{"id":25931,"date":"2022-09-30T12:39:28","date_gmt":"2022-09-30T12:39:28","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25931"},"modified":"2022-10-01T08:05:09","modified_gmt":"2022-10-01T08:05:09","slug":"tybost","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tybost\/","title":{"rendered":"Tybost &#8211; Cobicistat uses, dose and side effects"},"content":{"rendered":"\n<p>150 mg&nbsp;film-coated tablets<br>cobicistat<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tybost is and what it is used for<\/h2>\n\n\n\n<p>Tybost contains the active substance cobicistat.<\/p>\n\n\n\n<p>Tybost is used to treat&nbsp;infection&nbsp;by human immunodeficiency virus type 1 (&nbsp;HIV&nbsp;-1 ), the&nbsp;virus&nbsp;that causes acquired immunodeficiency syndrome (&nbsp;AIDS&nbsp;).&nbsp;It is used in adults and adolescents aged 12 years and older who are infected with&nbsp;HIV&nbsp;and who:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>weigh at least 35 kg (when Tybost is given together with atazanavir 300 mg) or<\/li><li>weighing at least 40 kg (when Tybost is given together with darunavir 800 mg).<\/li><\/ul>\n\n\n\n<p>Tybost acts as a&nbsp;<strong>booster<\/strong>&nbsp;of&nbsp;<em>atazanavir&nbsp;<\/em><strong>or darunavir&nbsp;<\/strong><strong>(<\/strong>&nbsp;both&nbsp;of which are&nbsp;protease inhibitors&nbsp;) to enhance their effect (see section 3 of this leaflet).<strong><\/strong><\/p>\n\n\n\n<p><strong>Tybost does not treat your&nbsp;HIV&nbsp;directly but works by boosting the levels of atazanavir and darunavir<\/strong>&nbsp;in the blood.&nbsp;It does this by slowing the breakdown of atazanavir and darunavir, which then remain longer in the body.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Tybost<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Tybost<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic to cobicistat<\/strong>&nbsp;or any of the other ingredients of this medicine (listed in section 6 of this leaflet).<\/li><li><strong>If you are taking medicines containing any of the following:<\/strong><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>alfuzosin<\/strong>\u00a0used to treat enlarged prostate gland<\/li><li>amiodarone,\u00a0and quinidine,\u00a0used to correct irregular heartbeats<\/li><li>dabigatran\u00a0used to prevent and treat blood clots<\/li><li>carbamazepine, phenobarbital,\u00a0and phenytoin\u00a0used to prevent seizures<\/li><li>rifampicin\u00a0used\u00a0to prevent and treat\u00a0tuberculosis\u00a0and other\u00a0infections<\/li><li>dihydroergotamine, ergometrine,\u00a0and ergotamine\u00a0are used to treat migraine headaches<\/li><li>St. John&#8217;s wort\u00a0(\u00a0Hypericum perforatum\u00a0), a natural remedy, is used for depression and mild anxiety<\/li><li>lovastatin,\u00a0simvastatin,\u00a0is used to lower the cholesterol level in the blood<\/li><li>pimozide, and lurasidone,\u00a0used to treat abnormal thoughts or feelings<\/li><li>sildenafil\u00a0is used to treat\u00a0pulmonary\u00a0arterial\u00a0hypertension\u00a0&#8211; a lung disease that makes breathing difficult<\/li><li><strong>midazolam<\/strong>\u00a0(administered orally),\u00a0<strong>triazolam,<\/strong>\u00a0used to help you sleep and\/or reduce anxiety)<\/li><\/ul>\n\n\n\n<p><strong>\u2192If any of these apply to you, do not take Tybost and inform your doctor immediately.<\/strong><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Your treatment with Tybost must be followed up by a doctor at all times.<\/p>\n\n\n\n<p><strong>You can still transmit\u00a0HIV<\/strong>\u00a0while taking this medicine, although the risk is reduced with effective\u00a0antiretroviral\u00a0therapy.\u00a0Talk to your doctor about the precautions needed to avoid infecting other people.\u00a0This medicine does\u00a0not treat your\u00a0HIV\u00a0infection\u00a0directly.\u00a0You can still develop\u00a0an infection\u00a0or other diseases associated\u00a0with\u00a0HIV\u00a0infection.\u00a0You must have regular contact with your doctor.<\/p>\n\n\n\n<p><strong>Talk to your doctor before taking Tybost:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you take another\u00a0protease inhibitor<\/strong>.\u00a0Tybost taken with atazanavir or darunavir should not be used with any other antiviral medicine that needs to be boosted.