{"id":26049,"date":"2022-10-10T14:24:39","date_gmt":"2022-10-10T14:24:39","guid":{"rendered":"https:\/\/zeepedia.com\/?p=26049"},"modified":"2022-10-11T08:15:22","modified_gmt":"2022-10-11T08:15:22","slug":"vagifem","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vagifem\/","title":{"rendered":"Vagifem &#8211; Estradiol uses, dose and side effects"},"content":{"rendered":"\n<p>10 microgram&nbsp;vaginal<br>tablet estradiol<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Vagifem is and what it is used for<\/h2>\n\n\n\n<p>Vagifem contains estradiol<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Estradiol is a female sex hormone.<\/li><li>It belongs to the group of\u00a0hormones\u00a0known as\u00a0estrogens.<\/li><li>It is identical to the estradiol produced in the woman&#8217;s ovaries.<\/li><\/ul>\n\n\n\n<p>Vagifem&nbsp;belongs to a group&nbsp;of drugs called hormone replacement therapy (&nbsp;HRT&nbsp;)&nbsp;and&nbsp;is for&nbsp;vaginal&nbsp;use.<\/p>\n\n\n\n<p><strong>Vagifem is used for the<\/strong>&nbsp;local treatment of complaints such as dryness or irritation caused by a lack of estrogen in the vagina in women after the last regular menstrual period (&nbsp;menopause&nbsp;).<\/p>\n\n\n\n<p>The estrogen deficiency must first be diagnosed by a doctor to ensure the correct diagnosis.<\/p>\n\n\n\n<p>The medical term for this is\u00a0vaginal\u00a0atrophy.\u00a0It is caused by falling estrogen levels in the body, which occurs after\u00a0menopause.<\/p>\n\n\n\n<p><strong>Vagifem works by<\/strong>\u00a0replacing the\u00a0estrogen\u00a0that is normally produced in the woman&#8217;s ovaries.\u00a0Vagifem is inserted into the vagina so that the\u00a0hormone\u00a0is released where it is needed.\u00a0This can relieve discomfort in the\u00a0vagina.<\/p>\n\n\n\n<p>Experience in the treatment of women older than 65 years is limited.&nbsp;Women over the age of 65 can use Vagifem if this is followed up carefully through medical checks.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Vagifem<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Vagifem<\/h2>\n\n\n\n<p><strong>Medical background and regular medical check-ups<\/strong><\/p>\n\n\n\n<p>The use of\u00a0HRT\u00a0entails risks that must be taken into account when deciding to start treatment or continue an ongoing treatment.\u00a0Consult a doctor before starting a treatment or discuss whether you should continue treatment.<\/p>\n\n\n\n<p>Experience is limited for the treatment of women whose menstruation has stopped prematurely (when the ovaries stopped working or because of surgery).&nbsp;If your period has stopped prematurely, the risks of using&nbsp;HRT&nbsp;may be different.&nbsp;Talk to your doctor.<\/p>\n\n\n\n<p>Before starting treatment (or resuming treatment), your doctor will ask about your own and your family&#8217;s medical history.\u00a0The doctor may perform a general medical and gynecological examination, which also includes an examination of the breasts.<\/p>\n\n\n\n<p>Once you have started treatment with Vagifem, you must go for regular medical check-ups, at least once a year.&nbsp;During these checks, you must discuss with the doctor the benefits and risks of continued treatment.<\/p>\n\n\n\n<p>Do regular breast examinations as recommended by your doctor.<\/p>\n\n\n\n<p><strong>Do not use Vagifem:<\/strong><\/p>\n\n\n\n<p>if any of the following apply to you.&nbsp;<strong>Talk to your doctor<\/strong>&nbsp;before using Vagifem.<\/p>\n\n\n\n<p>Do not use Vagifem if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have or have had\u00a0<strong>breast cancer<\/strong>\u00a0or there is a suspicion that you may have it<\/li><li>you have or have had\u00a0<strong>estrogen-dependent<\/strong> cancer, such as cancer of the lining of the womb (endometrium), or if such cancer is suspected<\/li><li>you have\u00a0unexpected abdominal bleeding\u00a0that has not been investigated by a doctor<\/li><li>you have severe\u00a0thickening of the lining of the uterus\u00a0(\u00a0endometrial hyperplasia\u00a0) and are not being treated for it<\/li><li>you have or have had\u00a0blood clots in a vein\u00a0(venous\u00a0thromboembolism\u00a0), in the legs (deep\u00a0vein thrombosis\u00a0), or the lungs (\u00a0pulmonary