{"id":26008,"date":"2022-10-10T07:01:17","date_gmt":"2022-10-10T07:01:17","guid":{"rendered":"https:\/\/zeepedia.com\/?p=26008"},"modified":"2022-10-10T08:22:26","modified_gmt":"2022-10-10T08:22:26","slug":"uromitexan-2","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/uromitexan-2\/","title":{"rendered":"Uromitexan &#8211; Mesna uses, dose and side effects"},"content":{"rendered":"\n<p>(with preservative) 100 mg\/ml solution for injection<br>mesna<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Uromitexan is and what it is used for<\/h2>\n\n\n\n<p>Uromitexan&nbsp;solution for injection&nbsp;is only given by healthcare professionals, who can answer any additional questions you may have after reading the information below.<\/p>\n\n\n\n<p>Uromitexan is used to prevent mucosal damage in the bladder during treatment with ifosfamide or cyclophosphamide.&nbsp;Some&nbsp;cytostatics&nbsp;(ifosfamide, cyclophosphamide) can damage the lining of the bladder so that there is blood in the urine.&nbsp;If Uromitexan is given at the same time, it has a protective effect and the risk of&nbsp;inflammation&nbsp;in the bladder and blood in the urine is reduced.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before receiving Uromitexan<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Uromitexan<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to mesna, other similar medicines (\u00a0thiols\u00a0), or any of the other ingredients, including benzyl alcohol in this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Uromitexan:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have previously experienced breathing difficulties, wheezing, skin redness,\u00a0itching,\u00a0or swelling after receiving Uromitexan.<\/li><li>if you have any\u00a0autoimmune\u00a0disease, e.g.\u00a0rheumatoid arthritis, systemic lupus erythematosus (\u00a0SLE\u00a0), or kidney inflammation, as these diseases can increase the risk of certain\u00a0side effects.<\/li><li>if you have previously had a blockage or obstruction in the urinary tract, preventing normal urine output. Morning urine should be examined each day before treatment for microscopic blood findings (\u00a0hematuria\u00a0).<\/li><\/ul>\n\n\n\n<p>Urine test strips for&nbsp;ketone bodies&nbsp;or&nbsp;red blood cells&nbsp;(&nbsp;erythrocytes&nbsp;) can give incorrect results during medication with Uromitexan.&nbsp;Contact a doctor or nurse if you are unsure.<\/p>\n\n\n\n<p>Stop using Uromitexan and contact your doctor immediately if you experience any of the following symptoms (&nbsp;angioedema&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, tongue, or throat<\/li><li>difficulty swallowing<\/li><li>hives\u00a0and difficulty breathing.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Uromitexan<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are using, have recently used, or might be using other medicines.<\/p>\n\n\n\n<p>The blood-thinning effect of medicines containing&nbsp;warfarin&nbsp;may increase with simultaneous treatment with Uromitexan.&nbsp;Coagulation values \u200b\u200bshould be taken regularly.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.<\/p>\n\n\n\n<p>There is a limited amount of data on the use of Uromitexan in pregnant and lactating women.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, consult a doctor or pharmacist before using this medicine.\u00a0See also the section &#8220;Uromitexan contains benzyl alcohol&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Some\u00a0side effects\u00a0such as fainting, dizziness, drowsiness, and blurred vision can affect the ability to drive and use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Uromitexan contains sodium and benzyl alcohol<\/h2>\n\n\n\n<p><strong>Uromitexan contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains approximately 59 mg&nbsp;sodium&nbsp;per 400 mg mesna.&nbsp;This is equivalent to 2.95% of the maximum recommended daily intake of&nbsp;sodium&nbsp;for adults.<\/p>\n\n\n\n<p><strong>Uromitexan contains benzyl alcohol<\/strong><\/p>\n\n\n\n<p>Uromitexan (with&nbsp;preservative&nbsp;) contains 10.4 mg of benzyl alcohol per ml.&nbsp;Benzyl alcohol can cause allergic reactions.&nbsp;Benzyl alcohol is associated with the risk of serious&nbsp;side effects&nbsp;such as breathing difficulties in young children.<\/p>\n\n\n\n<p>The medicine should not be used by newborns (up to 4 weeks of age) unless a doctor has prescribed it.&nbsp;Do not use the medicine for more than 1 week in newborns (younger than 3 years) unless a doctor has recommended it.