{"id":25700,"date":"2022-09-24T12:28:24","date_gmt":"2022-09-24T12:28:24","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25700"},"modified":"2022-09-26T07:28:56","modified_gmt":"2022-09-26T07:28:56","slug":"triumeq","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/triumeq\/","title":{"rendered":"Triumeq &#8211; Dolutegravir\/Abacavir\/Lamivudine uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg\/600 mg\/300 mg&nbsp;film-coated tablets<br>dolutegravir\/abacavir\/lamivudine<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Triumeq is and what it is used for<\/h2>\n\n\n\n<p>Triumeq is a medicine that contains three active substances used to treat&nbsp;HIV&nbsp;infection: abacavir, lamivudine, and <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/dovato\/\">dolutegravir<\/a>.&nbsp;Abacavir and lamivudine belong to a group of antiretroviral medicines called&nbsp;nucleoside analog<em> reverse transcriptase inhibitors<\/em>&nbsp;(NRTIs) and dolutegravir belongs to a group of antiretroviral medicines called&nbsp;<em>integrase inhibitors<\/em>&nbsp;(INIs).<\/p>\n\n\n\n<p>Triumeq is used to treat&nbsp;<strong>HIV&nbsp;<\/strong><strong>infection&nbsp;(&nbsp;HIV&nbsp;=&nbsp;human immunodeficiency virus)<\/strong>&nbsp;in adults and children over the age of 12 who weigh at least 40 kg.<\/p>\n\n\n\n<p>Before your doctor prescribes Triumeq, you will be tested to see if you have a certain type of gene called HLA B*5701.&nbsp;Carriers of the HLA B*5701 gene should not be treated with Triumeq.&nbsp;Patients with this gene are at greater risk of developing a serious&nbsp;hypersensitivity reaction&nbsp;(&nbsp;allergic reaction&nbsp;) if they use Triumeq (see \u201cHypersensitivity reactions\u201d in section 4).<\/p>\n\n\n\n<p>Triumeq does not cure&nbsp;HIV&nbsp;infection,&nbsp;but it reduces the amount of&nbsp;virus&nbsp;in the body and keeps it at a low level.&nbsp;It also increases the number of CD4 cells in the blood.&nbsp;CD4 cells are a type of&nbsp;white blood cell&nbsp;that is important for the body&#8217;s ability to fight&nbsp;infection.<\/p>\n\n\n\n<p>Not everyone reacts to treatment with Triumeq in the same way.&nbsp;Your doctor will check how effective the treatment is for you.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Triumeq<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Triumeq<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<strong>allergic<\/strong>&nbsp;(&nbsp;<em>hypersensitive<\/em>&nbsp;) to dolutegravir, abacavir (or any other medicine containing abacavir) or lamivudine, or to any of the other ingredients of this medicine (listed in section 6). Read all information about&nbsp;hypersensitivity reactions<strong>&nbsp;in Section 4 carefully.<\/strong><\/li><li>if you are taking another medicine called&nbsp;<strong>fampridine<\/strong>&nbsp;(also called dalfampridine; used in&nbsp;multiple sclerosis&nbsp;).<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>If you think any of these apply to you, tell your doctor.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p><strong>IMPORTANT &#8211;&nbsp;Hypersensitivity reaction&nbsp;er<\/strong><\/p>\n\n\n\n<p><strong>Triumeq contains abacavir and dolutegravir.&nbsp;<\/strong>Both of these active substances can cause a serious&nbsp;allergic reaction, a so-called&nbsp;hypersensitivity reaction.&nbsp;You should never take abacavir or medicines containing abacavir again if you have had a hypersensitivity reaction: it can be life-threatening.<\/p>\n\n\n\n<p><strong>You must read all the information under \u201cHypersensitivity reactions\u201d in the text box in section 4 carefully.<\/strong><\/p>\n\n\n\n<p>On the packaging of Triumeq, there is a&nbsp;<strong>Warning<\/strong>&nbsp;card to alert you and the healthcare staff about hypersensitivity.&nbsp;<strong>Detach this card and carry it with you at all times.<\/strong><\/p>\n\n\n\n<p>Some people taking Triumeq or other combination&nbsp;HIV treatments&nbsp;are at greater risk of serious&nbsp;side effects&nbsp;than others.&nbsp;You need to be aware of these additional risks:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have moderate or severe liver disease<\/li><li>if you have previously had&nbsp;<strong>liver disease<\/strong>, including&nbsp;hepatitis&nbsp;B or C (if you have&nbsp;hepatitis&nbsp;B&nbsp;infection, do not stop taking Triumeq without consulting a doctor, as&nbsp;hepatitis&nbsp;A may come back)<\/li><li>if you have kidney problems.