{"id":25695,"date":"2022-09-24T12:23:35","date_gmt":"2022-09-24T12:23:35","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25695"},"modified":"2022-09-26T07:29:08","modified_gmt":"2022-09-26T07:29:08","slug":"trisenox","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/trisenox\/","title":{"rendered":"TRISENOX &#8211; Arsenic trioxide uses, dose and side effects"},"content":{"rendered":"\n<p>1 mg\/ml,\u00a0concentrate for solution for\u00a0injection, solution<br>arsenic trioxide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What TRISENOX is and what it is used for<\/h2>\n\n\n\n<p>TRISENOX is used in adult patients with newly diagnosed\u00a0acute\u00a0promyelocytic\u00a0leukemia\u00a0(APL) with low to\u00a0intermediate\u00a0risk, as well as in adult patients when the disease has not improved after other treatments.\u00a0APL is a unique form of\u00a0myeloid\u00a0leukemia, a disease in which abnormal\u00a0white blood cells\u00a0are produced and abnormal bleeding and bruising occur.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you are given TRISENOX<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should not receive TRISENOX<\/h2>\n\n\n\n<p>If you are allergic to arsenic trioxide or any of the other ingredients of this medicine (listed in section 6).<\/p>\n\n\n\n<p>TRISENOX must be given under the supervision of a doctor experienced in treating acute\u00a0leukemia.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>You must talk to your doctor or nurse before you are given TRISENOX<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have reduced kidney function<\/li><li>you have liver problems<\/li><\/ul>\n\n\n\n<p>Your doctor will take the following precautions:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tests are performed to check the amount of\u00a0potassium,\u00a0magnesium,\u00a0calcium,\u00a0and\u00a0creatinine\u00a0in your blood before your first\u00a0dose\u00a0of TRISENOX.<\/li><li>The electrical activity of the heart (\u00a0electrocardiogram,\u00a0EKG\u00a0) should be measured before you receive the first\u00a0dose.<\/li><li>Blood tests (\u00a0potassium,\u00a0calcium,\u00a0magnesium,\u00a0and liver function) are then repeated during your treatment with TRISENOX.<\/li><li>In addition, an\u00a0EKG\u00a0is taken on you twice a week.<\/li><li>If you are at risk of a certain type of abnormal heart rhythm (eg\u00a0torsade de pointes\u00a0or QTc prolongation), your heart will be continuously monitored.<\/li><li>The doctor can monitor your health during and after treatment, because arsenic trioxide, the active substance in TRISENOX, can cause other types of <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a>.\u00a0You must report any new and unusual symptoms and circumstances each time you see the doctor.<\/li><li>Follow-up of your cognitive functions and your mobility if you are at risk of\u00a0vitamin\u00a0B1 deficiency.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>TRISENOX is not recommended for children under 18 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and TRISENOX<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including those without a prescription<\/p>\n\n\n\n<p>In particular, tell the doctor if you are taking any of the different types of medicine that could cause a change in the heart rhythm.&nbsp;These include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>certain types of\u00a0antiarrhythmics\u00a0(medicines used to correct irregular heart rhythms eg\u00a0quinidine,\u00a0amiodarone, sotalol, and dofetilide)<\/li><li>medicines for the treatment of\u00a0psychosis\u00a0(loss of perception of reality, eg thioridazine)<\/li><li>medicines for depression (eg amitriptyline)<\/li><li>certain types of medicines to treat bacterial infections (eg erythromycin and sparfloxacin)<\/li><li>certain medicines for the treatment of\u00a0allergies\u00a0such as <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/pollen-allergy\/\">hay fever<\/a>, so-called\u00a0antihistamines\u00a0(e.g. terfenadine and astemizole)<\/li><li>any medicine that causes a decrease in the amount of\u00a0magnesium\u00a0or potassium in the blood (eg amphotericin B)<\/li><li>cisapride a medicine used to relieve some stomach problems).<\/li><\/ul>\n\n\n\n<p>The effect of these medicines on your heart rhythm may be worsened by TRISENOX.&nbsp;Therefore, you must inform the doctor about all the medicines you are taking.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are taking or have recently taken any medication that may affect your liver.\u00a0Show the bottle or packaging to the doctor if you are unsure.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">TRISENOX with food, drink, and alcohol<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>There are no restrictions on food and drink while you are receiving TRISENOX.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n<p>TRISENOX can harm the fetus when used by pregnant women.