{"id":25757,"date":"2022-09-26T07:33:31","date_gmt":"2022-09-26T07:33:31","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25757"},"modified":"2022-09-28T07:50:16","modified_gmt":"2022-09-28T07:50:16","slug":"trivina","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/trivina\/","title":{"rendered":"Trivina &#8211; Estradiol valerate\/medroxyprogesterone acetate uses, dose and side effects"},"content":{"rendered":"\n<p>tablets<br>estradiol valerate\/medroxyprogesterone acetate<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Trivina is and what it is used for<\/h2>\n\n\n\n<p>Trivina is a preparation used\u00a0for\u00a0hormone\u00a0replacement\u00a0therapy\u00a0(\u00a0HRT\u00a0).\u00a0It contains two female sex hormones;\u00a0estrogen\u00a0and progestin.\u00a0Trivina is used in women whose menstruation has stopped (\u00a0menopause\u00a0), at least 6 months after their last natural period.<\/p>\n\n\n\n<p>Trivina is used to:<\/p>\n\n\n\n<p><strong>Relieve symptoms during and after menopause<\/strong><\/p>\n\n\n\n<p>When menstruation stops (\u00a0menopause\u00a0), the woman&#8217;s\u00a0estrogen\u00a0drops.\u00a0It can cause problems such as sweating and hot flashes.\u00a0Trivina relieves these symptoms after\u00a0menopause.\u00a0Trivina should only be used if the symptoms cause problems in daily life.<\/p>\n\n\n\n<p><strong>Prevent osteoporosis<\/strong><\/p>\n\n\n\n<p>After\u00a0menopause, some women suffer from osteoporosis.\u00a0Discuss all possible options with your doctor.<\/p>\n\n\n\n<p>If you have an increased risk of\u00a0fractures\u00a0(broken bones) and other medicines are not suitable for you, you can use Trivina to prevent osteoporosis after\u00a0menopause.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Trivina<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Medical background and regular check-ups<\/h2>\n\n\n\n<p>The use of&nbsp;HRT&nbsp;entails risks that must be taken into account when deciding to start treatment or continue an ongoing treatment.<\/p>\n\n\n\n<p>Experience is limited for the treatment of women whose menstruation has stopped prematurely (when the ovaries have stopped working or the uterus has been surgically removed).&nbsp;If you belong to that group, the risks of&nbsp;HRT&nbsp;may be different.&nbsp;Talk to your doctor.<\/p>\n\n\n\n<p>Before starting treatment (or resuming treatment), your doctor will ask about your own, and your family&#8217;s, medical background.\u00a0The doctor may perform a general medical and gynecological examination, which also includes an examination of the breasts.\u00a0Once you have started treatment, you must go for regular medical check-ups, at least once a year.\u00a0During these checks, you must discuss with the doctor the benefits and risks of continued treatment.<\/p>\n\n\n\n<p>Do regular breast examinations as recommended by your doctor.<\/p>\n\n\n\n<p><strong>Do not take Trivina:<\/strong><\/p>\n\n\n\n<p>Do not take Trivina if any of the following apply to you.&nbsp;<strong>Talk to your doctor<\/strong>&nbsp;before taking Trivina if you are not sure:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have or have had\u00a0<strong>breast cancer<\/strong>\u00a0or there is a suspicion that you may have it<\/li><li>If you have or have had\u00a0<strong>estrogen-dependent<\/strong> cancer, such as cancer of the lining of the womb (endometrium), or if such cancer is suspected.<\/li><li>If you have\u00a0unexpected abdominal bleeding\u00a0that has not been investigated by a doctor.<\/li><li>If you have\u00a0endometrial hyperplasia\u00a0(severe thickening of the lining of the uterus) and are not being treated for it.<\/li><li>If you have or have had\u00a0blood clots in a vein\u00a0(venous\u00a0thromboembolism\u00a0), in the legs (deep\u00a0vein thrombosis\u00a0), or the lungs (\u00a0pulmonary embolism\u00a0).