{"id":26088,"date":"2022-10-11T12:31:13","date_gmt":"2022-10-11T12:31:13","guid":{"rendered":"https:\/\/zeepedia.com\/?p=26088"},"modified":"2022-10-12T11:22:53","modified_gmt":"2022-10-12T11:22:53","slug":"valaciclovir-sandoz","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/valaciclovir-sandoz\/","title":{"rendered":"Valaciclovir Sandoz &#8211; Valaciclovir uses, dose and side effects"},"content":{"rendered":"\n<p>250 mg, 500 mg&nbsp;film-coated tablets<br>valaciclovir<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Valaciclovir Sandoz is and what it is used for<\/h2>\n\n\n\n<p>Valaciclovir Sandoz belongs to a group of medicines called antiviral medicines.&nbsp;It works by killing or stopping the growth of&nbsp;viruses&nbsp;called&nbsp;herpes&nbsp;simplex (&nbsp;HSV&nbsp;),&nbsp;varicella zoster&nbsp;(&nbsp;VZV&nbsp;), and&nbsp;cytomegalovirus&nbsp;(&nbsp;CMV&nbsp;).<\/p>\n\n\n\n<p>Valaciclovir Sandoz can be used for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>treatment of&nbsp;shingles&nbsp;(in adults)<\/li><li>treatment of&nbsp;HSV&nbsp;skin infections and genital&nbsp;herpes&nbsp;(in adults and adolescents over 12 years of age).&nbsp;It is also used to help prevent these&nbsp;infections&nbsp;from recurring<\/li><li>treatment of mouth ulcers (in adults and adolescents over 12 years of age)<\/li><li>to prevent&nbsp;infection&nbsp;with&nbsp;CMV&nbsp;after organ transplantation (in adults and adolescents over 12 years of age)<\/li><li>to treat and prevent&nbsp;HSV&nbsp;eye&nbsp;infections&nbsp;that keep coming back (in adults and adolescents over 12 years of age).<\/li><\/ul>\n\n\n\n<p>Valaciclovir contained in Valaciclovir Sandoz may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Valaciclovir Sandoz<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Valaciclovir Sandoz<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to valaciclovir, aciclovir, or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have previously developed widespread skin rash with associated fever, enlarged\u00a0lymph nodes, elevated levels of liver enzymes, and\/or\u00a0eosinophilia\u00a0(drug reaction with\u00a0eosinophilia\u00a0and systemic symptoms) after taking valaciclovir.<\/li><\/ul>\n\n\n\n<p>\u2192 Do not take Valaciclovir Sandoz if the above applies to you.&nbsp;If you are not sure, talk to your doctor or pharmacist before taking Valaciclovir Sandoz.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Valaciclovir Sandoz if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do you have any kidney disease<\/li><li>Do you have any liver disease<\/li><li>you are over 65 years old<\/li><li>your immune system is weak.<\/li><\/ul>\n\n\n\n<p>If you are not sure if the above applies to you, talk to your doctor or pharmacist before taking Valaciclovir Sandoz.<\/p>\n\n\n\n<p>Drug reaction with\u00a0eosinophilia\u00a0and systemic symptoms (drug hypersensitivity syndrome, DRESS) has been reported in association with the use of valaciclovir.\u00a0DRESS\u00a0initially\u00a0occurs as\u00a0flu-like symptoms\u00a0with skin rashes on the face that then spread, with elevated body temperature, increased levels of liver enzymes detected in blood tests, and an increase in a certain type of\u00a0white blood cells\u00a0(eosinophilia\u00a0), and enlarged\u00a0lymph nodes.<\/p>\n\n\n\n<p>If you develop a skin rash along with fever and enlarged\u00a0lymph nodes, stop taking valaciclovir and contact a doctor or seek medical attention immediately.<\/p>\n\n\n\n<p><strong>Avoid infecting others with genital&nbsp;herpes<\/strong><\/p>\n\n\n\n<p>If you are taking Valaciclovir Sandoz to treat or prevent genital\u00a0herpes, or if you previously had genital\u00a0herpes, you should still practice safe sex, including the use of condoms.\u00a0This is important to prevent you from passing the\u00a0infection\u00a0on to others.\u00a0You should not have sex if you have genital sores or blisters.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Valaciclovir Sandoz<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription and herbal medicines.<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking any other medicines that affect the kidneys.