{"id":25834,"date":"2022-09-28T10:39:55","date_gmt":"2022-09-28T10:39:55","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25834"},"modified":"2022-09-30T12:26:42","modified_gmt":"2022-09-30T12:26:42","slug":"tukysa","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tukysa\/","title":{"rendered":"Tukysa &#8211; Tukatinib uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg&nbsp;Film-coated tablet<br>Tukatinib<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tukysa is and what it is used for<\/h2>\n\n\n\n<p>TUKYSA is a medicine against breast cancer.&nbsp;It contains the active substance tukatinib and it belongs to the drug group tyrosine kinase inhibitors, which prevent the growth of certain types of cancer cells in the body.<\/p>\n\n\n\n<p><strong>What TUKYSA is used for<\/strong><\/p>\n\n\n\n<p>TUKYSA is used in adults with breast cancer:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>which has a\u00a0receptor\u00a0(target) on the cancer cells called\u00a0human\u00a0epidermal\u00a0growth factor receptor 2 (\u00a0HER2\u00a0-positive breast cancer)<\/li><li>where thecer has spread beyond the original\u00a0tumor\u00a0or to other organs such as the brain, or which cannot be removed with\u00a0surgery\u00a0.<\/li><li>ho have previously been treated with certain other breast cancer treatments<\/li><\/ul>\n\n\n\n<p>TU?KYSA is taken together with two other cancer medicines,\u00a0trastuzumab\u00a0an,d\u00a0capecitabine\u00a0.\u00a0eparate leaflets are available for these medicines.\u00a0<strong>Ask your doctor<\/strong>\u00a0to tell you about them.<\/p>\n\n\n\n<p><strong>How TUKYSA works<\/strong><\/p>\n\n\n\n<p>TUKYSA&nbsp;works by blocking the&nbsp;HER2&nbsp;receptors&nbsp;on cancer cells.&nbsp;Signals from&nbsp;HER2&nbsp;can help the cancer grow, and blocking&nbsp;HER2&nbsp;can therefore slow or stop the growth of cancer cells or destroy them altogether.<br><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Tukysa<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Tukysa<\/h2>\n\n\n\n<p><strong>Do not take TUKYSA<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to tukatinib or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Talk to your doctor before taking TUKYSA if you have liver problems.\u00a0During treatment, the doctor takes samples to check that your liver is working as it should.<\/li><li>TUSA can cause severe diarrhea.\u00a0Talk to your doctor immediately at the first sign of diarrhea.<\/li><li>TUKYSA can cause birth defects if taken by a pregnant woman.\u00a0Tell your doctor if you are taking, have recently taken or might take any other medicines.\u00a0See the section on &#8220;Pregnancy and breast-feeding below&#8221;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>TUKYSA should not be used in children under 18 years of age.&nbsp;The safety of TUKYSA and its effectiveness have not been studied in this age group.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tukysa<\/h2>\n\n\n\n<p><strong>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.<\/strong><\/p>\n\n\n\n<p>Certain medicines can affect how TUKYSA works or TURKYSA can affect how they work.&nbsp;These medicines include certain medicines in the following groups:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>St. John&#8217;s wort&nbsp;\u2013 a plant-based medicine used as a treatment for mild depression and mild anxiety<\/li><li>itraconazole,&nbsp;ketoconazole&nbsp;, voriconazole, posaconazole \u2013 used to treat fungal infections<\/li><li>rifampicin \u2013 used to treat bacterial infections<\/li><li>darunavir, saquinavir, tipranavir \u2013 used to treat&nbsp;HIV<\/li><li>phenytoin&nbsp;, carbamazepine &#8211; used to treat&nbsp;epilepsy&nbsp;or a painful facial condition called&nbsp;trigeminal neuralgia&nbsp;or to control severe mood disorders when other medicines don&#8217;t work<\/li><li>buspirone &#8212; used for