<\/li><li><strong>If any of these apply to you, talk to your doctor before taking Triumeq.&nbsp;<\/strong>You may need extra checks, including blood tests, while you are taking the medicine.&nbsp;See section 4 for more information.<\/li><\/ul>\n\n\n\n<p>Hypersensitivity reaction&nbsp;to abacavir<\/p>\n\n\n\n<p>Even patients who do not have the HLA B*5701 gene can develop a&nbsp;<strong>hypersensitivity reaction<\/strong>&nbsp;(a severe&nbsp;allergic reaction&nbsp;).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Read all information about&nbsp;hypersensitivity reactions&nbsp;in section 4 of this leaflet carefully.<\/strong><\/li><\/ul>\n\n\n\n<p>Risk of heart attack<\/p>\n\n\n\n<p>The possibility that abacavir increases the risk of having a heart attack cannot be ruled out.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor<\/strong>&nbsp;if you have heart problems if you smoke, or have other diseases that can increase your risks of heart diseases, such as high&nbsp;blood pressure&nbsp;or&nbsp;diabetes.&nbsp;Do not stop taking Triumeq unless your doctor advises you to do so.<\/li><\/ul>\n\n\n\n<p>Pay attention to important symptoms<\/p>\n\n\n\n<p>Some people who take medicines for&nbsp;HIV infection&nbsp;develop&nbsp;other&nbsp;conditions, which can be serious.&nbsp;These are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>symptoms&nbsp;of&nbsp;infection&nbsp;and&nbsp;inflammation<\/li><li>joint pain, stiffness, and bone problems.<\/li><\/ul>\n\n\n\n<p>You need to know the important signs and symptoms to look out for while taking Triumeq.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Read the information under &#8220;Other possible&nbsp;side effects&nbsp;of combination therapy against HIV&#8221; in section 4 of this leaflet.<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>This medicine must not be given to children under 12 years of age.&nbsp;The use of Triumeq in children under 12 years of age has not yet been studied.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Triumeq<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Do not take Triumeq together with the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fampridine (also called dalfampridine), is used to treat&nbsp;multiple sclerosis.&nbsp;<\/li><\/ul>\n\n\n\n<p>Some medicines can affect how Triumeq works, or increase the risk of&nbsp;side effects.&nbsp;Triumeq can also affect how some other medicines work.<\/p>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if you are taking any medicine&nbsp;<em>in the following list:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/competact\/\">metformin<\/a>, for the treatment of&nbsp;diabetes<\/li><li>so-called&nbsp;antacids&nbsp;(acid neutralizers), medicines for&nbsp;indigestion&nbsp;and&nbsp;heartburn.&nbsp;Do not take antacids&nbsp;for 6 hours before taking Triumeq, or for the next 2 hours after taking Triumeq (see also section 3).<\/li><li>dietary supplements or multivitamins containing&nbsp;calcium, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/diafer\/\">iron<\/a>, or&nbsp;magnesium.&nbsp;If you take Triumeq with food, you can take dietary supplements or multivitamins containing&nbsp;calcium, iron, or&nbsp;magnesium&nbsp;at the same time as Triumeq.&nbsp;If you do not take Triumeq with food, do not take dietary supplements or multivitamins containing&nbsp;calcium, iron, or&nbsp;magnesium&nbsp;within 6 hours before taking Triumeq, or in the next 2 hours after taking Triumeq (see also section 3).<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/biktarvy\/\">emtricitabine<\/a>, etravirine, efavirenz, nevirapine or tipranavir\/ritonavir, for the treatment&nbsp;of&nbsp;HIV&nbsp;infection<\/li><li>medicines (usual liquids) containing sorbitol and other sugar alcohols (such as xylitol, mannitol, lactitol, and maltitol), if taken regularly<\/li><li>other medicines containing lamivudine for the treatment&nbsp;of&nbsp;HIV&nbsp;infection&nbsp;or&nbsp;hepatitis&nbsp;B&nbsp;infection<\/li><li>cladribine used to treat&nbsp;hairy cell leukemia<\/li><li>rifampicin, to treat&nbsp;tuberculosis&nbsp;(TB) and other&nbsp;bacterial infections<\/li><li>trimethoprim\/sulfamethoxazole, an&nbsp;antibiotic&nbsp;used to treat&nbsp;bacterial infections<\/li><li>phenytoin&nbsp;and phenobarbital, for the treatment of&nbsp;epilepsy<\/li><li>oxcarbazepine and carbamazepine, for the treatment of&nbsp;epilepsy&nbsp;and&nbsp;bipolar disorder<\/li><li>St. John&#8217;s wort&nbsp;(&nbsp;Hypericum perforatum&nbsp;), is a herbal remedy for&nbsp;mild depression&nbsp;and&nbsp;mild anxiety.