1 mg\/ml, 2.5 mg\/ml, 5 mg\/ml and 10 mg\/ml respectively , solution for <\/p>\n\n\n\n
infusion What Trepulmix is<\/strong><\/p>\n\n\n\n The active substance in Trepulmix is \u200b\u200btreprostinil.<\/p>\n\n\n\n Treprostinil belongs to a group of drugs that act in a similar way to naturally occurring\u00a0prostacyclins.\u00a0Prostacyclins\u00a0are hormone-like substances that lower\u00a0blood pressure\u00a0by reducing the resistance in the blood vessels, causing them to widen so that blood flows more easily.\u00a0Prostacyclin\u00a0er can also prevent the blood from clotting.<\/p>\n\n\n\n What Trepulmix is \u200b\u200bused to treat<\/strong><\/p>\n\n\n\n Trepulmix is \u200b\u200bused to treat adult patients with chronic thromboembolic pulmonary hypertension (CTEPH) that cannot be cured by surgery, or CTEPH that persists or recurs after surgery (severity classified as WHO functional class III or IV), to improve exercise capacity and disease symptoms. Chronic thromboembolic pulmonary hypertension (CTEPH) is a condition in which blood pressure is too high in the blood vessels between the heart and lungs, causing shortness of breath, dizziness, fatigue, fainting spells, palpitations or abnormal heartbeats, dry cough<\/a>, chest pain, and swollen ankles or legs.<\/p>\n\n\n\n How Trepulmix works<\/strong><\/p>\n\n\n\n Trepulmix lowers blood pressure inside the pulmonary artery by improving blood flow and reducing the heart’s workload. Improved blood flow leads to an increased supply of oxygen to the body and reduced strain on the heart, making it work more efficiently. Trepulmix improves symptoms associated with CTEPH and exercise capacity in patients with limited activity capacity. Talk to your doctor before using Trepulmix if you<\/p>\n\n\n\n Inform your doctor during treatment with Trepulmix<\/p>\n\n\n\n Trepulmix must not be given to children and adolescents.<\/a><\/p>\n\n\n\n Tell the doctor if you are taking\/using, have recently taken\/used, or maybe taking\/using other medicines.\u00a0Tell your doctor if you are taking<\/p>\n\n\n\n Trepulmix is \u200b\u200bnot recommended if you are pregnant, planning to become pregnant, or think you may be pregnant unless your doctor considers it necessary.\u00a0The safety of this medicine, when given to pregnant women, has not been established.<\/p>\n\n\n\n Contraception is strongly recommended during treatment with Trepulmix.<\/p>\n\n\n\n Use of Trepulmix is \u200b\u200bnot recommended during breastfeeding unless the doctor considers it necessary.\u00a0You are advised to stop breastfeeding if you have been prescribed Trepulmix.\u00a0It is not known whether this medicine passes into breast milk.<\/p>\n\n\n\n If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.<\/p>\n\n\n\n Trepulmix can cause low blood pressure with dizziness or fainting. In this case, you must not drive vehicles or use machines. Ask your doctor for advice<\/a><\/p>\n\n\n\n Trepulmix contains sodium<\/strong><\/p>\n\n\n\n Tell your doctor if you are on a low salt (low sodium) diet. They will take this into account.<\/p>\n\n\n\n Trepulmix 1 mg\/ml solution for infusion<\/em><\/p>\n\n\n\n This medicine contains 36.8 mg of\u00a0sodium\u00a0(the main ingredient in common\/table salt) in each\u00a0vial.\u00a0This corresponds to 1.8 percent of the maximum recommended daily intake of dietary\u00a0sodium\u00a0for adults.<\/p>\n\n\n\n Trepulmix 2.5 mg\/ml solution for infusion<\/em><\/p>\n\n\n\n This medicine contains 37.3 mg of\u00a0sodium\u00a0(the main ingredient in common\/table salt) in each\u00a0vial.\u00a0This corresponds to 1.9 percent of the maximum recommended daily intake of dietary\u00a0sodium\u00a0for adults.<\/p>\n\n\n\n Trepulmix 5 mg\/ml solution for infusion<\/em><\/p>\n\n\n\n This medicine contains 39.1 mg of\u00a0sodium\u00a0(the main ingredient in common\/table salt) in each\u00a0vial.\u00a0This is equivalent to 2.0 percent of the maximum recommended daily intake of dietary\u00a0sodium\u00a0for adults.