<\/li><li>Talk to your doctor or pharmacist if you have or have had kidney disease or if tests have shown that you have problems with your kidneys.\u00a0Your doctor will carefully consider whether you should be treated with Tybost.<\/li><li><strong>Talk to your doctor or pharmacist if you have or have had serious liver disease or if tests have shown that you have liver problems.\u00a0<\/strong>Your doctor will carefully consider whether you should be treated with Tybost.<\/li><\/ul>\n\n\n\n<p><strong>\u2192If any of these apply to you, talk to your doctor before taking Tybost.<\/strong><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p><strong>Do not give this medicine to children<\/strong>&nbsp;under 12 years of age, or who weigh less than 35 kg (or 40 kg), as explained in section 3 of this leaflet.&nbsp;The use of Tybost in children under 12 years of age or weighing less than 35 kg has not been studied.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tybost<\/h2>\n\n\n\n<p><strong>Tell your doctor or pharmacist if you are taking, have recently taken,<\/strong> or might take any other medicines.\u00a0Tybost can affect or be affected by other substances.\u00a0This can lead to the amount of Tybost or other medicines in the blood being affected.\u00a0The medicines may then not work properly or any\u00a0side effects\u00a0may worsen.\u00a0In some cases, the doctor may need to change the\u00a0dose\u00a0or check the amount of medicine in the blood.<\/p>\n\n\n\n<p><strong>Certain medicines should never be taken with Tybost.<\/strong><\/p>\n\n\n\n<p>These are under the heading &#8220;Do not take Tybost &#8211; If you take medicines that contain any of the following&#8221;.<\/p>\n\n\n\n<p><strong>Medicines used to treat&nbsp;HIV&nbsp;infection:<\/strong><\/p>\n\n\n\n<p>You should not take Tybost with other medicines that contain:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>ritonavir<\/strong><\/li><li><strong>cobicistat<\/strong><\/li><li>Talk to your doctor if you are taking<\/li><li><strong>another&nbsp;protease inhibitor<\/strong><\/li><li><strong>efavirenz<\/strong><\/li><li><strong>etravirine<\/strong><\/li><li><strong>nevirapine<\/strong><\/li><li><strong>maraviroc<\/strong><\/li><\/ul>\n\n\n\n<p><strong>\u2192Inform the doctor<\/strong>&nbsp;if you are taking any of these&nbsp;HIV&nbsp;medicines.<\/p>\n\n\n\n<p><strong>Other types of medicines:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>ketoconazole\u00a0, itraconazole, voriconazole, posaconazole<\/strong>\u00a0and<strong>\u00a0fluconazole<\/strong>\u00a0, medicines used to treat fungal infections<\/li><li><strong>clarithromycin<\/strong>\u00a0and\u00a0<strong>rifabutin<\/strong>, medicines used to treat bacterial infections such as\u00a0tuberculosis<\/li><li>dasatinib, nilotinib, vinblastine,\u00a0and\u00a0vincristine, medicines used to treat cancer<\/li><li>corticosteroids\u00a0include\u00a0betamethasone, budesonide,\u00a0fluticasone, mometasone, prednisone, and triamcinolone.\u00a0These medicines are used to treat\u00a0allergies,\u00a0asthma, inflammatory bowel diseases, inflammatory conditions in the skin, eyes, joints, and muscles, and other inflammatory conditions.\u00a0These drugs are usually taken orally, inhaled, injected, or applied to the skin or eye.\u00a0If there are no alternatives, the drug should be used only after medical judgment and under close monitoring by your doctor for side\u00a0effects\u00a0of\u00a0corticosteroids<\/li><li>metformin, a medicine used to treat type 2\u00a0diabetes<\/li><li>oral or implanted hormonal contraceptives\u00a0used to prevent pregnancy<\/li><li>amlodipine,\u00a0digoxin,\u00a0diltiazem,\u00a0disopyramide, felodipine,\u00a0flecainide,\u00a0lidocaine,\u00a0metoprolol, mexiletine, nicardipine, nifedipine,\u00a0propafenone,\u00a0timolol\u00a0and\u00a0verapamil, drugs used to treat heart problems<\/li><li>bosentan, a drug used to treat\u00a0pulmonary\u00a0arterial\u00a0hypertension<\/li><li>apixaban, edoxaban, rivaroxaban\u00a0and\u00a0warfarin\u00a0,\u00a0medicines used to prevent and treat blood clots<\/li><li>salmeterol, a medicine used to treat\u00a0asthma<\/li><li>atorvastatin, fluvastatin, pitavastatin, pravastatin,\u00a0and\u00a0rosuvastatin, medicines used to lower