<\/li><li>methadone, used as a&nbsp;heroin substitute.&nbsp;Abacavir increases the rate at which&nbsp;methadone&nbsp;is eliminated from the body.&nbsp;If you are taking&nbsp;methadone, you will be monitored for withdrawal symptoms.&nbsp;The methadone dose may need to be changed.<\/li><li>riociguat, to treat&nbsp;<strong>high&nbsp;blood pressure&nbsp;in the blood vessels<\/strong>&nbsp;(pulmonary arteries) that carry blood from the heart to the lungs.&nbsp;Your doctor may need to lower your riociguat&nbsp;dose&nbsp;because abacavir can increase riociguat blood levels.<\/li><li><strong>Tell your doctor or pharmacist<\/strong>&nbsp;if you are taking any of these medicines.&nbsp;The doctor may decide that the&nbsp;dose&nbsp;needs to be changed or that you need to go for more checks.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor<\/strong>&nbsp;about the risks and benefits of taking Triumeq.<\/li><\/ul>\n\n\n\n<p>Taking Triumeq at the time of conception or during the first six weeks of pregnancy may increase the risk of a type of malformation called a neural tube defect, e.g.&nbsp;spina bifida (deformed spinal cord).<\/p>\n\n\n\n<p>If you could become pregnant while receiving Triumeq:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor<\/strong>&nbsp;and discuss whether you need to use contraception, for example, condoms or&nbsp;birth control pills.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you become pregnant or plan to become pregnant.&nbsp;Your doctor will review your treatment.&nbsp;Do not stop taking Triumeq without talking to your doctor as this may harm you and your unborn baby.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Breast-feeding<\/h2>\n\n\n\n<p>Breastfeeding&nbsp;<strong>is not recommended<\/strong>&nbsp;for women living with&nbsp;HIV&nbsp;because&nbsp;HIV&nbsp;infection&nbsp;can be transmitted to&nbsp;the baby through breast milk.<\/p>\n\n\n\n<p>A small amount of the ingredients in Triumeq can also pass into breast milk<\/p>\n\n\n\n<p>If you are breastfeeding or thinking about starting to breastfeed,&nbsp;<strong>discuss this with your doctor as soon as possible.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p><strong>Triumeq can make you dizzy<\/strong>&nbsp;and have other&nbsp;side effects&nbsp;that reduce your attention.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Do not drive or operate machinery<\/strong>&nbsp;unless you are sure that your attention has not been affected.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Important information about the contents of Triumeq tablets<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Triumeq<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>The usual&nbsp;dose&nbsp;is one tablet once daily.<\/strong><\/li><\/ul>\n\n\n\n<p>Swallow the tablet with some liquid.&nbsp;Triumeq can be taken with or without food.<\/p>\n\n\n\n<p><strong>Do not take antacids<\/strong>&nbsp;within 6 hours before taking Triumeq, or in the next 2 hours after taking Triumeq.&nbsp;Other antacids such as ranitidine and omeprazole can be taken at the same time as Triumeq.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Talk to your doctor for more information about antacids with Triumeq.<\/li><\/ul>\n\n\n\n<p><strong>If you take Triumeq with food, you can take dietary supplements or multivitamins containing&nbsp;calcium<\/strong>, iron, or&nbsp;magnesium&nbsp;at the same time as Triumeq.&nbsp;If you do not take Triumeq with food, do not take dietary supplements or multivitamins containing&nbsp;calcium, iron, or&nbsp;magnesium&nbsp;within 6 hours before taking Triumeq, or in the next 2 hours after taking Triumeq.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Talk to your doctor for more advice about taking supplements or multivitamins containing&nbsp;calcium, iron, or&nbsp;magnesium&nbsp;with Triumeq.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Children and young people between the ages of 12 and 17 who weigh at least 40 kg can take the adult dose, i.e.