{"id":25590,"date":"2022-09-21T07:20:22","date_gmt":"2022-09-21T07:20:22","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25590"},"modified":"2022-09-23T10:48:37","modified_gmt":"2022-09-23T10:48:37","slug":"tresiba","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tresiba\/","title":{"rendered":"Tresiba &#8211; Insulin\u00a0degludec uses, dose and side effects"},"content":{"rendered":"\n<p>100 units\/ml&nbsp;solution for injection&nbsp;in&nbsp;cartridge<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tresiba is and what it is used for<\/h2>\n\n\n\n<p>Tresiba contains long-acting basal insulin called\u00a0insulin\u00a0degludec.\u00a0It is used to treat\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">diabetes<\/a> mellitus\u00a0in adults, adolescents, and children from 1 year of age.\u00a0Tresiba helps your body lower <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar levels<\/a>.\u00a0It is dosed once daily.\u00a0At times when you cannot follow your usual dosing schedule, you can change the timing of\u00a0dosing\u00a0because Tresiba lowers <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar<\/a> for a long time (see section 3 \u201cFlexibility in dosing timing\u201d).\u00a0Tresiba can be used with rapid-acting\u00a0insulin\u00a0taken with meals.\u00a0In\u00a0diabetes mellitus\u00a0type 2, Tresiba can be used together with diabetes medicines in the form of tablets or with injectable diabetes medicines of a different type than\u00a0insulin.<\/p>\n\n\n\n<p>In&nbsp;diabetes mellitus&nbsp;type 1, Tresiba must always be used in combination with rapid-acting mealtime insulin.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Tresiba<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Tresiba<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to&nbsp;insulin&nbsp;degludec or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before you start using Tresiba.\u00a0Pay particular attention to the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Low blood sugar (hypoglycemia) \u2013 if your blood sugar is too low, follow the advice for low blood sugar in section 4.<\/li><li>High blood sugar (hyperglycemia) \u2013 if your blood sugar is too high, follow the advice for high blood sugar in section 4.<\/li><li>Switching from other insulin preparations \u2013 the insulin dose may need to be changed if you switch from another type, brand, or manufacturer of\u00a0insulin.\u00a0Talk to a doctor.<\/li><li>Concomitant use of pioglitazone, see \u201cPioglitazone\u201d below.<\/li><li>Eye disease \u2013 rapid improvement in blood sugar control may lead to a temporary worsening of diabetic eye disease.\u00a0If you get eye problems, talk to a doctor.<\/li><li>Make sure you are using the right type of\u00a0insulin\u00a0&#8211; always check the label of the insulin before each\u00a0injection\u00a0to avoid confusing Tresiba with other insulin preparations.<\/li><\/ul>\n\n\n\n<p>If you have poor vision, see section 3.<\/p>\n\n\n\n<p><strong>Skin changes at the injection site<\/strong><\/p>\n\n\n\n<p>To help prevent changes in the fatty tissue under the skin, e.g.\u00a0skin thickening, skin shrinkage, or nodules under the skin, you should constantly change the injection site.\u00a0Insulin\u00a0may\u00a0not work as well if you inject it into an area with nodules or a thickened or shriveled area (see \u201cHow to use Tresiba\u201d).\u00a0Contact the doctor if you notice skin changes at the injection site and before changing the injection site if you are currently injecting into an affected area.\u00a0The doctor may advise you to check your blood sugar more often and to adjust your insulin dose or the\u00a0dose\u00a0of other diabetes medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Tresiba can be used for adolescents and children from the age of 1.&nbsp;There is no experience with Tresiba in children under 1 year of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tresiba<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines.\u00a0Some medicines affect your blood sugar level and this may mean that your insulin dose needs to be changed.<\/p>\n\n\n\n<p>Below is a list of the most common medicines that can affect your insulin treatment.<\/p>\n\n\n\n<p><strong>Your blood sugar level may drop (hypoglycemia) if you take:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>other medicines, against\u00a0diabetes\u00a0(tablets or as an\u00a0injection\u00a0)<\/li><li>sulfonamides, against\u00a0infection\u00a0er<\/li><li>anabolic\u00a0steroids, eg\u00a0testosterone<\/li><li>beta-blockers, against high\u00a0blood pressure.