<\/p>\n\n\n\n<p>If you have impaired liver or kidney function, or are pregnant or breastfeeding, consult a doctor or pharmacist before using this medicine.\u00a0Large amounts of benzyl alcohol can be stored in the body and cause\u00a0side effects\u00a0(metabolic\u00a0acidosis\u00a0).<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to receive Uromitexan<\/h2>\n\n\n\n<p>The dose&nbsp;is determined by the doctor, who adjusts it individually for you depending on your treatment with&nbsp;cytostatics&nbsp;(ifosfamide or cyclophosphamide).<\/p>\n\n\n\n<p>Uromitexan&nbsp;solution for injection&nbsp;is given as an&nbsp;injection&nbsp;or as a drip (&nbsp;infusion&nbsp;) and is only given by healthcare professionals, who can provide more detailed information.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have been given too much Uromitexan<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>As the Uromitexan\u00a0solution for injection\u00a0is always given by healthcare professionals, you should first talk to them if you suspect that you have received too much of a\u00a0dose.<\/p>\n\n\n\n<p>Symptoms of overdose can be nausea, vomiting, stomach ache, diarrhea, headache, fatigue, pain in arms and legs, and joints, skin rash, hot flushes, low\u00a0blood pressure, slow\u00a0pulse, fast\u00a0pulse, numbness, fever, and spasm in the muscles of the trachea.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>However, since Uromitexan is always taken at the same time as ifosfamide or cyclophosphamide, it is difficult to determine which of these preparations caused a\u00a0side effect.<\/p>\n\n\n\n<p>Contact a doctor immediately if you appear to have had an\u00a0allergic reaction.\u00a0Symptoms of this can be difficulty breathing, wheezing, skin redness,\u00a0itching,\u00a0or swelling.<\/p>\n\n\n\n<p>An allergic or allergy-like reaction can occur with the medication being given or up to a few days after the medication has ended.<\/p>\n\n\n\n<p><em>Very common&nbsp;side effects&nbsp;(may affect more than 1 in 10 users):<\/em><\/p>\n\n\n\n<p>Headache, feeling faint, persistent unconsciousness\/drowsiness, hot flashes, abdominal pain\/painful intestinal cramping, nausea, diarrhea, rash, infusion site reactions such as\u00a0itching\u00a0and rash, fever, and flu-like illness.<\/p>\n\n\n\n<p><em>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 users)<\/em>&nbsp;:<\/p>\n\n\n\n<p>Swollen\/enlarged&nbsp;lymph nodes&nbsp;(&nbsp;lymphadenopathy&nbsp;), vomiting, decreased appetite, flatulence, constipation,&nbsp;anorexia&nbsp;, feeling dehydrated, insomnia, nightmares, dizziness, crawling or tingling in the skin (&nbsp;paresthesia&nbsp;), increased skin sensitivity (&nbsp;hyperesthesia&nbsp;), fainting (&nbsp;syncope&nbsp;), reduced sensitivity to touch (&nbsp;hypoaesthesia&nbsp;), impaired attention,&nbsp;inflammation&nbsp;of the&nbsp;conjunctiva&nbsp;of the eye , sensitivity to light, blurred vision, palpitation&nbsp;,&nbsp;nasal congestion, severe sharp pain when inhaling (pleuritic pain),&nbsp;dry mouth, spasm of the trachea, labored breathing, discomfort in the larynx, nosebleeds (epitaxy), stiffness, fatigue, chest pain, malaise,&nbsp;flushing&nbsp;, cough, pharyngitis,&nbsp;mucosal&nbsp;irritation , burning pain in the pit of the stomach\/sternum, bleeding in the gums, increased levels in the blood of certain liver enzymes (&nbsp;transaminases&nbsp;),&nbsp;itching&nbsp;, greatly increased sweating which is usually pathological (&nbsp;hyperhidrosis&nbsp;), joint pain (&nbsp;arthralgia&nbsp;), back pain, muscle pain (&nbsp;myalgia&nbsp;), discomfort in the arms and legs, pain in the jaw, pain when emptying the&nbsp;bladder&nbsp;(&nbsp;dysuria&nbsp;), reactions at the infusion site such as pain, skin redness,hives&nbsp;and swelling.<\/p>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users):<\/em><\/p>\n\n\n\n<p>Hypersensitivity reaction&nbsp;er, severe&nbsp;allergic reaction&nbsp;with a rapid course (allergic shock, anaphylactoid reaction), decrease in all cells (red and&nbsp;white blood cells&nbsp;and&nbsp;platelets&nbsp;) in the blood (pancytopenia), decrease in the number of&nbsp;white blood cells&nbsp;that fight&nbsp;infection&nbsp;er (&nbsp;leukopenia&nbsp;, lymphopenia), abnormal high amounts of&nbsp;eosinophils&nbsp;(type of&nbsp;blood cells&nbsp;formed in the&nbsp;bone marrow&nbsp;) in the blood or in body tissues (&nbsp;eosinophilia&nbsp;), lack of&nbsp;platelets&nbsp;(&nbsp;thrombocytopenia&nbsp;), seizures, swelling around the eyes (periorbital&nbsp;oedema), changes on the&nbsp;EKG&nbsp;(ST elevation or other abnormal result), fast&nbsp;heart rate&nbsp;, circulatory