&nbsp;one tablet once daily.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Triumeq<\/h2>\n\n\n\n<p>If you take too many Triumeq tablets,&nbsp;<strong>contact your doctor or pharmacist for advice.&nbsp;<\/strong>If possible, show them the Triumeq packaging.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Triumeq<\/h2>\n\n\n\n<p>If you have forgotten a&nbsp;dose, take it as soon as you remember.&nbsp;If it is time for the next&nbsp;dose&nbsp;within 4 hours, however, you should skip the&nbsp;dose&nbsp;you missed and take the next&nbsp;dose&nbsp;at the usual time.&nbsp;Then continue with your treatment as before.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Do not take a double&nbsp;dose<\/strong>&nbsp;to make up for a missed&nbsp;dose.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have stopped taking Triumeq<\/h2>\n\n\n\n<p>If you have stopped taking Triumeq for any reason \u2013 especially if the reason is that you think you have a&nbsp;side effect&nbsp;or because you have another illness:<\/p>\n\n\n\n<p><strong>Talk to your doctor before you start taking the medicine again.&nbsp;<\/strong>The doctor will investigate whether your symptoms were due to a&nbsp;hypersensitivity reaction.&nbsp;If the doctor thinks there is a connection between your symptoms and a&nbsp;hypersensitivity reaction,&nbsp;you will be told not to take Triumeq or any other medicine containing abacavir or dolutegravir ever again.&nbsp;You must follow this advice.<\/p>\n\n\n\n<p>If your doctor advises you to start taking Triumeq again, you may be told to take the first&nbsp;doses&nbsp;in a place where you have immediate access to medical care if needed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>During&nbsp;HIV&nbsp;treatment, weight gain and increased levels of&nbsp;lipids&nbsp;and&nbsp;glucose&nbsp;in the blood may occur.&nbsp;This is partly related to restored health and lifestyle, but in the case of blood lipids, there can sometimes be a connection with HIV&nbsp;drugs.&nbsp;The doctor will perform tests to find such changes.<\/p>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>When you are being treated for&nbsp;HIV, it can be difficult to determine whether a symptom is a&nbsp;side effect&nbsp;of Triumeq or other medicines you are taking, or whether it is due to the&nbsp;HIV&nbsp;infection&nbsp;itself.&nbsp;Therefore, you must talk<strong> to your doctor if your health changes in any way.<\/strong><\/p>\n\n\n\n<p>Abacavir can cause a&nbsp;hypersensitivity reaction&nbsp;(a severe&nbsp;allergic reaction&nbsp;), especially in people who have a particular type of gene called HLA-B*5701.&nbsp;Even patients who do not have the HLA\u2011B*5701 gene can develop a&nbsp;<strong>hypersensitivity reaction<\/strong>&nbsp;as described in this leaflet under the heading &#8220;Hypersensitivity reactions&#8221;.&nbsp;You must read<strong> and understand the information about this serious reaction.<\/strong><\/p>\n\n\n\n<p><strong>In addition to the&nbsp;side effects&nbsp;mentioned below for Triumeq<\/strong>, other conditions may develop during combination anti-HIV&nbsp;therapy.<\/p>\n\n\n\n<p>You must read the information in this section under &#8220;Other possible&nbsp;side effects&nbsp;during combination treatment against HIV&#8221;.<\/p>\n\n\n\n<p><strong>Hypersensitivity&nbsp;reaction<\/strong><\/p>\n\n\n\n<p>Triumeq contains abacavir and dolutegravir.&nbsp;Both of these active substances can cause a serious&nbsp;allergic reaction, a so-called&nbsp;hypersensitivity reaction.<\/p>\n\n\n\n<p>Such&nbsp;hypersensitivity reactions&nbsp;are more common in people taking medicines containing abacavir.<\/p>\n\n\n\n<p><strong>Who gets these reactions?<\/strong><\/p>\n\n\n\n<p>Anyone taking Triumeq can develop a&nbsp;hypersensitivity reaction, which can be life-threatening if they continue to take Triumeq.<\/p>\n\n\n\n<p>You are more likely to develop this reaction if you have a gene called HLA B*5701 (but you can react even if you do not have this gene).&nbsp;You should have been tested for this gene before being prescribed Triumeq.&nbsp;If you know you have this gene, tell your doctor.<\/p>\n\n\n\n<p><strong>What are the symptoms?<\/strong><\/p>\n\n\n\n<p>The most common symptoms are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>fever<\/strong>&nbsp;(high body temperature) and&nbsp;<strong>skin rash<\/strong>.