{"id":25838,"date":"2022-09-28T10:44:58","date_gmt":"2022-09-28T10:44:58","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25838"},"modified":"2022-09-30T12:26:25","modified_gmt":"2022-09-30T12:26:25","slug":"twinrix-adult","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/twinrix-adult\/","title":{"rendered":"Twinrix Adult uses, dose and side effects"},"content":{"rendered":"\n<p>solution for injection,\u00a0suspension\u00a0in pre-filled\u00a0syringe<br>Hepatitis\u00a0A (inactivated) and\u00a0hepatitis\u00a0B (rDNA) (HAB) vaccine (\u00a0adsorbed\u00a0)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Twinrix Adult is and what it is used for<\/h2>\n\n\n\n<p>Twinrix Vuxen is a vaccine that is used for adults and young people aged 16 and over and that protects against two different diseases:\u00a0hepatitis\u00a0A and\u00a0hepatitis\u00a0B. The vaccine works by causing the body to produce its protection (\u00a0antibodies\u00a0) against these diseases.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Hepatitis\u00a0A:\u00a0<\/strong>Hepatitis\u00a0A is an\u00a0infectious\u00a0disease that can affect the liver.\u00a0The disease is caused by the\u00a0hepatitis\u00a0A\u00a0virus.\u00a0Hepatitis\u00a0A\u00a0virus\u00a0can be transmitted from one person to another through food and drink, or when swimming in water contaminated with sewage.\u00a0Symptoms of\u00a0hepatitis\u00a0A begin 3 to 6 weeks after coming into contact with the\u00a0virus.\u00a0Symptoms consist of nausea (general malaise), fever, and aches and pains.\u00a0After a few days, the whites of the eyes and the skin may turn yellowish (jaundice).\u00a0The severity and type of symptoms can vary.\u00a0Young children do not always develop jaundice.\u00a0Most people make a full recovery, but the illness is often severe enough to make you feel sick for about a month.<\/li><li>Hepatitis\u00a0B:\u00a0Hepatitis\u00a0B is caused by the\u00a0hepatitis\u00a0B\u00a0virus.\u00a0It causes swelling of the liver (\u00a0inflammation\u00a0).\u00a0Virus\u00a0et is found in body fluids such as blood, semen, vaginal secretions, or saliva (spit) from infected people.<\/li><\/ul>\n\n\n\n<p>Vaccination is the best way to protect yourself against these diseases.\u00a0The vaccine does not contain any components that can cause\u00a0infection.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you receive Twinrix Adult<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Twinrix Adult<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>you are allergic to:<ul><li>the active substances or any other ingredient in this medicine (listed in section 6)<\/li><li>neomycin.<br>Signs of an\u00a0allergic reaction\u00a0may include an itchy rash, shortness of breath, and swelling of the face or tongue.<\/li><\/ul><\/li><li>you have previously had an\u00a0allergic reaction\u00a0to any\u00a0hepatitis\u00a0A or\u00a0hepatitis\u00a0B vaccine.<\/li><li>you have a severe\u00a0infection\u00a0with a high fever (over 38 \u00b0C).\u00a0A minor\u00a0infection\u00a0such as a common cold is probably not a problem, but talk to the doctor first.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before receiving Twinrix Adult if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have had any health problems after previous vaccinations<\/li><li>you have a poor immune system due to illness or drug treatment.<\/li><li>you have a bleeding disorder or bruise easily.<\/li><\/ul>\n\n\n\n<p>Fainting may occur (mainly in young people) after, or even before, any needle injection.\u00a0Therefore, tell the doctor or nurse if you have fainted during a previous\u00a0injection.<\/p>\n\n\n\n<p>In obese patients, a poor response to the vaccine has been seen, possibly without achieving protection against\u00a0hepatitis\u00a0A. A poor response to the vaccine, possibly without achieving protection against\u00a0hepatitis\u00a0B, has also been seen in older people, men rather than women, smokers, obese, long-term sick, or people with a certain type of drug treatment.\u00a0Your doctor may advise you to have a blood test after you have completed the vaccination program to check whether you have achieved a sufficient response.\u00a0If not, your doctor will let you know if you need an additional\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Twinrix Adult<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before receiving this vaccine.