{"id":26002,"date":"2022-10-10T06:50:19","date_gmt":"2022-10-10T06:50:19","guid":{"rendered":"https:\/\/zeepedia.com\/?p=26002"},"modified":"2022-10-10T08:22:54","modified_gmt":"2022-10-10T08:22:54","slug":"uptravi","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/uptravi\/","title":{"rendered":"Uptravi &#8211; Selexipag uses, dose and side effects"},"content":{"rendered":"\n<p>200, 400, 600, 800, 1000, 1200, 1400 and 1600 micrograms&nbsp;film-coated tablets<br>selexipag<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Uptravi is and what it is used for<\/h2>\n\n\n\n<p>Uptravi is a medicine that contains the active substance selexipag.\u00a0It acts on blood vessels in a similar way to the natural substance\u00a0prostacyclin, which causes\u00a0vessels\u00a0to relax and dilate.<\/p>\n\n\n\n<p>Uptravi is used for the long-term treatment of\u00a0pulmonary\u00a0arterial\u00a0hypertension\u00a0(PAH) in adult patients whose disease cannot be controlled by treatment with other types of anti-PAH drugs, so-called endothelin receptor\u00a0antagonists,\u00a0and\u00a0phosphodiesterase\u00a05 inhibitors.\u00a0Uptravi can be used alone if these medicines are not suitable for the patient.<\/p>\n\n\n\n<p>In PAH, the pressure is too high in the blood vessels that carry blood from the heart to the lungs (pulmonary arteries).\u00a0In people with PAH, these\u00a0arteries\u00a0become narrower and the heart, therefore, has to work harder to pump blood through them.\u00a0It can make you feel tired, dizzy, short of breath, or get other symptoms.<\/p>\n\n\n\n<p>By mimicking the action of the natural substance\u00a0prostacyclin, this medicine widens the pulmonary arteries and makes them less stiff.\u00a0It then becomes easier for the heart to pump blood through the pulmonary arteries.\u00a0Uptravi reduces the pressure in the pulmonary arteries, relieves the symptoms of PAH, and slows the progression of the disease.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Uptravi<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Uptravi<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to selexipag or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have heart problems, for example:<ul><li>poor blood flow to the heart muscle (severe heart disease or unstable angina), with symptoms such as chest pain<\/li><li>had a heart attack in the last 6 months<\/li><li>weak heart (decompensated\u00a0heart failure\u00a0) that is not under close medical control<\/li><li>very irregular heartbeat<\/li><li>heart valve defects (congenital or acquired) that cause the heart to function poorly (unrelated to\u00a0pulmonary\u00a0hypertension\u00a0)<\/li><\/ul><\/li><li>if you have had a\u00a0stroke\u00a0in the last 3 months or any other event that reduced the blood supply to the brain (e.g. transient ischemic attack, so-called\u00a0TIA\u00a0).<\/li><li>if you are taking gemfibrozil (a medicine to reduce the number of fatty substances (\u00a0lipids\u00a0) in the blood).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your PAH doctor or nurse before taking Uptravi if you<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>taking medication for high&nbsp;blood pressure<\/li><li>have low&nbsp;blood pressure&nbsp;with symptoms such as dizziness<\/li><li>have recently had a major blood loss or fluid loss, e.g.&nbsp;severe diarrhea or vomiting<\/li><li>have problems with the thyroid gland<\/li><li>have severe kidney problems or are undergoing&nbsp;dialysis<\/li><li>have or have had severe problems with the liver not working properly<\/li><\/ul>\n\n\n\n<p>If you notice any of the above signs or if your condition changes,\u00a0<strong>tell your doctor immediately<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this medicine to children under 18 years of age.&nbsp;Uptravi has not been tested in children.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Elderly patients<\/h2>\n\n\n\n<p>Experience using Uptravi in \u200b\u200bpatients older than 75 years is limited.&nbsp;Uptravi should be used with caution in this age group.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Uptravi<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Other medicines can affect the effect of Uptravi.