<\/li><li>If you have a\u00a0coagulation disorder, a condition with an increased risk of blood clots (lack of\u00a0protein\u00a0C,\u00a0protein\u00a0S, or antithrombin).<\/li><li>If you have or have recently had a disease caused by blood clots in the\u00a0arteries, such as a\u00a0heart attack,\u00a0stroke,\u00a0or\u00a0angina pectoris.<\/li><li>If you have or have had any\u00a0liver disease\u00a0and still have abnormal liver values.<\/li><li>If you have\u00a0porphyria, a rare inherited blood disorder.<\/li><li>If you are\u00a0<strong>allergic<\/strong>\u00a0to estradiol valerate or medroxyprogesterone acetate or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If any of the above affects you the first time you use Trivina, stop taking Trivina and contact your doctor immediately.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor if you have or have had any of the following problems before starting treatment.&nbsp;They may recur or worsen during treatment with Trivina.&nbsp;Should this occur, you should have more frequent check-ups with a doctor.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have any disease affecting the endometrium, as well as muscle knots (\u00a0myoma\u00a0),\u00a0endometriosis,\u00a0or have had\u00a0endometrial hyperplasia\u00a0(severe thickening of the endometrium)<\/li><li>If you have an increased risk of blood clots (see below &#8220;Blood clots in a vein (\u00a0thrombosis\u00a0)&#8221;)<\/li><li>If a close relative has had breast cancer or another estrogen-dependent cancer<\/li><li>High\u00a0blood pressure<\/li><li>Liver disease, e.g. liver adenoma (benign\u00a0tumor\u00a0)<\/li><li>Diabetes<\/li><li>Gallstone disease<\/li><li>If you get a\u00a0migraine\u00a0or severe headache<\/li><li>If you have systemic lupus erythematosus (\u00a0SLE\u00a0) &#8211; an\u00a0autoimmune\u00a0disease that attacks many organs in the body<\/li><li>Epilepsy<\/li><li>Asthma<\/li><li>Otosclerosis (ossification of the middle ear leading to hearing loss<\/li><li>Hypertriglyceridemia\u00a0(elevated level of blood fats)<\/li><li>Fluid retention due to heart or kidney disease<\/li><li>Hereditary and acquired\u00a0angioedema.<\/li><\/ul>\n\n\n\n<p><strong>You should immediately contact a doctor and stop the treatment if any of the following occurs<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Any of the things mentioned in the section &#8216;Do not take Trivia<\/li><li>If the skin or whites of the eyes turn yellow (jaundice);\u00a0it could be symptoms of liver disease<\/li><li>If you develop symptoms suggestive of\u00a0angioedema, such as swelling of the face, tongue, and\/or throat and\/or difficulty swallowing or\u00a0hives\u00a0along with difficulty breathing<\/li><li>If your\u00a0blood pressure\u00a0rises sharply (symptoms may include headache, tiredness, or dizziness)<\/li><li>If you get a migraine-like headache for the first time<\/li><li>If you become pregnant<\/li><li>If you get symptoms of a blood clot, such as:<ul><li>painful swelling and redness of the legs<\/li><li>sudden chest pain<\/li><li>breathing difficulties further information, see below &#8220;Blood clots in a vein (\u00a0thrombosis\u00a0)&#8221;<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Please note:<\/strong>&nbsp;Trivina is not a contraceptive.&nbsp;If it has been less than 12 months since your last period, or if you are under 50, you may still need to use contraception to avoid pregnancy.&nbsp;Consult your doctor.<\/p>\n\n\n\n<p><strong>HRT&nbsp;and cancer<\/strong><\/p>\n\n\n\n<p><strong>Strong thickening of the lining of the uterus (&nbsp;endometrial hyperplasia&nbsp;) and cancer of the lining of the uterus (endometrial cancer)<\/strong><\/p>\n\n\n\n<p>The use of\u00a0estrogen-only\u00a0HRT\u00a0increases the risk of severe thickening of the endometrium and cancer of the endometrium.