<\/p>\n\n\n\n<p>It is not known whether Twinrix Adult passes into breast milk.&nbsp;However, the vaccine is not expected to cause any problems for children who are breastfed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Twinrix Adult contains neomycin and sodium<\/h2>\n\n\n\n<p>Tell your doctor if you have previously had\u00a0an allergic reaction\u00a0to\u00a0neomycin\u00a0( an\u00a0antibiotic\u00a0).<\/p>\n\n\n\n<p>This vaccine contains less than 1 mmol (23 mg) of\u00a0sodium\u00a0per\u00a0dose, i.e. it is almost &#8220;sodium-free&#8221;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Twinrix Adult should be used<\/h2>\n\n\n\n<p>You will receive a total of three\u00a0injections\u00a0over 6 months.\u00a0Each\u00a0injection\u00a0is given at a separate visit.\u00a0The first\u00a0dose\u00a0will be given as agreed.\u00a0The other two\u00a0doses\u00a0will be given one month and six months after the first\u00a0dose.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>First&nbsp;dose&nbsp;one<\/td><td>as agreed<\/td><\/tr><tr><td>Second dose:<\/td><td>1 month later<\/td><\/tr><tr><td>Third dose:<\/td><td>6 months after the first\u00a0dose\u00a0one<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Twinrix Adult can also be given as a total of 3\u00a0doses\u00a0within 1 month.\u00a0This schedule should only be given to adults who need quick protection (eg international travelers).\u00a0The first\u00a0dose\u00a0is given as agreed.\u00a0The remaining 2\u00a0doses\u00a0are given 7 days and 21 days after the first\u00a0dose.\u00a0A fourth\u00a0dose\u00a0is recommended at 12 months.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>First dose:<\/td><td>as agreed<\/td><\/tr><tr><td>Second dose:<\/td><td>7 days later<\/td><\/tr><tr><td>Third dose:<\/td><td>21 days after the first&nbsp;dose&nbsp;a<\/td><\/tr><tr><td>Fourth dose:<\/td><td>12 months after the first&nbsp;dose&nbsp;a<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>If an additional&nbsp;dose&nbsp;or a top-up dose is needed, the doctor will let you know.<\/p>\n\n\n\n<p>As described in Section 2, a poor response to the vaccine, possibly without achieving protection against\u00a0hepatitis\u00a0B, is more common in older people, men rather than women, smokers, the obese, the chronically ill, or people on certain types of drug therapy.\u00a0Your doctor may advise you to have a blood test after you have completed the vaccination program to check whether you have achieved a sufficient response.\u00a0If not, your doctor will let you know if you need an additional\u00a0dose.<\/p>\n\n\n\n<p>If you miss an appointment for vaccination, you must talk to the doctor and get a new appointment.<\/p>\n\n\n\n<p>Make sure you complete the vaccination program of three\u00a0injections.\u00a0Otherwise, you will not have complete protection against the diseases.<\/p>\n\n\n\n<p>The doctor will give you Twinrix Adult as an&nbsp;injection&nbsp;into the upper arm muscle.<\/p>\n\n\n\n<p>The vaccine should not be given on the skin or\u00a0intramuscularly\u00a0in the buttock, as the protection may be reduced.<\/p>\n\n\n\n<p>The vaccine must never be given into a vein.<\/p>\n\n\n\n<p>If you have any further questions about this vaccine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this vaccine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Side effects\u00a0that may occur are the following:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Very common<\/strong>&nbsp;(1 in 10 vaccine doses or more often):<\/td><\/tr><tr><td>&nbsp;<\/td><td>HeadachePain and\u00a0redness\u00a0at the injection site fatigue<\/td><\/tr><tr><td><strong>Common<\/strong>&nbsp;(up to 1 in 10 vaccine doses):<\/td><\/tr><tr><td>&nbsp;<\/td><td>Diarrhea, nausea welling, bruising or\u00a0itching\u00a0at the injection site feeling of illness.<\/td><\/tr><tr><td><strong>Uncommon<\/strong>&nbsp;(up to 1 in 100 vaccine doses):<\/td><\/tr><tr><td>&nbsp;<\/td><td>DizzinessVomiting, stomach ache muscle pain upper respiratory tract infectionFever 37.5\u00b0C or higher.<\/td><\/tr><tr><td><strong>Rare<\/strong>&nbsp;(up to 1 in 1000 vaccine doses):<\/td><\/tr><tr><td>&nbsp;<\/td><td>Swollen\u00a0glands\u00a0in the neck, armpits, or groin (\u00a0lymphadenopathy\u00a0)Decreased sensitivity to pain or touch (\u00a0hypesthesia\u00a0)Tingling and crawling (\u00a0paresthesia\u00a0)Rash,\u00a0itchingJoint painless of appetite low\u00a0blood pressureFlu-like symptoms\u00a0such as high fever, sore throat, runny nose, cough, and chills.