{"id":26042,"date":"2022-10-10T14:19:45","date_gmt":"2022-10-10T14:19:45","guid":{"rendered":"https:\/\/zeepedia.com\/?p=26042"},"modified":"2022-10-11T08:15:46","modified_gmt":"2022-10-11T08:15:46","slug":"vaborem","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/vaborem\/","title":{"rendered":"Vaborem &#8211; Meropenem\/Vaborbactam uses, dose and side effects"},"content":{"rendered":"\n<p>1g\/1g powder for concentrate for infusion solution, solution<br>meropenem\/vaborbactam<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Vaborem is and what it is used for<\/h2>\n\n\n\n<p><strong>What Vaborem is<\/strong><\/p>\n\n\n\n<p>Vaborem is an&nbsp;antibiotic&nbsp;that contains two active substances: meropenem and vaborbactam.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Meropenem belongs to a group of medicines called &#8220;carbapenems&#8221;.&nbsp;It can kill many types of bacteria by preventing them from building the protective pathways that surround their cells.<\/li><li>Vaborbactam is a \u201cbetalactamase inhibitor\u201d.&nbsp;It blocks the effect of an&nbsp;enzyme&nbsp;that makes some bacteria resistant to the effect of meropenem.&nbsp;This helps meropenem kill certain bacteria that it cannot kill on its own.<\/li><\/ul>\n\n\n\n<p><strong>What Vaborem is used for<\/strong><\/p>\n\n\n\n<p>Vaborem is used in adults to treat certain serious bacterial infections:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>in the bladder or kidneys (urinary tract infections)<\/li><li>in the stomach and intestines (intra-abdominal infections)<\/li><li>in the lungs (&nbsp;pneumonia&nbsp;).<\/li><\/ul>\n\n\n\n<p>It is also used to treat infections:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>in the blood associated with any of the&nbsp;infections&nbsp;listed above<\/li><li>which is caused by bacteria that other&nbsp;antibiotics&nbsp;cannot kill.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you are given Vaborem<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should not be given Vaborem<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to meropenem, vaborbactam, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are allergic to other carbapenem antibiotics (the group to which meropenem belongs).<\/li><li>if you have ever had a severe\u00a0allergic reaction\u00a0in connection with treatment with\u00a0antibiotics\u00a0belonging to the beta-lactam group (including\u00a0penicillins,\u00a0cephalosporins,\u00a0or monobactams).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before you receive Vaborem:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have ever had a severe\u00a0allergic reaction\u00a0to other beta-lactam\u00a0antibiotics\u00a0(including carbapenems,\u00a0penicillins,\u00a0cephalosporins,\u00a0or monobactams).<\/li><li>if you have ever had severe diarrhea during or after antibiotic treatment<\/li><li>if you have ever had seizures<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you, or if you are not sure, talk to your doctor or pharmacist before using Vaborem.<\/p>\n\n\n\n<p>You may develop signs and symptoms of serious skin reactions (see section 4).&nbsp;If this happens, talk to a doctor or nurse immediately so the symptoms can be treated.<\/p>\n\n\n\n<p>Talk to your doctor or nurse if you get diarrhea during treatment.<\/p>\n\n\n\n<p>This medicine can affect the liver.&nbsp;The doctor may take certain blood tests to check how well your liver is working while you are taking this medicine.<\/p>\n\n\n\n<p>New&nbsp;infection<\/p>\n\n\n\n<p>Although Vaborem can fight some bacteria, there is a possibility that you may get another&nbsp;infection&nbsp;caused by another&nbsp;organism&nbsp;during or after treatment.&nbsp;The doctor will check you carefully for any new&nbsp;infection&nbsp;and, if necessary, give you another treatment.<\/p>\n\n\n\n<p>Blood samples<\/p>\n\n\n\n<p>Tell the doctor that you are taking Vaborem if you are going to give blood samples.&nbsp;This is because you can get an abnormal result on something called a &#8220;Coombs test&#8221;.