<\/p>\n\n\n\n<p>Talk to your PAH doctor or nurse if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Gemfibrozil (used to reduce the number of fatty substances (\u00a0lipids\u00a0) in the blood)<\/li><li>Clopidogrel (used to prevent blood clots from forming in coronary artery disease)<\/li><li>Deferasirox (used to reduce the amount of iron in the blood)<\/li><li>Teriflunomide (for the treatment of relapsing-remitting\u00a0multiple sclerosis\u00a0)<\/li><li>Carbamazepine (to treat certain forms of\u00a0epilepsy, nerve pain, or to manage severe mood swings when certain other medicines have not worked)<\/li><li>Phenytoin\u00a0(a drug for\u00a0epilepsy\u00a0)<\/li><li>Valproic acid\u00a0(medicine against\u00a0epilepsy\u00a0)<\/li><li>Probenecid (a drug for\u00a0gout\u00a0)<\/li><li>Fluconazole\u00a0, rifampicin or rifapentine (\u00a0antibiotics\u00a0against\u00a0infection\u00a0)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Uptravi is not recommended during pregnancy and breastfeeding.\u00a0If you are a woman and could become pregnant, you must use effective contraception while taking Uptravi.\u00a0If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Uptravi can cause\u00a0side effects\u00a0such as headaches and low\u00a0blood pressure\u00a0(see section 4), which may affect your ability to drive.\u00a0The symptoms of your illness can also make you unfit to drive.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Uptravi<\/h2>\n\n\n\n<p>Uptravi should only be prescribed by a doctor experienced in treating PAH.&nbsp;Always take this medicine as directed by your doctor.&nbsp;Consult a doctor if you are unsure or have any questions.<\/p>\n\n\n\n<p>If you experience\u00a0side effects, talk to your doctor, as he\/she may recommend that you change your\u00a0Uptravidose.<\/p>\n\n\n\n<p>If you are taking other medicines, tell your doctor, as he\/she may recommend that you take Uptravi only once a day.<\/p>\n\n\n\n<p>If you have reduced vision or loss of vision, be sure to have someone help you when you take Uptravi during your&nbsp;dose&nbsp;titration period (the process of gradually increasing your&nbsp;dose&nbsp;).<\/p>\n\n\n\n<p><strong>Find the right&nbsp;dose&nbsp;for you<\/strong><\/p>\n\n\n\n<p>When treatment begins, you start with the lowest\u00a0dose\u00a0one.\u00a0The lowest\u00a0dose\u00a0is\u00a0<strong>one 200-microgram tablet in the morning and one 200-microgram tablet in the evening,\u00a0<\/strong><strong>approximately 12 hours apart<\/strong>.\u00a0It is recommended that the treatment be started in the evening.\u00a0The doctor will give you instructions to increase the\u00a0dose\u00a0step by step.\u00a0This is called &#8220;titration&#8221;.\u00a0The titration allows the body to get used to the new drug.\u00a0The goal is to find the most appropriate dose.\u00a0The most appropriate\u00a0dose\u00a0is the highest maintenance dose that you can tolerate, but no more than 1600 micrograms in the morning and the evening.<\/p>\n\n\n\n<p>The first pack of tablets you receive contains light yellow 200-microgram tablets.<\/p>\n\n\n\n<p>The doctor gives you instructions to increase the&nbsp;dose&nbsp;step by step, usually once a week, but it can also be longer between increases.<\/p>\n\n\n\n<p>At each step, add one 200-microgram tablet in the morning and one 200-microgram tablet in the evening.\u00a0<strong>The first time you take the higher\u00a0dose<\/strong>,\u00a0it\u00a0is\u00a0recommended that\u00a0it takes place in the evening.\u00a0The chart below shows the number of tablets you should take\u00a0<strong>each morning<\/strong>\u00a0and\u00a0<strong>each evening<\/strong>\u00a0during the first four steps.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20150108000014#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/fef1b6ea-d213-4db1-8f73-7625f4c3daf9\" alt=\"Picture 1\" title=\"Picture 1\"\/><\/a><\/figure>\n\n\n\n<p>If your doctor tells you to increase the\u00a0dose\u00a0by one more, add one 200-microgram tablet in the morning and one 200-microgram tablet in the evening for each new step.\u00a0The first time you take the higher\u00a0dose, it is recommended that it takes place in the evening.