blood cholesterol levels<\/li><li>sildenafil\u00a0and\u00a0vardenafil, drugs used to treat\u00a0impotence,\u00a0and\u00a0tadalafil, a drug used to treat\u00a0impotence\u00a0and\u00a0pulmonary\u00a0hypertension<\/li><li>trazodone, a drug used to treat depression<\/li><li>ciclosporin, sirolimus,\u00a0and\u00a0tacrolimus, medicines used to control the body&#8217;s immune system after a transplant<\/li><li><strong>buspirone, clorazepate,\u00a0diazepam\u00a0, estazolam, flurazepam, perphenazine,\u00a0risperidone\u00a0, thioridazine,<\/strong>\u00a0or\u00a0<strong>zolpidem,<\/strong>\u00a0medicines used to treat disorders of the nervous system<\/li><li><strong>colchicine,<\/strong>\u00a0a medicine used to treat\u00a0gout<\/li><li><strong>clopidogrel,<\/strong>\u00a0a medicine used to reduce the risk of blood clots<\/li><\/ul>\n\n\n\n<p><strong>\u2192Inform the doctor<\/strong>&nbsp;if you are taking any of these medicines.<\/p>\n\n\n\n<p><strong>\u2192Tell the doctor if you are taking any of these or other medicines.&nbsp;<\/strong>You should not stop treatment without talking to your doctor.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor or pharmacist before using this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor immediately if you are pregnant, think you may be pregnant,<\/strong>\u00a0or are planning to have a baby.\u00a0Pregnant women should not take Tybost with atazanavir or darunavir.\u00a0The amount of this medicine in the blood may decrease during pregnancy, which may cause it to stop working properly.<\/li><li>Do not breastfeed during treatment with Tybost.\u00a0It is unknown whether the active substance in this medicine can pass into human breast milk.\u00a0If you are an\u00a0HIV\u00a0-infected woman, you should not breastfeed your infant to avoid transmission of\u00a0HIV\u00a0to the baby through breast milk.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Some patients reported dizziness when Tybost was taken at the same time as atazanavir or darunavir.\u00a0If you are affected while taking Tybost, you should not drive a car or use any tools or machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tybost contains para-orange aluminum lacquer (E110)<\/h2>\n\n\n\n<p><strong>Tell the doctor if you are allergic to para-orange aluminum lacquer (E110).<\/strong><\/p>\n\n\n\n<p>Tybost contains para orange aluminum lacquer which can cause allergic reactions.<\/p>\n\n\n\n<p><strong>Ty cheese contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Tybost<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>The recommended\u00a0dose\u00a0for adults:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>One tablet a day by mouth with food<\/strong>.\u00a0You must not chew, crush or split the tablet.<\/li><li><strong>Tybost must be taken together with atazanavir (300 mg) or darunavir (800 mg).<\/strong><\/li><\/ul>\n\n\n\n<p><strong>The recommended\u00a0dose\u00a0for adolescents aged 12 to under 18 years:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>One tablet every day by mouth, in conjunction with food.\u00a0<\/strong>The tablet must not be chewed, crushed, or split.<\/li><li>When Tybost is taken together with\u00a0atazanavir (300 mg), adolescents\u00a0must weigh at least 35 kg.<\/li><li>When Tybost is taken together with\u00a0darunavir (800 mg), adolescents\u00a0<strong>must weigh at least 40 kg.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Always take the&nbsp;dose&nbsp;prescribed by the doctor<\/strong>&nbsp;to ensure that the medicine is effective.&nbsp;Do not change the&nbsp;dose&nbsp;unless your doctor tells you to.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Tybost<\/h2>\n\n\n\n<p>If you accidentally take more than the prescribed&nbsp;dose&nbsp;of Tybost, the risk of&nbsp;side effects&nbsp;with this medicine may increase (see section 4 of this leaflet).<\/p>\n\n\n\n<p>Contact your doctor or nearest emergency department immediately for advice.&nbsp;Save the jar so you can easily describe what you have taken.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Tybost<\/h2>\n\n\n\n<p>You mustn&#8217;t miss a\u00a0dose\u00a0of Tybost.<\/p>\n\n\n\n<p>If you miss a&nbsp;dose&nbsp;and notice it:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>within 12 hours<\/strong>\u00a0of the time, you usually take Tybost, you must take the tablet as soon as possible.