taking ganciclovir capsules and the doctor wants you to switch to Valganciclovir Accord tablets.\u00a0You mustn&#8217;t take more tablets than the doctor prescribes, otherwise, there is a risk of overdose.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Valganciclovir Accord<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, even those without a prescription.<\/p>\n\n\n\n<p>If you take other medicines at the same time as Valganciclovir Accord, the combination may affect the amount of medicine absorbed into your blood or possibly cause harmful effects.&nbsp;Tell the doctor if you are already taking medicines that contain any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Imipenem-cilastatin (an\u00a0antibiotic\u00a0) Can cause seizures if taken with Valganciclovir Accord<\/li><li>zidovudine, didanosine, lamivudine, stavudine, tenofovir, abacavir, emtricitabine or similar medicines used to treat\u00a0AIDS<\/li><li>adefovir or other medicines used to treat\u00a0hepatitis\u00a0B<\/li><li>probenecid (medicine for\u00a0gout\u00a0).\u00a0The amount of ganciclovir in the blood may increase if probenecid and Valganciclovir Accord are taken at the same time<\/li><li>mycophenolate mofetil, cyclosporin, or tacrolimus (used after transplantation)<\/li><li>vincristine, vinblastine, doxorubicin, hydroxyurea, or similar anticancer drugs<\/li><li>trimethoprim, combinations with trimethoprim\/sulfa and dapsone (\u00a0antibiotics\u00a0)<\/li><li>pentamidine (medicine to treat parasites or lung infections)<\/li><li>flucytosine or amphotericin B (antifungal)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Valganciclovir Accord with food, drink, and alcohol<\/h2>\n\n\n\n<p>Valganciclovir Accord should be taken with a meal.&nbsp;If for some reason you cannot eat, you should still take Valganciclovir Accord as usual.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>You must not take Valganciclovir Accord if you are pregnant unless your doctor advises you to do so.\u00a0You must tell the doctor if you are pregnant or planning to become pregnant.\u00a0Taking Valganciclovir Accord during pregnancy may harm your unborn baby.<\/p>\n\n\n\n<p>You should not take Valganciclovir Accord if you are breastfeeding.\u00a0If your doctor wants to start treatment with Valganciclovir Accord, you must stop breastfeeding before you start taking the tablets.<\/p>\n\n\n\n<p>Women of childbearing potential must use effective contraception while being treated with Valganciclovir Accord and for at least 30 days after stopping treatment.<\/p>\n\n\n\n<p>Men whose partners may become pregnant should use a condom while being treated with Valganciclovir Accord and they should continue to use a condom for 90 days after stopping treatment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Do not drive or use tools or machines if you feel dizzy, tired, shaky, or confused while taking this medicine.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<a><\/a><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Valganciclovir Accord<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>You must handle the tablets carefully.&nbsp;The tablets must not be split or crushed.&nbsp;You should swallow the tablets whole and they should, if possible, be taken with a meal.&nbsp;If you accidentally touch damaged tablets, wash your hands thoroughly with soap and water.&nbsp;If any powder from the tablets gets in your eyes, rinse your eyes with sterile water or clean water if sterile water is not available.<\/p>\n\n\n\n<p><strong>You must stick to the number of tablets prescribed by your doctor to avoid overdose.<\/strong><\/p>\n\n\n\n<p>Valganciclovir Accord tablets should, if possible, be taken with food (see section 2).<\/p>\n\n\n\n<p><strong>Adults:<\/strong><\/p>\n\n\n\n<p><strong>Prevention of&nbsp;CMV&nbsp;disease in organ transplant patients<\/strong><\/p>\n\n\n\n<p>You should start taking this medicine within 10 days after the transplant.