{"id":25548,"date":"2022-09-20T07:00:01","date_gmt":"2022-09-20T07:00:01","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25548"},"modified":"2022-09-21T07:08:32","modified_gmt":"2022-09-21T07:08:32","slug":"tremfya","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tremfya\/","title":{"rendered":"Tremfya &#8211; Guselkumab uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg&nbsp;solution for injection&nbsp;in pre-filled&nbsp;pen&nbsp;guselkumab<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tremfya is and what it is used for<\/h2>\n\n\n\n<p>Tremfya contains the active substance guselkumab which is a type of\u00a0protein\u00a0called a monoclonal\u00a0antibody.<\/p>\n\n\n\n<p>This medicine works by blocking the activity of a\u00a0protein\u00a0called IL-23 that occurs at elevated levels in people with\u00a0psoriasis\u00a0and psoriatic arthritis.<\/p>\n\n\n\n<p><strong>Plaque psoriasis<\/strong><\/p>\n\n\n\n<p>Tremfya is used to treat adults with moderate to severe &#8216;plaque psoriasis, an\u00a0inflammatory\u00a0disease that affects the skin and nails.<\/p>\n\n\n\n<p>Tremfya can improve the condition of the skin and the appearance of the nails and reduce symptoms such as scaling, skin irritation, flaking,\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/dry-skin-and-itching\/\">itching<\/a>, pain, and burning.<\/p>\n\n\n\n<p><strong>Psoriatic arthritis<\/strong><\/p>\n\n\n\n<p>Tremfya is used to treat a condition called psoriatic arthritis, an&nbsp;inflammatory&nbsp;disease of the joints that is often accompanied by plaque psoriasis.&nbsp;If you have psoriatic arthritis, you will first receive other medicines.&nbsp;If these medicines do not work well enough or in case of intolerance, you will be given Tremfya to reduce the signs and symptoms of the disease.&nbsp;Tremfya can be used alone or with another medicine called methotrexate.<\/p>\n\n\n\n<p>Using Tremfya for psoriatic arthritis reduces the signs and symptoms of the disease, slows down the damage to the\u00a0cartilage\u00a0and bone in the joints, and improves your ability to carry out normal activities.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Tremfya<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Tremfya<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to guselkumab or any of the other ingredients of this medicine (listed in section 6).\u00a0Consult a doctor before using Tremfya if you think you may be allergic.<\/li><li>if you have an active\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/infection-and-inflammation\/\">infection<\/a>, including active\u00a0tuberculosis.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Tremfya:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are being treated for an\u00a0infection<\/li><li>if you have an\u00a0infection\u00a0that does not go away or is recurrent<\/li><li>if you have\u00a0tuberculosis\u00a0or have been in close contact with someone who has\u00a0tuberculosis<\/li><li>if you think you have an\u00a0infection\u00a0or have symptoms of an\u00a0infection\u00a0(see below under \u201cBe aware of\u00a0the infection\u00a0and allergic reactions\u201d)<\/li><li>if you have recently received a vaccination or if you have a planned vaccination during treatment with Tremfya.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Tremfya if you are not sure if any of the above apply to you.<\/p>\n\n\n\n<p>You may need blood tests to check if you have high levels of liver enzymes before you start Tremfya and while you are using it.&nbsp;Your doctor will decide on this.&nbsp;Elevated liver enzymes may occur more often in patients receiving Tremfya every 4 weeks than in patients receiving Tremfya every 8 weeks (see \u201cHow to use Tremfya\u201d in section 3).<\/p>\n\n\n\n<p><strong>Be aware of\u00a0the infection\u00a0and allergic reactions<\/strong><\/p>\n\n\n\n<p>Tremfya can potentially cause serious\u00a0side effects, including allergic reactions and\u00a0infection.\u00a0You need to be alert for signs of these conditions while taking Tremfya.<\/p>\n\n\n\n<p>Signs of\u00a0infection\u00a0may include fever or flu-like symptoms;\u00a0muscle pain;\u00a0cough;\u00a0shortness of breath;\u00a0burning sensation when you urinate or that you urinate more often than usual;\u00a0blood in expectoration (phlegm);\u00a0weight loss;\u00a0diarrhea or stomach pain;\u00a0hot, red, or painful skin or sores on the body that are different from your\u00a0psoriasis.