\u00a0The progestin\u00a0in Trivina protects you against this extra risk.<\/p>\n\n\n\n<p><strong>Unexpected bleeding<\/strong><\/p>\n\n\n\n<p>You will have a bleed every three months (so-called withdrawal bleed) when you take Trivina.&nbsp;But if you have unexpected bleeding or spotting in addition to your period, and these:<\/p>\n\n\n\n<p>&#8211; lasts longer than 6 months<\/p>\n\n\n\n<p>&#8211; starts after you have taken Trivina for 6 months<\/p>\n\n\n\n<p>&#8211; continues after you stop taking Trivina<\/p>\n\n\n\n<p><strong>you should see a doctor as soon as possible.<\/strong><\/p>\n\n\n\n<p><strong>Breast cancer<\/strong><\/p>\n\n\n\n<p>Data indicate that treatment with combined\u00a0estrogen\u00a0&#8211;\u00a0progestagen, and possibly also with\u00a0estrogen\u00a0alone, increases the risk of breast cancer.\u00a0The risk depends on the treatment time.\u00a0The extra risk depends on how long you take\u00a0HRT.\u00a0The increased risk is seen within a few years but returns to normal within a few years (maximum 5 years) after treatment stops.<\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>For women aged 50-79 who do not take\u00a0HRT, an average of 9-17 out of 1,000 will be diagnosed with breast cancer over 5 years.\u00a0For women aged 50-79 taking\u00a0estrogen-progestogen\u00a0HRT\u00a0for 5 years, 13-23 out of 1,000 users will be diagnosed (ie 4-6 extra cases).<\/p>\n\n\n\n<p><strong>Check your breasts regularly.&nbsp;Contact a doctor if you notice changes such as<\/strong>&nbsp;:<\/p>\n\n\n\n<p>&#8211; indentations or pits<\/p>\n\n\n\n<p>&#8211; nipple changes<\/p>\n\n\n\n<p>&#8211; nodules you can see or feel<\/p>\n\n\n\n<p>It is also recommended that you participate in mammography screening when you are called to do so.\u00a0During the mammogram, you must tell the nurse\/healthcare staff doing the examination that you are using\u00a0HRT, as this medicine can increase the density of the breasts.\u00a0An increase in the density of the breasts can make it more difficult to detect lumps on mammogram images.<\/p>\n\n\n\n<p><strong>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/strong><\/p>\n\n\n\n<p>Ovarian cancer is rare &#8211; much rarer than breast cancer.\u00a0The use of\u00a0estrogen-only\u00a0or combined\u00a0estrogen-progestogen HRT\u00a0has\u00a0been associated with a slightly increased risk of ovarian cancer.\u00a0The risk of ovarian cancer varies with age.\u00a0For example, the diagnosis of ovarian cancer will be given to around 2 women out of 2,000 aged 50 to 54 who do not take\u00a0HRT\u00a0for 5 years.\u00a0For women who have been taking\u00a0HRT\u00a0for 5 years, there will be about 3 cases per 2,000 users (ie about 1 extra case).<br><br><\/p>\n\n\n\n<p><strong>How&nbsp;HRT&nbsp;affects the heart and blood circulation<\/strong><\/p>\n\n\n\n<p><strong>Blood clots in a vein (&nbsp;thrombosis&nbsp;)<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;<strong>blood clots in vein<\/strong>&nbsp;a is 1.3\u20133 times higher for women who take&nbsp;HRT&nbsp;than for those who do not, especially during the first year of treatment.<\/p>\n\n\n\n<p>Blood clots can be serious.&nbsp;If a blood clot ends up in the lungs, it can cause chest pain, shortness of breath, collapse or even lead to death.<\/p>\n\n\n\n<p>You are more likely to get a blood clot in a vein if any of the following apply to you.