\u00a0The usual\u00a0dose\u00a0is two tablets taken ONCE daily.\u00a0You should continue with this\u00a0dose\u00a0up to 100 days after the transplant.\u00a0If you have received a kidney transplant, your doctor may advise you to take the tablets for 200 days.<\/p>\n\n\n\n<p><strong>Treatment of active&nbsp;CMV&nbsp;&#8211;&nbsp;infection&nbsp;in the&nbsp;retina&nbsp;of the eye in patients with&nbsp;AIDS&nbsp;(so-called induction treatment)<\/strong><\/p>\n\n\n\n<p>The usual\u00a0dose\u00a0is two tablets of Valganciclovir Accord taken TWICE daily for 21 days (three weeks).\u00a0Do not take this\u00a0dose\u00a0for more than 21 days, unless your doctor tells you to, as your risk of\u00a0side effects\u00a0may increase.<\/p>\n\n\n\n<p><strong>Long-term treatment to&nbsp;prevent recurrent active&nbsp;inflammation&nbsp;in&nbsp;AIDS&nbsp;patients with&nbsp;CMV&nbsp;infection&nbsp;in the&nbsp;retina&nbsp;of the eye (so-called maintenance treatment)<\/strong><\/p>\n\n\n\n<p>The usual\u00a0dose\u00a0is two tablets taken ONCE daily.\u00a0You should try to take the tablets at the same time each day.\u00a0The doctor will tell you how long to continue taking Valganciclovir Accord.\u00a0If the retinitis worsens while taking this\u00a0dose, the doctor may ask you to repeat the induction treatment (as above) or decide to give you another medicine to treat\u00a0CMV\u00a0infection.<\/p>\n\n\n\n<p><strong>Elderly patients<\/strong><\/p>\n\n\n\n<p>Valganciclovir Accord has not been studied in elderly patients.<\/p>\n\n\n\n<p><strong>Patients with kidney problems<\/strong><\/p>\n\n\n\n<p>If your kidneys are not fully functioning, your doctor may instruct you to take fewer tablets per day or to only take the tablets on certain days of the week.&nbsp;It is very important that you only take the number of tablets prescribed by the doctor.<\/p>\n\n\n\n<p><strong>Patients with liver problems<\/strong><\/p>\n\n\n\n<p>Valganciclovir Accord has not been studied in patients with liver problems.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p><strong>Prevention of&nbsp;CMV&nbsp;disease in organ transplant patients<\/strong><\/p>\n\n\n\n<p>Children should start taking this medicine within 10 days of the transplant.\u00a0The dose\u00a0given varies depending on the size of the child and should be taken ONCE daily.\u00a0The doctor will decide on the most appropriate\u00a0dose\u00a0based on your child&#8217;s height, weight, and kidney function.\u00a0You should continue with this\u00a0dose\u00a0up to 100 days after the transplant.\u00a0If your child has received a kidney transplant, the doctor may advise you to take the medicine for 200 days.<\/p>\n\n\n\n<p>For children who cannot swallow Valganciclovir Accord film-coated tablets, valganciclovir powder for\u00a0an oral\u00a0solution can be used.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Valganciclovir Accord<\/h2>\n\n\n\n<p>If you have taken, or think you have taken, too much medicine or if e.g.\u00a0a child has ingested the drug by mistake, immediately contact a doctor or hospital for an assessment of the risk and advice.\u00a0If you have taken too many tablets, you can have serious\u00a0side effects, especially in the blood and kidneys can be affected.\u00a0You may need hospital care.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Valganciclovir Accord<\/h2>\n\n\n\n<p>If you forget to take your tablets, take the missed&nbsp;dose&nbsp;as soon as you remember and take the next&nbsp;dose&nbsp;at the usual time.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for missed tablets.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Valganciclovir Accord<\/h2>\n\n\n\n<p>Do not stop taking this medicine unless your doctor tells you to.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Allergic reactions<\/strong><\/p>\n\n\n\n<p>Up to 1 in 1,000 users may have a sudden and severe&nbsp;allergic reaction&nbsp;to valganciclovir (anaphylactic&nbsp;shock&nbsp;).