{"id":25646,"date":"2022-09-23T11:22:00","date_gmt":"2022-09-23T11:22:00","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25646"},"modified":"2022-09-24T08:02:17","modified_gmt":"2022-09-24T08:02:17","slug":"trilafon-decanoate","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/trilafon-decanoate\/","title":{"rendered":"Trilafon decanoate &#8211; Decanoate uses, dose and side effects"},"content":{"rendered":"\n<p>108 mg\/ml&nbsp;solution for injection&nbsp;perphenazine<br>decanoate<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Trilafon decanoate is and what it is used for<\/h2>\n\n\n\n<p>Trilafon decanoate belongs to a group of medicines used in the treatment of\u00a0psychoses.<\/p>\n\n\n\n<p>Trilafon decanoate blocks certain signaling substances in the\u00a0central nervous system\u00a0and thereby acts with a pronounced antipsychotic effect (reduces delusions, delusions, disturbance in thought process, confusion, and disturbance of consciousness) and also acts to suppress\u00a0psychomotor\u00a0restlessness (psychologically conditioned movement patterns).<\/p>\n\n\n\n<p>Trilafon decanoate is used for delusions, leaps in thought, disturbance of consciousness, lack of understanding of illness, hallucinations (delusions), with several symptoms of <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/being-related-to-someone-who-has-a-psychotic-illness\/\">mental illness<\/a>.<\/p>\n\n\n\n<p>Perphenazine decanoate contained in Trilafon decanoate may also be approved to treat other conditions not mentioned in this leaflet.&nbsp;Ask your doctor, pharmacist or other healthcare professional if you have any further questions and always follow their instructions.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you receive Trilafon decanoate<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You cannot get Trilafon decanoate<\/h2>\n\n\n\n<p>&#8211; if you are allergic to the active substance or any of the other ingredients in this medicine (listed in section 6).<\/p>\n\n\n\n<p>&#8211; if you have&nbsp;leukopenia&nbsp;or&nbsp;agranulocytosis&nbsp;(blood count changes).<\/p>\n\n\n\n<p>&#8211; if you have pheochromocytoma (a rare benign&nbsp;tumor&nbsp;of the adrenal glands).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist or nurse before you receive Trilafon decanoate<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you or someone in your family has a history of blood clots, as this type of medicine has been associated with blood clot formation.<\/li><li>if you have&nbsp;epilepsy&nbsp;and convulsions<\/li><li>if you have pronounced&nbsp;arteriosclerosis&nbsp;(hardening of the arteries).<\/li><li>if you have&nbsp;circulatory failure&nbsp;.<\/li><li>if you have cardiovascular disease or changes in heart rhythm.<\/li><li>if you are at risk of brain bleeding (&nbsp;stroke&nbsp;).<\/li><li>if you have liver or kidney disease.<\/li><\/ul>\n\n\n\n<p>If you have any of these diseases, you should tell your doctor before starting treatment with Trilafon decanoate.<\/p>\n\n\n\n<p>Trilafon decanoate can cause&nbsp;dry mouth&nbsp;and can cause damage to the teeth and oral mucosa during long-term treatment.&nbsp;The teeth should be thoroughly cleaned with fluoride toothpaste 2 times a day.<\/p>\n\n\n\n<p>Trilafon decanoate can&nbsp;cause extrapyramidal symptoms (involuntary movements) at higher&nbsp;dosages .&nbsp;These can often be counteracted by simultaneous treatment with an anti-parkinsonian drug.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Trilafon decanoate<\/h2>\n\n\n\n<p>The treatment effect can be affected if this medicine is given at the same time as certain other medicines.&nbsp;Doses&nbsp;may need to be adjusted.&nbsp;Treating physicians need to be aware of other concomitant medications.<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, even those without a prescription.<\/p>\n\n\n\n<p>Always consult a doctor before combining Trilafon decanoate with sleeping pills or strong painkillers (opiates).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Trilafon decanoate with alcohol<\/h2>\n\n\n\n<p>Never combine alcohol and Trilafon decanoate.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p>The following symptoms may occur in newborn babies of mothers who used Trilafon decanoate during the last trimester (the last three months of pregnancy): tremors, muscle stiffness and\/or weakness, sleepiness, restlessness, breathing problems and difficulty eating.&nbsp;If your child shows any of these symptoms, you may need to see a doctor.<\/p>\n\n\n\n<p>Trilafon decanoate passes into breast milk but is unlikely to affect children who are breastfed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Trilafon decanoate can impair the ability to react in some people, which should be taken into account at times when increased attention is required, for example when driving a car and working with precision.<\/p>\n\n\n\n<p>You yourself are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects&nbsp;.&nbsp;Description of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;Discuss with your doctor or pharmacist if you are unsure.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Trilafon decanoate contains propyl paraben and sesame oil<\/h2>\n\n\n\n<p>Propylparaben (E216) can cause&nbsp;an allergic reaction&nbsp;(possibly delayed) and exceptionally spasms in the trachea.<\/p>\n\n\n\n<p>In rare cases, sesame oil can cause a severe&nbsp;allergic reaction&nbsp;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to get Trilafon decanoate<\/h2>\n\n\n\n<p><strong>How Trilafon decanoate is given<\/strong><\/p>\n\n\n\n<p>Trilafon decanoate is given to you by a doctor or other healthcare professional.&nbsp;The doctor decides how much Trilafon decanoate you will receive.<\/p>\n\n\n\n<p>Trilafon decanoate is injected into a muscle.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<\/p>\n\n\n\n<p>If you experience serious&nbsp;side effects&nbsp;, contact your doctor or pharmacist.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately if you:<\/strong><\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 100 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>at higher&nbsp;dosage&nbsp;experience involuntary movements (especially extrapyramidal symptoms).