{"id":25595,"date":"2022-09-21T07:24:15","date_gmt":"2022-09-21T07:24:15","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25595"},"modified":"2022-09-23T10:48:16","modified_gmt":"2022-09-23T10:48:16","slug":"trevicta","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/trevicta\/","title":{"rendered":"TREVICTA &#8211; Paliperidone uses, dose and side effects"},"content":{"rendered":"\n<p>175 mg, 263 mg, 350 mg, 525 mg\u00a0solution for injection, depot suspension<br>paliperidone<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What TREVICTA is and what it is used for<\/h2>\n\n\n\n<p>TREVICTA contains the active substance paliperidone, which is an antipsychotic drug and is used as a maintenance treatment for the symptoms of schizophrenia in adult patients.<\/p>\n\n\n\n<p>If you have responded well to treatment with paliperidone palmitate for&nbsp;injection&nbsp;given once a month, your doctor may start treatment with TREVICTA.<\/p>\n\n\n\n<p>Schizophrenia is a disease with &#8220;positive&#8221; and &#8220;negative&#8221; symptoms.\u00a0Positive symptoms mean the presence of symptoms that normally do not occur.\u00a0For example, a person with schizophrenia may hear voices or see things that are not there (called hallucinations), believe things that are not true (called delusions), or feel unusually suspicious of others.\u00a0Negative symptoms mean a lack of behaviors or feelings that normally occur.\u00a0For example, a person with schizophrenia may appear withdrawn, emotionally depleted, and may have difficulty speaking clearly and logically.\u00a0People with this disorder may also feel depressed, anxious, burdened with guilt, or tense.<\/p>\n\n\n\n<p>TREVICTA can help relieve the symptoms of your disease and prevent your symptoms from coming back.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use TREVICTA<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use TREVICTA<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to paliperidone or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are allergic to any other antipsychotic drug, including the substance\u00a0risperidone.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using TREVICTA.<\/p>\n\n\n\n<p>This medicine has not been studied in elderly patients with dementia.&nbsp;However, elderly patients with dementia who are treated with other similar types of medicine may have an increased risk of having a&nbsp;stroke&nbsp;or dying (see section 4).<\/p>\n\n\n\n<p>All medicines can cause&nbsp;side effects&nbsp;and some of the&nbsp;side effects&nbsp;caused by this medicine can worsen the symptoms of other medical conditions.&nbsp;It is therefore important that you consult your doctor about any of the following conditions that could worsen during treatment with this medicine:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have\u00a0Parkinson&#8217;s disease<\/li><li>if you have ever been diagnosed with the neuroleptic malignant syndrome, a condition where symptoms include fever and muscle stiffness<\/li><li>if you have ever had involuntary jerking movements of the face, tongue, or other parts of the body (\u00a0tardive dyskinesia\u00a0)<\/li><li>if you know that you have had low levels of\u00a0white blood cells\u00a0in the past (this may or may not have been caused by other medicines)<\/li><li>if you are diabetic or have a predisposition to\u00a0diabetes<\/li><li>if you have had breast cancer or a\u00a0tumor in the\u00a0pituitary gland\u00a0of the brain<\/li><li>if you have heart disease or are being treated for a heart disease that can cause your\u00a0blood pressure\u00a0to become low<\/li><li>if you have low\u00a0blood pressure\u00a0when you stand up or sit up quickly<\/li><li>if you have previously had seizures<\/li><li>if you have kidney problems<\/li><li>if you have liver problems<\/li><li>if you\u00a0have prolonged and\/or painful\u00a0erections<\/li><li>if you have disturbances in the regulation of body temperature or have an elevated body temperature<\/li><li>if you have an abnormally high level of the\u00a0hormone\u00a0et\u00a0prolactin\u00a0in your blood or if you have a\u00a0tumor\u00a0that may be prolactin dependent<\/li><li>if you or someone in your family has had blood clots, antipsychotic medicines have been associated with the formation of blood clots<\/li><\/ul>\n\n\n\n<p>If you have any of these conditions, talk to your doctor as he\/she may want to adjust your\u00a0dose\u00a0or monitor you for some time.