&nbsp;Tell your doctor if any of the following apply to you:<\/p>\n\n\n\n<p>&#8211; You have not been able to walk or stand for an extended period due to a major operation, injury or illness (see also section 3, &#8220;If you need surgery&#8221;)<\/p>\n\n\n\n<p>&#8211; You are severely overweight (&nbsp;BMI&nbsp;over 30 kg\/m&nbsp;<sup>2<\/sup>&nbsp;)<\/p>\n\n\n\n<p>&#8211; You have a coagulation disorder that requires long-term treatment with drugs that prevent blood clots<\/p>\n\n\n\n<p>&#8211; If a close relative has had a blood clot in a leg, lung, or another organ<\/p>\n\n\n\n<p>&#8211; You have&nbsp;SLE&nbsp;(systemic lupus erythematosus)<\/p>\n\n\n\n<p>&#8211; You have cancer<\/p>\n\n\n\n<p>The symptoms of blood clots are described in the section &#8220;You should immediately contact a doctor and stop the treatment&#8221;.<\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>For women in their 50s who do not take\u00a0HRT, over 5 years an average of 47 out of 1,000 are expected to have a blood clot in a vein.\u00a0For women in their 50s who have been taking\u00a0estrogen-progestin\u00a0HRT\u00a0for\u00a0more than 5 years, 9-12 out of 1,000 users are expected to develop a blood clot in a vein (ie 5 extra cases).<\/p>\n\n\n\n<p><strong>Heart disease (heart attack)<\/strong><\/p>\n\n\n\n<p>There is no evidence that&nbsp;HRT&nbsp;prevents heart attacks.<\/p>\n\n\n\n<p>For women over 60 who take\u00a0HRT\u00a0with\u00a0estrogen-progestogen, the risk of developing heart disease is slightly higher than for those who do not take\u00a0HRT.<\/p>\n\n\n\n<p><strong>Stroke&nbsp;_<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;stroke&nbsp;is approximately 1.5 times higher for those who take&nbsp;HRT&nbsp;compared to those who do not.&nbsp;The risk of&nbsp;stroke&nbsp;is age dependent, therefore the number of cases of&nbsp;stroke&nbsp;due to the use of&nbsp;HRT increases&nbsp;with increasing age.<\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>For women in their 50s, who do not take\u00a0HRT, over 5 years, an average of 8 out of 1,000 are expected to have a\u00a0stroke.<\/p>\n\n\n\n<p>For women in their 50s who have taken&nbsp;HRT&nbsp;for more than 5 years, 11 out of 1,000 users are expected to have a&nbsp;stroke&nbsp;(ie 3 extra cases)\u00b6<\/p>\n\n\n\n<p><strong>Other conditions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>HRT&nbsp;use&nbsp;does not prevent memory loss.&nbsp;The risk of memory loss may be slightly higher in women who start using&nbsp;HRT&nbsp;after the age of 65.&nbsp;Consult your doctor.<\/li><li>Estrogen treatment can cause fluid to accumulate in the body (&nbsp;edema&nbsp;), especially in women who suffer from impaired heart or kidney function.<\/li><li>The results of some laboratory tests (eg tests that measure thyroid function and liver function) may be affected by Trivina treatment.<\/li><li>Estrogen treatment can cause an increase in blood fat values \u200b\u200b(&nbsp;triglycerides&nbsp;), which in women with elevated levels of blood fats can lead to the risk of&nbsp;inflammation&nbsp;of the pancreas (&nbsp;pancreatitis&nbsp;).<\/li><li>Women prone to skin discoloration (chloasma) should minimize exposure to sunlight or ultraviolet light during treatment with Trivina.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Trivina<\/h2>\n\n\n\n<p>Some medicines can affect the effect of Trivina, which can lead to irregular bleeding.&nbsp;This applies to the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines for\u00a0<strong>epilepsy<\/strong>\u00a0(eg phenobarbital,\u00a0phenytoin,\u00a0and carbamazepine)<\/li><li>Medicines for\u00a0tuberculosis\u00a0(e.g. rifampicin, rifabutin)<\/li><li>Medicines for\u00a0HIV\u00a0infection\u00a0\u00a0(eg nevirapine, efavirenz, ritonavir and nelfinavir)<\/li><li>Natural remedies containing\u00a0St. John&#8217;s wort\u00a0(Hypericum perforatum)<\/li><li>Medicines against\u00a0hepatitis\u00a0C\u00a0virus\u00a0(\u00a0HCV\u00a0) (e.g. combination treatment ombitasvir\/paritaprevir\/ritonavir with or without dasabuvir as well as treatment with glecaprevir\/pibrentasvir) can cause increased liver values \u200b\u200bwhich can be seen in blood tests (increase in\u00a0ALT\u00a0liver enzyme) in women using combined hormonal contraceptives containing ethinylestradiol.