\u00a0They can make it harder to recognize the warning signs of low blood sugar (see section 4, &#8216;Warning signs of low blood sugar)<\/li><li>acetylsalicylic acid\u00a0(and other salicylates), for pain and mild <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a><\/li><li>MAO inhibitors, against depression<\/li><li>ACE inhibitors, against certain heart problems or high\u00a0blood pressure<\/li><\/ul>\n\n\n\n<p><strong>Your blood sugar level may increase (hyperglycemia) if you take:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>danazol, for\u00a0endometriosis\u00a0(endometrial tissue that grows outside the uterus)<\/li><li>contraceptives (\u00a0birth control pills\u00a0), for birth control<\/li><li>thyroid hormones, against thyroid diseases<\/li><li>growth hormone, against growth hormone deficiency<\/li><li>glucocorticoids,\u00a0e.g.\u00a0cortisone, against\u00a0inflammation<\/li><li>sympathomimetics, eg\u00a0adrenaline,\u00a0salbutamol,\u00a0or\u00a0terbutaline, against\u00a0asthma<\/li><li>thiazides, for high\u00a0blood pressure\u00a0or if your body retains too much fluid (fluid retention).<\/li><\/ul>\n\n\n\n<p><em>Octreotide and lanreotide<\/em>: used to treat a rare disorder of overproduction of\u00a0growth hormone\u00a0(\u00a0acromegaly\u00a0).\u00a0These can either raise or lower your blood sugar level.<\/p>\n\n\n\n<p><em>Pioglitazone<\/em>: diabetes medicine (tablets) for the treatment of\u00a0diabetes mellitus\u00a0type 2. Some patients who had type 2\u00a0diabetes\u00a0and heart disease for many years or had a previous\u00a0stroke\u00a0developed\u00a0heart failure\u00a0when treated with pioglitazone and\u00a0insulin.\u00a0Inform your doctor immediately if you develop signs of\u00a0heart failure\u00a0such as unexpected shortness of breath, rapid weight gain, or local swelling (edema).<\/p>\n\n\n\n<p>If any of the above apply to you (or if you are unsure), talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tresiba and alcohol<\/h2>\n\n\n\n<p>Your insulin needs may change if you drink alcohol.&nbsp;The blood sugar level can either be raised or lowered.&nbsp;You should therefore check your blood sugar level more often than usual.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.\u00a0The insulin dose may need to be changed during pregnancy and after delivery.\u00a0It is necessary to have close control of your\u00a0diabetes\u00a0during pregnancy.\u00a0Avoiding low blood sugar (hypoglycemia) is particularly important for your child&#8217;s health.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Too low or too high blood sugar can affect your ability to drive or use tools or machines.&nbsp;Too low or too high blood sugar can affect your ability to concentrate and react.&nbsp;This can be dangerous to yourself and others.&nbsp;Ask your doctor if you should drive or use machines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you often get low blood sugar<\/li><li>if you find it difficult to recognize signs of low blood sugar.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Important information about some ingredients in Tresiba<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose.\u00a0This means that Tresiba is almost &#8220;sodium-free&#8221;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Tresiba<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor.\u00a0Consult a doctor, pharmacist, or nurse if you are unsure.<\/p>\n\n\n\n<p>If you are blind or have severe vision problems and cannot read the dose counter on the pen, you should not use this insulin preparation without help.&nbsp;Get the help of someone who has good eyesight and knows how to use the injection pen.<\/p>\n\n\n\n<p><strong>Doctors will decide together with you:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>how much Tresiba do you need each day.<\/li><li>when to check your blood sugar level and if you need a higher or lower\u00a0dose.<\/li><\/ul>\n\n\n\n<p><strong>Flexibility in dosing time<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Always follow your doctor&#8217;s dosage recommendations.<\/li><li>Use Tresiba once a day, preferably at the same time each day.<\/li><li>When you cannot take Tresiba at the same time of day, you can change the time you take Tresiba.\u00a0Make sure there are at least 8 hours between\u00a0doses.\u00a0There is no experience with flexible dosing timing for Tresiba in children and adolescents.