\u00a0These include\u00a0aminoglycosides, organoplatinum compounds, iodinated contrast agents, methotrexate, pentamidine, foscarnet, cyclosporine, tacrolimus, cimetidine, and probenecid.<\/p>\n\n\n\n<p>Always tell your doctor or pharmacist if you are taking other medicines while being treated with Valaciclovir Sandoz for&nbsp;shingles&nbsp;or if you have had an organ transplant.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Valaciclovir Sandoz is not normally recommended during pregnancy.\u00a0If you are pregnant, think you may be pregnant, or are planning to have a baby, do not take Valaciclovir Sandoz without consulting your doctor.\u00a0Your doctor will weigh the benefit to you against the risk to your baby of taking Valaciclovir Sandoz while you are pregnant or breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Valaciclovir Sandoz can cause&nbsp;side effects&nbsp;that affect your ability to drive.<\/p>\n\n\n\n<p>\u2192 Avoid driving or using machines unless you are sure that you are unaffected.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Valaciclovir Sandoz<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Your&nbsp;dosage&nbsp;depends on why you have been prescribed Valaciclovir Sandoz by your doctor.&nbsp;Your doctor should discuss this with you.<\/p>\n\n\n\n<p><strong>Treatment of&nbsp;shingles<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual&nbsp;dose&nbsp;is 1000 mg (two 500 mg tablets) three times daily.<\/li><li>You should take Valaciclovir Sandoz for seven days.<\/li><\/ul>\n\n\n\n<p><strong>Treatment of mouth ulcers<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual\u00a0dose\u00a0is 2000 mg (four 500 mg tablets) twice daily.<\/li><li>The second\u00a0dose\u00a0should be taken 12 hours (not earlier than 6 hours) after the first\u00a0dose.<\/li><li>You should only take Valaciclovir Sandoz for one day (two\u00a0doses\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>Treatment of&nbsp;HSV&nbsp;skin infections and genital&nbsp;herpes<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual\u00a0dose\u00a0is 500 mg (one 500 mg tablet or two 250 mg tablets) twice daily.<\/li><li>At the first\u00a0infection, you should take Valaciclovir Sandoz for five days or up to ten days if your doctor prescribes it.\u00a0In case of recurrent\u00a0infection, the treatment period is normally 3-5 days.<\/li><\/ul>\n\n\n\n<p><strong>To help prevent&nbsp;HSV&nbsp;infection&nbsp;from&nbsp;coming back after you&#8217;ve had them<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual\u00a0dose\u00a0is one 500 mg tablet once daily.<\/li><li>Some patients with frequent relapses may benefit from taking one 250 mg tablet twice daily.<\/li><li>You should take Valaciclovir Sandoz until your doctor prescribes you stop.<\/li><\/ul>\n\n\n\n<p><strong>To prevent you from becoming infected with&nbsp;CMV&nbsp;(&nbsp;cytomegalovirus&nbsp;)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual&nbsp;dose&nbsp;is 2000 mg (four 500 mg tablets) four times daily.<\/li><li>You should take each&nbsp;dose&nbsp;about 6 hours apart.<\/li><li>You will usually start taking Valaciclovir Sandoz as soon as possible after the doctor&#8217;s appointment.<\/li><li>You should take Valaciclovir Sandoz for about 90 days after the doctor&#8217;s visit, as long as your doctor has prescribed it.<\/li><\/ul>\n\n\n\n<p><strong>The dose&nbsp;of Valaciclovir Sandoz may be adjusted by your doctor if:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you are over 65 years old<\/li><li>you have a weak immune system<\/li><li>Do you have any kidney disease?<\/li><\/ul>\n\n\n\n<p>\u2192 Consult your doctor before taking Valaciclovir Sandoz if any of the above applies to you.<\/p>\n\n\n\n<p><strong>Ingestion of this medicine<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take this medicine by mouth.<\/li><li>Swallow the tablets whole with a glass of water.<\/li><li>Take Valaciclovir Sandoz at the same time every day.<\/li><li>Take Valaciclovir Sandoz as directed by your doctor or pharmacist.