<\/p>\n\n\n\n<p>If your doctor tells you to increase the\u00a0dose\u00a0by one more and go to step 5, you can do this by taking one green 800 microgram tablet and one light yellow 200 microgram tablet in the morning and one 800 microgram tablet, and one 200 microgram tablet in the evening.<\/p>\n\n\n\n<p>The highest single\u00a0dose\u00a0of Uptravi is 1600 micrograms in the morning and 1600 micrograms in the evening.\u00a0However, not all patients reach this\u00a0dose\u00a0because different patients need different\u00a0doses.<\/p>\n\n\n\n<p>The diagram below shows how many tablets to take&nbsp;<strong>each morning<\/strong>&nbsp;and&nbsp;<strong>each evening<\/strong>&nbsp;in each step, starting at step 5.&nbsp;<\/p>\n\n\n\n<p><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20150108000014#\" rel=\"noopener\"><\/a>You will receive the titration pack containing a titration guide and package insert.\u00a0The titration guide contains information about titration.\u00a0There you can write down the number of tablets you take each day.<\/p>\n\n\n\n<p>Remember to write down the number of tablets you take each day in the titration diary.&nbsp;Each stage lasts about a week.&nbsp;If your doctor tells you to continue with a step for longer than a week, there are extra pages in the diary where you can continue to write.&nbsp;<strong>Remember to talk to your PAH doctor or nurse periodically during titration.<\/strong><\/p>\n\n\n\n<p><strong>Step down to a lower&nbsp;dose&nbsp;due to&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p>During titration, you may experience\u00a0side effects\u00a0such as headache, diarrhea, nausea, vomiting, jaw pain, muscle pain, leg pain, joint pain, or facial flushing (see section 4).\u00a0If you have difficulty coping with the\u00a0side effects, talk to your doctor about how they can be managed or treated.\u00a0Some treatments can alleviate the\u00a0side effects.\u00a0Pain and headaches can, for example, be treated with painkillers such as paracetamol.<\/p>\n\n\n\n<p>If the\u00a0side effects\u00a0cannot be treated or do not gradually improve on the\u00a0dose\u00a0you are taking, your doctor may change the\u00a0dose\u00a0by reducing the number of light yellow 200 microgram tablets that you take, one in the morning and one in the evening.\u00a0The diagram below shows how to taper down to a lower\u00a0dose.\u00a0Do this only if your doctor has told you to.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20150108000014#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/d2b693f0-fec1-4888-8595-57bda042b007\" alt=\"Image 3\" title=\"Image 3\"\/><\/a><\/figure>\n\n\n\n<p>If the\u00a0side effects\u00a0can be managed after you have reduced the\u00a0dose, the doctor may decide that you should stay on that\u00a0dose.\u00a0See the maintenance dose section below for more information.<\/p>\n\n\n\n<p><strong>Maintenance dose<\/strong><\/p>\n\n\n\n<p>The highest&nbsp;dose&nbsp;you can tolerate during the titration phase will be your maintenance dose.&nbsp;The maintenance dose is the&nbsp;dose&nbsp;that you should continue to take regularly.<\/p>\n\n\n\n<p>Your doctor will prescribe an appropriate tablet strength for the maintenance dose.&nbsp;<strong>Then you only need to take one tablet in the morning and one in the evening in the future, instead of several.<\/strong><\/p>\n\n\n\n<p>A full description of the Uptravi tablets, with color and marking, can be found in section 6 of this leaflet.<\/p>\n\n\n\n<p>Your doctor may adjust your maintenance dose later if necessary.<\/p>\n\n\n\n<p>If you get\u00a0side effects\u00a0that you cannot tolerate or\u00a0side effects\u00a0that affect your daily life, after taking the same\u00a0dose\u00a0for a long time, you should contact your doctor because the\u00a0dose\u00a0may need to be lowered.\u00a0The doctor can then prescribe a tablet with lower strength.\u00a0Remember to handle unused tablets correctly (see section 5).<\/p>\n\n\n\n<p><strong>Take Uptravi once in the morning and once in the evening about 12 hours apart.<\/strong><\/p>\n\n\n\n<p>Take the tablets with a meal because you can tolerate the medicine better then.