<\/p>\n\n\n\n<p>If you can become pregnant, you must use effective contraception during treatment with TRISENOX and for 6 months after stopping treatment.<\/p>\n\n\n\n<p><br><br>If you are pregnant or if you become pregnant during treatment with TRISENOX, you must consult your doctor.<br><\/p>\n\n\n\n<p>Men receiving TRISENOX must use effective contraception and should be advised not to make a woman pregnant while receiving TRISENOX and for 3 months after stopping treatment.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n<p>The arsenic in TRISENOX passes into breast milk.<\/p>\n\n\n\n<p>Because TRISENOX can harm breastfed babies, you must not breastfeed while you are being treated with TRISENOX and within two weeks after the last\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>TRISENOX is expected to have no or negligible effect on the ability to drive and use machines.<\/p>\n\n\n\n<p>If you experience discomfort or if you feel unwell after a TRISENOX\u00a0injection, you should wait until the symptoms disappear before driving or operating machinery.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">TRISENOX contains sodium<\/h2>\n\n\n\n<p>TRISENOX contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per&nbsp;dose&nbsp;.&nbsp;This means that the medicine is almost &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How TRISENOX is given<\/h2>\n\n\n\n<p><strong>Treatment time and treatment frequency<\/strong><\/p>\n\n\n\n<p><strong>Patients with newly diagnosed&nbsp;acute&nbsp;promyelocytic&nbsp;leukemia<\/strong><\/p>\n\n\n\n<p>Your doctor will give you TRISENOX once a day as an\u00a0infusion.\u00a0In your first round of treatment, you may receive treatment every day for up to a maximum of 60 days or until your doctor judges that your disease has improved.\u00a0If your disease is improved by TRISENOX, you will receive 4 more cycles.\u00a0Each cycle consists of 20\u00a0doses\u00a0given 5 days a week (followed by 2 days off) for 4 weeks, followed by 4 weeks off.\u00a0Your doctor will decide exactly how long you should continue to be treated with TRISENOX.<\/p>\n\n\n\n<p><strong>Patients with&nbsp;acute&nbsp;promyelocytic&nbsp;leukemia&nbsp;who have not responded to other treatments<\/strong><\/p>\n\n\n\n<p>Your doctor will give you TRISENOX once a day as an\u00a0infusion.\u00a0In your first treatment cycle, you may receive treatment every day for up to a maximum of 50 days or until your doctor judges that your disease has improved.\u00a0If your disease improves with TRISENOX, you will have another treatment cycle of 25\u00a0doses\u00a0given 5 days a week (followed by 2 days off) for 5 weeks.\u00a0Your doctor will decide exactly how long you should continue to be treated with TRISENOX.<\/p>\n\n\n\n<p><strong>Method of administration and route of administration<\/strong><\/p>\n\n\n\n<p>TRISENOX must be diluted with a solution containing&nbsp;glucose&nbsp;or a solution containing sodium chloride.<\/p>\n\n\n\n<p>TRISENOX is normally given by a doctor or nurse. It is given as a drip (an&nbsp;infusion&nbsp;) into a vein over 1\u20132 hours, but it may take longer if&nbsp;side effects&nbsp;such as skin redness and dizziness occur.<\/p>\n\n\n\n<p>TRISENOX should not be mixed with or passed through the same tube together with, other medicines.<\/p>\n\n\n\n<p><strong>If your doctor or nurse gives you more TRISENOX than he\/she should<\/strong><\/p>\n\n\n\n<p>You may experience convulsions, muscle weakness, and confusion.\u00a0If this happens, stop treatment with TRISENOX immediately and your doctor will treat the arsenic overdose.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Tell your doctor or nurse straight away if you notice the following\u00a0side effects, as they may be signs of a serious condition called &#8216;differentiation syndrome&#8217; which can be fatal:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hard to breathe<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a><\/li><li>chest pain<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a><\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor or nurse immediately if you notice one or more of the following\u00a0side effects, as these may be signs of an allergic reaction:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hard to breathe<\/li><li>fever<\/li><li>sudden weight gain<\/li><li>water accumulation<\/li><li>fainting<\/li><li>palpitations&nbsp;(strong heartbeats that you can feel in your chest)<\/li><\/ul>\n\n\n\n<p>While you are being treated with TRISENOX, you may experience some of the following reactions:<\/p>\n\n\n\n<p><em>Very common (may affect more than 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dullness (fatigue), pain, fever, and headache.