&nbsp;This test checks for&nbsp;antibodies&nbsp;that can destroy&nbsp;red blood cells&nbsp;and can be affected by how the immune system responds to Vaborem.<\/p>\n\n\n\n<p>Contraceptive<\/p>\n\n\n\n<p>Tell the doctor if you are taking hormonal contraceptives that contain\u00a0estrogen\u00a0and\/or\u00a0progesterone, as simultaneous use with Vaborem can lead to a reduction in their effectiveness.\u00a0Women of childbearing potential should be advised to use alternative effective contraception during treatment with Vaborem and for 28 days after stopping treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Vaborem should not be used by children or young people under the age of 18.&nbsp;This is because it is not known whether the medicine is safe to use in these age groups.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Vaborem<\/h2>\n\n\n\n<p>Tell your doctor if you are using, have recently used, or might be using other medicines.<\/p>\n\n\n\n<p>You must tell the doctor if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines used to treat\u00a0epilepsy\u00a0called\u00a0valproic acid, sodium valproate, or valpromide because Vaborem can reduce their effect<\/li><li>a\u00a0gout\u00a0medicine called probenecid<\/li><li>oral\u00a0anticoagulants, such as\u00a0warfarin\u00a0(used to treat or prevent blood clots)<\/li><li>hormonal contraceptives taken by mouth as Vaborem can reduce their effectiveness.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor before using Vaborem if any of the above applies to you.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby, consult your doctor before receiving this medicine.<\/p>\n\n\n\n<p>You must tell your doctor if you are breastfeeding or intend to breastfeed before receiving Vaborem.\u00a0Small amounts of the medicine can pass into breast milk and it can affect the baby.\u00a0You must therefore stop breastfeeding before you are given Vaborem.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Vaborem can make you feel dizzy, sleepy, and lethargic, give you a headache or a tingling sensation (such as numbness and tingling), or, in rare cases, induce a seizure or seizure.\u00a0This may affect your ability to drive, and use tools and machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vaborem contains sodium<\/h2>\n\n\n\n<p>This medicine contains 250 mg of\u00a0sodium\u00a0(the main ingredient in common\/table salt) per\u00a0vial.\u00a0This corresponds to 12.5% \u200b\u200bof the maximum recommended daily intake of\u00a0sodium\u00a0for adults.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How you are given Vaborem<\/h2>\n\n\n\n<p>You will be given Vaborem by a doctor or nurse as an&nbsp;infusion&nbsp;(a drip) into a vein over 3 hours.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0is 2 vials (a total of 2 g meropenem and 2 g vaborbactam), given every 8 hours.\u00a0The doctor decides how many days you need to be treated, depending on the type of\u00a0infection.<\/p>\n\n\n\n<p><strong>Patients with kidney problems<\/strong><\/p>\n\n\n\n<p>If you have kidney problems, your doctor may lower your\u00a0dose.\u00a0The doctor may also want to do some blood tests to see how well your kidneys are working.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have been given too much Vaborem<\/h2>\n\n\n\n<p>You will be given Vaborem by a doctor or nurse, so it is unlikely that you will receive the wrong\u00a0dose.\u00a0If you think you have received too much Vaborem, contact a doctor or nurse immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have forgotten a dose of Vaborem<\/h2>\n\n\n\n<p>If you think you have forgotten a\u00a0dose, contact your doctor or nurse immediately.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or nurse.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Tell your doctor immediately if you notice any of the following serious&nbsp;side effects&nbsp;&#8211; you may need&nbsp;urgent&nbsp;medical treatment:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe allergic reactions may include swelling of the lips, face, throat, or tongue, difficulty swallowing or breathing or a severe rash or other severe skin reactions, or low\u00a0blood pressure\u00a0(which may make you faint or dizzy).