\u00a0The tablet coating provides protection.\u00a0Swallow them whole with a glass of water.\u00a0The tablets must not be split, crushed, or chewed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Uptravi<\/h2>\n\n\n\n<p>If you have taken more tablets than you should, you must consult your doctor.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Uptravi<\/h2>\n\n\n\n<p>If you forget to take Uptravi, take a&nbsp;dose&nbsp;as soon as you remember.&nbsp;Then continue taking the tablets at the usual time.&nbsp;If it is almost time for the next&nbsp;dose&nbsp;(less than 6 hours until you are due to take it), skip the missed&nbsp;dose&nbsp;and then continue taking the tablets at the usual time.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Uptravi<\/h2>\n\n\n\n<p>If you suddenly stop taking Uptravi, it may cause your symptoms to get worse.&nbsp;Do not stop taking Uptravi unless your doctor tells you to.&nbsp;You may need to lower the&nbsp;dose&nbsp;gradually before stopping completely.<\/p>\n\n\n\n<p>If for any reason you miss taking Uptravi for more than three days in a row (if you miss three mornings and three evening doses, or six\u00a0doses\u00a0in a row or more),\u00a0\u00a0contact your doctor immediately as the\u00a0dose\u00a0may need to be changed for you to avoid\u00a0side\u00a0effects.\u00a0Your doctor may decide that you should restart treatment with a lower\u00a0dose\u00a0and gradually increase it until you have reached the previous maintenance dose.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or nurse.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0Side effects\u00a0can occur not only during the titration period when the\u00a0dose\u00a0is increased, but also later when you have taken the same\u00a0dose\u00a0for a long time.<\/p>\n\n\n\n<p><strong>If you get any of the following\u00a0side effects\u00a0and cannot tolerate them or cannot be treated, contact your doctor as the\u00a0dose\u00a0may be too high for you and need to be reduced: headache, diarrhea, nausea, vomiting, jaw pain, muscle pain, leg pain, joint pain or facial flushing.<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect more than 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Facial flushing<\/li><li>Nausea and vomiting<\/li><li>Diarrhea<\/li><li>Jaw pain, muscle pain, joint pain, leg pain<\/li><li>Nasopharyngitis&nbsp;(nasal congestion)<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anemia&nbsp;(low&nbsp;red blood cell count&nbsp;)<\/li><li>Hyperthyroidism&nbsp;(overactive&nbsp;thyroid gland&nbsp;)<\/li><li>Decreased appetite<\/li><li>Weight loss<\/li><li>Hypotension&nbsp;(low&nbsp;blood pressure&nbsp;)<\/li><li>Stomach pain, including indigestion<\/li><li>Pain<\/li><li>Change in certain blood tests that, for example, show the number of&nbsp;blood cells&nbsp;or thyroid function<\/li><li>Skin rash, including&nbsp;hives&nbsp;that can cause a burning or stinging sensation and redness<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Faster heartbeat<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Uptravi<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton and blister pack after &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>No special instructions for destruction.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is selexipag.<br>Uptravi 200 micrograms film-coated tablets contain 200 micrograms of selexipag<\/p>\n\n\n\n<p>Uptravi 400 micrograms film-coated tablets contain 400 micrograms of selexipag<\/p>\n\n\n\n<p>Uptravi 600 micrograms film-coated tablets contain 600 micrograms of selexipag<\/p>\n\n\n\n<p>Uptravi 800 micrograms film-coated tablets contain 800 micrograms of selexipag<\/p>\n\n\n\n<p>Uptravi 1000 micrograms film-coated tablets contain 1000 micrograms of selexipag<\/p>\n\n\n\n<p>Uptravi 1200 micrograms film-coated tablets contain 1200 micrograms of selexipag<\/p>\n\n\n\n<p>Uptravi 1400 micrograms film-coated tablets contain 1400 micrograms of selexipag<\/p>\n\n\n\n<p>Uptravi 1600 micrograms film-coated tablets contain 1600 micrograms of selexipag<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p>Tablet core<\/p>\n\n\n\n<p>Mannitol (E421)<\/p>\n\n\n\n<p>Cornstarch<\/p>\n\n\n\n<p>Low-substituted hydroxypropyl cellulose<\/p>\n\n\n\n<p>Hydroxypropyl cellulose<\/p>\n\n\n\n<p>Magnesium stearate<\/p>\n\n\n\n<p>Film coating<\/p>\n\n\n\n<p>Hypromellose<\/p>\n\n\n\n<p>Propylene glycol<\/p>\n\n\n\n<p>Titanium dioxide (E171)<\/p>\n\n\n\n<p>Iron oxides (E172)<\/p>\n\n\n\n<p>Carnauba wax<\/p>\n\n\n\n<p>Uptravi 200 micrograms film-coated tablets contain yellow iron oxide (E172).