<\/li><\/ul>\n\n\n\n<p><strong>People who are over 65 years of age or who have any kidney disease<\/strong><\/p>\n\n\n\n<p><strong>It is very important that during treatment with Valaciclovir Sandoz you drink water regularly during the day.\u00a0<\/strong>This will help reduce\u00a0side effects\u00a0that may affect the kidneys or nervous system.\u00a0Your doctor will carefully monitor you for signs of this.\u00a0Nervous system side effects\u00a0may include feeling confused or anxious, unusually sleepy, or drowsy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Valaciclovir Sandoz<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has accidentally ingested the medicine, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>Valaciclovir Sandoz is normally not harmful unless you take too much for several days.\u00a0If you take too many tablets, you may experience nausea, vomiting, kidney problems, become confused, and anxious, feel less aware, see things that are not there, or pass out.\u00a0Talk to your doctor or pharmacist if you have taken too much Valaciclovir Sandoz.\u00a0Take the medicine package with you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Valaciclovir Sandoz<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you forget to take Valaciclovir Sandoz, take it as soon as you remember.\u00a0If it is almost time for the next\u00a0dose, skip the missed\u00a0dose.<\/li><li>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0The following\u00a0side effects\u00a0may occur with this medicine:<\/p>\n\n\n\n<p><strong>Conditions you need to pay attention to<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe allergic reactions (\u00a0anaphylaxis\u00a0).\u00a0These are rare in users of Valaciclovir Sandoz.\u00a0The rapid development of symptoms such as:<\/li><li>redness, itchy rash<\/li><li>swelling of the lips, face, neck, and throat, causing difficulty breathing (\u00a0angioedema\u00a0)<\/li><li>drop in blood pressure leading to collapse.<\/li><\/ul>\n\n\n\n<p>\u2192 Stop taking Valaciclovir Sandoz and see a doctor immediately if you have an\u00a0allergic reaction.<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea<\/li><li>dizziness<\/li><li>vomiting<\/li><li>diarrhea<\/li><li>skin reaction after exposure to sunlight (&nbsp;<em>photosensitivity<\/em>&nbsp;).<\/li><li>rash<\/li><li>itching&nbsp;(&nbsp;<em>pruritus<\/em>&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>feeling of confusion<\/li><li>seeing and hearing things that are not there (\u00a0<em>hallucinations<\/em>\u00a0)<\/li><li>the feeling of extreme drowsiness<\/li><li>tremors\u00a0_\u00a0_<\/li><li>feeling of worry<\/li><\/ul>\n\n\n\n<p>These\u00a0side effects\u00a0on the nervous system usually occur in users with any kidney disease, the elderly, or in organ transplant patients who take high\u00a0doses\u00a0of 8 grams or more of Valaciclovir Sandoz per day.\u00a0They usually get better when Valaciclovir Sandoz is stopped or when the\u00a0dose\u00a0is reduced.<\/p>\n\n\n\n<p><strong>Other less common side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>shortness of breath (&nbsp;<em>dyspnea<\/em>&nbsp;)<\/li><li>stomach upset<\/li><li>skin rash, sometimes itchy,&nbsp;hives&nbsp;(&nbsp;urticaria&nbsp;)<\/li><li>low back pain (kidney pain)<\/li><li>blood in the urine (&nbsp;<em>hematuria<\/em>&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Less common&nbsp;side effects&nbsp;that can be detected with a blood test:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decrease in the number of\u00a0white blood cells\u00a0(\u00a0<em>leukopenia<\/em>\u00a0)<\/li><li>reduction in the number of\u00a0platelets, which are cells that help the blood clot (\u00a0<em>thrombocytopenia<\/em>\u00a0)<\/li><li>increase in substances produced in the liver<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>unsteady gait and lack of coordination (&nbsp;<em>ataxia<\/em>&nbsp;)<\/li><li>slow, slurred speech (&nbsp;<em>dysarthria<\/em>&nbsp;)<\/li><li>seizures (convulsions)<\/li><li>altered brain function (&nbsp;<em>encephalopathy<\/em>&nbsp;)<\/li><li>unconsciousness (&nbsp;<em>coma<\/em>&nbsp;)<\/li><li>confused or distorted thoughts (&nbsp;<em>delirium<\/em>&nbsp;)<\/li><\/ul>\n\n\n\n<p>These\u00a0side effects\u00a0from the nervous system usually occur in users with any kidney disease, elderly, or organ transplant patients who take high\u00a0doses\u00a0of 8 grams or more of Valaciclovir Sandoz per day.