{"id":26078,"date":"2022-10-11T12:22:05","date_gmt":"2022-10-11T12:22:05","guid":{"rendered":"https:\/\/zeepedia.com\/?p=26078"},"modified":"2022-10-12T11:23:22","modified_gmt":"2022-10-12T11:23:22","slug":"vagirux","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vagirux\/","title":{"rendered":"Vagirux &#8211; Estradiol uses, dose and side effects"},"content":{"rendered":"\n<p>10 microgram&nbsp;vaginal tablets<br>estradiol<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Vagirux is and what it is used for<\/h2>\n\n\n\n<p>Vagirux contains estradiol.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Estradiol is a female sex hormone.<\/li><li>It belongs to a group of\u00a0hormones\u00a0called\u00a0estrogens.<\/li><li>It is identical to the estradiol produced in the woman&#8217;s ovaries.<\/li><\/ul>\n\n\n\n<p>Varilux\u00a0is part of a drug group called hormone replacement\u00a0therapy\u00a0(\u00a0HRT\u00a0)\u00a0and is for\u00a0vaginal\u00a0use.<\/p>\n\n\n\n<p><strong>Varilux<\/strong> is used to\u00a0relieve discomfort in the\u00a0vagina\u00a0after\u00a0menopause\u00a0(when menstruation stops in conjunction with menopause) such as dryness or irritation.\u00a0The medical term for this is\u00a0vaginal\u00a0atrophy.\u00a0It is caused by falling estrogen levels in the body, which is natural after\u00a0menopause.<\/p>\n\n\n\n<p><strong>Varilux<\/strong> works by\u00a0replacing the\u00a0estrogen\u00a0that is normally produced in the woman&#8217;s ovaries.\u00a0The medicine is introduced into the vagina so that the\u00a0hormone\u00a0it is released where it is needed.\u00a0This can relieve discomfort in the\u00a0vagina.<\/p>\n\n\n\n<p>The estradiol contained in Vagirux may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Vagirux<\/h2>\n\n\n\n<p><strong>Medical background and regular medical check-ups<\/strong><\/p>\n\n\n\n<p>There are risks to using\u00a0HRT.\u00a0These must be taken into account when deciding whether a woman should start treatment or continue with ongoing treatment.<\/p>\n\n\n\n<p>Experience in treating women whose menstruation has stopped prematurely (due to ovarian failure or surgery) is limited.&nbsp;If your period has stopped prematurely, the risks of using&nbsp;HRT&nbsp;may be different.&nbsp;Talk to your doctor about this.<\/p>\n\n\n\n<p>Before starting\u00a0HRT\u00a0(or resuming treatment), your doctor will ask questions about your own and your family&#8217;s medical history.\u00a0The doctor may perform a general medical and gynecological examination, which also includes an examination of the breasts.<\/p>\n\n\n\n<p>Once you have started Vagirux, you should go for regular medical check-ups, at least once a year.&nbsp;At these checks, you can discuss the benefits and risks of continuing with Vagirux with your doctor.<\/p>\n\n\n\n<p>Get regular mammograms as recommended by your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Vagirux<\/h2>\n\n\n\n<p>if any of the following apply to you.&nbsp;<strong>Talk to your doctor<\/strong>&nbsp;before using Vagirux if you are unsure about any of the points below.<\/p>\n\n\n\n<p>Do not use Vagirux:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have or have had\u00a0<strong>breast cancer<\/strong>\u00a0or are suspected of having it.<\/li><li>if you have or have had\u00a0<strong>estrogen-dependent<\/strong> cancer, for example, cancer of the lining of the womb (endometrium), or if it is suspected that you have it.<\/li><li>if you have\u00a0unexpected bleeding from the abdomen.<\/li><li>if you have a severely\u00a0thickened lining of the uterus\u00a0(\u00a0endometrial hyperplasia\u00a0) that is not treated.<\/li><li>if you have or have had\u00a0a blood clot in a vein\u00a0(\u00a0thrombosis\u00a0), e.g.\u00a0in the legs (deep\u00a0vein thrombosis\u00a0) or the lungs (\u00a0pulmonary embolism\u00a0).<\/li><li>if you have a\u00a0coagulation disorder\u00a0(e.g.\u00a0protein\u00a0C,\u00a0protein\u00a0S or antithrombin deficiency).<\/li><li>if you have or have previously had a disease caused by blood clots in the\u00a0arteries, e.g.\u00a0heart attack,\u00a0stroke,\u00a0or\u00a0angina pectoris.<\/li><li>if you have or have had\u00a0liver disease\u00a0and your liver values \u200b\u200bare still abnormal.