&nbsp;<strong>STOP<\/strong>&nbsp;taking Valganciclovir Accord and go to the emergency department of your nearest hospital if you get any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>raised, itchy rash (\u00a0hives\u00a0)<\/li><li>sudden swelling of the throat, face, lips, and mouth which may cause difficulty in swallowing and breathing<\/li><li>sudden swelling of hands, feet, or ankles.<\/li><\/ul>\n\n\n\n<p><strong>Serious side effects&nbsp;<\/strong><\/p>\n\n\n\n<p>Tell your doctor immediately if you notice any of the following serious&nbsp;side effects&nbsp;&#8211; your doctor may tell you to stop taking Valgancoclovir Accord and you may need&nbsp;urgent&nbsp;medical treatment:<\/p>\n\n\n\n<p><strong>Very common: may affect more than 1 in 10 patients<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low\u00a0white blood cell count\u00a0&#8211; with signs of\u00a0infection\u00a0such as sore throat, mouth sores, or fever<\/li><li>low\u00a0red blood cell count\u00a0&#8211; signs include shortness of breath or tiredness, palpitations, or pale skin<\/li><\/ul>\n\n\n\n<p><strong>Common: may affect 1 to 10 patients<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood poisoning (\u00a0sepsis\u00a0) \u2013 signs include fever, chills, palpitations, confusion, and slurred speech<\/li><li>low\u00a0platelet count\u00a0&#8211; signs include bleeding or bruising more easily than usual, blood in the urine or stool, or bleeding from the gums.\u00a0Bleeding can be heavy<\/li><li>severely low blood levels<\/li><li>inflammation\u00a0of the pancreas &#8211; signs are severe abdominal pain that spreads to the back<\/li><li>cramps<\/li><\/ul>\n\n\n\n<p><strong>Uncommon: may affect 1 to 100 patients<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>failure of the bone marrow&#8217;s ability to form&nbsp;blood&nbsp;cells<\/li><li>hallucinations \u2013 hearing or seeing things that are not real<\/li><li>abnormal thoughts or feelings, losing touch with reality<\/li><li>impaired kidney function<\/li><\/ul>\n\n\n\n<p>Side effects&nbsp;that occurred during treatment with valganciclovir or ganciclovir are reported below.<\/p>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0are<\/strong>\u00a0<\/p>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you notice any of the following side effects:<\/p>\n\n\n\n<p><strong>Very common: may affect more than 1 in 10 patients<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>mushrooms and cod in the mouth<\/li><li>upper respiratory tract infection (e.g. sinusitis,&nbsp;inflammation&nbsp;of the tonsils)<\/li><li>loss of appetite<\/li><li>headache<\/li><li>cough<\/li><li>shortness of breath<\/li><li>diarrhea<\/li><li>nausea or vomiting<\/li><li>abdominal pain<\/li><li>eczema<\/li><li>fatigue<\/li><li>fever<\/li><\/ul>\n\n\n\n<p><strong>Common: may affect up to 1 in 10 patients<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>influenza<\/li><li>urinary tract infection &#8211; signs include fever, urinating more often than usual, pain when urinating<\/li><li>infection\u00a0in the skin and\u00a0tissues\u00a0under the skin<\/li><li>mild\u00a0allergic reaction\u00a0&#8211; signs may include red and itchy skin<\/li><li>weight loss<\/li><li>feeling depressed, anxious, or confused<\/li><li>sleep difficulties<\/li><li>hands or feet feel weak and numb, which can affect balance<\/li><li>changes in sensation, tingling, tickling, stinging, or burning sensation<\/li><li>taste changes<\/li><li>overindulge<\/li><li>eye inflammation (\u00a0conjunctivitis\u00a0), pain in the eyes, or vision problems<\/li><li>earache<\/li><li>low\u00a0blood pressure, which can make you feel dizzy or faint<\/li><li>trouble swallowing<\/li><li>constipation, flatulence, indigestion, stomach ache, swollen abdomen<\/li><li>mouth ulcers<\/li><li>abnormal results on liver and kidney