<\/p>\n\n\n\n<p>Serious allergic reactions, which may include symptoms such as swelling of the face, lips, mouth, tongue, or throat, difficulty swallowing or breathing and\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/hives\/\">hives<\/a>, have occurred with Tremfya (see \u201cSerious side effects\u201d in section 4).<\/p>\n\n\n\n<p>Stop using Tremfya and tell the doctor or seek medical attention\u00a0<strong>immediately<\/strong>\u00a0if you observe any signs of a possible serious\u00a0allergic reaction\u00a0or an\u00a0infection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Tremfya is not recommended for children and adolescents under 18 years of age as it has not been studied in this age group.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tremfya<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are using, have recently used, or may be using other medicines<\/li><li>if you have recently received or are about to receive a vaccination.\u00a0You should not receive certain types of vaccines (live vaccines) while using Tremfya.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Tremfya should not be used during pregnancy as the effects of this medicine on pregnant women are not known.\u00a0If you are a woman of\u00a0childbearing potential, it is recommended that you avoid becoming pregnant and you must use adequate contraception while using Tremfya and for at least 12 weeks after the last\u00a0dose\u00a0of Tremfya.\u00a0Talk to your doctor if you are pregnant, think you may be pregnant, or are planning to have a baby.<\/li><li>Talk to your doctor if you are breastfeeding or plan to breastfeed.\u00a0You and your doctor should decide whether you should breastfeed or use Tremfya.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Tremfya is unlikely to affect your ability to drive or use machines.<a><\/a><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Tremfya<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How much Tremfya is given and for how long<\/strong><\/p>\n\n\n\n<p>Your doctor will decide how long you need to use Tremfya.<\/p>\n\n\n\n<p>Plaque psoriasis<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dose\u00a0one is 100 mg (the content of 1 pre-filled\u00a0injection pen\u00a0) and is given by\u00a0injection\u00a0under the skin (\u00a0subcutaneous\u00a0injection\u00a0).\u00a0It can be given by a doctor or nurse.<\/li><li>You will receive the next\u00a0dose\u00a04 weeks after the first\u00a0dose, and then every 8 weeks.<\/li><\/ul>\n\n\n\n<p>Psoriatic arthritis<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dose\u00a0one is 100 mg (the content of 1 pre-filled\u00a0injection pen\u00a0) and is given by\u00a0injection\u00a0under the skin (\u00a0subcutaneous\u00a0injection\u00a0).\u00a0It can be given by a doctor or nurse.<\/li><li>You will receive the next\u00a0dose\u00a04 weeks after the first\u00a0dose, and then every 8 weeks.\u00a0In some patients, Tremfya can be given every 4 weeks, after the first\u00a0dose.\u00a0Your doctor will decide how often you can receive Tremfya.<\/li><\/ul>\n\n\n\n<p>In the beginning, the doctor or nurse will inject Tremfya, but you can decide together with your doctor to give Tremfya yourself.\u00a0If so, you will receive the necessary training on how to inject Tremfya.\u00a0Talk to the doctor or nurse if you have any questions about giving yourself an\u00a0injection.\u00a0You mustn&#8217;t try to inject yourself until you have been trained by a doctor or nurse.<\/p>\n\n\n\n<p>Carefully read the &#8220;Handling instructions&#8221; leaflet, which is supplied in the box, before using it for detailed instructions on how to use Tremfya.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Tremfya<\/h2>\n\n\n\n<p>Inform the doctor if you have received too much Tremfya or if a&nbsp;dose&nbsp;has been given earlier than prescribed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Tremfya<\/h2>\n\n\n\n<p>Tell your doctor if you forget to inject a&nbsp;dose&nbsp;of Tremfya.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Tremfya<\/h2>\n\n\n\n<p>You should not stop using Tremfya without first talking to your doctor.&nbsp;If you stop treatment, symptoms may return.