<\/li><li>if you have\u00a0porphyria, a rare inherited blood disorder.<\/li><li>if you are\u00a0<strong>allergic<\/strong>\u00a0to\u00a0<strong>estradiol<\/strong>\u00a0or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If any of the above affects you for the first time while using Vagirux, stop using Vagirux immediately and contact your doctor immediately.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Tell the doctor, before starting treatment, if you have or have had any of the following problems as these may return or get worse during treatment with Vagirux.&nbsp;If this should occur, you should go for more frequent medical check-ups.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fibroids in the uterus.<\/li><li>Endometrial lining that grows outside the uterus (\u00a0endometriosis\u00a0) or you have previously had greatly thickened endometrial lining (\u00a0endometrial hyperplasia\u00a0).<\/li><li>Increased risk of blood clots (see &#8220;Blood clots in a vein (\u00a0thrombosis\u00a0)&#8221;).<\/li><li>Increased risk of getting estrogen-dependent cancer (e.g. if mother, sister, or grandmother\/grandmother has had breast cancer).<\/li><li>High\u00a0blood pressure.<\/li><li>Liver disease, e.g.\u00a0benign liver tumor.<\/li><li>Diabetes.<\/li><li>Gallstones.<\/li><li>Migraine\u00a0or severe headache.<\/li><li>A disease of the immune system that attacks many organs in the body (systemic lupus erythematosus (\u00a0SLE\u00a0).<\/li><li>Epilepsy.<\/li><li>Asthma.<\/li><li>A disease affecting the eardrum and hearing (otosclerosis).<\/li><li>Hypertriglyceridemia\u00a0(elevated level of blood fats).<\/li><li>Fluid retention is caused by heart or kidney disease.<\/li><li>Hereditary and acquired\u00a0angioedema.<\/li><\/ul>\n\n\n\n<p><strong>Stop using Vagirux immediately and consult a doctor<\/strong><\/p>\n\n\n\n<p>If any of the following occurs while you are using HRT:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Any of the conditions mentioned above in the &#8220;Do not use Vagirux&#8221; section.<\/li><li>The skin or the whites of the eyes become yellow (jaundice).\u00a0It may indicate liver disease.<\/li><li>swelling of the face, tongue, and\/or throat and\/or difficulty swallowing or\u00a0hives, along with difficulty breathing which may indicate\u00a0angioedema.<\/li><li>Your\u00a0blood pressure\u00a0rises sharply (symptoms may be headache, fatigue, or dizziness).<\/li><li>Migraine-like headache that occurs for the first time.<\/li><li>You get pregnant.<\/li><li>You get symptoms of a blood clot, for example:<ul><li>painful swelling and\u00a0redness\u00a0of the legs<\/li><li>sudden chest pain<\/li><li>breathing difficulties.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>For more information, see \u201cBlood clots in a vein (&nbsp;thrombosis&nbsp;)\u201d below.<\/p>\n\n\n\n<p><strong>Please note:<\/strong>&nbsp;Vagirux is not a contraceptive.&nbsp;If it has been less than 12 months since your last period or you are under the age of 50, you may still need to use contraception to prevent pregnancy.&nbsp;Consult your doctor about this.<\/p>\n\n\n\n<p><strong>HRT&nbsp;and cancer<\/strong><\/p>\n\n\n\n<p><strong>Strong thickening of the lining of the uterus (&nbsp;endometrial hyperplasia&nbsp;) and cancer of the lining of the uterus (endometrial cancer)<\/strong><\/p>\n\n\n\n<p>Long-term use of\u00a0estrogen-only\u00a0HRT\u00a0tablets\u00a0can increase the risk of cancer of the lining of the uterus (endometrium).<\/p>\n\n\n\n<p>It is unclear whether there is a similar risk with Vagirux when used for repeated treatment or long-term treatment (more than a year).\u00a0However, Vagirux is absorbed into the blood to a very small extent and therefore no addition of the\u00a0progestin\u00a0is needed.<\/p>\n\n\n\n<p>If you experience\u00a0a breakthrough\u00a0or\u00a0spotting, it is usually nothing to worry about, but you should contact your doctor.\u00a0It could be a sign that your endometrium has thickened.<\/p>\n\n\n\n<p><em>The following risks apply to hormone replacement preparations (&nbsp;HRT&nbsp;) that circulate in the blood.&nbsp;However, Vagirux is intended for local treatment in the&nbsp;vagina&nbsp;and is only absorbed into the blood to a very small extent.