tests<\/li><li>night sweats<\/li><li>itching, rash<\/li><li>hair loss<\/li><li>back pain, pain in muscles or joints, muscle cramps<\/li><li>feel dizzy, weak, or generally unwell<\/li><\/ul>\n\n\n\n<p><strong>Uncommon: may affect up to 1 in 100 patients<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>feel upset<\/li><li>tremors, tremors<\/li><li>deafness<\/li><li>irregular heartbeat<\/li><li>hives, dry skin<\/li><li>blood in the urine<\/li><li>infertility&nbsp;in men &#8211; see section &#8220;fertility&#8221;<\/li><li>chest pain<\/li><\/ul>\n\n\n\n<p>Separation of the inner part of the eye (retinal detachment) has only occurred in\u00a0AIDS\u00a0patients\u00a0treated with valganciclovir for\u00a0CMV\u00a0infection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Additional side effects in children and adolescents<\/h2>\n\n\n\n<p>The side effects&nbsp;reported in children and adolescents are similar to the&nbsp;side effects&nbsp;reported in adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Valganciclovir Accord<\/h2>\n\n\n\n<p>Keep this medicine out of the sight&nbsp;<strong>and<\/strong>&nbsp;reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is 450 mg of valganciclovir, as 496.3 mg of valganciclovir hydrochloride.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p>Tablet core: microcrystalline cellulose, crospovidone (type A), povidone (K30) and stearic acid (50).<\/p>\n\n\n\n<p>Film coating: hypromellose 3cP, hypromellose 6cP, titanium dioxide (E171), macrogol 400, red iron oxide (E172), and polysorbate 80.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Valganciclovir Accord is supplied as 450 mg film-coated tablets.&nbsp;The tablets are described below.<\/p>\n\n\n\n<p>Approximately 16.7 x 7.8 mm, pink, oval, biconvex film-coated tablets, marked with \u201cJ\u201d on one side and \u201c156\u201d on the other side.<\/p>\n\n\n\n<p>Valganciclovir Accord is supplied in OPA-aluminium-PVC\/aluminum blisters in cartons: 30, 60, 90, and 120 tablets.<\/p>\n\n\n\n<p>High-density polyethylene (HDPE) container filled with pure cotton and polypropylene child-resistant screw cap with an insert of cardboard material (made of liner, wax, foil, PET plastic, and heat seal) containing 60 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 VK Utrecht<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>Paradox Healthcare Ltd.<\/p>\n\n\n\n<p>KW20A Kordin Industrial Park, Paola<\/p>\n\n\n\n<p>PLA 3000, Malta<\/p>\n\n\n\n<p>Accord Healthcare Limited<\/p>\n\n\n\n<p>Sage House, 319 Pinner Road, North Harrow<\/p>\n\n\n\n<p>Middlesex, HA1 4HF<\/p>\n\n\n\n<p>UK<\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomirska 50,95-200 Pabianice, Poland<\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 VK Utrecht<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>450 mg\u00a0film-coated tablets<br \/>\nvalganciclovir<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[26825,26895,26898,26899,26828,26874,26826,26896,26897,26827],"class_list":["post-26179","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-valganciclovir","tag-valganciclovir-accord","tag-valganciclovir-accord-side-effects","tag-valganciclovir-accord-tablet","tag-valganciclovir-side-effects","tag-valganciclovir-tablet","tag-what-is-valganciclovir","tag-what-is-valganciclovir-accord","tag-what-valganciclovir-accord-is-used-for","tag-what-valganciclovir-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26179","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=26179"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26179\/revisions"}],"predecessor-version":[{"id":26396,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26179\/revisions\/26396"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=26179"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=26179"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=26179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}