reactions, low or high&nbsp;blood pressure&nbsp;, shortness of breath, decreased levels of oxygen in the body (&nbsp;hypoxia&nbsp;, decreased oxygen saturation), coughing up blood from the lungs or airways (hemoptysis) ,&nbsp;inflammation&nbsp;of the mucous membrane of the mouth, bad taste in the mouth, inflammation of the liver, increased blood levels of certain liver enzymes (gamma-glutamyltransferase, alkaline phosphatase), blistering (vesiculation), life-threatening conditions that cause rashes, ulcers, sore throat,&nbsp;conjunctivitis&nbsp;and separation of the skin layers (&nbsp;Lyells syndrome&nbsp;, Stevens Johnson syndrome), local tissue swelling (urticarial&nbsp;edema), itchy, red rashes that may develop into ulcers (erythema multiforme), redness of the skin (&nbsp;erythema&nbsp;),&nbsp;hypersensitivity reaction&nbsp;to drugs characterized by skin rashes, ulcers and\/or larger blisters\/bleeding of the skin and mucous membranes, swelling of the deeper layer of the skin caused by of fluid accumulation (&nbsp;angioedema&nbsp;), skin lesions that recur in the same area when the same drug is given (fixed drug eruption), skin rash due to increased sensitivity to light,&nbsp;hives&nbsp;(&nbsp;urticaria&nbsp;), burning sensation in the skin,&nbsp;acute&nbsp;kidney failure&nbsp;, weakness (&nbsp;asthenia&nbsp;, lack of energy) , mucosal reactions, swelling of the face (facial oedema), swelling of&nbsp;tissueusually in the legs due to accumulation of fluid (peripheral&nbsp;oedema&nbsp;), increased respiratory rate, reactions at the injection site (&nbsp;thrombophlebitis&nbsp;, irritation), signs of severe coagulation disorder that increases the risk of blood clotting in&nbsp;vessels&nbsp;(disseminated intravascular&nbsp;coagulation&nbsp;(&nbsp;DIC&nbsp;)), altered laboratory results (eg, prolonged prothrombin time, prolonged activated&nbsp;partial&nbsp;thromboplastin).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Uromitexan<\/h2>\n\n\n\n<p>Store out of sight and reach of children.<\/p>\n\n\n\n<p>Store at a maximum of 30 \u00b0C.&nbsp;Do not freeze.<\/p>\n\n\n\n<p>Use before the expiry date stated on the packaging and label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>The opened\u00a0vial\u00a0must be used within 8 days.<\/p>\n\n\n\n<p>For solutions with additives, chemical and physical in-use stability has been demonstrated for 24 hours at 25 \u00b0C.\u00a0For microbiological reasons, it is recommended that mixed solutions be used immediately after\u00a0preparation.\u00a0If not used immediately, it is the user&#8217;s responsibility to ensure that instructions for shelf life and storage conditions are followed.\u00a0However, 24 hours at 25 \u00b0C should not be exceeded.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures are to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active ingredient is mesna.<\/li><li>Other ingredients are disodium edetate, sodium hydroxide, benzyl alcohol (\u00a0preservative\u00a0), and water for injections<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Vials 1 x 10 ml and 1 x 50 ml.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Baxter Medical AB<\/p>\n\n\n\n<p>Box 63<\/p>\n\n\n\n<p>164 94 Coffin<\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Baxter Oncology GmbH<\/p>\n\n\n\n<p>Kantstrasse 2<\/p>\n\n\n\n<p>33790 Halle\/Westphalia<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Uromitexan\u00a0solution for injection\u00a0is only given by healthcare professionals, who can answer any additional questions you may have after reading the information below.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22501],"tags":[26709,26705,26708,26710,26714,26713,26706,26711,26707,26712],"class_list":["post-26008","post","type-post","status-publish","format-standard","hentry","category-medicines","category-u","tag-benefits-of-mesna","tag-mesna","tag-mesna-side-effects","tag-uromitexan","tag-uromitexan-benefits","tag-uromitexan-side-effects","tag-what-is-mesna","tag-what-is-uromitexan","tag-what-mesna-is-used-for","tag-what-uromitexan-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26008","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=26008"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26008\/revisions"}],"predecessor-version":[{"id":26026,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26008\/revisions\/26026"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=26008"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=26008"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=26008"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}