certain types of mental disorders<\/li><li>sirolimus, tacrolimus \u2013 used to control the body&#8217;s&nbsp;immune response&nbsp;after a transplant<\/li><li>digoxin&nbsp;\u2013 used as a treatment for heart problems<\/li><li>lomitapide, lovastatin \u2013 used to treat high cholesterol levels<\/li><li>alfentanil \u2013 used to relieve pain<\/li><li>avanafil, vardenafil \u2013 used as a treatment for&nbsp;erectile dysfunction<\/li><li>darifenacin \u2013 used to treat urinary incontinence<\/li><li>midazolam, triazolam \u2013 used to treat seizures, anxiety disorders, panic, restlessness and insomnia<\/li><li>repaglinide \u2013 used to treat type 2&nbsp;diabetes<\/li><li>ebastine \u2013 an&nbsp;antihistamine&nbsp;used to treat seasonal and&nbsp;perennial&nbsp;allergic&nbsp;rhinitis&nbsp;and rhinoconjunctivitis.<\/li><li>everolimus, ibrutinib \u2013 used to treat certain types of cancer<\/li><li>naloxegol \u2013 used to treat constipation<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>TUKYSA may cause harmful effects to the unborn baby if taken by a pregnant woman.&nbsp;You may give a pregnancy test to the doctor before you start taking TUKYSA.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are&nbsp;<strong>pregnant,<\/strong>&nbsp;think you&nbsp;<strong>may be pregnant<\/strong>&nbsp;or&nbsp;<strong>are planning to have a baby<\/strong>&nbsp;,&nbsp;<strong>consult your doctor<\/strong>&nbsp;before using this medicine.&nbsp;The doctor will weigh the potential benefit to you against the risk to the unborn baby.<\/li><li><strong>Use reliable birth control<\/strong>&nbsp;to avoid becoming pregnant while taking TUKYSA for at least 1 week after stopping treatment.<\/li><li><strong>If you are male and have a female&nbsp;fertile&nbsp;sexual partner, use reliable birth control<\/strong>&nbsp;to avoid pregnancy while taking TUKYSA for at least 1 week after stopping treatment.<\/li><li>If you&nbsp;<strong>become pregnant<\/strong>&nbsp;during treatment with TUKYSA,&nbsp;<strong>tell your doctor<\/strong>&nbsp;.&nbsp;The doctor will assess the potential benefit to you of continuing to take this medicine and the risk to the unborn baby.<\/li><\/ul>\n\n\n\n<p>It is unknown if TUKYSA is excreted in breast milk.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you&nbsp;<strong>are breastfeeding<\/strong>&nbsp;or&nbsp;<strong>plan to breastfeed<\/strong>&nbsp;,&nbsp;<strong>consult<\/strong>&nbsp;your doctor before using this medicine.&nbsp;You should not breastfeed during treatment with TUKYSA and for at least 1 week after the last&nbsp;dose&nbsp;.&nbsp;Talk to the doctor about the best way to feed your baby during treatment.<\/li><\/ul>\n\n\n\n<p><strong>Ask your doctor or pharmacist<\/strong>&nbsp;before taking TUKYSA if you have any questions.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>TUKYSA is not expected to affect the ability to drive or use machines.&nbsp;You yourself are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tukysa contains excipients<\/h2>\n\n\n\n<p><strong>TUKYSA contains&nbsp;sodium&nbsp;and&nbsp;potassium<\/strong><\/p>\n\n\n\n<p>This medicine contains 55.3 mg of&nbsp;sodium&nbsp;(the main ingredient in common\/table salt) per 300 mg&nbsp;dose&nbsp;.<\/p>\n\n\n\n<p>This corresponds to 2.75% of the maximum recommended daily intake of&nbsp;sodium&nbsp;for adults.<\/p>\n\n\n\n<p>This medicine contains 60.6 mg&nbsp;of potassium&nbsp;per 300 mg&nbsp;dose&nbsp;.&nbsp;This should be taken into account by patients with&nbsp;reduced&nbsp;renal function or patients prescribed a potassium-poor diet.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Tukysa<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 300 mg (two 150 mg tablets) twice a day.&nbsp;The tablets should be swallowed.<\/p>\n\n\n\n<p>The doctor can change the&nbsp;dose&nbsp;of TUKYSA if you get certain&nbsp;side effects&nbsp;.