{"id":25836,"date":"2022-09-28T10:42:21","date_gmt":"2022-09-28T10:42:21","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25836"},"modified":"2022-09-30T12:26:35","modified_gmt":"2022-09-30T12:26:35","slug":"twinrix-pediatric","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/twinrix-pediatric\/","title":{"rendered":"Twinrix Pediatric uses, dose and side effects"},"content":{"rendered":"\n<p>solution for injection, suspension in pre-filled syringe<br>Hepatitis&nbsp;A (inactivated) and&nbsp;hepatitis&nbsp;B (rDNA) (HAB) vaccines (&nbsp;adsorbed&nbsp;)<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Twinrix Pediatric is and what it is used for<\/h2>\n\n\n\n<p>Twinrix Pediatric is a vaccine used in infants, children, and adolescents from 1 year up to and including 15 years of age and which protects against two different diseases:\u00a0hepatitis\u00a0A and\u00a0hepatitis\u00a0B. The vaccine works by causing the body to produce its protection (\u00a0antibody\u00a0ar) against these diseases.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Hepatitis\u00a0A:\u00a0<\/strong>Hepatitis\u00a0A is an\u00a0infectious\u00a0disease that can affect the liver.\u00a0The disease is caused by the\u00a0hepatitis\u00a0A\u00a0virus.\u00a0Hepatitis\u00a0A\u00a0virus\u00a0can be transmitted from one person to another through food and drink, or when swimming in water contaminated with sewage.\u00a0Symptoms of\u00a0hepatitis\u00a0A begin 3 to 6 weeks after coming into contact with the\u00a0virus.\u00a0Symptoms consist of nausea (general malaise), fever, and aches and pains.\u00a0After a few days, the whites of the eyes and the skin may turn yellowish (jaundice).\u00a0The severity and type of symptoms can vary.\u00a0Young children do not always develop jaundice.\u00a0Most recover completely, but the illness is often severe enough to require you to stay home from work for at least a month.<br><\/li><li>Hepatitis\u00a0B:\u00a0Hepatitis\u00a0B is caused by the\u00a0hepatitis\u00a0B\u00a0virus.\u00a0It causes swelling of the liver (\u00a0inflammation\u00a0).\u00a0Virus\u00a0et is found in body fluids such as blood, semen, vaginal secretions, or saliva (spit) from infected people.<\/li><\/ul>\n\n\n\n<p>Vaccination is the best way to protect yourself against these diseases.\u00a0The vaccine does not contain any components that can cause\u00a0infection.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you receive Twinrix Pediatric<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Twinrix Pediatric if<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>you are allergic to:<ul><li>the active substances or any other ingredient in this medicine (listed in section 6)<\/li><li>neomycin.<br>Signs of an\u00a0allergic reaction\u00a0may include an itchy rash, shortness of breath, and swelling of the face or tongue.<\/li><\/ul><\/li><li>you have previously had an\u00a0allergic reaction\u00a0to any\u00a0hepatitis\u00a0A or\u00a0hepatitis\u00a0B vaccine.<\/li><li>you have a severe\u00a0infection\u00a0with a high fever (over 38 \u00b0C).\u00a0A minor\u00a0infection\u00a0such as a common cold is probably not a problem, but talk to the doctor first.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Before receiving Twinrix Pediatric, talk to your doctor or pharmacist<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have had any health problems after previous vaccinations<\/li><li>you have a weak immune system due to illness or drug treatment<\/li><li>you have a bleeding disorder or bruise easily.<\/li><\/ul>\n\n\n\n<p>Fainting may occur (mainly in young people) after, or even before, any needle injection.\u00a0Therefore, tell the doctor or nurse if you have fainted during a previous\u00a0injection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Twinrix Pediatric<\/h2>\n\n\n\n<p>Twinrix Pediatric can be given at the same time as a human papillomavirus vaccine (HPV vaccine).&nbsp;When the vaccines are given at the same visit, however, different injection sites (different body part, e.g. opposite arm) must be used.