{"id":25933,"date":"2022-09-30T12:41:59","date_gmt":"2022-09-30T12:41:59","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25933"},"modified":"2022-10-01T08:05:00","modified_gmt":"2022-10-01T08:05:00","slug":"tygacil","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tygacil\/","title":{"rendered":"Tygacil &#8211; Tigecycline uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg\u00a0powder for\u00a0infusion, solution<br>tigecycline<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tygacil is and what it is used for<\/h2>\n\n\n\n<p>Tygacil is an\u00a0antibiotic\u00a0in the group of glycylcyclines that works by stopping the growth of bacteria that cause\u00a0infection.<\/p>\n\n\n\n<p>Your doctor has prescribed Tygacil because you or your child over 8 years of age has one of the following serious\u00a0infections.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Complicated\u00a0infections\u00a0in the skin and soft tissues (\u00a0tissues\u00a0under the skin), excluding foot infections in patients with\u00a0diabetes.<\/li><li>Complicated\u00a0infection\u00a0in the abdominal cavity<\/li><\/ul>\n\n\n\n<p>Tygacil is only used when your doctor considers other&nbsp;antibiotics&nbsp;unsuitable.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you receive Tygacil<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Tygacil<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to tigecycline or any of the other ingredients of this medicine (listed in section 6).\u00a0If you are allergic to tetracycline antibiotics (eg,\u00a0minocycline,\u00a0doxycycline, etc.), you may be allergic to tigecycline.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p><strong>Talk to your doctor or nurse before receiving Tygacil:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If the wound does not heal normally.<\/li><li>If you suffer from diarrhea before receiving Tygacil.\u00a0If you get diarrhea during or after your treatment, tell your doctor right away.\u00a0Do not take any diarrhea medicine without first checking with your doctor.<\/li><li>If you have had any\u00a0side effects\u00a0in the past due to\u00a0antibiotics\u00a0belonging to the tetracycline class (eg skin sensitization to sunlight, discoloration of developing teeth, inflammation of the pancreas, and changes in certain laboratory values \u200b\u200bintended to measure how well your blood clots).<\/li><li>If you have or have previously had, liver problems.\u00a0Depending on the condition of your liver, your doctor may reduce the\u00a0dose\u00a0to avoid possible\u00a0side effects.<\/li><li>If you have a blockage of the bile ducts (cholestasis).<\/li><li>If you suffer from any type of\u00a0bleeding disorder\u00a0or are treated with\u00a0anticoagulants, as this medicine may affect blood clotting.<\/li><\/ul>\n\n\n\n<p><strong>During treatment with Tygacil:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor immediately if you experience symptoms of an\u00a0allergic reaction.<\/li><li>Tell your doctor immediately if you experience severe stomach pain, nausea, and vomiting.\u00a0These symptoms may be signs of inflammation of the pancreas (\u00a0acute\u00a0pancreatitis\u00a0).<\/li><li>For some severe\u00a0infections, your doctor may consider using Tygacil together with other\u00a0antibiotics.<\/li><li>Your doctor will monitor you closely to make sure no other bacterial\u00a0infection\u00a0develops.\u00a0If you suffer from another bacterial\u00a0infection, the doctor may prescribe another\u00a0antibiotic\u00a0that is specific to that\u00a0infection.<\/li><li>Although\u00a0antibiotics\u00a0including Tygacil work against some bacteria, other bacteria and fungi may continue to grow.\u00a0This is called overgrowth.\u00a0Your doctor will monitor you for possible\u00a0infection\u00a0and treat you if necessary.\u00a0If you receive Tygacil, your doctor will monitor you closely to make sure no other\u00a0infection\u00a0develops, and treat you if necessary.