&nbsp;To allow for a lower&nbsp;dose&nbsp;, the doctor may prescribe 50 mg tablets.<\/p>\n\n\n\n<p><strong>Mode of administration<\/strong><\/p>\n\n\n\n<p>TUKYSA can be taken with food or between meals.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swallow the tablets whole, one by one.<\/li><li>Take each&nbsp;dose&nbsp;approximately 12 hours apart, at the same time each day.<\/li><li>The tablet should not be chewed or crushed.<\/li><li>Do not take an additional&nbsp;dose&nbsp;if you vomit after taking TUKYSA, but take the next scheduled&nbsp;dose&nbsp;as usual.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Tukysa&nbsp;<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist immediately.&nbsp;If possible, show them the packaging.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Tukysa<\/h2>\n\n\n\n<p><strong>Do not take a double&nbsp;dose<\/strong>&nbsp;to make up for a missed&nbsp;dose&nbsp;.&nbsp;Just take the next&nbsp;dose&nbsp;at the regular dosing time.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Tukysa<\/h2>\n\n\n\n<p>TUKYSA is a long-term treatment and you must take it continuously.&nbsp;<strong>Do not stop taking TUKYSA<\/strong>&nbsp;without talking to your doctor.<\/p>\n\n\n\n<p><strong>While taking TUKYSA<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Depending on which&nbsp;side effects&nbsp;you get, the doctor may recommend a dose reduction or a temporary treatment break.<\/li><li>The doctor will also check your liver function during treatment with TUKYSA.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.&nbsp;The following&nbsp;side effects&nbsp;may occur with this medicine.<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea<\/li><li>nausea<\/li><li>vomiting<\/li><li>mouth ulcers,&nbsp;inflammation&nbsp;of the mouth, mouth ulcers<\/li><li>liver problems, which can cause&nbsp;itching&nbsp;, a yellowing of the eyes and skin, dark urine and pain or discomfort in the upper abdomen<\/li><li>rash<\/li><li>joint pain<\/li><li>weight loss<\/li><li>nosebleed.<\/li><\/ul>\n\n\n\n<p>If you get&nbsp;side effects&nbsp;,&nbsp;<strong>talk to your doctor or pharmacist.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Tukysa should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the blister and carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among household waste.&nbsp;Ask the pharmacist how to dispose of medicines that are no longer used.&nbsp;These measures will help to protect the environment.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The&nbsp;<strong>active substance<\/strong>&nbsp;is tukatinib.&nbsp;Each film-coated tablet contains either 50 mg or 150 mg of tukatinib.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tablet core &#8211; copovidone, crospovidone, sodium chloride, potassium chloride, sodium bicarbonate,&nbsp;colloidal&nbsp;, anhydrous silicon dioxide, magnesium stearate, microcrystalline cellulose (see section 2 &#8220;TUKYSA contains&nbsp;sodium&nbsp;and potassium&#8221;).<\/li><li>Film coating \u2013 poly(vinyl alcohol), titanium dioxide, macrogol, talc, yellow iron oxide.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>TUKYSA 50 mg film-coated tablets are round, yellow and debossed with \u201cTUC\u201d on one side and \u201c50\u201d on the other side.<\/p>\n\n\n\n<p>TUKYSA 150 mg film-coated tablets are oval, yellow and debossed with \u201cTUC\u201d on one side and \u201c150\u201d on the other side.<\/p>\n\n\n\n<p>TUKYSA is supplied in aluminum foil blisters.&nbsp;Each pack contains:<\/p>\n\n\n\n<p>TUKYSA 50 mg film-coated tablets<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>88 tablets (11 blisters with 8 tablets in each blister).<\/li><\/ul>\n\n\n\n<p>TUKYSA 150 mg film-coated tablets<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>84 tablets (21 blisters with 4 tablets in each blister).<\/li><\/ul>\n\n\n\n<p>Not all pack sizes may be marketed.