<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before receiving this vaccine.<\/p>\n\n\n\n<p>It is not known whether Twinrix Pediatric passes into breast milk.&nbsp;However, the vaccine is not expected to cause any problems for children who are breastfed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Twinrix Pediatric contains neomycin and sodium<\/h2>\n\n\n\n<p>Tell your doctor if you have previously suffered from&nbsp;an allergic reaction&nbsp;to&nbsp;neomycin&nbsp;( an&nbsp;antibiotic&nbsp;).<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg) of&nbsp;sodium&nbsp;per&nbsp;dose&nbsp;, i.e. it is almost &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Twinrix Pediatric should be used<\/h2>\n\n\n\n<p>You will receive a total of three&nbsp;injections&nbsp;over a period of 6 months.&nbsp;Each&nbsp;injection&nbsp;is given at a separate visit.&nbsp;First&nbsp;dose&nbsp;one will be given as agreed.&nbsp;The other two&nbsp;doses&nbsp;will be given one month and six months after the first&nbsp;dose&nbsp;.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>First dose: as agreed<\/li><li>Second dose: 1 month later<\/li><li>Third dose: 6 months after first&nbsp;dose&nbsp;one<\/li><\/ul>\n\n\n\n<p>If an additional&nbsp;dose&nbsp;or a top-up dose is needed, the doctor will let you know.<\/p>\n\n\n\n<p>If you miss an appointment for vaccination, you must talk to the doctor and get a new appointment.<\/p>\n\n\n\n<p>Make sure you complete the vaccination program with three&nbsp;injections&nbsp;.&nbsp;Otherwise, you will not have complete protection against the diseases.<\/p>\n\n\n\n<p>The doctor will give you Twinrix Pediatric as an&nbsp;injection&nbsp;into the upper arm muscle or thigh muscle of your child.<\/p>\n\n\n\n<p>The vaccine must never be given into a vein.<\/p>\n\n\n\n<p>If you have any further questions about this vaccine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this vaccine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<\/p>\n\n\n\n<p>Side effects&nbsp;that may occur are the following:<\/p>\n\n\n\n<p>Side effects\u00a0that have occurred during\u00a0clinical studies\u00a0, during routine use of the vaccine, with individual\u00a0hepatitis\u00a0A and\u00a0hepatitis\u00a0B vaccines or with the formulation intended for adults<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Very common<\/strong>&nbsp;(1 in 10 vaccine doses or more often):<\/td><\/tr><tr><td>&nbsp;<\/td><td>Pain and&nbsp;redness&nbsp;at the injection site.<\/td><\/tr><tr><td><strong>Common<\/strong>&nbsp;(up to 1 in 10 vaccine doses):<\/td><\/tr><tr><td>&nbsp;<\/td><td>Drowsiness, headacheNauseaLoss of appetiteSwelling or bruising at the injection siteFeeling sick, fatigueFever 37.5 \u00b0C or higherIrritability.<\/td><\/tr><tr><td><strong>Uncommon<\/strong>&nbsp;(up to 1 in 100 vaccine doses):<\/td><\/tr><tr><td>&nbsp;<\/td><td>Diarrhea, vomiting, stomach acheRashMuscle painUpper respiratory tract infection.<\/td><\/tr><tr><td><strong>Rare<\/strong>&nbsp;(up to 1 in 1000 vaccine doses):<\/td><\/tr><tr><td>&nbsp;<\/td><td>Swollen&nbsp;glands&nbsp;in the neck, armpits or groin (&nbsp;lymphadenopathy&nbsp;)DizzinessDecreased sensitivity to pain or touch (&nbsp;hypesthesia&nbsp;)Tingling and crawling (&nbsp;paresthesia&nbsp;)Hives,&nbsp;itchingJoint painLow&nbsp;blood pressureFlu-like symptoms&nbsp;such as high fever, sore throat, runny nose, cough and chills.<\/td><\/tr><tr><td><strong>Very rare<\/strong>&nbsp;(up to 1 in 10,000 vaccine doses):<\/td><\/tr><tr><td>&nbsp;<\/td><td>Reduction in the number of&nbsp;blood platelets&nbsp;, which increases the tendency to bleed and the risk of bruising (&nbsp;thrombocytopenia&nbsp;)Dark violet or brown-red spots visible through the skin (thrombocytopenic purpura)Swelling or&nbsp;inflammation&nbsp;of the brain (&nbsp;encephalitis&nbsp;)Degenerative&nbsp;brain disease (&nbsp;encephalopathy&nbsp;)Nerve inflammation (&nbsp;neuritis&nbsp;)Numbness or weakness in arms and legs (&nbsp;neuropathy&nbsp;), paralysisCrampsSwelling of the face, mouth or throat (&nbsp;angioneurotic oedema&nbsp;)Dark violet or red-violet skin nodules (&nbsp;lichen&nbsp;planus), severe skin rash (erythema multiforme)Joint swelling, muscle weaknessInflammation&nbsp;of the membranes around the brain, which can cause severe headaches with neck stiffness and sensitivity to light (&nbsp;meningitis&nbsp;)Inflammation&nbsp;in certain blood vessels (&nbsp;vasculitis&nbsp;)Severe allergic reactions (&nbsp;anaphylaxis&nbsp;, anaphylactoid reactions and symptoms similar to serum sickness).