\u00a0Trivina contains estradiol instead of ethinylestradiol.\u00a0It is not known whether an increase in\u00a0ALT\u00a0liver enzyme may occur when Trivina is used concurrently with this combination of anti-\u00a0HCV therapy.\u00a0Your doctor will advise you.<\/li><\/ul>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p><strong>Results from blood test analyses<\/strong><\/p>\n\n\n\n<p>If you need to have a blood test, you must tell the doctor, or whoever is taking the blood test, that you are taking Trivina as it may affect the results of some tests.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Trivina is intended for women whose menstruation has stopped.&nbsp;If you should become pregnant, stop taking Trivina and consult a doctor.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Trivina is not expected to affect the ability to drive or use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Trivina contains lactose<\/h2>\n\n\n\n<p>This medicine contains 82 mg (white tablet), 143 mg (blue tablet), and 82 mg (yellow tablet) of\u00a0lactose\u00a0(in the form of monohydrate).\u00a0If you have an intolerance to certain sugars, you should consult your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Trivina<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>Each pack contains three blister cards numbered 1\u20113.\u00a0One tablet is taken daily without a break, preferably at the same time every day.\u00a0First, take the white, then the blue, and finally the yellow tablets.\u00a0Then continue without a break on the next Trivina pack.\u00a0On blister card number 3 there are mini bubbles to mark the first day of treatment.\u00a0If you choose to start on a Monday, a hole is dotted over Monday.\u00a0You will have a bleed every 3 months (so-called withdrawal bleed) while taking Trivina.<\/p>\n\n\n\n<p>If you change from a hormone treatment that causes bleeding once a month, you must start the treatment with Trivina the day after you stop the previous medicine.<\/p>\n\n\n\n<p>The doctor aims for you to take the lowest&nbsp;dose&nbsp;that gives you symptom relief and for you to use Trivina for the shortest possible time.&nbsp;Talk to your doctor if you do not get any relief from your symptoms, or feel that&nbsp;dose&nbsp;one would be too high.<\/p>\n\n\n\n<p><em>Bleeding pattern<\/em><\/p>\n\n\n\n<p>During the first months of treatment, breakthroughs or small bleeding may occur.\u00a0If bleeding persists, contact the doctor for a re-evaluation of the treatment.\u00a0Continuous or prolonged bleeding during a hormone treatment may in rare cases indicate\u00a0endometrial hyperplasia\u00a0or that the\u00a0dosage\u00a0is not right for you.\u00a0If breakthrough or light bleeding only occurs later in the treatment or if it persists after the end of the treatment, contact the doctor.<\/p>\n\n\n\n<p><strong>If you need surgery<\/strong><\/p>\n\n\n\n<p>If you are going to have surgery, you must inform the operating doctor that you are taking Trivina.&nbsp;You may need to stop taking Trivina for 4 to 6 weeks before surgery to avoid the risk of blood clots (see section 2, \u201cBlood clots in a vein (&nbsp;thrombosis&nbsp;)\u201d).&nbsp;Ask the doctor when it is appropriate to start taking Trivina again.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Trivina<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has ingested the medicine by mistake, contact a doctor or\u00a0pharmacist\u00a0for an assessment of the risk and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Trivina<\/h2>\n\n\n\n<p>If you forget to take a tablet at the regular time, skip the tablet and take the next tablet at the next regular time.