<\/p>\n\n\n\n<p>In very rare cases, a dangerously low level of a certain type of\u00a0white blood cell\u00a0needed to fight\u00a0infection\u00a0in the blood has been seen in patients taking this medicine.\u00a0Your doctor may check your levels of\u00a0white blood cells.<\/p>\n\n\n\n<p>Even if you have previously tolerated oral paliperidone or\u00a0risperidone, allergic reactions may rarely occur after you receive\u00a0an injection\u00a0of TREVICTA.\u00a0Seek immediate medical attention if you develop a rash, swelling of the throat,\u00a0itching, or breathing problems\u00a0as\u00a0these may be signs of a serious\u00a0allergic reaction.<\/p>\n\n\n\n<p>This medicine may cause weight gain.\u00a0Significant weight gain can hurt your health.\u00a0Your doctor should check your body weight regularly.<\/p>\n\n\n\n<p>Your doctor should watch for signs of high blood sugar because\u00a0diabetes mellitus\u00a0or worsening of existing\u00a0diabetes\u00a0has been seen in patients using this medicine.\u00a0In patients with existing\u00a0diabetes, blood sugar should be checked regularly.<\/p>\n\n\n\n<p>Because this medicine can reduce the urge to vomit, there is a risk that it may mask the body&#8217;s normal response to toxic substances or other medical conditions.<\/p>\n\n\n\n<p>During cataract\u00a0surgery, it may happen that\u00a0pupil\u00a0one (the black circle in the center of the eye) does not increase in size as much as needed.\u00a0In addition, you can get reduced muscle tension in the\u00a0iris\u00a0(the colored part of the eye) during the operation and this can lead to eye damage.\u00a0If you have eye surgery planned, you must inform your eye doctor that you are using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not use this medicine in children and adolescents under 18 years of age.&nbsp;It is not known whether it is safe and effective in these patients.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and TREVICTA<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Taking this medicine with carbamazepine (used for&nbsp;epilepsy&nbsp;and as a mood stabilizer) may require a change in your&nbsp;dose&nbsp;of this medicine.<\/p>\n\n\n\n<p>As this medicine primarily has an effect on the brain, the use of other medicines that also work in the brain may cause a worsening of\u00a0side effects\u00a0such as drowsiness or other effects on the brain, e.g.\u00a0other medicines to treat mental conditions,\u00a0opioids,\u00a0antihistamines,\u00a0and sleeping pills.<\/p>\n\n\n\n<p>As this medicine can lower&nbsp;blood pressure&nbsp;et, caution should be taken when the medicine is used together with other medicines that lower&nbsp;blood pressure&nbsp;et.<\/p>\n\n\n\n<p>This medicine can reduce the effect of medicines for&nbsp;Parkinson&#8217;s disease&nbsp;and leg cramps (eg&nbsp;levodopa&nbsp;).<\/p>\n\n\n\n<p>This medicine can cause abnormal\u00a0ECGs\u00a0in that it takes longer than usual for an electrical impulse to travel to a certain part of the heart (the condition is called &#8216;QT prolongation).\u00a0Other drugs that cause such an effect include certain drugs used to treat\u00a0heart arrhythmias\u00a0or to treat\u00a0infections, as well as other antipsychotic drugs.<\/p>\n\n\n\n<p>If you have had seizures in the past, this medicine may increase your risk of having them.\u00a0Other drugs that cause such an effect include certain drugs used to treat depression or to treat\u00a0infection, as well as other antipsychotic drugs.<\/p>\n\n\n\n<p>TREVICTA should be used with caution with drugs that increase activity in the&nbsp;central nervous system&nbsp;(psychostimulants, eg methylphenidate).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">TREVICTA with alcohol<\/h2>\n\n\n\n<p>Alcohol should be avoided.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.\u00a0You should not use this medicine during pregnancy unless you have discussed this with your doctor.\u00a0In newborn babies whose mothers have taken paliperidone during the last trimester (the last three months of pregnancy), the following symptoms may occur: tremors, stiff and weak muscles, sleepiness, agitation, breathing problems, and difficulty eating.\u00a0If your child develops any of these symptoms, you should contact your doctor.<\/p>\n\n\n\n<p>This medicine can be passed from mother to baby through breast milk, which may be harmful to the baby.