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong><u>Serious&nbsp;side effects&nbsp;are<\/u><\/strong><\/p>\n\n\n\n<p>Tell your doctor or seek medical attention immediately if you experience any of the following side effects:<\/p>\n\n\n\n<p><strong>Possible serious&nbsp;allergic reaction<\/strong>&nbsp;&nbsp;(may affect up to 1 in 100 users) &#8211; symptoms may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty breathing or swallowing<\/li><li>swelling of the face, lips, tongue, or throat<\/li><li>severe skin itching, with red rashes or raised nodules<\/li><\/ul>\n\n\n\n<p><strong><u>Other\u00a0side effects\u00a0are<\/u><\/strong><\/p>\n\n\n\n<p>All of the following\u00a0side effects\u00a0are mild to moderate.\u00a0Tell your doctor, pharmacist, or nurse immediately if any of these\u00a0side effects\u00a0become serious.<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>respiratory tract infections<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/headache\/\">headache<\/a><\/li><li>joint pain (\u00a0arthralgia\u00a0)<\/li><li>diarrhea<\/li><li>redness, irritation, or pain at the injection site<\/li><li>elevated liver enzymes in the blood<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reaction<\/li><li>rash<\/li><li>reduced number of a type of&nbsp;white blood&nbsp;cell&nbsp;called&nbsp;neutrophils<\/li><li>herpes&nbsp;simplex&nbsp;infection&nbsp;_<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/fungal-infections\/\">fungal infection<\/a> of the skin, e.g.&nbsp;between the toes (e.g.&nbsp;athlete&#8217;s foot&nbsp;)<\/li><li>stomach ailment (&nbsp;gastroenteritis&nbsp;)<\/li><li>hives<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tremfya<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the pre-filled pen label and the outer carton after &#8216;EXP&#8217;.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store the pre-filled pen in the outer carton.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C\u20138 \u00b0C).&nbsp;Do not freeze.<\/p>\n\n\n\n<p>Must not be shaken.<\/p>\n\n\n\n<p>Do not use this medicine if the medicine is cloudy or discolored or contains large particles.&nbsp;Remove the carton from the refrigerator and leave the pre-filled pen in the carton for 30 minutes to reach room temperature before use.<\/p>\n\n\n\n<p>This medicine is for single use only.\u00a0Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is guselkumab.\u00a0Each pre-filled\u00a0pen\u00a0contains 100 mg of guselkumab in 1 ml of solution.<\/li><li>Other ingredients are histidine, histidine monohydrochloride monohydrate, polysorbate 80, sucrose, and water for\u00a0injection.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tremfya is a clear, colorless pale yellow\u00a0solution for injection\u00a0(\u00a0solution for injection\u00a0).\u00a0It is supplied in packs containing one pre-filled\u00a0pen\u00a0and in multipacks consisting of 2 cartons, each containing 1 pre-filled\u00a0pen.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Janssen-Cilag International NV<\/p>\n\n\n\n<p>Turnhoutseweg 30<\/p>\n\n\n\n<p>B-2340 Beerse<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Janssen Biologics BV<\/p>\n\n\n\n<p>Einsteinweg 101<\/p>\n\n\n\n<p>2333CB Leiden<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tremfya is used to treat adults with moderate to severe &#8216;plaque psoriasis&#8217;, an\u00a0inflammatory\u00a0disease that affects the skin and nails.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[26345,26352,26343,26347,26346,26350,26348,26344,26349,26351],"class_list":["post-25548","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-guselkumab","tag-benefits-of-tremfya","tag-guselkumab","tag-guselkumab-side-effects","tag-tremfya","tag-tremfya-side-effects","tag-what-guselkumab-is-used-for","tag-what-is-guselkumab","tag-what-is-tremfya","tag-what-tremfya-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25548","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25548"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25548\/revisions"}],"predecessor-version":[{"id":25574,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25548\/revisions\/25574"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25548"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25548"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25548"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}