\u00a0Such reactions can be life-threatening.<\/li><li>Diarrhea that gets worse or does not go away, or stools that contain blood or mucus &#8211; this may occur during treatment or after treatment with Vaborem has stopped.\u00a0This may be due to a\u00a0bacteria\u00a0called\u00a0Clostridium difficile.\u00a0If this occurs, do not take medications that stop or impair bowel movements.<\/li><\/ul>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>Tell your doctor or nurse if you notice any of the following side effects:<\/p>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Increased number of\u00a0platelets\u00a0(a type of\u00a0blood cell\u00a0) \u2013 seen in blood tests<\/li><li>Decrease in the amount of\u00a0potassium\u00a0or sugar &#8211; seen in blood tests<\/li><li>Headache<\/li><li>Low\u00a0blood pressure<\/li><li>Diarrhea<\/li><li>Nausea or vomiting<\/li><li>Swelling,\u00a0redness,\u00a0and\/or pain around the needle where you get medicine into a vein<\/li><li>Fever<\/li><li>Increase in the number of\u00a0enzymes\u00a0produced in the liver called\u00a0alanine aminotransferase\u00a0or\u00a0aspartate aminotransferase\u00a0&#8211; seen in blood tests<\/li><li>Increase in the amount of\u00a0an enzyme\u00a0called alkaline phosphatase which can be a sign that the liver, gallbladder, or bones are not working well &#8211; seen in blood tests<\/li><li>An increase in the amount of\u00a0an enzyme\u00a0called\u00a0lactate dehydrogenase\u00a0which can be a sign of damage to certain organs in the body &#8211; seen in blood tests<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;(may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling and irritation in the colon \u2013 this can cause diarrhea, fever, and stomach cramps and is due to another\u00a0infection\u00a0in the colon<\/li><li>Fungal infections, including those in the vagina or mouth<\/li><li>Decreased number of\u00a0white blood cells\u00a0or certain types of\u00a0white blood cells\u00a0called\u00a0neutrophils\u00a0and decreased number of\u00a0platelets\u00a0&#8211; seen in blood tests<\/li><li>Increase in a type of\u00a0white blood cell\u00a0called\u00a0eosinophils\u00a0&#8211; seen in blood tests<\/li><li>Sudden and severe\u00a0allergic reactions\u00a0requiring\u00a0emergency\u00a0medical treatment and may include\u00a0itching, skin discoloration, stomach cramps, swelling, difficulty breathing, fainting, and a drop in blood pressure<\/li><li>The less severe\u00a0allergic reactions\u00a0which may include\u00a0redness, red bumps, skin peeling,\u00a0itching,\u00a0and general malaise<\/li><li>A feeling of being less hungry<\/li><li>Decrease in the amount of\u00a0potassium\u00a0or sugar &#8211; seen in blood tests<\/li><li>Insomnia<\/li><li>See, hear or sense things that are not there<\/li><li>Dizziness<\/li><li>Trembling or shaking<\/li><li>A tingling sensation (numbness and tingling)<\/li><li>Drowsiness and lethargy<\/li><li>Swollen and red and irritated veins<\/li><li>Painful veins<\/li><li>Breathing problems<\/li><li>Bloating or feeling of fullness in the abdomen<\/li><li>Stomach ache<\/li><li>Itchy skin<\/li><li>Rash<\/li><li>Raised, itchy rash (\u00a0hives\u00a0)<\/li><li>Difficulty controlling the bladder<\/li><li>Impaired kidney function<\/li><li>Abnormal feeling in the chest<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>The following reactions may occur, alone or in combination, when Vaborem is given into a vein: reddening of the skin (\u00a0erythema\u00a0);\u00a0feeling of warmth, tenderness, and swelling of the vein around the needle (\u00a0phlebitis\u00a0);\u00a0a blood clot in the vein where the needle has passed through the skin ( infusion\u00a0site thrombosis\u00a0)<\/li><li>Pain<\/li><li>Increase of a substance in the blood called creatine phosphokinase which is a sign of possible damage to certain\u00a0tissues\u00a0such as muscles and\/or other organs &#8211; seen in blood tests<\/li><li>An increase of a substance in the blood called\u00a0bilirubin\u00a0which is a sign of possible damage to the red\u00a0blood