<\/li><li>If you want to change your dietary habits, you should first consult with your doctor, pharmacist, or nurse, as changing your dietary habits may change your need for\u00a0insulin.<\/li><\/ul>\n\n\n\n<p>The doctor may change your&nbsp;dose&nbsp;depending on your blood sugar level.<\/p>\n\n\n\n<p>When using other medicines, ask the doctor if your treatment needs to be adjusted.<\/p>\n\n\n\n<p><strong>Use in the elderly (\u226565 years)<\/strong><\/p>\n\n\n\n<p>Tresiba can be used by the elderly, but you may need to check your blood sugar level more often if you are elderly.\u00a0Talk to your doctor about\u00a0dose\u00a0changes.<\/p>\n\n\n\n<p><strong>If you have problems with your kidneys or liver<\/strong><\/p>\n\n\n\n<p>If you have problems with your kidneys or liver, you may need to check your blood sugar level more often.\u00a0Talk to your doctor about changes to your Tresiba\u00a0dose.<\/p>\n\n\n\n<p><strong>To inject the drug<\/strong><\/p>\n\n\n\n<p>Before you use Tresiba for the first time, your doctor or nurse will show you how to use it.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Also, read the manual that comes with your insulin\u00a0injection device.<\/li><li>Check the name and strength on the label to make sure it is Tresiba 100 units\/ml.<\/li><\/ul>\n\n\n\n<p><strong>Do not use Tresiba<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>in\u00a0insulin\u00a0infusion pumps.<\/li><li>if the\u00a0cartridge\u00a0or the injection aid you are using is damaged.\u00a0In that case, return it to the pharmacy\/point of purchase.\u00a0Further instructions can be found in the manual for the injection device.<\/li><li>if the\u00a0cartridge\u00a0has been damaged or has not been stored correctly (see section 5 &#8220;How to store Tresiba&#8221;).<\/li><li>if\u00a0insulin\u00a0it is not clear and colorless.<\/li><\/ul>\n\n\n\n<p><strong>How to inject<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tresiba is given as an\u00a0injection\u00a0under the skin (\u00a0subcutaneous\u00a0injection\u00a0).\u00a0It must not be injected into a vein or muscle.<\/li><li>The best places to inject are the front of the thighs, the upper arms, or the front of the waist (abdomen).<\/li><li>Alternate injection sites within the same area where you inject each day reduce the risk of developing nodules or pits in the skin (see section 4).<\/li><li>Always use a new injection needle for each\u00a0injection.\u00a0Reusing needles can increase the risk of clogged needles and lead to incorrect\u00a0dosing.\u00a0Dispose of the needle safely after each use.\u00a0<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Tresiba<\/h2>\n\n\n\n<p>If you use too much\u00a0insulin, your blood sugar can become too low (hypoglycemia).\u00a0See the advice in section 4 &#8220;Too low blood sugar&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Tresiba<\/h2>\n\n\n\n<p>If you forget a\u00a0dose, inject the missed\u00a0dose\u00a0once you realize the mistake, but make sure there are at least 8 hours between\u00a0doses.\u00a0If you find that you have missed the previous\u00a0dose, when it is time to take the next scheduled\u00a0dose, do not inject a double\u00a0dose\u00a0but resume your once-a-day\u00a0dosing.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Tresiba<\/h2>\n\n\n\n<p>Do not stop using\u00a0insulin\u00a0without first talking to your doctor.\u00a0If you stop using\u00a0insulin, it can lead to very high blood sugar and\u00a0ketoacidosis\u00a0(a condition with too much acid in the blood).\u00a0See the advice in section 4 &#8220;Too high blood sugar&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Low blood sugar (hypoglycemia) is very common with insulin treatment (may affect more than 1 in 10 users).\u00a0It can be very serious.\u00a0If your blood sugar level drops too much, you may pass out.\u00a0Severe\u00a0hypoglycemia\u00a0can cause brain damage and be life-threatening.\u00a0If you have symptoms of low blood sugar (insulin sensitivity), get your blood sugar level raised immediately.\u00a0See the advice below under &#8220;Too low blood sugar&#8221;.<\/p>\n\n\n\n<p>If you have a serious\u00a0allergic reaction\u00a0(which occurs in rare cases) to\u00a0insulin\u00a0et or any of the ingredients in Tresiba, stop using Tresiba and see a doctor immediately.\u00a0The signs of a serious\u00a0allergic reaction\u00a0are that:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the local reactions spread to other parts of the body<\/li><li>you suddenly feel sick and sweat<\/li><li>you start vomiting<\/li><li>you have difficulty breathing<\/li><li>you get palpitations or feel dizzy.