<\/li><\/ul>\n\n\n\n<p>Other common symptoms are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea, vomiting, diarrhea, abdominal (stomach) pains, and pronounced fatigue.<\/li><\/ul>\n\n\n\n<p>Other symptoms are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>joint or muscle pain, swollen throat, shortness of breath, sore throat, cough, temporary headache,&nbsp;inflammation&nbsp;of the eye (&nbsp;conjunctivitis&nbsp;), mouth sores, low&nbsp;blood pressure, tingling, and numbness in the hands and feet.<\/li><\/ul>\n\n\n\n<p><strong>When do these reactions occur?<\/strong><\/p>\n\n\n\n<p>Hypersensitivity reactions&nbsp;can occur at any time during treatment with Triumeq but are more likely during the first 6 weeks of treatment.<\/p>\n\n\n\n<p><strong>Contact your doctor immediately:<\/strong><\/p>\n\n\n\n<p><strong>1. if you get a rash OR<\/strong><\/p>\n\n\n\n<p><strong>2. if you get symptoms from at least 2 of the following groups:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>fever<\/strong><\/li><li><strong>shortness of breath, sore throat, or cough<\/strong><\/li><li><strong>nausea or vomiting, diarrhea or abdominal pain<\/strong><\/li><li><strong>pronounced fatigue or aches and pains or general malaise.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Your doctor may advise you to stop taking Triumeq.<\/strong><\/p>\n\n\n\n<p><strong>If you have stopped taking Triumeq<\/strong><\/p>\n\n\n\n<p>If you have stopped taking Triumeq because of a&nbsp;hypersensitivity reaction,&nbsp;you must NEVER AGAIN take Triumeq, or any other medicine containing abacavir.&nbsp;If you do, you can develop dangerously low blood pressure&nbsp;within hours, which can lead to death.&nbsp;You should also never take any medicine that contains dolutegravir.<\/p>\n\n\n\n<p>If you have stopped taking Triumeq for any reason \u2013 especially if the reason is that you think you have a&nbsp;side effect&nbsp;or because of another illness:<\/p>\n\n\n\n<p><strong>Talk to your doctor before you start taking the medicine again<\/strong>.&nbsp;The doctor will investigate whether your symptoms were due to a&nbsp;hypersensitivity reaction.&nbsp;If the doctor thinks there is a connection,&nbsp;you will be told not to take Triumeq or any other medicine containing abacavir ever again.&nbsp;You may also be told not to take any other medicine containing dolutegravir ever again.&nbsp;You must follow this advice.<\/p>\n\n\n\n<p>Occasionally,&nbsp;hypersensitivity reactions&nbsp;have developed in people who restarted an abacavir-containing medicine but had only one of the symptoms on the Warning Card before they stopped taking it.<\/p>\n\n\n\n<p>In very rare cases, patients who previously took medicines containing abacavir and who had no symptoms of hypersensitivity have developed a&nbsp;hypersensitivity reaction&nbsp;when they start taking these medicines again.<\/p>\n\n\n\n<p>If your doctor advises you to start taking Triumeq again, you may be told to take the first&nbsp;doses&nbsp;in a place where you have immediate access to medical care if needed.<\/p>\n\n\n\n<p>If you are allergic to Triumeq, you should return any remaining Triumeq tablets for safe disposal.&nbsp;Consult a doctor or pharmacist.<\/p>\n\n\n\n<p>On the packaging of Triumeq, there is a&nbsp;<strong>Warning<\/strong>&nbsp;card to alert you and the healthcare staff about hypersensitivity.&nbsp;<strong>Detach this card and carry it with you at all times.<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>more than 1 in 10 people<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>diarrhea<\/li><li>nausea<\/li><li>sleep difficulties (&nbsp;<em>insomnia<\/em>&nbsp;)<\/li><li>lack of energy (&nbsp;<em>powerlessness<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>up to 1 in 10 people<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hypersensitivity reaction&nbsp;(&nbsp;<em>see \u201cHypersensitivity reactions\u201d earlier in this section<\/em>&nbsp;)<\/li><li>loss of appetite<\/li><li>rash<\/li><li>itching&nbsp;(&nbsp;<em>pruritus<\/em>&nbsp;)<\/li><li>vomiting<\/li><li>stomach pain<\/li><li>stomach upset<\/li><li>indigestion<\/li><li>flatulence (&nbsp;<em>flatulence<\/em>&nbsp;)<\/li><li>dizziness<\/li><li>abnormal dreams<\/li><li>nightmares<\/li><li>depression&nbsp;<em>(feelings of deep sadness and worthlessness)<\/em><\/li><li>concern<\/li><li>fatigue<\/li><li>drowsiness<\/li><li>fever (&nbsp;<em>high body temperature<\/em>&nbsp;)<\/li><li>cough<\/li><li>irritated or runny nose<\/li><li>hair loss<\/li><li>pain and discomfort in muscles<\/li><li>joint pain<\/li><li>feeling of weakness<\/li><li>general malaise.