\u00a0You should therefore not breastfeed while using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Dizziness, extreme tiredness, and vision problems may occur during treatment with this medicine (see section 4).\u00a0This must be taken into account in situations where full vigilance is required, e.g.\u00a0when driving a car or operating machinery.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">TREVICTA contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg) of\u00a0sodium\u00a0per\u00a0dose, i.e. it is almost &#8220;sodium-free&#8221;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use TREVICTA<\/h2>\n\n\n\n<p>This medicine is given to you by your doctor or other healthcare professional.\u00a0The doctor will let you know when you need the next\u00a0injection.\u00a0You mustn&#8217;t miss a scheduled\u00a0dose.\u00a0If you cannot come to a scheduled visit with the doctor, you should immediately contact him or her to get a new appointment as soon as possible.<\/p>\n\n\n\n<p>You will receive an&nbsp;injection&nbsp;of TREVICTA in either the upper arm or the buttock once every 3 months.<\/p>\n\n\n\n<p>Depending on your symptoms, the doctor may increase or decrease the amount of medicine you receive when it is time for the next scheduled\u00a0injection.<\/p>\n\n\n\n<p>Patients with kidney problems<\/p>\n\n\n\n<p>If you have mild kidney problems, your doctor will determine which\u00a0dose\u00a0of TREVICTA is appropriate based on the\u00a0dose\u00a0of paliperidone palmitate for\u00a0injection\u00a0once a month that you have received.\u00a0If you have moderate or severe kidney problems, this medicine should not be used.<\/p>\n\n\n\n<p>Older<\/p>\n\n\n\n<p>Your doctor will decide your&nbsp;dose&nbsp;of this medicine if you have impaired kidney function.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have been given too much TREVICTA<\/h2>\n\n\n\n<p>You will be given this medicine by trained healthcare professionals, so it is unlikely that you will be given too much.<\/p>\n\n\n\n<p>Patients who have received too much paliperidone may experience the following symptoms:<\/p>\n\n\n\n<p>drowsiness or sleepiness, fast heartbeat, low\u00a0blood pressure, abnormal\u00a0EKG\u00a0(electrical monitoring of the heart), or slow or abnormal movements of the face, body, arms, or legs.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using TREVICTA<\/h2>\n\n\n\n<p>If you stop taking your\u00a0injections, your symptoms of schizophrenia may get worse.\u00a0You should not stop using this medicine unless your doctor tells you to.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately if you:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>get blood clots, especially in the legs (symptoms are swelling, pain, and\u00a0redness\u00a0of the legs), which can travel through the blood vessels to the lungs and cause chest pain and breathing difficulties.\u00a0If you experience any of these symptoms, seek medical attention immediately.<\/li><li>have dementia and experience a sudden mental change or sudden weakness or numbness in the face, arms, or legs, especially on one side, or slurred speech, even for a short period.\u00a0This could be a sign of a\u00a0stroke.<\/li><li>experience fever, muscle stiffness, sweating, or reduced level of consciousness (a condition known as &#8216;neuroleptic malignant syndrome).\u00a0Immediate medical treatment may be needed.<\/li><li>are a man and experience persistent or painful\u00a0erections.\u00a0This is called priapism.\u00a0Immediate medical treatment may be required.<\/li><li>experience involuntary rhythmic movements of the tongue, mouth, and face.<br>Treatment with paliperidone may need to be discontinued.<\/li><li>suffer from a severe\u00a0allergic reaction\u00a0with fever, swelling of the mouth, face, lips, or tongue, shortness of breath,\u00a0itching, skin rash, and sometimes a drop in blood pressure (a so-called\u00a0anaphylactic reaction\u00a0).\u00a0Even if you have previously tolerated\u00a0risperidone\u00a0taken by mouth or paliperidone took by mouth, allergic reactions may rarely occur after\u00a0injection\u00a0of paliperidone.<\/li><li>have eye surgery planned, you must inform your eye doctor that you are using this medicine.\u00a0During cataract\u00a0surgery, it can happen that you get reduced muscle tension in the\u00a0iris\u00a0(the colored part of the eye) during the operation (so-called &#8220;floppy\u00a0iris\u00a0syndrome&#8221;) and this can lead to eye damage.