<\/li><\/ul>\n\n\n\n<p><strong>Skin changes at the injection site:<\/strong><\/p>\n\n\n\n<p>If you inject\u00a0insulin\u00a0in the same place, the fat tissue may either shrink (lipoatrophy) or thicken (lipohypertrophy) (which\u00a0may affect up to 1 in 100 people\u00a0).\u00a0Nodules under the skin can also be caused by the accumulation of a\u00a0protein\u00a0called amyloid (\u00a0cutaneous\u00a0amyloidosis. How often this occurs is not known).\u00a0Insulin\u00a0it may\u00a0not work as well if you inject it into an area with nodules or a thickened or shriveled area.\u00a0Change the injection site for each\u00a0injection\u00a0to prevent these skin changes.<\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;include:<\/p>\n\n\n\n<p><strong>Common&nbsp;<\/strong><em>(may affect up to 1 in 10 users)<\/em><\/p>\n\n\n\n<p><em>Local reactions:<\/em>\u00a0There may be local reactions at the\u00a0injection site.\u00a0It can include the following symptoms: pain,\u00a0redness,\u00a0hives, swelling, and\u00a0itching.\u00a0The reactions usually disappear after a few days.\u00a0See your doctor if they don&#8217;t go away after a few weeks.\u00a0Stop using Tresiba and see a doctor immediately if the reactions become severe.\u00a0More information can be found above under the section on severe allergic reactions.<\/p>\n\n\n\n<p><strong>Uncommon&nbsp;<\/strong><em>(may affect up to 1 in 100 users<\/em><\/p>\n\n\n\n<p><em>Swelling around the joints:<\/em>&nbsp;When you start treatment, more fluid than normal may accumulate in the body.&nbsp;This causes swelling around the ankles and other joints.&nbsp;Most of the time it is short-lived.<\/p>\n\n\n\n<p><strong>Rare&nbsp;<\/strong><em>(may affect up to 1 in 1,000 users<\/em><\/p>\n\n\n\n<p>This medicine can cause allergic reactions such as\u00a0hives, swelling of the tongue and lips, diarrhea, nausea, fatigue, and\u00a0itching.<\/p>\n\n\n\n<p><strong>General complications of diabetes treatment<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Too low blood sugar (hypoglycemia)<\/li><\/ul>\n\n\n\n<p><strong>You can get too low blood sugar:<\/strong><\/p>\n\n\n\n<p>if you drink alcohol, use too much\u00a0insulin, exercise more than usual, eat too little, or skip a meal.<\/p>\n\n\n\n<p><strong>Warning signs of low blood sugar \u2013 these can come on suddenly:<\/strong><\/p>\n\n\n\n<p>Headache, slurred speech, palpitations, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">cold<\/a> sweats, cool and pale skin, nausea, strong hunger, tremors or nervousness\/anxiety, feeling unusually tired, weakness and drowsiness, confusion and difficulty concentrating, and short-term vision changes.<\/p>\n\n\n\n<p><strong>This is what you do if you get low blood sugar<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Eat dextrose tablets or any other high-sugar snack, such as candy, cookies, or fruit juice.\u00a0(Always carry dextrose tablets or high-sugar snacks with you just in case.)<\/li><li>If possible, check your blood sugar and rest.\u00a0You may need to check your blood sugar more than once, as with all basal insulins the recovery from the period of low blood sugar may be delayed.<\/li><li>When the symptoms of low blood sugar have disappeared or when your blood sugar level has stabilized, continue your insulin treatment as usual<\/li><\/ul>\n\n\n\n<p><strong>So should others if you lose consciousness<\/strong><\/p>\n\n\n\n<p>Tell everyone you associate with that you have\u00a0diabetes.\u00a0Tell them what can happen if your blood sugar gets too low, for example, you may lose consciousness.<\/p>\n\n\n\n<p>Tell them that if you lose consciousness, they must do the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>turn on your side<\/li><li>get medical attention right away<\/li><li><strong>do not<\/strong>&nbsp;give yourself anything to eat or drink as you may suffocate.<\/li><\/ul>\n\n\n\n<p>You may regain consciousness more quickly if you receive an&nbsp;injection&nbsp;of glucagon.&nbsp;Such an&nbsp;injection&nbsp;should only be given by a person who knows how to use it.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are given glucagon, you will need sugar or a snack containing sugar as soon as you regain consciousness.<\/li><li>If you do not respond to the glucagon injection, you must be treated in the hospital.<\/li><li>If severely low blood sugar is not treated, it can eventually cause brain damage.\u00a0These can be short or long-term.\u00a0Low blood sugar can even cause death.