<\/p>\n\n\n\n<p>Uptravi 400 micrograms film-coated tablets contain red iron oxide (E172).<\/p>\n\n\n\n<p>Uptravi 600 micrograms film-coated tablets contain red and black iron oxide (E172).<\/p>\n\n\n\n<p>Uptravi 800 micrograms film-coated tablets contain yellow and black iron oxide (E172).<\/p>\n\n\n\n<p>Uptravi 1000 micrograms film-coated tablets contain red and yellow iron oxide (E172).<\/p>\n\n\n\n<p>Uptravi 1200 micrograms film-coated tablets contain black and red iron oxide (E172).<\/p>\n\n\n\n<p>Uptravi 1400 micrograms film-coated tablets contain yellow iron oxide (E172).<\/p>\n\n\n\n<p>Uptravi 1600 micrograms film-coated tablets contain black, red, and yellow iron oxide (E172).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Uptravi 200 microgram film-coated tablets: Round, pale yellow film-coated tablets, debossed with \u201c2\u201d on one side.<\/p>\n\n\n\n<p>Uptravi 400 micrograms film-coated tablets: Round, red film-coated tablets debossed with \u201c4\u201d on one side.<\/p>\n\n\n\n<p>Uptravi 600 micrograms film-coated tablets: Round, light purple film-coated tablets debossed with \u201c6\u201d on one side.<\/p>\n\n\n\n<p>Uptravi 800 micrograms film-coated tablets: Round, green film-coated tablets debossed with \u201c8\u201d on one side.<\/p>\n\n\n\n<p>Uptravi 1000 micrograms film-coated tablets: Round, orange film-coated tablets debossed with \u201c10\u201d on one side.<\/p>\n\n\n\n<p>Uptravi 1200 micrograms film-coated tablets: Round, dark purple film-coated tablets debossed with \u201c12\u201d on one side.<\/p>\n\n\n\n<p>Uptravi 1400 micrograms film-coated tablets: Round, dark yellow film-coated tablets debossed with \u201c14\u201d on one side.<\/p>\n\n\n\n<p>Uptravi 1600 micrograms film-coated tablets: Round, brown film-coated tablets debossed with \u201c16\u201d on one side.<\/p>\n\n\n\n<p>Uptravi 200 micrograms film-coated tablets are packed in blister cards of 10 or 60 tablets and 60 or 140 tablets (titration packs).<\/p>\n\n\n\n<p>Uptravi 400 micrograms, 600 micrograms, 800 micrograms, 1000 micrograms, 1200 micrograms, 1400 micrograms, and 1600 micrograms film-coated tablets are packed in blister cards of 60 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Janssen\u2011Cilag International NV<\/p>\n\n\n\n<p>Turnhoutseweg 30<\/p>\n\n\n\n<p>B\u20112340 Beerse<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Janssen Pharmaceutica NV<\/p>\n\n\n\n<p>Turnhoutseweg 30<\/p>\n\n\n\n<p>B-2340 Beerse<\/p>\n\n\n\n<p>Belgium<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Uptravi is a medicine that contains the active substance selexipag.\u00a0It acts on blood vessels in a similar way to the natural substance\u00a0prostacyclin\u00a0, which causes\u00a0vessels\u00a0to relax and dilate.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22501],"tags":[26722,26725,26726,26727,26731,26730,26724,26728,26723,26729],"class_list":["post-26002","post","type-post","status-publish","format-standard","hentry","category-medicines","category-u","tag-selexipag","tag-selexipag-side-effects","tag-selexipag-tablet","tag-uptravi","tag-uptravi-side-effects","tag-uptravi-tablet","tag-what-is-selexipag","tag-what-is-uptravi","tag-what-selexipag-is-used-for","tag-what-uptravi-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26002","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=26002"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26002\/revisions"}],"predecessor-version":[{"id":26029,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/26002\/revisions\/26029"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=26002"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=26002"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=26002"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}