\u00a0The tablet must always be taken with food.\u00a0Then take the next\u00a0dose\u00a0as usual in combination with atazanavir or darunavir.<\/li><li>12 hours or more\u00a0after the time you usually take Tybost, do not take the missed\u00a0dose.\u00a0Wait and take the next\u00a0dose\u00a0with food at its regular time.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Do not stop taking Tybost<\/h2>\n\n\n\n<p><strong>Do not stop taking Tybost without talking to your doctor<\/strong>.\u00a0If you stop taking Tybost and atazanavir or darunavir, it may seriously affect the success of future treatments prescribed by your doctor.<\/p>\n\n\n\n<p><strong>Make sure you always have enough Tybost so you don&#8217;t run out<\/strong>.\u00a0When your supply of Tybost starts to run low, get more from your doctor or pharmacist.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0When treating\u00a0HIV\u00a0infection, it is not always possible to know which of the unwanted effects are caused by Tybost, by other medicines you are taking, or by the\u00a0HIV\u00a0disease.\u00a0The following\u00a0side effects\u00a0may occur when Tybost is taken together with atazanavir.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may affect more than 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea<\/li><li>yellow skin and\/or yellow whites of the eyes&nbsp;<em>(jaundice)<\/em><\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may affect up to 1 in 10&nbsp;<\/em><em>people&nbsp;<\/em><em>)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high blood sugar\u00a0<em>(\u00a0hyperglycemia\u00a0)<\/em><\/li><li>increased appetite, taste changes,\u00a0dry mouth<\/li><li>headache, dizziness<\/li><li>vomiting, diarrhea, stomach ache, problems with digestion causing pain after eating\u00a0(\u00a0dyspepsia\u00a0), feeling bloated, gas formation\u00a0<em>(\u00a0flatulence\u00a0)<\/em><\/li><li>increased levels of\u00a0bilirubin\u00a0in the blood\u00a0<em>(hyperbilirubinemia)<\/em><\/li><li>rash<\/li><li>difficulty sleeping, abnormal dreams, sleepiness, tiredness<\/li><\/ul>\n\n\n\n<p><strong>Less common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may affect&nbsp;<\/em><em>up to&nbsp;<\/em><em>1 in 100&nbsp;<\/em><em>people&nbsp;<\/em><em>)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood in the urine&nbsp;<em>(&nbsp;hematuria&nbsp;)<\/em><\/li><li>protein&nbsp;in the urine&nbsp;<em>(&nbsp;proteinuria&nbsp;)<\/em><\/li><li>Depression<\/li><li>itching<\/li><li>muscle pain, weakness<\/li><li>kidney stones&nbsp;are<\/li><li>fever<\/li><li>sleep disorder<\/li><\/ul>\n\n\n\n<p>For more information about the&nbsp;side effects&nbsp;of atazanavir or darunavir, see the package leaflets for these medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Tybost should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the can and carton after {EXP}.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p><strong>The active substance is<\/strong>&nbsp;cobicistat.&nbsp;One film-coated tablet contains 150 mg of cobicistat.<\/p>\n\n\n\n<p><strong>Other ingredients are<\/strong><\/p>\n\n\n\n<p><em>Tablet core<\/em><\/p>\n\n\n\n<p>Croscarmellose sodium, magnesium stearate, microcrystalline cellulose (E460), silicon dioxide (E551).<\/p>\n\n\n\n<p><em>Film coating<\/em><\/p>\n\n\n\n<p>Para-orange aluminum lake (E110), macrogol 3350 (E1521), polyvinyl alcohol (partially hydrolyzed) (E1203), talc (E553), titanium dioxide (E171), yellow iron oxide (E172) (see section 2 of this leaflet).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tybost film-coated tablets are orange, round, biconvex tablets, debossed on one side with \u201cGSI\u201d and plain on the other side.<\/p>\n\n\n\n<p>Tybost is supplied in cans containing 30 tablets (with desiccant in the form of silica gel in&nbsp;a sachet&nbsp;or container which must be kept in the can to protect the tablets from moisture).&nbsp;The desiccant (silica gel) is in a separate&nbsp;sachet&nbsp;or container and should not be swallowed.<\/p>\n\n\n\n<p>The following pack sizes are available: Outer cartons containing 1 bottle of 30 film-coated tablets and 90 (3 bottles of 30) film-coated tablets.