<\/li><\/ul>\n\n\n\n<p>Common&nbsp;side effects&nbsp;that can show up in blood tests are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>elevated liver enzyme levels.<\/li><\/ul>\n\n\n\n<p><strong>Less common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>up to 1 in 100 people<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation&nbsp;of the liver (&nbsp;<em>hepatitis<\/em>&nbsp;)<\/li><li>suicidal thoughts and behavior (especially in patients who previously had depression or mental problems)<\/li><li>panic attack.<\/li><\/ul>\n\n\n\n<p>Less common&nbsp;side effects&nbsp;that can show up in blood tests are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>reduced number of cells that participate in blood&nbsp;coagulation&nbsp;(&nbsp;<em>thrombocytopenia<\/em>&nbsp;)<\/li><li>the low number of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;) or a low number of&nbsp;white blood cells&nbsp;(&nbsp;<em>neutropenia<\/em>&nbsp;)<\/li><li>increased level of sugar (&nbsp;glucose&nbsp;) in the blood<\/li><li>increased levels of&nbsp;triglycerides&nbsp;(type of fat) in the blood.<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These may occur in up to&nbsp;<strong>1 in 1,000 people<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation&nbsp;of the pancreas (&nbsp;<em>pancreatitis<\/em>&nbsp;)<\/li><li>breakdown of muscle tissue<\/li><li>liver failure (signs of this may be yellowing of the skin and whites of the eyes, or unusually dark urine)<\/li><li>suicide (especially in patients who previously had depression or mental problems).<\/li><\/ul>\n\n\n\n<p><strong>\u2192 Talk to your doctor immediately<\/strong>&nbsp;if you experience mental health problems (see also other mental health problems above).<\/p>\n\n\n\n<p>Rare&nbsp;side effects&nbsp;that can show up in blood tests are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased levels of&nbsp;bilirubin&nbsp;(a test of liver function) in your blood<\/li><li>elevated levels of an&nbsp;enzyme&nbsp;called&nbsp;<em>amylase<\/em>.<\/li><\/ul>\n\n\n\n<p><strong>Very rare&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p>These may occur in up to&nbsp;<strong>1 in 10,000 people<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>numbness and tingling in the skin<\/li><li>the feeling of weakness in arms and legs<\/li><li>skin rash, which may blister and look like small targets (dark spot in the center of a lighter area surrounded by a dark ring) (&nbsp;erythema multiforme&nbsp;)<\/li><li>a widespread skin rash with blisters and scaly skin, especially around the mouth, nose, eyes, and genitals (&nbsp;Stevens-Johnson syndrome&nbsp;), and a more severe form that causes skin peeling on more than 30% of the body surface (&nbsp;<em>toxic epidermal necrolysis<\/em>&nbsp;)<\/li><li>lactic acidosis (excess&nbsp;lactic acid&nbsp;in the blood)<\/li><\/ul>\n\n\n\n<p>Very rare&nbsp;side effects&nbsp;that can show up in blood tests are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the inability of the&nbsp;bone marrow&nbsp;to form new&nbsp;red blood cells&nbsp;(&nbsp;<em>pure erythrocyte aplasia<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<p>If you get a&nbsp;side effect&nbsp;ar<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor.&nbsp;<\/strong>This also applies to&nbsp;side effects&nbsp;that are not mentioned in this information.<\/li><\/ul>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;are with combination treatment against&nbsp;HIV<\/strong><\/p>\n\n\n\n<p>Combination therapy such as Triumeq can cause other conditions to develop during&nbsp;HIV&nbsp;treatment.<\/p>\n\n\n\n<p><strong>Symptoms&nbsp;of&nbsp;infection&nbsp;and&nbsp;inflammation<\/strong><\/p>\n\n\n\n<p>People with advanced&nbsp;HIV&nbsp;infection&nbsp;(&nbsp;AIDS ) have a weak immune system and the risk&nbsp;<em>is<\/em>&nbsp;greater that they will get serious&nbsp;infections&nbsp;(&nbsp;<em>opportunistic&nbsp;<\/em>infections&nbsp;<em>)<\/em>.