<\/li><li>nausea, vomiting, diarrhea<\/li><li>dizziness, muscle pain, numbness, or tingling<\/li><li>rash or\u00a0itching<\/li><li>high <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar<\/a>,\u00a0edema\u00a0(swelling due to excess fluid)<\/li><li>shortness of breath, palpitations, abnormal\u00a0ECG\u00a0measurement<\/li><li>decreased\u00a0potassium\u00a0or\u00a0magnesium\u00a0in the blood, abnormal liver function tests including excess\u00a0bilirubin\u00a0or gamma glutamyltransferase in the blood.<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of\u00a0blood cells\u00a0(\u00a0platelets, red and\/or\u00a0white blood cells\u00a0), increased number of\u00a0white blood cells<\/li><li>chills, weight gain<\/li><li>fever due to\u00a0infection\u00a0and low\u00a0white blood cell count,\u00a0herpes\u00a0zoster\u00a0infection<\/li><li>chest pain, bleeding in the lungs,\u00a0hypoxia\u00a0(lack of oxygen), fluid accumulation around the heart or lungs, low\u00a0blood pressure, abnormal heart rhythm<\/li><li>cramps, joint or leg pain,\u00a0inflammation\u00a0of the blood vessels<\/li><li>increased\u00a0sodium\u00a0or\u00a0magnesium, ketones in blood and urine (\u00a0ketoacidosis\u00a0), abnormal kidney function tests,\u00a0kidney failure<\/li><li>stomach pain (abdominal pain)<\/li><li>redness, swollen face, and blurred vision.<\/li><\/ul>\n\n\n\n<p><em>Frequency not known (frequency cannot be estimated from available data):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection\u00a0in the lungs,\u00a0infection\u00a0in the blood<\/li><li>pneumonia-causing chest pain and shortness of breath,\u00a0heart failure<\/li><li>dehydration, confusion<\/li><li>brain disease (\u00a0encephalopathy, Wernicke&#8217;s\u00a0encephalopathy\u00a0) with various\u00a0manifestations\u00a0including difficulty using arms and legs, speech disorders, and confusion.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store TRISENOX<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the ampoule label and carton.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>If the solution is not used immediately after dilution, your doctor, pharmacist, or nurse is responsible for storage times and conditions before use.\u00a0Normally, this time should not be longer than 24 hours at 2 to 8 \u00baC, unless dilution has taken place in a\u00a0sterile\u00a0environment.<\/p>\n\n\n\n<p>The medicine must not be used if you see that the solution contains foreign particles or if the solution is discolored.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is arsenic trioxide.\u00a0Each ml of concentrate contains 1 mg of arsenic trioxide.\u00a0Each\u00a0ampoule\u00a0of 10 ml contains 10 mg of arsenic trioxide.<\/li><li>Other ingredients are sodium hydroxide,\u00a0hydrochloric acid,\u00a0and water for injections.\u00a0See section 2 &#8220;TRISENOX contains sodium&#8221;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>TRISENOX is a concentrate for\u00a0infusion liquid, solution (sterile concentrate).\u00a0TRISENOX is supplied in\u00a0glass\u00a0ampoules in the form of a concentrated, clear, colorless\u00a0aqueous solution.\u00a0Each carton contains 10\u00a0glass\u00a0ampoules for single use.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>TEVA BV Swensweg 5, 2031 GA Haarlem, The Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Almac Pharma Services Limited, Almac House, 20 Seagoe Industrial Estate, Craigavon, BT63 5QD, United Kingdom<\/p>\n\n\n\n<p>Almac Pharma Services (Ireland) Limited;&nbsp;Finnabair Industrial Estate, Dundalk, Co.&nbsp;Louth, A91 P9KD, Ireland<\/p>\n\n\n\n<p>Teva Pharmaceuticals Europe BV, Swensweg 5, 2031 GA Haarlem, The Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>TRISENOX is used in adult patients with newly diagnosed\u00a0acute\u00a0promyelocytic\u00a0leukemia\u00a0(APL) with low to\u00a0intermediate\u00a0risk, as well as in adult patients when the disease has not improved after other treatments.\u00a0APL is a unique form of\u00a0myeloid\u00a0leukemia\u00a0, a disease in which abnormal\u00a0white blood cells\u00a0are produced and abnormal bleeding and bruising occur.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[9997,10000,26489,26493,26488,26492,9999,9998,26490,26491],"class_list":["post-25695","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-arsenic-trioxide","tag-arsenic-trioxide-side-effects","tag-benefits-of-arsenic-trioxide","tag-benefits-of-trisenox","tag-trisenox","tag-trisenox-side-effects","tag-what-arsenic-trioxide-is-used-for","tag-what-is-arsenic-trioxide","tag-what-is-trisenox","tag-what-trisenox-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25695","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25695"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25695\/revisions"}],"predecessor-version":[{"id":25748,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25695\/revisions\/25748"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25695"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25695"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25695"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}