&nbsp;It is less likely that the conditions mentioned below would worsen or recur during treatment with Vagirux, but you should see a doctor if you are concerned.<\/em><\/p>\n\n\n\n<p><strong>Breast cancer<\/strong><\/p>\n\n\n\n<p>Data suggest that the use of Vagirux does not increase the risk of breast cancer in women who have not had breast cancer before.\u00a0It is unknown whether Vagirux can be used safely in women who have had breast cancer in the past.<\/p>\n\n\n\n<p><strong>Check your breasts regularly.&nbsp;Contact a doctor if you notice changes such as:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>indentations or dimples in the skin<\/li><li>nipple changes<\/li><li>knots that you can see or feel.<\/li><\/ul>\n\n\n\n<p>It is also recommended that you undergo a mammogram examination when you are called.<\/p>\n\n\n\n<p><strong>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/strong><\/p>\n\n\n\n<p>Ovarian cancer is rare \u2013 much rarer than breast cancer.\u00a0The use of\u00a0estrogen-only\u00a0HRT\u00a0has been associated with a slightly increased risk of ovarian cancer.<\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>The risk of ovarian cancer varies with age.\u00a0Out of 2,000 women aged 50 to 54 who do not take\u00a0HRT, about 2 will develop ovarian cancer over 5 years.\u00a0For women who have taken\u00a0HRT\u00a0for 5 years, it is about 3 cases per 2,000 users (ie about 1 extra case).<\/p>\n\n\n\n<p><strong>How&nbsp;HRT&nbsp;affects the heart and blood circulation<\/strong><\/p>\n\n\n\n<p><strong>Blood clots in a vein (&nbsp;thrombosis&nbsp;)<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;<strong>blood clots in the veins<\/strong>&nbsp;is about 1.3\u20133 times higher for women who take&nbsp;HRT&nbsp;than for women who do not, especially during the first year of treatment.<\/p>\n\n\n\n<p>Blood clots can be serious.&nbsp;If a blood clot ends up in the lungs, it can cause chest pain, shortness of breath, collapse or even lead to death.<\/p>\n\n\n\n<p>The likelihood of getting a blood clot in a vein is higher if you are older and if you have any of the following problems.&nbsp;Tell your doctor if any of these situations apply to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you cannot walk for a longer period due to a major operation, injury or illness (see also section 3, &#8220;If you have to have an operation&#8221;)<\/li><li>you are severely overweight (\u00a0BMI\u00a0over 30 kg\/m\u00a02\u00a0)<\/li><li>you have a blood coagulation disorder that requires long-term treatment with drugs that prevent blood clots<\/li><li>a close relative has ever had a blood clot in a leg, lung, or another organ.<\/li><li>you have\u00a0SLE\u00a0(systemic lupus erythematosus)<\/li><li>you have cancer.<\/li><\/ul>\n\n\n\n<p>The symptoms of blood clots are described in the section &#8220;Stop using Vagirux immediately and consult a doctor&#8221;.<\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>Among women in their 50s who do not take\u00a0HRT, an average of 4\u20137 in 1,000 are expected to develop a blood clot in a vein over 5 years.<\/p>\n\n\n\n<p>Among women in their 50s taking\u00a0estrogen-only\u00a0HRT\u00a0for more than 5 years, 5\u20138 cases are expected per 1,000 users (ie 1 extra case).<\/p>\n\n\n\n<p><strong>Heart disease (heart attack)<\/strong><\/p>\n\n\n\n<p>Women treated with&nbsp;estrogen&nbsp;alone have no increased risk of developing heart disease.<\/p>\n\n\n\n<p><strong>Stroke&nbsp;_<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;stroke&nbsp;is about 1.5 times higher in women who take&nbsp;HRT&nbsp;than in women who do not.&nbsp;The number of extra cases of&nbsp;stroke&nbsp;due to&nbsp;HRT&nbsp;use increases with age.<\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>Among women in their 50s who do not take\u00a0HRT, an average of 8 in 1,000 are expected to have a\u00a0stroke\u00a0over 5 years.\u00a0Among women in their 50s taking\u00a0HRT\u00a0for more than 5 years, 11 cases are expected per 1,000 users (ie 3 extra cases).<\/p>\n\n\n\n<p><strong>Other conditions<\/strong><\/p>\n\n\n\n<p>HRT&nbsp;use&nbsp;does not prevent memory loss.