embolism\u00a0)<\/li><li>you have a\u00a0coagulation disorder\u00a0(lack of\u00a0protein\u00a0C,\u00a0protein\u00a0S, or antithrombin)<\/li><li>you have or have recently had a disease caused by blood clots in the\u00a0arteries, such as a\u00a0heart attack,\u00a0stroke,\u00a0or\u00a0angina pectoris<\/li><li>you have or have had any\u00a0liver disease\u00a0and still have abnormal liver values<\/li><li>you have\u00a0porphyria<strong>,<\/strong>\u00a0a rare inherited blood disorder<\/li><li>you are\u00a0<strong>allergic<\/strong>\u00a0(hypersensitive) to\u00a0<strong>estradiol<\/strong>\u00a0or any other ingredient in Vagifem (specified in section 6 &#8220;Contents of the package and other information&#8221;).<\/li><\/ul>\n\n\n\n<p>If any of the above affects you the first time you use Vagifem, stop using Vagifem and contact your doctor immediately.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor if you or have had any of the following problems before starting treatment as these may return or get worse during treatment with Vagifem.\u00a0Should this occur, you should have more frequent check-ups with a doctor.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Asthma.<\/li><li>Epilepsy.<\/li><li>Diabetes.<\/li><li>Gallstone disease.<\/li><li>High\u00a0blood pressure.<\/li><li>Migraine\u00a0or severe headache.<\/li><li>Liver disease eg benign\u00a0tumor.<\/li><li>Endometrial tissue that grows outside the uterus (\u00a0endometriosis\u00a0) or you have previously had heavy growth of the endometrial lining (\u00a0endometrial hyperplasia\u00a0).<\/li><li>A disease affecting hearing (otosclerosis).<\/li><li>The disease of the immune system attacks many organs in the body (systemic lupus erythematosus,\u00a0SLE\u00a0).<\/li><li>Increased risk of getting estrogen-dependent cancer (such as a close relative having breast cancer or other estrogen-dependent cancer).<\/li><li>Increased risk of blood clots (see &#8220;Blood clots in a vein (\u00a0thrombosis\u00a0)&#8221;).<\/li><li>Muscle knots in the uterus.<\/li><li>Hypertriglyceridemia\u00a0(elevated level of blood fats).<\/li><li>Fluid retention due to heart or kidney disease.<\/li><li>Hereditary and acquired\u00a0angioedema.<\/li><\/ul>\n\n\n\n<p><strong>You should immediately contact a doctor and stop treatment with Vagifem<\/strong><\/p>\n\n\n\n<p>if any of the following occurs:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you get a migraine-like headache for the first time<\/li><li>If the skin or whites of the eyes turn yellow (jaundice);\u00a0it could be a symptom of liver disease<\/li><li>If you develop swelling of the face, tongue, and\/or throat and\/or difficulty swallowing or\u00a0hives, along with breathing difficulties which may indicate\u00a0angioedema<\/li><li>If your\u00a0blood pressure\u00a0rises sharply (symptoms may include headache, tiredness, or dizziness)<\/li><li>Any of the things mentioned above in the section \u201cDo not use Vagifem\u201d<\/li><li>If you become pregnant<\/li><li>If you get symptoms of a blood clot, such as:<ul><li>painful swelling and redness of the legs<\/li><li>sudden chest pain<\/li><li>breathing difficulties.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>For further information see below &#8220;Blood clots in a vein (&nbsp;thrombosis&nbsp;)&#8221;.<\/p>\n\n\n\n<p><strong>Please note:<\/strong>&nbsp;Vagifem is not a contraceptive.&nbsp;If it has been less than 12 months since your last period, or if you are under 50, you may still need to use contraception to avoid pregnancy.&nbsp;Consult your doctor.<\/p>\n\n\n\n<p><strong>HRT&nbsp;and cancer<\/strong><\/p>\n\n\n\n<p><strong>Strong thickening of the lining of the uterus (&nbsp;endometrial hyperplasia&nbsp;) and cancer of the lining of the uterus (endometrial cancer)<\/strong><\/p>\n\n\n\n<p>Long-term use of\u00a0estrogen-only\u00a0HRT\u00a0tablets\u00a0can increase the risk of developing cancer in the lining of the uterus (endometrium).<\/p>\n\n\n\n<p>It is unclear whether there is a similar risk with Vagifem when used for repeated treatment or long-term treatment (more than a year).\u00a0However, Vagifem has been shown to have very low\u00a0absorption\u00a0into the blood, so the addition of a progestin\u00a0is not necessary.