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Tygacil should not be used in children under 8 years of age because there is a lack of data on safety and efficacy in this age group and because it can cause permanent\u00a0defects\u00a0in the teeth, such as discoloration of developing teeth.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tygacil<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tygacil may prolong certain tests that measure how well your blood clots.\u00a0You must tell your doctor if you are taking medicines to avoid excess blood clotting (so-called\u00a0anticoagulants\u00a0).\u00a0If so, your doctor will monitor you closely.<\/p>\n\n\n\n<p>Tygacil can affect the effectiveness of\u00a0birth control pills.\u00a0Talk to your doctor about the need for additional contraception while using Tygacil.<\/p>\n\n\n\n<p>Tygacil can increase the effect of medicines used to\u00a0suppress\u00a0the immune system (such as tacrolimus and ciclosporin).\u00a0You must tell your doctor if you are taking these medicines so that you can be monitored closely.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Tygacil may be harmful to the fetus.\u00a0If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before receiving Tygacil.<\/p>\n\n\n\n<p>It is not known whether Tygacil passes into breast milk.&nbsp;Consult a doctor before breastfeeding your baby.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Tygacil can cause&nbsp;side effects&nbsp;such as dizziness.&nbsp;This may impair the ability to drive and operate machinery.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tygacil contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per 5 ml solution, i.e. it is almost &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Tygacil is given<\/h2>\n\n\n\n<p>Tygacil will be administered to you by a doctor or nurse.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0for adults is 100 mg as an initial dose followed by 50 mg every 12 hours.\u00a0This\u00a0dose\u00a0is given\u00a0intravenously\u00a0(directly into the blood) over 30 to 60 minutes.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for children aged 8 to &lt;12 years is 1.2 mg\/kg given every 12 hours&nbsp;intravenously&nbsp;up to a maximum dose of 50 mg every 12 hours.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for adolescents aged 12 to &lt;18 years is 50 mg given every 12 hours.<\/p>\n\n\n\n<p>Usually, the treatment lasts for 5 to 14 days.\u00a0Your doctor will decide how long you will be treated.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you receive too much Tygacil<\/h2>\n\n\n\n<p>If you are concerned that you may have received too much Tygacil, talk to your doctor or nurse immediately.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have forgotten a dose of Tygacil<\/h2>\n\n\n\n<p>If you are concerned that you may have missed a\u00a0dose, talk to your doctor or nurse straight away.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Tygacil can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Pseudomembranous\u00a0colitis\u00a0can occur during treatment with most\u00a0antibiotics, including Tygacil.\u00a0It presents as severe, persistent, or bloody diarrhea associated with abdominal pain or fever.\u00a0This may be a sign of serious intestinal inflammation, which may occur during or after your treatment.