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0The following diseases are more common in women who take\u00a0HRT\u00a0than those who do not:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Breast cancer<\/li><li>Severe thickening of the lining of the uterus (&nbsp;endometrial hyperplasia&nbsp;) or cancer of the lining of the uterus (endometrial cancer)<\/li><li>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/li><li>Blood clots in veins in legs or lungs (venous&nbsp;thromboembolism&nbsp;)<\/li><li>Heart disease<\/li><li>Stroke&nbsp;_<\/li><li>Probable memory loss, if treatment with&nbsp;HRT&nbsp;is started after the age of 65<\/li><\/ul>\n\n\n\n<p>See section 2 for more information about these\u00a0side effects.<\/p>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>The most common\u00a0side effects\u00a0usually decrease with continued treatment.\u00a0With Trivina treatment, breakthrough bleeding and painful withdrawal bleeding are more frequent in the first 2 years after\u00a0menopause.<\/p>\n\n\n\n<p>Other\u00a0<em>common\u00a0side effects\u00a0are (\u00a0<\/em><em>may affect up to 1 in 10 users\u00a0<\/em><em>):<\/em>\u00a0Chest tightness\/pain.\u00a0Headache, dizziness.\u00a0Nervousness, low mood, lethargy.\u00a0Hot flashes.\u00a0Abdominal cramps, nausea, vomiting, flatulence.\u00a0Irregular bleeding from the abdomen, breakthrough bleeding, spotting, discharge, and diseases of the abdomen.\u00a0Weight gain, weight loss, fluid accumulation (edema).\u00a0Increased tendency to sweat.<\/p>\n\n\n\n<p><em>Uncommon&nbsp;side effects&nbsp;(&nbsp;<\/em><em>may affect up to 1 in 100 users&nbsp;<\/em><em>):<\/em><\/p>\n\n\n\n<p>High\u00a0blood pressure, superficial\u00a0inflammation\u00a0in the leg blood vessels, minor bleeding in the skin and mucous membranes.\u00a0Migraine, loss of sensation, tremors.\u00a0Visual impairment, dry eyes.\u00a0Palpitation.\u00a0Benign cancer of the breast or uterus.\u00a0Allergic reaction.\u00a0Increased appetite, and increased levels of\u00a0cholesterol\u00a0in the blood.\u00a0Anxiety, insomnia,\u00a0apathy, emotional instability, difficulty concentrating, change in sexual desire, mood swings,\u00a0euphoria, agitation.\u00a0Shortness of breath (\u00a0dyspnoea\u00a0), runny nose.\u00a0Constipation, digestive problems (\u00a0dyspepsia\u00a0), diarrhea, and diseases of the rectum.\u00a0Acne, hair loss, dry skin, skin nodules, increased hair growth, hives (raised, itchy rash), painful red-purple bumps on the skin (erythema nodosum),\u00a0hives.\u00a0Joint diseases, muscle cramps.\u00a0Urinary urges, increased need to urinate, urinary incontinence, urinary tract infection, discoloration of urine, and blood in the urine.\u00a0Tender and swollen breasts, abnormal growth of the lining of the uterus (\u00a0endometrial hyperplasia\u00a0), and diseases of the uterus.\u00a0Fatigue, abnormal laboratory values, weakness, fever,\u00a0flu-like symptoms, and malaise.<\/p>\n\n\n\n<p><em>Rare&nbsp;side effects&nbsp;(&nbsp;<\/em><em>may affect up to 1 in 1,000 users&nbsp;<\/em><em>):<\/em>&nbsp;Hypersensitivity to contact lenses.&nbsp;Blood clots in the legs or lungs (venous&nbsp;thromboembolism&nbsp;).&nbsp;Altered liver function and bile flow.&nbsp;Rash.&nbsp;Painful periods, premenstrual syndrome.<\/p>\n\n\n\n<p><em>Side effects\u00a0that have been reported (occurring in an unknown number of users):<\/em>\u00a0Enlargement of tissue nodules in the uterus (Uterine fibroids).\u00a0Worsening of symptoms of\u00a0angioedema\u00a0(hereditary and acquired as a severe\u00a0allergic reaction\u00a0with swelling of the tongue, throat, and eyes).\u00a0Lack of oxygen in the brain.\u00a0Stomach pain, flatulence (air in the stomach).\u00a0The liver disease leads to yellowing of the skin.\u00a0Eczema.