cells\u00a0or that the liver is not working well &#8211; seen in blood tests<\/li><li>Increases in certain types of substances in the blood called\u00a0urea\u00a0or\u00a0creatinine\u00a0which are signs that the kidneys are working less well &#8211; seen in blood tests<\/li><li>The reaction that occurs during or soon after you receive Vaborem that manifests as a general feeling of being unwell, possibly with any of the following: low\u00a0blood pressure, nausea, vomiting, stomach cramps, fever,\u00a0flushing, fast heartbeat or breathing problems, headache<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Convulsions (seizures)<\/li><\/ul>\n\n\n\n<p><strong>Frequency not known<\/strong>&nbsp;(cannot be estimated from available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe and very low\u00a0white blood cell count\u00a0&#8211; seen in blood tests<\/li><li>Hemolytic anemia\u00a0(a condition where the red\u00a0blood cells\u00a0are damaged or reduced in number), which makes you feel tired and the skin and eyes turn yellow<\/li><li>Swelling of the tongue, face, lips, or throat<\/li><li>Sudden onset of a severe rash with target-like spots or blisters or skin peeling, possibly with high fever, joint pain, abnormal liver, kidney, or lung function (these may be signs of more serious medical conditions called\u00a0toxic epidermal necrolysis,\u00a0Stevens-Johnson syndrome, erythema multiforme,\u00a0acute\u00a0generalized exanthematous\u00a0pustulosis, or a condition known as drug reaction with\u00a0eosinophilia\u00a0and systemic symptoms (DRESS))<\/li><li>A positive result on a test called &#8216;Coombs&#8217; which is used to identify\u00a0hemolytic anemia\u00a0(see above) or immune system reaction to Vaborem<\/li><li>Acute\u00a0disorientation and\u00a0confusion\u00a0(\u00a0delirium\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Vaborem<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the container.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 25 \u00b0C.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medications that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are meropenem and vaborbactam.\u00a0Each\u00a0vial\u00a0contains 1 g of meropenem (as meropenem trihydrate) and 1 g of vaborbactam.<\/li><li>Another ingredient is sodium carbonate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Vaborem is a white to light yellow powder to concentrate for\u00a0infusion, a solution supplied in a\u00a0vial.<\/p>\n\n\n\n<p>Vaborem is available in packs containing 6 vials.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Menarini International Operations Luxembourg SA 1, Avenue de la Gare L-1611, Luxembourg Luxembourg<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>ACS Dobfar, SpA<\/p>\n\n\n\n<p>Nucleo Industriale S. Atto<\/p>\n\n\n\n<p>(loc. S. Nicolo&#8217; a Tordino) 64100 Teramo (TE)<\/p>\n\n\n\n<p>Italy<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vaborem is an\u00a0antibiotic\u00a0that contains two active substances: meropenem and vaborbactam.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22502],"tags":[17112,17116,26793,26796,26789,26792,17113,26794,26790,17114,26795,26791],"class_list":["post-26042","post","type-post","status-publish","format-standard","hentry","category-medicines","category-v","tag-meropenem","tag-meropenem-side-effects","tag-vaborbactam","tag-vaborbactam-side-effects","tag-vaborem","tag-vaborem-side-effects","tag-what-is-meropenem","tag-what-is-vaborbactam","tag-what-is-vaborem","tag-what-meropenem-is-used-for","tag-what-vaborbactam-is-used-for","tag-what-vaborem-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26042","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=26042"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26042\/revisions"}],"predecessor-version":[{"id":26070,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26042\/revisions\/26070"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=26042"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=26042"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=26042"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}