&nbsp;Not all pack sizes may be marketed.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>County Cork, T45 DP77<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>IDA Business &amp; Technology Park<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>County Cork<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder if you want to know more about this medicine.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Gilead Sciences Belgium SPRL-BVBATel\/Tel: + 32 (0) 24 01 35 50<\/td><td><strong>Lithuania<\/strong>Gilead Sciences Poland Sp.\u00a0z o. iPhone: + 48 22 262 8702<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Gilead Sciences Ireland UCTel.: + 353 (0) 1 686 1888<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>Gilead Sciences Belgium SPRL-BVBATel\/Tel: + 32 (0) 24 01 35 50<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Gilead Sciences s.r.oPhone: + 420 910 871 986<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Gilead Sciences Ireland UCTel.: + 353 (0) 1 686 1888<\/td><\/tr><tr><td><strong>Denmark<\/strong>Gilead Sciences Sweden ABTel: + 46 (0) 8 5057 1849<\/td><td><strong>Malta<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><\/tr><tr><td><strong>Deutschland<\/strong>Gilead Sciences GmbHPhone: + 49 (0) 89 899890-0<\/td><td><strong>The Netherlands<\/strong>Gilead Sciences Netherlands BVPhone: + 31 (0) 20 718 36 98<\/td><\/tr><tr><td><strong>Estonia<\/strong>Gilead Sciences Poland Sp.\u00a0z o. iPhone: + 48 22 262 8702<\/td><td><strong>Norway<\/strong>Gilead Sciences Sweden ABTel: + 46 (0) 8 5057 1849<\/td><\/tr><tr><td><strong>Greece<\/strong>Gilead Sciences \u0395\u03bb\u03bb\u03ac\u03c2 \u039c.\u0395\u03a0\u0395.Tel: + 30 210 8930 100<\/td><td><strong>Austria<\/strong>Gilead Sciences GesmbHPhone: + 43 1 260 830<\/td><\/tr><tr><td><strong>Spain<\/strong>Gilead Sciences, SLPhone: + 34 91 378 98 30<\/td><td><strong>Polish<\/strong>Gilead Sciences Poland Sp.&nbsp;z o. oTel.: + 48 22 262 8702<\/td><\/tr><tr><td><strong>France<\/strong>Gilead SciencesTel: + 33 (0) 1 46 09 41 00<\/td><td><strong>Portugal<\/strong>Gilead Sciences, Lda.Phone: + 351 21 7928790<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><td><strong>Romania<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><\/tr><tr><td><strong>Ireland<\/strong>Gilead Sciences Ireland UCPhone: + 353 (0) 214 825 999<\/td><td><strong>Slovenija<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><\/tr><tr><td><strong>Iceland<\/strong>Gilead Sciences Sweden ABPhone: + 46 (0) 8 5057 1849<\/td><td><strong>Slovenian Republic<\/strong>Gilead Sciences Slovakia s.r.oPhone: + 421 232 121 210<\/td><\/tr><tr><td><strong>Italy<\/strong>Gilead Sciences SrlPhone: + 39 02 439201<\/td><td><strong>Finland\/Finland<\/strong>Gilead Sciences Sweden ABTel: + 46 (0) 8 5057 1849<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Gilead Sciences \u0395\u03bb\u03bb\u03ac\u03c2 \u039c.\u0395\u03a0\u0395.Tel: + 30 210 8930 100<\/td><td><strong>Sweden<\/strong>Gilead Sciences Sweden ABTel: + 46 (0) 8 5057 1849<\/td><\/tr><tr><td><strong>Latvia<\/strong>Gilead Sciences Poland Sp.&nbsp;z o. Phone: + 48 22 262 8702<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Gilead Sciences Ireland UCTel: + 44 (0) 8000 113 700<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Tybost contains the active substance cobicistat.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[3362,3366,22927,26700,26704,26703,22926,22925,26701,26702],"class_list":["post-25931","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-cobicistat","tag-cobicistat-side-effects","tag-cobicistat-tablet","tag-tybost","tag-tybost-side-effects","tag-tybost-tablet","tag-what-cobicistat-is-used-for","tag-what-is-cobicistat","tag-what-is-tybost","tag-what-tybost-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25931","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25931"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25931\/revisions"}],"predecessor-version":[{"id":25984,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25931\/revisions\/25984"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25931"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25931"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25931"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}