<\/li><\/ul>\n\n\n\n<p><strong>Talk to your doctor about:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have had blood sugar so low that you have lost consciousness<\/li><li>you have used an&nbsp;injection&nbsp;of glucagon<\/li><li>you have had low blood sugar several times recently.<\/li><\/ul>\n\n\n\n<p>The dose\u00a0or timing of your insulin injections, your meals, or your exercise habits may need to be changed.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Too high blood sugar (&nbsp;hyperglycemia&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>You can get too high blood sugar:<\/strong><\/p>\n\n\n\n<p>if you eat more or exercise less than usual, drink alcohol, get an\u00a0infection\u00a0or fever, have not used enough\u00a0insulin, regularly use less\u00a0insulin\u00a0than you need, forget to use your\u00a0insulin, or stop using\u00a0insulin\u00a0without talking to your doctor first.<\/p>\n\n\n\n<p><strong>Warning signs of high blood sugar &#8211; these usually occur gradually:<\/strong><\/p>\n\n\n\n<p>Reddened dry skin;\u00a0drowsiness or tiredness;\u00a0dry mouth, fruity (acetone-like) breath;\u00a0frequent urination, thirst;\u00a0loss of appetite, nausea, or vomiting.<\/p>\n\n\n\n<p>These signs may indicate a very serious condition called\u00a0ketoacidosis.\u00a0It means an accumulation of acid in the blood because the body breaks down fat instead of sugar.\u00a0If left untreated, it can lead to diabetic coma and eventually death.<\/p>\n\n\n\n<p><strong>This is what you do if you get high blood sugar<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Test your blood sugar level.<\/li><li>Do a urine or blood ketone test.<\/li><li>Seek medical attention immediately.<\/li><\/ul>\n\n\n\n<p>If you get\u00a0side effects, talk to your doctor, pharmacist, or nurse.\u00a0This also applies to any\u00a0side effects\u00a0that are not mentioned in this information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tresiba<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the&nbsp;Penfill&nbsp;label and carton after &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><strong>Before first use<\/strong><\/p>\n\n\n\n<p>Store in a refrigerator (2\u00b0C to 8\u00b0C).&nbsp;Do not freeze.&nbsp;Do not store near the cooling element.<\/p>\n\n\n\n<p><strong>After first use or if included as a spare<\/strong><\/p>\n\n\n\n<p>Do not store it in a refrigerator.\u00a0You can take the Tresiba cartridge\u00a0( Penfill\u00a0)\u00a0with\u00a0you and store it at room temperature (maximum 30\u00b0C) for up to 8 weeks.<\/p>\n\n\n\n<p>To protect Tresiba&nbsp;Penfill&nbsp;from light, always store it in the outer carton when not in use.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is\u00a0insulin\u00a0degludec.\u00a0Each ml of solution contains 100 units of\u00a0insulin\u00a0degludec.\u00a0Each\u00a0cartridge\u00a0contains 300 units of\u00a0insulin\u00a0degludec in 3 ml of solution.<\/li><li>Other ingredients are\u00a0glycerol, metacresol, phenol, zinc acetate,\u00a0hydrochloric acid\u00a0and sodium hydroxide (for\u00a0pH\u00a0adjustment), and water for injections (see section 2).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tresiba is a clear and colorless&nbsp;solution for injection&nbsp;in a&nbsp;cartridge&nbsp;(300 units per 3 ml).<\/p>\n\n\n\n<p>Pack sizes: 5 and 10&nbsp;cartridges&nbsp;of 3 ml.&nbsp;Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Novo Nordisk A\/S<\/p>\n\n\n\n<p>Novo All\u00e9<\/p>\n\n\n\n<p>DK-2880 Bagsv\u00e6rd, Denmark<\/p>\n","protected":false},"excerpt":{"rendered":"<p>100 units\/ml\u00a0solution for injection\u00a0in\u00a0cartridge<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[26400,26405,26401,26397,26396,26403,26398,26399,26402,26404],"class_list":["post-25590","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-insulin-degludec","tag-benefits-of-tresiba","tag-insulin-degludec","tag-insulin-degludec-side-effects","tag-tresiba","tag-tresiba-side-effects","tag-what-insulin-degludec-is-used-for","tag-what-is-insulin-degludec","tag-what-is-tresiba","tag-what-tresiba-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25590","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25590"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25590\/revisions"}],"predecessor-version":[{"id":25619,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25590\/revisions\/25619"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25590"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25590"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25590"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}