<\/li><li>know that you have dangerously low levels of a certain type of\u00a0white blood cell\u00a0that is needed to protect you against\u00a0infection\u00a0in the blood.<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;may occur:<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 in 10 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty falling asleep or staying asleep without interruption.<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cold symptoms, urinary tract infection, flu-like symptoms<\/li><li>TREVICTA can increase your levels of a\u00a0hormone\u00a0called &#8216;prolactin&#8217; in a blood test (this may or may not cause symptoms).\u00a0Symptoms of high prolactin levels in men can include swollen breasts, difficulty getting or maintaining\u00a0an erection, or other sexual\u00a0dysfunction.\u00a0In women, symptoms may include breast discomfort, milk leakage, missed periods, or other problems with the menstrual cycle.<\/li><li>high blood sugar, weight gain, weight loss, decreased appetite<\/li><li>irritability, depression, anxiety<\/li><li>restlessness<\/li><li>parkinsonism: this condition can include decreased or weakened body movements, feeling of tight or stiff muscles (making your movements jerky), and sometimes even a feeling that movement stops and then start again.\u00a0Other signs of\u00a0parkinsonism\u00a0include a slow shuffling gait, tremors at rest, increased saliva production and\/or drooling, and a lack of facial expression.<\/li><li>restlessness, feeling sleepy or less alert<\/li><li>dystonia: a condition involving slow or sustained involuntary muscle contractions.\u00a0Dystonia\u00a0can affect any part of the body (and lead to abnormal posture) but often affects the muscles of the face, including abnormal movements of the eyes, mouth, tongue, or jaw.<\/li><li>dizziness<\/li><li>dyskinesia: this is a condition involving involuntary muscle movements and may include repetitive, spastic, or distorted movements or jerks<\/li><li>tremors\u00a0_<\/li><li>headache<\/li><li>fast heartbeat<\/li><li>high\u00a0blood pressure<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a>, nasal congestion<\/li><li>abdominal pain, vomiting, nausea, constipation, diarrhea, poor digestion, toothache<\/li><li>increased liver transaminases in the blood<\/li><li>bone or muscle pain, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/back-hurts\/\">back pain<\/a>, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/joint-pain\/\">joint pain<\/a><\/li><li>absence of menstruation, milk leakage from the breasts<\/li><li>fever, weakness, fatigue<\/li><li>reaction at the injection site, including\u00a0itching, pain, or swelling.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pneumonia,\u00a0trachea\u00a0(\u00a0bronchitis\u00a0), respiratory tract infection, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sinusitis\/\">sinusitis<\/a>,\u00a0cystitis, ear infection, strep throat, nail fungus, skin infection<\/li><li>decrease in the number of\u00a0white blood cells, decrease in the type of\u00a0white blood cells\u00a0that help protect you against\u00a0infection, decrease in the number of\u00a0platelets\u00a0(\u00a0blood cells\u00a0that stop bleeding),\u00a0anemia<\/li><li>allergic reaction<\/li><li>diabetes\u00a0or worsening of\u00a0diabetes, increased amount of\u00a0insulin\u00a0(a\u00a0hormone\u00a0that regulates blood sugar levels) in the blood<\/li><li>increased appetite<\/li><li>loss of appetite leading to malnutrition and low body weight<\/li><li>high level of\u00a0triglycerides\u00a0in the blood (a type of blood fat), increased cholesterol level in the blood<\/li><li>sleep disturbance, excited mood (mania), decreased sex drive, nervousness, nightmares<\/li><li>tardive dyskinesia\u00a0(involuntary twitching movements of the face, tongue, or other parts of the body).\u00a0Tell your doctor right away if you experience involuntary rhythmic movements of the tongue, mouth, or face.\u00a0Treatment with this medicine may need to be discontinued.