<\/p>\n\n\n\n Trepulmix 10 mg\/ml solution for infusion<\/em><\/p>\n\n\n\n This medicine contains 37.4 mg of\u00a0sodium\u00a0(the main ingredient in common\/table salt) in each\u00a0vial.\u00a0This corresponds to 1.9 percent of the maximum recommended daily intake of dietary\u00a0sodium\u00a0for adults. Always use this medicine as directed by your doctor. Consult your doctor if you are unsure.<\/p>\n\n\n\n Trepulmix is \u200b\u200bgiven undiluted as a continuous subcutaneous infusion (under the skin) via a thin tube (a cannula) placed in the abdomen or thigh.<\/p>\n\n\n\n Trepulmix is \u200b\u200bpushed through the tube by a portable pump.<\/p>\n\n\n\n Before you leave the hospital or clinic, your doctor will tell you how to prepare Trepulmix and at what rate the pump should deliver your treprostinil. You should also receive information on how to use the pump correctly and what to do if it stops working. The information must also explain who to contact in an emergency.<\/p>\n\n\n\n Flushing the infusion set while it is connected can cause an accidental overdose.<\/p>\n\n\n\n Adult patients<\/em><\/p>\n\n\n\n Trepulmix is \u200b\u200bavailable as 1 mg\/ml, 2.5 mg\/ml, 5 mg\/ml or 10 mg\/ml infusion solution , solution. Your doctor will determine the appropriate infusion rate and dose for your condition.<\/p>\n\n\n\n Elderly patients<\/em><\/p>\n\n\n\n No special dose adjustments are needed for these patients.<\/p>\n\n\n\n Patients with liver or kidney disease<\/em><\/p>\n\n\n\n Your doctor will determine the appropriate infusion rate and dose for your condition.<\/p>\n\n\n\n Infusion rate<\/em><\/p>\n\n\n\n The infusion rate can be decreased or increased based on an individual assessment\u00a0only under medical supervision<\/strong>.<\/p>\n\n\n\n The purpose of adjusting the infusion rate is to establish an effective maintenance rate at which CTEPH symptoms improve while\u00a0minimizing potential\u00a0side effects.<\/p>\n\n\n\n If your symptoms increase you need complete rest, or are bedridden or confined to a chair, or if any physical activity causes discomfort and your symptoms occur at rest, do not increase the\u00a0dose\u00a0without consulting a doctor.\u00a0Trepulmix may no longer be enough to treat your illness, and another treatment may be needed.<\/p>\n\n\n\n If you have accidentally overdosed on Trepulmix, you may experience nausea, vomiting, diarrhea, low\u00a0blood pressure\u00a0(dizziness, lightheadedness, or fainting), skin flushing, and\/or headache.<\/p>\n\n\n\n If any of these effects become serious, contact your doctor or hospital immediately. The doctor may lower or stop the infusion until your symptoms have disappeared. Trepulmix solution for infusion will then be reintroduced at a dose level recommended by the doctor.<\/a><\/p>\n\n\n\n Always use Trepulmix as directed by your doctor or hospital specialist. Do not stop taking Trepulmix unless your doctor tells you to.<\/p>\n\n\n\n Abrupt discontinuation or sudden dose reductions of Trepulmix may lead to a return of pulmonary arterial hypertension and your condition may rapidly and severely deteriorate.<\/p>\n\n\n\n If you have any further questions about this medicine, ask your doctor.<\/a><\/p>\n\n\n\n Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n Very common (may affect more than 1 in 10 users):<\/em><\/p>\n\n\n\n Common (may affect up to 1 in 10 users):<\/em><\/p>\n\n\n\n Uncommon (may affect up to 1 in 100 users):<\/em><\/p>\n\n\n\n
treprostinil<\/a><\/p>\n\n\n\n What Trepulmix is \u200b\u200band what it is used for<\/h2>\n\n\n\n
<\/a><\/p>\n\n\n\nWhat you need to know before using Trepulmix<\/h2>\n\n\n\n
Do not use Trepulmix<\/h2>\n\n\n\n
Warnings and precautions<\/h2>\n\n\n\n
Children and young people<\/h2>\n\n\n\n
Other medicines and Trepulmix<\/h2>\n\n\n\n
Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n
Driving ability and use of machinery<\/h2>\n\n\n\n
Trepulmix contains excipients<\/h2>\n\n\n\n
<\/p>\n\n\n\nHow to use Trepulmix<\/h2>\n\n\n\n
If you have used too much Trepulmix <\/h2>\n\n\n\n
If you stop using Trepulmix<\/h2>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n