<\/p>\n\n\n\n<p>If you experience\u00a0<strong>breakthrough\u00a0<\/strong><strong>bleeding<\/strong>\u00a0or\u00a0<strong>spotting<\/strong>, it is usually nothing to worry about, but you should contact your doctor.\u00a0It could be a sign that your endometrium has thickened.<\/p>\n\n\n\n<p><em>The following described risks refer to treatment with hormone replacement preparations (\u00a0HRT\u00a0) that circulate in the blood.\u00a0However, Vagifem is for local treatment in the\u00a0vagina,<\/em>\u00a0and\u00a0absorption\u00a0into the blood is very small.\u00a0The conditions<em> mentioned below are less likely to worsen or recur during treatment with Vagifem, but you should see your doctor if you are concerned.<\/em><\/p>\n\n\n\n<p><strong>Breast cancer<\/strong><\/p>\n\n\n\n<p>Data suggest that the use of Vagifem does not increase the risk of breast cancer in women who have not had breast cancer before.\u00a0It is unknown whether Vagifem can be used safely in women who have had breast cancer in the past.<\/p>\n\n\n\n<p><strong>Check your breasts regularly.&nbsp;Contact a doctor if you notice changes such as:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>indentations or pits<\/li><li>nipple changes<\/li><li>lumps you can see or feel.<\/li><\/ul>\n\n\n\n<p>It is also recommended that you participate in mammography screening when you are called to do so.<\/p>\n\n\n\n<p><strong>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/strong><\/p>\n\n\n\n<p>Ovarian cancer is rare &#8211; much rarer than breast cancer.\u00a0The use of\u00a0estrogen-only\u00a0HRT\u00a0has been associated with a slightly increased risk of ovarian cancer.<\/p>\n\n\n\n<p>The risk of ovarian cancer varies with age.\u00a0For example, the diagnosis of ovarian cancer will be given to around 2 women out of 2,000 aged 50 to 54 who do not take\u00a0HRT\u00a0for 5 years.\u00a0For women who have taken\u00a0HRT\u00a0for 5 years, it is about 3 cases per 2000 users (ie about 1 extra case).<\/p>\n\n\n\n<p><strong>How&nbsp;HRT&nbsp;affects the heart and blood circulation<\/strong><\/p>\n\n\n\n<p><strong>Blood clots in a vein (&nbsp;thrombosis&nbsp;)<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;<strong>blood clots in the veins<\/strong>&nbsp;is 1.3-3 times higher for women who take&nbsp;HRT&nbsp;than for those who do not, especially during the first year of treatment.<\/p>\n\n\n\n<p>Blood clots can be serious.&nbsp;If a blood clot ends up in the lungs, it can cause chest pain, shortness of breath, collapse or even lead to death.<\/p>\n\n\n\n<p>You are more likely to get a blood clot in a vein if you are older and if any of the following apply to you.&nbsp;Tell your doctor if any of these situations apply to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You have not been able to walk for a long time due to a major operation, injury or illness.<\/li><li>You are severely overweight (\u00a0BMI\u00a0over 30 kg\/m\u00a0<sup>2<\/sup>\u00a0).<\/li><li>You have a coagulation disorder that requires long-term treatment with drugs that prevent blood clots.<\/li><li>If a close relative has had a blood clot in a leg, lung, or another organ.<\/li><li>You have\u00a0SLE\u00a0(systemic lupus erythematosus).<\/li><li>You have cancer.<\/li><\/ul>\n\n\n\n<p>The symptoms of blood clots are described in the section &#8220;You must immediately contact a doctor and stop treatment with Vagifem if any of the following occur:&#8221;.<\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>For women in their 50s, who do not take\u00a0HRT, over a 5-year period an average of 4\u20137 in 1,000 are expected to have a blood clot in a vein.<\/p>\n\n\n\n<p>For women in their 50s taking&nbsp;estrogen&nbsp;alone for more than 5 years, 5\u20138 in 1,000 users are expected to develop a blood clot in a vein (ie 1 extra case).<\/p>\n\n\n\n<p><strong>Heart disease (heart attack)<\/strong><\/p>\n\n\n\n<p>For women taking\u00a0estrogen\u00a0alone, there is no increased risk of developing heart disease.<\/p>\n\n\n\n<p><strong>Stroke&nbsp;_<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;stroke&nbsp;is about 1.5 times higher for those who take&nbsp;HRT&nbsp;compared to those who do not.&nbsp;The risk of&nbsp;stroke&nbsp;is age dependent, therefore the number of cases of&nbsp;stroke&nbsp;due to the use of&nbsp;HRT increases&nbsp;with increasing age.