<\/td><\/tr><tr><td><strong>Very rare<\/strong>\u00a0(up to 1 in 10,000 vaccine doses): Adverse reactions\u00a0that have occurred very rarely during\u00a0clinical trials, with routine use of the vaccine, or with individual\u00a0hepatitis\u00a0A and\u00a0hepatitis\u00a0B vaccines include:<\/td><\/tr><tr><td>&nbsp;<\/td><td>Reduction in the number of\u00a0blood platelets, which increases the tendency to bleed and the risk of bruising (\u00a0thrombocytopenia\u00a0)Dark violet or brown-red spots visible through the skin (thrombocytopenic purpura)Swelling or\u00a0inflammation\u00a0of the brain (\u00a0encephalitis\u00a0)Degenerative\u00a0brain disease (\u00a0encephalopathy\u00a0)Nerve inflammation (\u00a0neuritis\u00a0)Numbness or weakness in arms and legs (\u00a0neuropathy\u00a0), paralysisCrampsSwelling of the face, mouth or throat (\u00a0angioneurotic edema)Dark violet or red-violet skin nodules (\u00a0lichen\u00a0planus), severe skin rash (erythema multiforme), gives joint swelling, muscle weaknessInflammation\u00a0of the membranes around the brain, which can cause severe headaches with neck stiffness and sensitivity to light (\u00a0meningitis\u00a0)Inflammation\u00a0in certain blood vessels (\u00a0vasculitis\u00a0)Severe allergic reactions (\u00a0anaphylaxis, anaphylactoid reactions and symptoms similar to serum sickness).\u00a0Signs of severe allergic reactions may include a skin rash that may itch or blister, swelling around the eyes and face, difficulty breathing or swallowing sudden drop in blood pressure and loss of consciousness.\u00a0Such reactions can occur before you have time to leave the reception.\u00a0If you experience any of these symptoms, contact your doctor immediately. Abnormal liver values multiple sclerosis, swelling of the spinal cord (\u00a0myelitis\u00a0)Drooping eyelids, and paralysis of the muscles in one half of the face (facial paralysis)Transient nerve inflammation causes pain, weakness, and paralysis of the arms and legs, often progressing to the chest and face (\u00a0Guillain-Barr\u00e9 syndrome\u00a0). The disease of\u00a0optic nerve\u00a0one (\u00a0optic neuritis\u00a0)Immediate pain at the injection site, stinging and burning sensation.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">How Twinrix Adult should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00baC-8 \u00baC).<br>Store in the original packaging.&nbsp;Light sensitive.<br>Do not freeze.&nbsp;Freezing destroys the vaccine.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">What Twinrix Adult contains<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td>The active substances are:<\/td><td>&nbsp;<\/td><\/tr><tr><td>&nbsp;<\/td><td>Hepatitis&nbsp;A&nbsp;virus&nbsp;(inactivated)&nbsp;<sup>1,2<\/sup><\/td><td>720 ELISA units<\/td><\/tr><tr><td>&nbsp;<\/td><td>Hepatitis&nbsp;B surface antigen&nbsp;<sup>3,4<\/sup><\/td><td>20 micrograms<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td>&nbsp;<\/td><td><sup>1<\/sup>&nbsp;Produced in human diploid cells (MRC-5)<\/td><td>&nbsp;<\/td><\/tr><tr><td>&nbsp;<\/td><td><sup>2&nbsp;<\/sup>Adsorbed&nbsp;on hydrated aluminum hydroxide<\/td><td>0.05 milligrams of Al&nbsp;<sup>3+<\/sup><\/td><\/tr><tr><td>&nbsp;<\/td><td><sup>3<\/sup>&nbsp;Produced in yeast cells (&nbsp;<em>Saccharomyces cerevisiae<\/em>&nbsp;) using&nbsp;recombinant DNA&nbsp;technology<\/td><\/tr><tr><td>&nbsp;<\/td><td><sup>4&nbsp;<\/sup>Adsorbed&nbsp;on aluminum phosphate<\/td><td>0.4 milligrams of Al&nbsp;<sup>3+<\/sup><\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td>&#8211;<\/td><td>The other ingredients in Twinrix Adults are sodium chloride and water for injections.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Solution for injection,\u00a0suspension\u00a0in a prefilled\u00a0syringe<\/p>\n\n\n\n<p>Twinrix Adult is a white, slightly milky liquid packaged in a pre-filled glass&nbsp;syringe&nbsp;(1 ml).<\/p>\n\n\n\n<p>Twinrix Adult is supplied in packs of 1, 10, and 25 with or without needles.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>GlaxoSmithKline Biologicals said<\/p>\n\n\n\n<p>Rue de l&#8217;Institut 89<\/p>\n\n\n\n<p>B-1330 Rixen species<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p>For information regarding this medicinal product, please contact the local representative of the marketing authorization holder.