&nbsp;Such&nbsp;infections&nbsp;may have been &#8220;silent&#8221; and not detected by the weak immune system before treatment began.&nbsp;Once treatment has started, the immune system becomes stronger and can fight&nbsp;infections, which can cause symptoms of infection or inflammation.&nbsp;Symptoms usually include <strong>fever<\/strong>&nbsp;and any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>gripe<\/li><li>breathing difficulties.<\/li><\/ul>\n\n\n\n<p>In rare cases, when the immune system becomes stronger, it can also attack healthy body tissue (&nbsp;<em>autoimmune diseases<\/em>&nbsp;).&nbsp;The symptoms of autoimmune diseases can develop several months after you start taking medicines for&nbsp;your&nbsp;HIV&nbsp;infection.&nbsp;Symptoms may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>palpitations (fast or irregular heartbeats) or tremors<\/li><li>hyperactivity (excessive restlessness and excessive movements)<\/li><li>weakness that starts in the hands and feet and moves up the trunk.<\/li><\/ul>\n\n\n\n<p><strong>If you develop symptoms of an&nbsp;infection&nbsp;and&nbsp;inflammation<\/strong>&nbsp;or if you notice any of the symptoms mentioned above:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor immediately.&nbsp;<\/strong>Do not take other anti-infection&nbsp;medicines unless the doctor has recommended them.<\/li><\/ul>\n\n\n\n<p><strong>Joint pain, stiffness, and bone problems<\/strong><\/p>\n\n\n\n<p>Some people take combination anti-HIV&nbsp;therapy to develop a condition called&nbsp;osteonecrosis.&nbsp;Osteonecrosis&nbsp;means that parts of the bone tissue die because the blood supply to the bone is reduced.&nbsp;The risk of being affected by this increases if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the combination treatment has been going on for a long time<\/li><li>anti-inflammatory medicines called&nbsp;corticosteroids&nbsp;are taken at the same time<\/li><li>you drink alcohol<\/li><li>the immune system is very weak<\/li><li>you are overweight.<\/li><\/ul>\n\n\n\n<p><strong>Signs of&nbsp;osteonecrosis&nbsp;are:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>stiffness in the joints<\/li><li>aches and pains (especially in the hips, knees, or shoulders)<\/li><li>difficulty moving.<\/li><\/ul>\n\n\n\n<p>If you get any of these symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor about it.<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Triumeq<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and can after &#8220;EXP&#8221;.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Moisture sensitive.&nbsp;Keep the jar tightly closed.&nbsp;Do not remove the desiccant.<\/p>\n\n\n\n<p>No special temperature instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.&nbsp;Ask the pharmacist how to dispose of medicines that are no longer used.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are dolutegravir, abacavir and lamivudine.&nbsp;Each film-coated tablet contains dolutegravir sodium equivalent to 50 mg dolutegravir, 600 mg abacavir (as <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/atropin-bausch-lomb\/\">sulfate<\/a>), and 300 mg lamivudine.<\/li><li>Other ingredients are mannitol (E421), microcrystalline cellulose, povidone, K29\/32, sodium starch glycolate, magnesium stearate, poly(vinyl) alcohol &#8211; partially hydrolyzed, titanium dioxide, macrogol\/PEG, talc, black iron oxide, and red iron oxide.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Triumeq film-coated tablets are purple, biconvex, oval, and debossed with \u201c572 Tri\u201d on one side.<\/p>\n\n\n\n<p>The film-coated tablets are available in cans of 30 tablets.<\/p>\n\n\n\n<p>The jar contains a desiccant to reduce moisture.&nbsp;Once the can has been opened, the desiccant should be left in the can, do not take it out.<\/p>\n\n\n\n<p>There are also multipacks of 90 film-coated tablets (3 packs of 30 film-coated tablets).&nbsp;Not all pack sizes may be available in your country.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>ViiV Healthcare BV, Van Asch van Wijckstraat 55H, 3811 LP Amersfoort, The Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Glaxo Wellcome, SA, Avda.&nbsp;Extremadura 3, 09400 Aranda De Duero, Burgos, Spain<\/p>\n\n\n\n<p>OR<\/p>\n\n\n\n<p>Delpharm Pozna\u0144 Sp\u00f3\u0142ka Akcyjna ul.