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been reported for other HRT:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Gallbladder disease<\/li><li>Myocardial infarction<\/li><li>Various skin diseases:<ul><li>dark skin spots, especially on the face and neck, so-called &#8220;pregnancy spots&#8221; (chloasma)<\/li><li>ring-shaped reddened or ulcerated rash (erythema multiforme)<\/li><\/ul><\/li><li>Inflammation&nbsp;of the pancreas (&nbsp;pancreatitis&nbsp;)<\/li><li>Possible dementia after age 65<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How Trivina should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store at a maximum of 25 \u00b0C.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton or blister.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p><strong>Trivina white tablet:<\/strong><\/p>\n\n\n\n<p><em>The active substance is<\/em>\u00a0estradiol valerate 2 mg.<\/p>\n\n\n\n<p><em>Other ingredients are<\/em>\u00a0lactose monohydrate\u00a086.6 mg, corn starch, gelatin, talc, and magnesium stearate.<\/p>\n\n\n\n<p><strong>Trivina blue tablet:<\/strong><\/p>\n\n\n\n<p><em>The active substances are<\/em>\u00a0estradiol valerate 2 mg, and medroxyprogesterone acetate 20 mg (MPA).<\/p>\n\n\n\n<p><em>Other ingredients are<\/em>\u00a0lactose monohydrate\u00a0150 mg, corn starch, indigo carmine (dye E 132), gelatin, and magnesium stearate.<\/p>\n\n\n\n<p><strong>Trivina yellow tablet:<\/strong><\/p>\n\n\n\n<p><em>Other ingredients are<\/em>\u00a0lactose monohydrate\u00a086.5 mg, corn starch, gelatin, yellow iron oxide (dye E 172), and magnesium stearate.<\/p>\n\n\n\n<p><strong>Appearance and package sizes of the medicine<\/strong><\/p>\n\n\n\n<p><em>White tablet:<\/em>\u00a0white or almost white, round, cupped with a score, marked T, \u00d8 7 mm.<\/p>\n\n\n\n<p><em>Blue tablet:<\/em>\u00a0light blue or light blue dotted, round, flat with a score, beveled edge, \u00d8 9 mm.<\/p>\n\n\n\n<p><em>Yellow tablet:<\/em>\u00a0yellow, round, flat with a score, beveled edge, \u00d8 7 mm.<\/p>\n\n\n\n<p><em>Packaging:<\/em>\u00a0Blister cards with 70 white, 14 blue, and 7 yellow tablets, 1 x 91 pieces.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder:<\/em><\/p>\n\n\n\n<p>Orion Corporation<\/p>\n\n\n\n<p>Orion Indie 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p><em>Manufacturer:<\/em><\/p>\n\n\n\n<p>Orion Corporation Orion Pharma<\/p>\n\n\n\n<p>Orion Indie 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Trivina is a preparation used\u00a0for\u00a0hormone\u00a0replacement\u00a0therapy\u00a0(\u00a0HRT\u00a0)\u00a0.\u00a0It contains two female sex hormones;\u00a0an\u00a0estrogen\u00a0and a\u00a0progestin\u00a0.\u00a0Trivina is used in women whose menstruation has stopped (\u00a0menopause\u00a0), at least 6 months after their last natural period.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[5406,5409,22084,26592,26588,26589,21858,5407,22085,26591,22086,26590],"class_list":["post-25757","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-estradiol-valerate","tag-estradiol-valerate-tablet","tag-medroxyprogesterone-acetate","tag-medroxyprogesterone-acetate-tablet","tag-trivina","tag-trivina-tablet","tag-what-estradiol-valerate-is-used-for","tag-what-is-estradiol-valerate","tag-what-is-medroxyprogesterone-acetate","tag-what-is-trivina","tag-what-medroxyprogesterone-acetate-is-used-for","tag-what-trivina-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25757","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25757"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25757\/revisions"}],"predecessor-version":[{"id":25822,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25757\/revisions\/25822"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25757"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25757"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}