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgique&nbsp;<\/strong><strong>\/ Belgi\u00eb&nbsp;<\/strong><strong>\/ Belgium<\/strong>GlaxoSmithKline Pharmaceuticals SA\/NVTel\/Tel: + 32 10 85 52 00<\/td><td><strong>Lithuania<\/strong>GlaxoSmithKline Biologicals Satel.\u00a0+370 80000334<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>GlaxoSmithKline Biologicals Satel.: +359 80018205<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>GlaxoSmithKline Pharmaceuticals SA\/NVTel\/Tel: + 32 10 85 52 00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>GlaxoSmithKline s.r.oPhone: + 420 222 001 111cz.info@gsk.com<\/td><td><strong>Magyarorsz\u00e1g<\/strong>GlaxoSmithKline Biologicals SATel.: +36 80088309<\/td><\/tr><tr><td><strong>Denmark<\/strong>GlaxoSmithKline Pharma A\/SPhone: + 45 36 35 91 00dk-info@gsk.com<\/td><td><strong>Malta<\/strong>GlaxoSmithKline Biologicals SAPhone: +356 80065004<\/td><\/tr><tr><td><strong>Deutschland<\/strong>GlaxoSmithKline GmbH &amp; Co.&nbsp;KGPhone: + 49 (0)89 360448701product.info@gsk.com<\/td><td><strong>The Netherlands<\/strong>GlaxoSmithKline BVPhone: + 31 (0)33 2081100<\/td><\/tr><tr><td><strong>Estonia<\/strong>GlaxoSmithKline BiologicalsPhone: +372 8002640<\/td><td><strong>Norway<\/strong>GlaxoSmithKline iPhone: + 47 22 70 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>GlaxoSmithKline \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b7 AEBETel: + 30 210 68 82 100<\/td><td><strong>Austria<\/strong>GlaxoSmithKline Pharma GmbH.Phone: + 43 (0) 1 970 75-0at.info@gsk.com<\/td><\/tr><tr><td><strong>Spain<\/strong>GlaxoSmithKline, SAPhone: + 34 902 202 700es-ci@gsk.com<\/td><td><strong>Polish<\/strong>GSK Services Sp.&nbsp;z o. oTel.: + 48 (22) 576 9000<\/td><\/tr><tr><td><strong>France<\/strong>Laboratory GlaxoSmithKlineTel: + 33 (0) 1 39 17 84 44diam@gsk.com<\/td><td><strong>Portugal<\/strong>Smith Kline &amp; French Portuguesa, Produtos Farmac\u00eauticos, Lda.Phone: + 351 21 412 95 00FI.PT@gsk.com<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>GlaxoSmithKline Biologicals SATel.: +385 800787089<\/td><td><strong>Romania<\/strong>GlaxoSmithKline Biologicals SAPhone: +40 800672524<\/td><\/tr><tr><td><strong>Ireland<\/strong>GlaxoSmithKline (Ireland) LtdPhone: + 353 (0)1 495 5000<\/td><td><strong>Slovenija<\/strong>GlaxoSmithKline Biologicals SAPhone: +386 80688869<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>GlaxoSmithKline Biologicals SAPhone: +421 800500589<\/td><\/tr><tr><td><strong>Italy<\/strong>GlaxoSmithKline SpATel: + 39 (0) 45 7741 111<\/td><td><strong>Finland\/Finland<\/strong>GlaxoSmithKline OyPuh\/Tel: + 358 (0) 10 30 30 30<\/td><\/tr><tr><td><strong>Cyprus<\/strong>GlaxoSmithKline Biologicals SAPhone: +357 80070017<\/td><td><strong>Sweden<\/strong>GlaxoSmithKline ABPhone: + 46 (0)8 638 93 00info.produkt@gsk.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>GlaxoSmithKline Biologicals SAPhone: +371 80205045<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>GlaxoSmithKline Biologicals SAPhone: +44(0)800 221441<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Twinrix Vuxen is a vaccine that is used for adults and young people aged 16 and over and that protects against two different diseases:\u00a0hepatitis\u00a0A and\u00a0hepatitis\u00a0B. The vaccine works by causing the body to produce its own protection (\u00a0antibodies\u00a0) against these diseases.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[26598,13905,26593,26597,26595,26599,26594,26596],"class_list":["post-25838","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-hepatitis-a-vaccine","tag-hepatitis-b-vaccine","tag-twinrix-adult","tag-twinrix-adult-benefits","tag-twinrix-adult-side-effects","tag-twinrix-adult-vaccine","tag-what-is-twinrix-adult","tag-what-twinrix-adult-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25838","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25838"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25838\/revisions"}],"predecessor-version":[{"id":25922,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25838\/revisions\/25922"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25838"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25838"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}