&nbsp;The risk of memory loss appears to be slightly higher in women who start using&nbsp;HRT&nbsp;after the age of 65.&nbsp;Consult your doctor about this.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Vagirux<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might be taking other medicines, including over-the-counter medicines and herbal remedies.<\/p>\n\n\n\n<p>However, since Vagirux is used for local treatment in the\u00a0vagina, it is unlikely that Vagirux will affect the effectiveness of other medicines.\u00a0Varilux may affect the effectiveness of other treatments given vaginally.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Varilux is only intended for women whose menstruation has stopped.\u00a0If you should become pregnant, stop using Vagirux and consult a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>No known effect.<a><\/a><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Vagirux<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Use of this medicine<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You can start Vagirux on any day that suits you.<\/li><li>For vaginal\u00a0use\u00a0only.\u00a0Do not take the tablet by mouth.<\/li><li>The vaginal tablet is inserted into the\u00a0vagina\u00a0with the applicator.<\/li><\/ul>\n\n\n\n<p>&#8220;DIRECTIONS FOR USE&#8221; at the end of this leaflet shows how Vagirux should be used.&nbsp;Read the instructions for use carefully before using Vagirux.<\/p>\n\n\n\n<p>The applicator is intended to be used a maximum of 24 times for the same patient (one tablet per time).\u00a0The applicator must then be thrown in the household waste.\u00a0Do not use an\u00a0applicator\u00a0that shows signs of damage.<\/p>\n\n\n\n<p><strong>How much to use<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Use 1 vaginal tablet daily for the first 2 weeks.<\/li><li>Then use 1 vaginal tablet 2 times a week with 3 or 4 days between each\u00a0dose.<\/li><\/ul>\n\n\n\n<p><strong>General information about the treatment of&nbsp;menopausal symptoms<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will aim to prescribe the lowest&nbsp;dose&nbsp;of Vagirux for the shortest possible time to treat your symptoms.&nbsp;Talk to your doctor if you think the&nbsp;dose&nbsp;seems too high or too low.<\/li><li>Treatment should only be continued if the benefits outweigh the risks.&nbsp;Talk to your doctor about this.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Vagirux &nbsp;<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have used too much medicine or if, for example,\u00a0a child accidentally ingested the medicine, contact a doctor or hospital for an assessment of the risk and advice.<\/li><li>Varilux is intended for local treatment in the\u00a0vagina.\u00a0The dose\u00a0of estradiol is so low that a large amount of tablets is required to reach the\u00a0dose\u00a0normally used in treatment taken by mouth.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Vagirux<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you forget a\u00a0dose, take it as soon as you remember.<\/li><li>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Vagirux<\/h2>\n\n\n\n<p>Do not stop treatment with Vagirux without talking to your doctor.&nbsp;The doctor will explain what happens if you stop the treatment and inform you about other treatment options.<\/p>\n\n\n\n<p><strong>If you have to have surgery<\/strong><\/p>\n\n\n\n<p>If you are going to have surgery, you must inform the operating doctor that you are using Vagirux.&nbsp;You may need to stop Vagirux about 4 to 6 weeks before surgery to reduce the risk of blood clots (see section 2, \u201cBlood clots in a vein \u2013 thrombosis\u201d).&nbsp;Ask the doctor when it is appropriate to start using Vagirux again.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The following diseases are more common in women who use\u00a0HRT\u00a0medicines that circulate in the blood than in women who do not use\u00a0HRT.\u00a0The risks are lower for drugs taken vaginally, such as Vagirux:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ovarian cancer (ovarian cancer)<\/li><li>blood clots in veins in legs or lungs (venous&nbsp;thromboembolism&nbsp;)<\/li><li>stroke&nbsp;_<\/li><li>probable memory loss if treatment with&nbsp;HRT&nbsp;is started after the age of 65.