&nbsp;Signs of severe allergic reactions may include skin rash that may itch or blister, swelling around the eyes and face, difficulty breathing or swallowing, sudden drop in blood pressure and loss of consciousness.&nbsp;Such reactions can occur before you have time to leave the reception.&nbsp;If you experience any of these symptoms, contact your doctor immediately.Abnormal liver valuesMultiple sclerosis&nbsp;, swelling of the spinal cord (&nbsp;myelitis&nbsp;)Drooping eyelids and paralysis of the muscles in one half of the face (facial paralysis)Transient nerve inflammation causing pain, weakness and paralysis of the arms and legs, often progressing to the chest and face (&nbsp;Guillain-Barr\u00e9 syndrome&nbsp;)Disease of the&nbsp;optic nerve (&nbsp;an&nbsp;optic neuritis&nbsp;)Immediate pain at the injection site, stinging and burning sensation.<\/td><td>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Twinrix Pediatric<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2\u00b0C &#8211; 8\u00b0C).<br>Store in the original packaging.&nbsp;Light sensitive.<br>Do not freeze.&nbsp;Freezing destroys the vaccine.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among household waste.&nbsp;Ask the pharmacist how to dispose of medicines that are no longer used.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">What Twinrix Pediatric contains<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td>The active substances are:<\/td><\/tr><tr><td>&nbsp;<\/td><td>Hepatitis&nbsp;A&nbsp;virus&nbsp;(inactivated)&nbsp;<sup>1,2<\/sup><\/td><td>360 ELISA Units<\/td><\/tr><tr><td>&nbsp;<\/td><td>Hepatitis&nbsp;B surface antigen&nbsp;<sup>3,4<\/sup><\/td><td>10 micrograms<\/td><\/tr><tr><td>&nbsp;<\/td><td><sup>1<\/sup>&nbsp;Produced in human diploid cells (MRC-5)<\/td><\/tr><tr><td>&nbsp;<\/td><td><sup>2&nbsp;<\/sup>Adsorbed&nbsp;on aluminum hydroxide hydrate<\/td><td>0.025 milligrams of Al&nbsp;<sup>3+<\/sup><\/td><\/tr><tr><td>&nbsp;<\/td><td><sup>3<\/sup>&nbsp;Produced in yeast cells&nbsp;<em>(Saccharomyces cerevisiae)<\/em>&nbsp;with&nbsp;recombinant DNA&nbsp;technology<\/td><\/tr><tr><td>&nbsp;<\/td><td><sup>4&nbsp;<\/sup>Adsorbed&nbsp;on aluminum phosphate<\/td><td>0.2 milligrams of Al&nbsp;<sup>3+<\/sup><\/td><\/tr><tr><td>&nbsp;&#8211;<\/td><td>&nbsp;The other ingredients in Twinrix Pediatric are: sodium chloride and water for injections.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Solution for injection&nbsp;,&nbsp;suspension&nbsp;in prefilled&nbsp;syringe<\/p>\n\n\n\n<p>Twinrix Pediatric is a white, slightly milky liquid packaged in a pre-filled glass&nbsp;syringe&nbsp;(0.5 ml).<\/p>\n\n\n\n<p>Twinrix Pediatric is supplied in packs of 1, 10 and 50 with or without needles.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>GlaxoSmithKline Biologicals said<\/p>\n\n\n\n<p>Rue de l&#8217;Institut 89<\/p>\n\n\n\n<p>B-1330 Rixen species<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p>For information regarding this medicinal product, please contact the local representative of the Marketing Authorization Holder:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgique\/&nbsp;<\/strong><strong>Belgium&nbsp;<\/strong><strong>\/Belgium<\/strong>GlaxoSmithKline Pharmaceuticals SA\/NVTel\/Tel: + 32 10 85 52 00<\/td><td><strong>Lithuania<\/strong>GlaxoSmithKline Biologicals SATel.