<\/li><li>fainting, a restless need to move parts of the body, dizziness when standing up, trouble paying attention, trouble speaking, loss of taste or abnormal sense of taste, decreased sensation in the skin to touch and pain, tingling or pricking, or numbness in the skin<\/li><li>blurred vision,\u00a0an eye infection\u00a0or &#8220;red eyes&#8221;, dry eyes<\/li><li>the feeling of spinning (\u00a0vertigo\u00a0), ringing in the ears, ear pain<\/li><li>disturbance in the conduction of impulses between the upper and lower parts of the heart, abnormal electrical conduction in the heart, prolonged\u00a0QT\u00a0interval from the heart, fast heart rate when standing up, slow heart rate, an abnormal electrical signal in the heart (\u00a0electrocardiogram\u00a0or\u00a0EKG\u00a0), a fluttering or pounding feeling in the chest (palpitations)<\/li><li>low\u00a0blood pressure, low\u00a0blood pressure\u00a0when standing up (as a result, some people taking this medicine may feel weak, dizzy, or faint when they sit or stand up suddenly)<\/li><li>shortness of breath, blood congestion in the airways, wheezing and wheezing, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sore-throat\/\">sore throat<\/a>, nosebleeds<\/li><li>abdominal pain, stomach or intestinal infection, difficulty swallowing,\u00a0dry mouth, greatly increased gas formation<\/li><li>increased gamma\u2011GT (a liver enzyme called gamma-glutamyltransferase) in the blood, increased levels of liver enzymes in the blood<\/li><li>rash (\u00a0hives\u00a0),\u00a0itching, rash, hair loss,\u00a0eczema, dry skin, skin redness,\u00a0acne<\/li><li>increase in CK (creatine phosphokinase) in the blood, an\u00a0enzyme\u00a0that is sometimes released when muscles are broken down<\/li><li>muscle spasms, joint stiffness, muscle weakness, neck pain<\/li><li>urinary incontinence, frequent urges, pain when urinating<\/li><li>erectile dysfunction, ejaculation disorder, missed periods or other problems with the menstrual cycle (women), breast development in men, sexual\u00a0dysfunction, breast pain<\/li><li>swelling of the face, mouth, eyes, or lips, swelling of the body, arms, or legs<\/li><li>an increase in body temperature<\/li><li>change in the way of walking<\/li><li>chest pain, chest discomfort, feeling unwell<\/li><li>skin calluses<\/li><li>case.<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>eye infection<\/li><li>skin inflammation caused by mites, accumulation under the skin<\/li><li>increase in\u00a0eosinophils\u00a0(a type of\u00a0white blood cell\u00a0) in the blood<\/li><li>insufficient secretion of a\u00a0hormone\u00a0that regulates urine volume<\/li><li>sugar in the urine<\/li><li>life-threatening complications of uncontrolled\u00a0diabetes<\/li><li>low blood sugar<\/li><li>excessive water drinking<\/li><li>confusion<\/li><li>immobility and lack of responsiveness when awake (catatonia)<\/li><li>sleepwalking<\/li><li>lack of emotions<\/li><li>inability to orgasm<\/li><li>neuroleptic malignant syndrome (confusion, decreased or loss of consciousness, high fever, and severe muscle stiffness), problems with blood vessels in the brain, including sudden reduction of blood supply to the brain (\u00a0stroke\u00a0or mini-stroke), lack of response to stimuli, loss of consciousness, low level of consciousness, seizures, balance disorder<\/li><li>abnormal coordination<\/li><li>glaucoma\u00a0(increased pressure inside the eyeball)<\/li><li>trouble moving the eyes, eye-rolling, hypersensitivity to light, increased tear flow, red eyes<\/li><li>atrial fibrillation\u00a0(an abnormal heart rhythm), irregular heart rhythm<\/li><li>blood clots in the veins, especially in the legs (symptoms include swelling, pain, and\u00a0redness\u00a0in the legs).\u00a0If you experience any of these symptoms, seek medical attention immediately.<\/li><li>flushing\u00a0(feeling of heat and\u00a0redness\u00a0in the skin)<\/li><li>difficulty breathing during sleep (\u00a0sleep apnea\u00a0)<\/li><li>pulmonary stasis<\/li><li>crackling breathing sounds<\/li><li>inflammation of the pancreas, swollen tongue, fecal incontinence, very hard stools<\/li><li>chapped lips<\/li><li>drug rash, thickening of the skin, dandruff<\/li><li>joint swelling<\/li><li>inability to urinate<\/li><li>breast discomfort, enlargement of the mammary glands, breast enlargement<\/li><li>vaginal\u00a0discharge<\/li><li>very low body temperature, chills, feeling thirsty<\/li><li>withdrawal symptoms<\/li><li>accumulation\u00a0of was caused by\u00a0infection\u00a0at the injection site, deep skin infection, a\u00a0cyst\u00a0at the injection site, and bruising at the injection site.