<\/p>\n\n\n\n<p>Very common&nbsp;side effects&nbsp;are (may affect more than 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea, vomiting, diarrhea<\/li><\/ul>\n\n\n\n<p>Common&nbsp;side effects&nbsp;are (may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>An abscess\u00a0(accumulation),\u00a0infection,\u00a0etc<\/li><li>Laboratory measurements show that the blood has a reduced ability to clot (coagulate)<\/li><li>Dizziness<\/li><li>Blood vessel irritation from\u00a0injection\u00a0includes pain,\u00a0inflammation, swelling, and\u00a0coagulation<\/li><li>Stomach pain, digestive problems, loss of appetite<\/li><li>Increased liver enzymes, hyperbilirubinemia (excess bile pigment in the blood)<\/li><li>Itching, rash<\/li><li>Poor or slow wound healing<\/li><li>Headache<\/li><li>Increased levels of amylase, which is an\u00a0enzyme\u00a0found in the salivary glands and pancreas, increased levels of blood\u00a0urea\u00a0nitrogen (BUN)<\/li><li>Pneumonia<\/li><li>Low blood sugar<\/li><li>Sepsis\/septic\u00a0shock\u00a0(a serious medical condition that can lead to multiple organ failures and death due to sepsis)<\/li><li>Injection site reaction (pain,\u00a0redness,\u00a0inflammation\u00a0)<\/li><li>Low levels of\u00a0protein\u00a0in the blood<\/li><\/ul>\n\n\n\n<p>Uncommon&nbsp;side effects&nbsp;are (may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Acute\u00a0pancreatitis\u00a0(inflammation of the pancreas, which can result in severe stomach pain, nausea, and vomiting)<\/li><li>Jaundice (yellowing of the skin), inflammation of the liver<\/li><li>Low levels of\u00a0platelets\u00a0in the blood (which can lead to an increased tendency to bleed and bruise\/hematoma)<\/li><\/ul>\n\n\n\n<p>Rare&nbsp;side effects&nbsp;are (may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Low levels of fibrinogen in the blood (a&nbsp;protein&nbsp;that is important for blood clotting)<\/li><\/ul>\n\n\n\n<p>Side effects&nbsp;that have been reported (occurring in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anaphylactic\/anaphylactoid&nbsp;hypersensitivity reaction&nbsp;(which can range from mild to severe, including sudden, generalized&nbsp;allergic reaction&nbsp;that can lead to life-threatening&nbsp;shock&nbsp;[eg difficulty breathing, drop in blood pressure, rapid&nbsp;pulse&nbsp;]).<\/li><li>Liver failure<\/li><li>Skin rash that can lead to severe blistering of the skin and peeling of the skin (&nbsp;Stevens-Johnson syndrome&nbsp;)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tygacil<\/h2>\n\n\n\n<p>Keep this medicine out of sight and reach of children.<\/p>\n\n\n\n<p>Store at a maximum of 25 \u00b0C.<\/p>\n\n\n\n<p>Use before the expiry date stated on the bottle.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><strong>Storage after&nbsp;preparation<\/strong><\/p>\n\n\n\n<p>After the powder is dissolved and diluted, it should be administered to you immediately.<\/p>\n\n\n\n<p>The Tygacil solution should be yellow to orange after the powder dissolves;&nbsp;otherwise, the solution should be discarded.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is tigecycline.\u00a0Each\u00a0vial\u00a0contains 50 mg of tigecycline.<\/p>\n\n\n\n<p>Other ingredients are\u00a0lactose monohydrate,\u00a0hydrochloric acid,\u00a0and sodium hydroxide.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tygacil is supplied as a powder for\u00a0infusion\u00a0in a\u00a0vial\u00a0and looks like an orange powder or cake before dilution.\u00a0These vials are distributed to hospitals in a pack of 10.\u00a0The powder should be dissolved in the bottle with a small amount of solution.\u00a0The vial is gently rotated until the medicine has dissolved.\u00a0The solution from the vial should then be immediately added to a 100 ml\u00a0infusion bag\u00a0or another suitable infusion container at the hospital, for\u00a0intravenous\u00a0use.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Marketing Authorisation Holder<\/strong><\/td><td><strong>Manufacturer<\/strong><\/td><\/tr><tr><td>Pfizer Europe MA EEIGBoulevard de la Plaine 171050 BrusselsBelgium<\/td><td>Wyeth Lederle Srl&nbsp;Via Franco Gorgone ZI95100 Catania (CT)Italy<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>For further information about this medicinal product, contact the representative of the marketing authorization holder:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong><strong>Luxembourg\/Luxembourg<\/strong>Pfizer SA \/ NVTel\/Tel: +32 (0)2 554 62 11<\/td><td><strong>Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaTel.&nbsp;+ 370 52 51 4000<\/td><\/tr><tr><td><strong>Bulgaria<\/strong><strong>Pfizer Luxembourg \u0421\u0410\u0420\u041b, \u041a\u043b\u043e\u043d \u0411\u0443\u043b\u0433\u0430\u0440\u0438\u044f<\/strong>Tel:: +359 2 970 4333<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Pfizer Kft.Phone: +36 1 488 3700<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Pfizer s.r.oPhone: +420-283-004-111<\/td><td><strong>Malta<\/strong>Vivian Corporation Ltd.Phone: +35621 344610<\/td><\/tr><tr><td><strong>Denmark<\/strong>Pfizer ApSPhone: +45 44 201 100<\/td><td><strong>The Netherlands<\/strong>Pfizer BVPhone: +31 (0)10 406 43 01<\/td><\/tr><tr><td><strong>Deutschland<\/strong>Pfizer Pharma PFE GmbHPhone: +49 (0)800 8535555&nbsp;<\/td><td><strong>Norway<\/strong>Pfizer iPhone: +47 67 526 100<\/td><\/tr><tr><td><strong>Estonia<\/strong>Pfizer Luxembourg SARL Eesti branches.: +372 666 7500<\/td><td><strong>Austria<\/strong>Pfizer Corporation Austria Ges.mbHPhone: +43 (0)1 521 15-0<\/td><\/tr><tr><td><strong>Greece<\/strong>Pfizer \u0395\u039b\u039b\u0391\u03a3 \u0391.\u0395.,Tel.: +30 210 67 85 800<\/td><td><strong>Polish<\/strong>Pfizer Polska Sp.&nbsp;z o. o.Tel.: +48 22 335 61 00<\/td><\/tr><tr><td><strong>Spain<\/strong>Pfizer, cellphone: +34914909900<\/td><td><strong>Portugal<\/strong>Laborat\u00f3rios Pfizer, Lda.Phone: (+351) 21 423 55 00<\/td><\/tr><tr><td><strong>France<\/strong>PfizerPhone +33 (0) 1 58 07 34 40<\/td><td><strong>Romania<\/strong>Pfizer Romania SRLPhone: +40 (0) 21 207 28 00<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Pfizer Croatia dooPhone: +385 1 3908 777<\/td><td><strong>Slovenija<\/strong>Pfizer Luxembourg SARLPfizer, branch of the field pharmaceuticals activities, LjubljanaTel.: + 386 (0) 1 52 11 400<\/td><\/tr><tr><td><strong>Ireland<\/strong>Pfizer Healthcare IrelandPhone: 1800 633 363 (toll free)+44 (0)1304 616161<\/td><td><strong>Slovenian Republic<\/strong>Pfizer Luxembourg SARL, organiza\u010dn\u00e1 zlo\u017ekaPhone: + 421 2 3355 5500<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hfSimi: +354 540 8000<\/td><td><strong>Finland\/Finland<\/strong>Pfizer OyPhone\/Tel: +358 (0)9 430 040<\/td><\/tr><tr><td><strong>Italy<\/strong>Pfizer SrlPhone: +39 06 33 18 21<\/td><td><strong>Sweden<\/strong>Pfizer ABPhone: +46 (0)8 550 520 00<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Pfizer \u0395\u039b\u039b\u0391\u03a3 \u0391.\u0395.&nbsp;(Cyprus Branch), \u03a4\u03b7\u03bb: +357 22 817690<\/td><td><strong>United Kingdom<\/strong><strong>(Northern Ireland)<\/strong>Pfizer Limited, Phone: +44 (0) 1304 616161<\/td><\/tr><tr><td><strong>in Latvia<\/strong>Pfizer Luxembourg SARL branch in LatviaTel.: + 371 670 35 775<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Tygacil is an\u00a0antibiotic\u00a0in the group of glycylcyclines that works by stopping the growth of bacteria that cause\u00a0infection\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[26699,25916,26695,25917,26694,26698,25918,26696,25921,26697],"class_list":["post-25933","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-tygacil","tag-tigecycline","tag-tigecycline-injection","tag-tigecycline-side-effects","tag-tygacil","tag-tygacil-side-effects","tag-what-is-tigecycline","tag-what-is-tygacil","tag-what-tigecycline-is-used-for","tag-what-tygacil-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25933","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25933"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25933\/revisions"}],"predecessor-version":[{"id":25983,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25933\/revisions\/25983"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25933"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25933"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}