\u00a0It usually gets better when Valaciclovir Sandoz is stopped or when the\u00a0dose\u00a0is reduced.<\/p>\n\n\n\n<p><strong>Other less common side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>kidney problems where little or no urine passes<\/li><\/ul>\n\n\n\n<p><strong>Has been reported&nbsp;<\/strong><strong>(<\/strong>&nbsp;occurring in an unknown number of users):&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drug reaction with\u00a0eosinophilia\u00a0and systemic symptoms, also called DRESS or drug hypersensitivity syndrome, characterized by widespread skin rash, high body temperature, elevated levels of liver enzymes, abnormal blood counts (\u00a0eosinophilia\u00a0), enlarged\u00a0lymph nodes,\u00a0and possibly other organ effects.\u00a0See also section 2.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Valaciclovir Sandoz<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton and printed packaging after Ex.date.&nbsp;or EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 30 \u00baC.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medications that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is valaciclovir. Valaciclovir Sandoz 250 mg: One film-coated tablet contains 278.1375 mg of valaciclovir hydrochloride equivalent to 250 mg of valaciclovir.Valaciclovir Sandoz 500 mg: One film-coated tablet contains 556.275 mg of valaciclovir hydrochloride equivalent to 500 mg of valaciclovir.<\/li><li>Other ingredients in the tablet core are crospovidone, microcrystalline cellulose, povidone, and magnesium stearate;\u00a0and in the tablet coating: hypromellose, titanium dioxide (E171), macrogol 400, and polysorbate 80.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>250 mg: White to off-white capsule-shaped, film-coated tablets, plain on both sides.<\/p>\n\n\n\n<p>500 mg: White to off-white, capsule-shaped, film-coated tablets marked \u201c500\u201d on one side and plain on the other side.<\/p>\n\n\n\n<p>The tablets are packed in PVC\/PE\/PVDC\/\/Aluminium pressure packs.<\/p>\n\n\n\n<p>Package sizes:<\/p>\n\n\n\n<p>250 mg: Carton with blister pack(s) containing: 10, 30, 42 or 60 film-coated tablets<\/p>\n\n\n\n<p>500 mg: Carton with blister pack(s) containing: 8, 10, 30, 42 or 90 film-coated tablets<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.&nbsp;<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder:<\/em><\/p>\n\n\n\n<p>Sandoz A\/S, Edvard Thomsens Vej 14, 2300 Copenhagen, Denmark<\/p>\n\n\n\n<p><em>Manufacturer:<\/em><\/p>\n\n\n\n<p>Lek Pharmaceuticals dd, Trimline 2D, 9220 Lendava, Slovenia<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Valaciclovir Sandoz belongs to a group of medicines called antiviral medicines.\u00a0It works by killing or stopping the growth of\u00a0viruses\u00a0called\u00a0herpes\u00a0simplex (\u00a0HSV\u00a0),\u00a0varicella zoster\u00a0(\u00a0VZV\u00a0), and\u00a0cytomegalovirus\u00a0(\u00a0CMV\u00a0).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[26835,26840,26842,26843,26839,26838,26836,26841,26837,26844],"class_list":["post-26088","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-valaciclovir","tag-valaciclovir-sandoz","tag-valaciclovir-sandoz-side-effects","tag-valaciclovir-sandoz-tablet","tag-valaciclovir-side-effects","tag-valaciclovir-tablet","tag-what-is-valaciclovir","tag-what-is-valaciclovir-sandoz","tag-what-valaciclovir-is-used-for","tag-what-valaciclovir-sandoz-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26088","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=26088"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26088\/revisions"}],"predecessor-version":[{"id":26138,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26088\/revisions\/26138"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=26088"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=26088"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=26088"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}