<\/li><\/ul>\n\n\n\n<p><strong>Frequency not known (cannot be estimated from available data):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dangerously low levels of a certain type of\u00a0white blood cell\u00a0needed to protect you against\u00a0infection\u00a0in the blood<\/li><li>severe allergic reactions characterized by fever, swollen mouth, face, lip, or tongue, shortness of breath,\u00a0itching, rash, and sometimes a drop in blood pressure<\/li><li>dangerously excessive intake of water<\/li><li>sleep-related eating disorder<\/li><li>coma\u00a0resulting from uncontrolled\u00a0diabetes<\/li><li>head shaking<\/li><li>blood clots in the lungs that can cause chest pain and difficulty breathing.\u00a0If you experience any of these symptoms, seek medical attention immediately.<\/li><li>rapid, shallow breathing,\u00a0pneumonia\u00a0due to inhalation of food, voice disturbance<\/li><li>reduced oxygen flow to parts of the body (due to reduced blood flow)<\/li><li>blockage in the bowel, lack of bowel muscle movements causing constipation<\/li><li>yellowing of the skin and eyes (jaundice)<\/li><li>serious or life-threatening rash with blisters and peeling skin that may start in and around the mouth, nose, eyes, or genitals and spread to other parts of the body (\u00a0Stevens-Johnson syndrome\u00a0or\u00a0toxic epidermal necrolysis\u00a0)<\/li><li>severe allergic reaction with swelling that may involve the throat and lead to breathing difficulties<\/li><li>skin discoloration, flaky itchy scalp or skin<\/li><li>abnormal posture<\/li><li>newborn babies, whose mothers have taken TREVICTA during pregnancy, may experience\u00a0side effects\u00a0from the drug and\/or withdrawal symptoms such as irritability, stiff and\/or persistent muscle contractions, tremors, sleepiness, breathing problems, and difficulty eating.<\/li><li>priapism (prolonged\u00a0erection\u00a0of the penis which may require surgical treatment)<\/li><li>lowered body temperature<\/li><li>dead skin cells at the injection site, and a wound at the injection site.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store TREVICTA<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is paliperidone.<\/p>\n\n\n\n<p>Each pre-filled&nbsp;syringe&nbsp;of TREVICTA 175 mg contains 273 mg of paliperidone palmitate.<\/p>\n\n\n\n<p>Each pre-filled&nbsp;syringe&nbsp;of TREVICTA 263 mg contains 410 mg of paliperidone palmitate.<\/p>\n\n\n\n<p>Each pre-filled&nbsp;syringe&nbsp;of TREVICTA 350 mg contains 546 mg of paliperidone palmitate.<\/p>\n\n\n\n<p>Each pre-filled&nbsp;syringe&nbsp;of TREVICTA 525 mg contains 819 mg of paliperidone palmitate.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p>Polysorbate 20<\/p>\n\n\n\n<p>Polyethylene glycol 4000<\/p>\n\n\n\n<p>Citric acid monohydrate<\/p>\n\n\n\n<p>Sodium dihydrogen phosphate monohydrate<\/p>\n\n\n\n<p>Sodium hydroxide (for&nbsp;pH&nbsp;adjustment)<\/p>\n\n\n\n<p>Water for injections<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>TREVICTA is a white to off-white\u00a0solution for injection, depot suspension, in a pre-filled\u00a0syringe\u00a0that your doctor or nurse should shake vigorously to resuspend the\u00a0suspension\u00a0before it is injected.<\/p>\n\n\n\n<p>Each pack contains 1 pre-filled&nbsp;syringe&nbsp;and 2 needles.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Janssen\u2011Cilag International NV<\/p>\n\n\n\n<p>Turnhoutseweg 30<\/p>\n\n\n\n<p>B\u20112340 Beerse<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Janssen Pharmaceutica NV<\/p>\n\n\n\n<p>Turnhoutseweg 30<\/p>\n\n\n\n<p>B\u20112340 Beerse<\/p>\n\n\n\n<p>Belgium<\/p>\n","protected":false},"excerpt":{"rendered":"<p>TREVICTA contains the active substance paliperidone, which is an antipsychotic drug and is used as a maintenance treatment for the symptoms of schizophrenia in adult patients.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[12537,26388,12533,20718,26386,26390,12534,26387,12535,26389],"class_list":["post-25595","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-paliperidone","tag-benefits-of-trevicta","tag-paliperidone","tag-paliperidone-side-effects","tag-trevicta","tag-trevicta-side-effects","tag-what-is-paliperidone","tag-what-is-trevicta","tag-what-paliperidone-is-used-for","tag-what-trevicta-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25595"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25595\/revisions"}],"predecessor-version":[{"id":25617,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25595\/revisions\/25617"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25595"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25595"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}