&nbsp;Grunwaldzka 189, 60-322 Poznan, Poland<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>ViiV Healthcare srl\/bvTel\/Tel: + 32 (0) 10 85 65 00<\/td><td><strong>Lithuania<\/strong>ViiV Healthcare BVPhone: + 370 80000334<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>ViiV Healthcare BVTel.: + 359 80018205<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>ViiV Healthcare srl\/bvBelgique\/BelgiumTel\/Tel: + 32 (0) 10 85 65 00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>GlaxoSmithKline, Serophene: + 420 222 001 111cz.info@gsk.com<\/td><td><strong>Magyarorsz\u00e1g<\/strong>ViiV Healthcare BVTel.: + 36 80088309<\/td><\/tr><tr><td><strong>Denmark<\/strong>GlaxoSmithKline Pharma A\/SPhone: + 45 36 35 91 00dk-info@gsk.com<\/td><td><strong>Malta<\/strong>ViiV Healthcare BVPhone: + 356 80065004<\/td><\/tr><tr><td><strong>Deutschland<\/strong>ViiV Healthcare GmbHTel.: + 49 (0)89 203 0038-10viiv.med.info@viivhealthcare.com<\/td><td><strong>The Netherlands<\/strong>ViiV Healthcare BVPhone: + 31 (0)33 2081199<\/td><\/tr><tr><td><strong>Estonia<\/strong>ViiV Healthcare BVPhone: + 372 8002640<\/td><td><strong>Norway<\/strong>GlaxoSmithKline iPhone: + 47 22 70 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>GlaxoSmithKline \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b7 AEBETel: + 30 210 68 82 100<\/td><td><strong>Austria<\/strong>GlaxoSmithKline Pharma GmbHTel: + 43 (0)1 97075 0at.info@gsk.com<\/td><\/tr><tr><td><strong>Spain<\/strong>Laboratorios ViiV Healthcare, SLPhone: + 34 900 923 501&nbsp;es-ci@viivhealthcare.com<\/td><td><strong>Polish<\/strong>GSK Services Sp.&nbsp;z o. oTel.: + 48 (0)22 576 9000<\/td><\/tr><tr><td><strong>France<\/strong>ViiV Healthcare SASTel.: + 33 (0)1 39 17 69 69Infomed@viivhealthcare.com<\/td><td><strong>Portugal<\/strong>VIIVHIV HEALTHCARE, UNIPESSOAL, LDAPhone: + 351 21 094 08 01viiv.fi.pt@viivhealthcare.com<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>ViiV Healthcare BVPhone: + 385 800787089<\/td><td><strong>Romania<\/strong>ViiV Healthcare BVPhone: + 40 800672524<\/td><\/tr><tr><td><strong>Ireland<\/strong>GlaxoSmithKline (Ireland) LimitedPhone: + 353 (0)1 4955000<\/td><td><strong>Slovenija<\/strong>ViiV Healthcare BVPhone: + 386 80688869<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>ViiV Healthcare BVPhone: + 421 800500589<\/td><\/tr><tr><td><strong>Italy<\/strong>ViiV Healthcare SrlPhone: + 39 (0)45 9212611<\/td><td><strong>Finland\/Finland<\/strong>GlaxoSmithKline OyPhone\/Tel: + 358 (0)10 30 30 30<\/td><\/tr><tr><td><strong>Cyprus<\/strong>ViiV Healthcare BVTel: + 357 80070017<\/td><td><strong>Sweden<\/strong>GlaxoSmithKline ABPhone: + 46 (0)8 638 93 00info.produkt@gsk.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>ViiV Healthcare BVPhone: + 371 80205045<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>ViiV Healthcare BVPhone: + 44 (0)800 221441customercontactuk@gsk.com<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Triumeq is a medicine that contains three active substances used to treat\u00a0HIV\u00a0infection: abacavir, lamivudine and dolutegravir.\u00a0Abacavir and lamivudine belong to a group of antiretroviral medicines called\u00a0nucleoside analogue reverse transcriptase inhibitors\u00a0(NRTIs) and dolutegravir belongs to a group of antiretroviral medicines called\u00a0integrase inhibitors\u00a0(INIs).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[12082,12085,5221,5224,4015,5225,26484,26487,12084,14840,12083,5222,4016,26485,12093,26486],"class_list":["post-25700","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-abacavir","tag-abacavir-tablet","tag-dolutegravir","tag-dolutegravir-tablet","tag-lamivudine","tag-lamivudine-tablet","tag-triumeq","tag-triumeq-tablet","tag-what-abacavir-is-used-for","tag-what-dolutegravir-is-used-for","tag-what-is-abacavir","tag-what-is-dolutegravir","tag-what-is-lamivudine","tag-what-is-triumeq","tag-what-lamivudine-is-used-for","tag-what-triumeq-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25700"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25700\/revisions"}],"predecessor-version":[{"id":25747,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25700\/revisions\/25747"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25700"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25700"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}