&nbsp;This may occur at higher&nbsp;dosages&nbsp;, however, with significant individual variations.<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>experience a rapid course (within 1-3 days) of <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a>, muscle stiffness, confusion and disturbed heart rhythm (neuroleptic malignant syndrome).&nbsp;This may require&nbsp;emergency&nbsp;treatment.<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>get blood clots, especially in the legs (symptoms such as swelling, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a> and&nbsp;redness&nbsp;of the legs).&nbsp;Blood clots in the lungs (symptoms such as chest pain and difficulty breathing) have been reported.&nbsp;If you experience any of these symptoms, seek medical attention immediately.<\/li><li>experience&nbsp;allergic reaction&nbsp;with skin reaction, facial swelling and\/or fever.&nbsp;Contact a doctor immediately if swelling of e.g.&nbsp;face, tongue and\/or throat and\/or difficulty swallowing or&nbsp;hives&nbsp;occurring together with difficulty breathing occurs (&nbsp;angioedema&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;that may occur:<\/strong><\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>somnolence<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/fatigue-syndrome\/\">fatigue<\/a><\/li><li>reduced mobility<\/li><li>tardive dyskinesia&nbsp;(abnormal repetitive movements)<\/li><li>akathisia&nbsp;(inability to sit still)<\/li><li>muscle stiffness<\/li><li>tremors<\/li><li>slow movements,<\/li><li>dry mouth<\/li><li>mammary gland enlargement (in men)<\/li><li>milk flow from breast<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>weight gain\/weight loss<\/li><li>dizziness<\/li><li>fainting<\/li><li>impaired ability to concentrate<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/constipation\/\">constipation<\/a><\/li><li>urination disorder<\/li><li>accommodation problems (difficulty reading fine print).<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>agranulocytosis&nbsp;(lack of&nbsp;white blood cells&nbsp;)<\/li><li>palpitation<\/li><li>impact on heart rhythm<\/li><li>irregular heart rhythm and&nbsp;EKG&nbsp;changes in connection with this<\/li><li>cardiac arrest<\/li><li>rhythm disorders of various kinds (including&nbsp;Torsade de Pointes&nbsp;)<\/li><li>heart fibrillation<\/li><li>headache<\/li><li>nausea<\/li><li>rash and&nbsp;itching&nbsp;.<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cases of sudden death, which may be caused by serious heart problems, have been reported with this type of medicine.<\/li><li>Trilafon decanoate can in rare cases affect the white&nbsp;blood cells&nbsp;so that the defense against infection deteriorates.&nbsp;If you get an&nbsp;infection&nbsp;with symptoms such as fever with a greatly worsened general condition or fever with local infection symptoms such as sore throat\/pharynx\/mouth or vomiting, you should see a doctor as soon as possible so that a lack of&nbsp;white blood cells&nbsp;(&nbsp;agranulocytosis&nbsp;) can be ruled out via a blood test&nbsp;.&nbsp;It is important that you then inform about your medication.<\/li><li>liver damage may occur.&nbsp;Jaundice, usually&nbsp;reversible&nbsp;, has been reported in rare cases.<\/li><\/ul>\n\n\n\n<p>With treatment for longer periods, problems with vision have been reported.<\/p>\n\n\n\n<p>In elderly people with dementia treated with antipsychotic drugs, a small increase in the number of deaths has been reported compared to those not receiving such treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Trilafon decanoate<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store at a maximum of 25\u00b0C.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton and on the&nbsp;ampoule&nbsp;.&nbsp;The first two digits indicate the month, the following four digits indicate the year.&nbsp;The expiration date is the last day of the specified month.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is perphenazine in the form of perphenazine decanoate.&nbsp;1 ml contains 108 mg perphenazine decanoate corresponding to 78 mg perphenazine.<\/li><li>Other ingredients are sesame oil and propylparaben (&nbsp;preservative&nbsp;E 216).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Trilafon decanoate is a&nbsp;solution for injection&nbsp;.<\/p>\n\n\n\n<p>Trilafon decanoate is available in&nbsp;glass&nbsp;ampoules, 10 x 1 ml.&nbsp;The ampoules&nbsp;have two colored rings.&nbsp;The upper ring is brown and the lower dark blue.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Orion Corporation<\/p>\n\n\n\n<p>Orion Intie 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Orion Corporation Orion Pharma<\/p>\n\n\n\n<p>Orion Intie 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p>For further information about this medicine, contact your local representative:<\/p>\n\n\n\n<p>Orion Pharma AB, Danderyd<\/p>\n\n\n\n<p>medinfo@orionpharma.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Trilafon decanoate belongs to a group of medicines used in the treatment of\u00a0psychoses\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[26429,26435,26427,26428,26432,26434,26431,26430,26433,26436],"class_list":["post-25646","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-decanoate","tag-benefits-of-trilafon-decanoate","tag-decanoate","tag-decanoate-side-effects","tag-trilafon-decanoate","tag-trilafon-decanoate-side-effects","tag-what-decanoate-is-used-for","tag-what-is-decanoate","tag-what-is-trilafon-decanoate","tag-what-trilafon-decanoate-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25646","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25646"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25646\/revisions"}],"predecessor-version":[{"id":25668,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25646\/revisions\/25668"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25646"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25646"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25646"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}