<\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>For women in their 50s who do not take\u00a0HRT, for over 5 years an average of 8 in 1,000 are expected to have a\u00a0stroke.<\/p>\n\n\n\n<p>For women in their 50s taking&nbsp;HRT&nbsp;for more than 5 years, 11 out of 1,000 users are expected to have a&nbsp;stroke&nbsp;(ie 3 extra cases).<\/p>\n\n\n\n<p><strong>Other conditions<\/strong><\/p>\n\n\n\n<p>HRT&nbsp;use&nbsp;does not prevent memory loss.&nbsp;The risk of memory loss may be slightly higher in women who start using&nbsp;HRT&nbsp;after the age of 65.&nbsp;Consult your doctor.<\/p>\n\n\n\n<p><strong>Other medicines and Vagifem<\/strong><\/p>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking or have recently taken any other medicines, including over-the-counter medicines and herbal medicines.\u00a0Since Vagifem is used for local treatment in the\u00a0vagina, however, it is unlikely that Vagifem will affect the effectiveness of other medicines.\u00a0Vagifem can affect the effectiveness of other treatments given vaginally.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Vagifem is intended for women whose menstruation has stopped.&nbsp;Do not use Vagifem if you are pregnant.&nbsp;If you become pregnant, stop using Vagifem and contact your doctor.&nbsp;Do not use Vagifem during breastfeeding.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>No known effect.<a><\/a><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Vagifem<\/h2>\n\n\n\n<p>Always use this medicine exactly as described in this leaflet or as directed by your doctor, nurse, or pharmacist.\u00a0Consult a doctor, nurse, or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Use of this medication<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Treatment with Vagifem can start on any day.<\/li><li>For vaginal\u00a0use\u00a0only.\u00a0The tablet must not be taken by mouth!<\/li><li>The vaginal tablet is inserted into the\u00a0vagina\u00a0with the applicator.<\/li><\/ul>\n\n\n\n<p>&#8220;DIRECTIONS FOR USE&#8221; at the end of this leaflet shows how Vagifem should be used.&nbsp;Read the instructions carefully before use.<\/p>\n\n\n\n<p><strong>How much to use<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Use 1 vaginal tablet daily for the first 2 weeks.<\/li><li>Then use 1 vaginal tablet 2 times a week with 3 or 4 days between each\u00a0dose.<\/li><\/ul>\n\n\n\n<p>You must talk to your doctor if you do not feel better or if you feel worse after 2-4 weeks or if other symptoms appear.<\/p>\n\n\n\n<p><strong>General information about the treatment of&nbsp;menopausal symptoms<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>When using medicines for menopausal symptoms, it is recommended to use the lowest&nbsp;dose&nbsp;that works and to use the medicine for the shortest possible time.<\/li><li>Treatment should only be continued if the benefits outweigh the risks.&nbsp;Talk to your doctor about this.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Vagifem<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have used too much medicine or if, for example, a child accidentally ingested the medicine, contact a doctor or hospital for an assessment of the risk and advice.<\/li><li>Vagifem is intended for local treatment in the\u00a0vagina.\u00a0The dose\u00a0of estradiol is so low that a large number of tablets must be taken to reach the\u00a0dose\u00a0normally used in oral treatment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Vagifem<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you forget a\u00a0dose, take it as soon as you remember.<\/li><li>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Vagifem<\/h2>\n\n\n\n<p>Talk to your doctor if you have questions about how long treatment should last or discuss other treatment options.<\/p>\n\n\n\n<p><strong>If you need surgery<\/strong><\/p>\n\n\n\n<p>If you are going to have surgery, you must inform the operating doctor that you are using Vagifem.&nbsp;You may need to stop using Vagifem for 4 to 6 weeks before surgery to avoid the risk of blood clots (see section 2, \u201cBlood clots in a vein (&nbsp;thrombosis&nbsp;)&nbsp;<strong>\u201d<\/strong>&nbsp;).