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Seagen BV<\/p>\n\n\n\n<p>Evert van de Beekstraat 1-104<\/p>\n\n\n\n<p>1118CL Schiphol<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Seagen BV (Nederland\/Pays-Bas\/Niederlande)Tel\/Tel: +32 7848 27 51<\/td><td><strong>Lithuania<\/strong>Swixx Biopharma UABPhone: +370 5 236 9140<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Swixx Biopharma EOODPhone: +359 2 4942 480<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>Seagen BV (Pays-Bas\/Netherlands)T\u00e9l\/Tel: +352 27 867 570<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Swixx Biopharma s.r.o. Tel: +420 242 434 222<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Swixx Biopharma Kft.Tel.: +36 1 9206 550<\/td><\/tr><tr><td><strong>Denmark<\/strong>Seagen Denmark ApSPhone: +45 89 88 83 53<\/td><td><strong>Malta<\/strong>Genesis Pharma (Cyprus) Ltd (\u010aipru\/Cyprus)Phone: +357 22 765715<\/td><\/tr><tr><td><strong>Deutschland<\/strong>Seagen Germany GmbHPhone: +49 893 803 6915<\/td><td><strong>The Netherlands<\/strong>Seagen BVPhone: +31 202 419041<\/td><\/tr><tr><td><strong>Estonia<\/strong>Swixx Biopharma O\u00dcPhone: +372 640 1030<\/td><td><strong>Norway<\/strong>Seagen BV (The Netherlands)Phone: +45 89 88 83 53<\/td><\/tr><tr><td><strong>Greece<\/strong>\u0393\u0395\u039d\u0395\u03a3\u0399\u03a3 \u03a6\u0391\u03a1\u039c\u0391 \u0391.\u0395Tel: +30 210 87 71 500<\/td><td><strong>Austria<\/strong>Seagen BV (Netherlands)Phone: (+43) 720 778105<\/td><\/tr><tr><td><strong>Spain<\/strong>Seagen Spain SLUPhone: (+34) 919 011 012<\/td><td><strong>Polish<\/strong>Swixx Biopharma Sp. z o. oTel.: +48 22 460 07 20<\/td><\/tr><tr><td><strong>France<\/strong>Seagen France SASPhone: +33 184 88 80 69<\/td><td><strong>Portugal<\/strong>Seagen BV (Pa\u00edses Baixos)Phone: (+351) 211 451 261<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Swixx Biopharma dooPhone: +385 1 2078 500<\/td><td><strong>Romania<\/strong>Swixx Biopharma SRLPhone: +40 371 530 850<\/td><\/tr><tr><td><strong>Ireland<\/strong>Seagen BV (Netherlands)Phone: +353 1903 9713<\/td><td><strong>Slovenija<\/strong>Swixx Biopharma dooPhone: +386 1 2355 100<\/td><\/tr><tr><td><strong>Iceland<\/strong>Seagen BV (Holland)Telephone: +354 539 0641<\/td><td><strong>Slovenian Republic<\/strong>Swixx Biopharma s.r.oPhone: +421 2 20833 600<\/td><\/tr><tr><td><strong>Italy<\/strong>Seagen Italy SrlPhone: (+39) 02 82952389<\/td><td><strong>Finland\/Finland<\/strong>Seagen BV (Alankomaat\/The Netherlands)Tel: +358 753 252 569<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Genesis Pharma (Cyprus) LtdPhone: +357 22 765715<\/td><td><strong>Sweden<\/strong>Seagen BV (The Netherlands)Phone: (+46) 108 885 437<\/td><\/tr><tr><td><strong>Latvia<\/strong>Swixx Biopharma SIAPhone: +371 6 6164 750<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Seagen BV (Netherlands)Phone: +44 330 818 0490<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>TUKYSA is a medicine against breast cancer.\u00a0It contains the active substance tukatinib and it belongs to the drug group tyrosine kinase inhibitors, which prevent the growth of certain types of cancer cells in the body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[26606,26609,26610,26611,26614,26613,26615,26608,26607,26612],"class_list":["post-25834","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-tukatinib","tag-tukatinib-side-effects","tag-tukatinib-tablet","tag-tukysa","tag-tukysa-side-effects","tag-tukysa-tablet","tag-what-is-tukatinib","tag-what-is-tukysa","tag-what-tukatinib-is-used-for","tag-what-tukysa-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25834"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25834\/revisions"}],"predecessor-version":[{"id":25924,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25834\/revisions\/25924"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}