&nbsp;+370 80000334<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>GlaxoSmithKline Biologicals SATel.: +359 80018205<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>GlaxoSmithKline Pharmaceuticals SA\/NVTel\/Tel: + 32 10 85 52 00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>GlaxoSmithKline s.r.oPhone: + 420 2 22 00 11 11cz.info@gsk.com<\/td><td><strong>Magyarorsz\u00e1g<\/strong>GlaxoSmithKline Biologicals SATel.: +36 80088309<\/td><\/tr><tr><td><strong>Denmark<\/strong>GlaxoSmithKline Pharma A\/SPhone: + 45 36 35 91 00dk-info@gsk.com<\/td><td><strong>Malta<\/strong>GlaxoSmithKline Biologicals SAPhone: +356 80065004<\/td><\/tr><tr><td><strong>Deutschland<\/strong>GlaxoSmithKline GmbH &amp; Co.&nbsp;KGPhone: + 49 (0)89 360448701product.info@gsk.com<\/td><td><strong>The Netherlands<\/strong>GlaxoSmithKline BVPhone: + 31 (0)33 2081100<\/td><\/tr><tr><td><strong>Estonia<\/strong>GlaxoSmithKline Biologicals SAPhone: +372 8002640<\/td><td><strong>Norway<\/strong>GlaxoSmithKline ASPhone: + 47 22 70 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>GlaxoSmithKline \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b7 AEBETel: + 30 210 68 82 100<\/td><td><strong>Austria<\/strong>GlaxoSmithKline Pharma GmbHPhone: + 43 (0) 1 970750at.info@gsk.com<\/td><\/tr><tr><td><strong>Spain<\/strong>GlaxoSmithKline, SAPhone: + 34 902 202 700es-ci@gsk.com<\/td><td><strong>Polish<\/strong>GSK Services Sp.&nbsp;z o. oTel.: + 48 (22) 576 9000<\/td><\/tr><tr><td><strong>France<\/strong>Laboratory GlaxoSmithKlineTel: + 33 (0) 1 39 17 84 44diam@gsk.com<\/td><td><strong>Portugal<\/strong>Smith Kline &amp; French Portuguesa, Produtos Farmac\u00eauticos, Lda.Phone: + 351 21 412 95 00FI.PT@gsk.com<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>GlaxoSmithKline Biologicals SATel.: +385 800787089<\/td><td><strong>Romania<\/strong>GlaxoSmithKline Biologicals SAPhone: +40 800672524<\/td><\/tr><tr><td><strong>Ireland<\/strong>GlaxoSmithKline (Ireland) LtdPhone: + 353 (0)1 495 5000<\/td><td><strong>Slovenija<\/strong>GlaxoSmithKline Biologicals SAPhone: +386 80688869<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>GlaxoSmithKline Biologicals SATel.: +421 800500589<\/td><\/tr><tr><td><strong>Italy<\/strong>GlaxoSmithKline SpATel: + 39 (0)45 7741 111<\/td><td><strong>Finland\/Finland<\/strong>GlaxoSmithKline OyPuh\/Tel: + 358 (0) 10 30 30 30<\/td><\/tr><tr><td><strong>Cyprus<\/strong>GlaxoSmithKline Biologicals SAPhone: +357 80070017<\/td><td><strong>Sweden<\/strong>GlaxoSmithKline ABPhone: + 46 (0)8 638 93 00info.produkt@gsk.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>GlaxoSmithKline Biologicals SAPhone: +371 80205045<\/td><td><strong>United Kingdom (Northern Ireland<\/strong>&nbsp;)GlaxoSmithKline Biologicals SAPhone: +44(0)800 221441customercontactuk@gsk.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Twinrix Pediatric is a vaccine used in infants, children and adolescents from 1 year up to and including 15 years of age and which provides protection against two different diseases:\u00a0hepatitis\u00a0A and\u00a0hepatitis\u00a0B. The vaccine works by causing the body to produce its own protection (\u00a0antibody\u00a0ar) against these diseases.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[26603,26598,13905,26600,26605,26601,26602,26604],"class_list":["post-25836","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-twinrix-pediatric","tag-hepatitis-a-vaccine","tag-hepatitis-b-vaccine","tag-twinrix-pediatric","tag-twinrix-pediatric-side-effects","tag-twinrix-pediatric-vaccine","tag-what-is-twinrix-pediatric","tag-what-twinrix-pediatric-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25836","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25836"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25836\/revisions"}],"predecessor-version":[{"id":25923,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25836\/revisions\/25923"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25836"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25836"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25836"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}