&nbsp;Ask the doctor when it is appropriate to start using Vagifem again.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The following diseases are more common in women who take\u00a0HRT\u00a0drugs that circulate in the blood compared to women who do not take\u00a0HRT.\u00a0These risks are less for vaginally administered treatments such as Vagifem:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/li><li>Blood clots in veins in legs or lungs (venous&nbsp;thromboembolism&nbsp;)<\/li><li>Stroke&nbsp;_<\/li><li>Probable memory loss, if treatment with&nbsp;HRT&nbsp;is started after the age of 65.<\/li><\/ul>\n\n\n\n<p>See section 2, \u201cWhat you need to know before you use Vagifem\u201d for more information about these\u00a0side effects.<\/p>\n\n\n\n<p><strong>Common<\/strong>:\u00a0<strong>may affect up to 1 in 10 people<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Stomach pain<\/li><li>Vaginal\u00a0bleeding, discharge, or discomfort.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon: may affect up to 1 in 100 people<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fungal infection in the vagina<\/li><li>Nausea<\/li><li>Rash<\/li><li>Weight gain<\/li><li>Heatwave<\/li><li>High\u00a0blood pressure.<\/li><\/ul>\n\n\n\n<p><strong>Very rare<\/strong>:\u00a0<strong>may affect up to 1 in 10,000 people<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea<\/li><li>Fluid retention<\/li><li>Worsening of&nbsp;migraines<\/li><li>General hypersensitivity (eg anaphylactic reaction\/shock).<\/li><\/ul>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;have&nbsp;<\/strong><strong>been reported&nbsp;<\/strong><strong>with systemic treatment with estrogen:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Gallbladder disease<\/li><li>Various skin diseases:<ul><li>dark skin spots, especially on the face and neck, so-called &#8220;pregnancy spots&#8221; (chloasma)<\/li><li>painful red-purple bumps on the skin (erythema nodosum)<\/li><li>ring-shaped reddening or ulcerated rash (erythema multiforme).<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Vagifem<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store protected from cold.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and blister after Ex. Date.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medications that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<p>This medicine may be a risk to the aquatic environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is estradiol 10 micrograms (as estradiol hemihydrate).\u00a0Each vaginal tablet contains 10 micrograms of estradiol (as estradiol hemihydrate).<\/li><li>Other ingredients are hypromellose,\u00a0lactose monohydrate, corn starch, and magnesium stearate.<\/li><li>The film coating contains hypromellose and macrogol 6000.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Each vaginal tablet is in a disposable applicator.<\/p>\n\n\n\n<p>Vagifem is marked NOVO 278 on one side.<\/p>\n\n\n\n<p>Package sizes<\/p>\n\n\n\n<p>18 vaginal tablets with\u00a0applicator.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Novo Nordisk A\/S<\/p>\n\n\n\n<p>Novo All\u00e9<\/p>\n\n\n\n<p>DK-2880 Bag Sword<\/p>\n\n\n\n<p>Denmark<\/p>\n","protected":false},"excerpt":{"rendered":"<p>10 microgram\u00a0vaginal<br \/>\ntablet estradiol<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[3093,3096,10344,26769,26773,26772,10343,5414,26770,26771],"class_list":["post-26049","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-estradiol","tag-estradiol-side-effects","tag-estradiol-tablet","tag-vagifem","tag-vagifem-side-effects","tag-vagifem-tablet","tag-what-estradiol-is-used-for","tag-what-is-estradiol","tag-what-is-vagifem","tag-what-vagifem-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26049","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=26049"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26049\/revisions"}],"predecessor-version":[{"id":26067,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26049\/revisions\/26067"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=26049"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=26049"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=26049"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}