<\/li><\/ul>\n\n\n\n<p>More information about these&nbsp;side effects&nbsp;can be found in section 2 &#8220;What you need to know before using Vagirux&#8221;.<\/p>\n\n\n\n<p><strong>Common &#8211; may affect up to 1 in 10 users:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache.<\/li><li>Stomach pain.<\/li><li>Bleeding or discharge from the\u00a0vagina, discomfort in the\u00a0vagina.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon &#8211; may affect up to 1 in 100 users:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fungal infection in the vagina<\/li><li>Nausea.<\/li><li>Rash.<\/li><li>Weight gain.<\/li><li>Heatwave.<\/li><li>High\u00a0blood pressure.<\/li><\/ul>\n\n\n\n<p><strong>Very rare &#8211; may affect up to 1 in 10,000 users:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea.<\/li><li>Fluid retention.<\/li><li>Worsening of\u00a0migraines.<\/li><li>General hypersensitivity (eg anaphylactic reaction\/shock).<\/li><\/ul>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;have been reported with systemic treatment with estrogen:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Gallbladder disease.<\/li><li>Various skin diseases:<ul><li>dark skin spots, especially on the face and neck, so-called &#8220;pregnancy spots&#8221; (chloasma)<\/li><li>painful red-purple bumps on the skin (erythema nodosum)<\/li><li>ring-shaped reddening or ulcerated rash (erythema multiforme).<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Vagirux<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store the blisters in the outer carton.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and blister pack after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medications that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<p>This medicine may be a risk to the aquatic environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is estradiol.\u00a0Each vaginal tablet contains estradiol hemihydrate corresponding to 10 micrograms of estradiol.<\/li><li>Other ingredients are hypromellose,\u00a0lactose monohydrate, corn starch, and magnesium stearate.\u00a0The film coating contains hypromellose and macrogol.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>The vaginal tablets are white, round, film-coated tablets marked with &#8220;E&#8221; on one side.&nbsp;The diameter of the tablet is approximately 6 mm.<\/p>\n\n\n\n<p>Package sizes:<\/p>\n\n\n\n<p>18 vaginal tablets per blister with a reusable applicator.<\/p>\n\n\n\n<p>24 vaginal tablets per blister with a reusable applicator.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Gedeon Richter Plc.<\/p>\n\n\n\n<p>Gy\u00f6mr\u0151i \u00fat Ut 19-21<\/p>\n\n\n\n<p>1103 Budapest<\/p>\n\n\n\n<p>Hungary<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Haupt Pharma M\u00fcnster GmbH<\/p>\n\n\n\n<p>Schleebr\u00fcggenkamp 15<\/p>\n\n\n\n<p>48159 M\u00fcnster<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Gedeon Richter Plc.<\/p>\n\n\n\n<p>Gy\u00f6mr\u0151i \u00fat 19-21<\/p>\n\n\n\n<p>1103 Budapest<\/p>\n\n\n\n<p>Hungary<\/p>\n","protected":false},"excerpt":{"rendered":"<p>10 microgram\u00a0vaginal tablets<br \/>\nestradiol<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[3093,3096,10344,26865,26869,26868,10343,5414,26866,26867],"class_list":["post-26078","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-estradiol","tag-estradiol-side-effects","tag-estradiol-tablet","tag-vagirux","tag-vagirux-side-effects","tag-vagirux-tablet","tag-what-estradiol-is-used-for","tag-what-is-estradiol","tag-what-is-vagirux","tag-what-vagirux-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26078","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=26078"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26078\/revisions"}],"predecessor-version":[{"id":26143,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26078\/revisions\/26143"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=26078"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=26078"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=26078"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}