{"id":25540,"date":"2022-09-20T06:55:06","date_gmt":"2022-09-20T06:55:06","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25540"},"modified":"2022-09-21T07:08:54","modified_gmt":"2022-09-21T07:08:54","slug":"trecondi","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/trecondi\/","title":{"rendered":"Trecondi &#8211; Treosulfan uses, dose and side effects"},"content":{"rendered":"\n<p>1 g and 5 g of\u00a0powder for\u00a0infusion,<br>treosulfan solution<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Trecondi is and what it is used for<\/h2>\n\n\n\n<p>Trecondi contains the active substance treosulfan, which belongs to a group of medicines called alkylating agents.<\/p>\n\n\n\n<p>Treosulfan is used to prepare patients for bone marrow transplantation (\u00a0hematopoietic\u00a0stem cell transplantation\u00a0).\u00a0Treosulfan destroys the bone marrow cells and enables the transplantation of new bone marrow cells so that the body can produce healthy\u00a0blood cells.<\/p>\n\n\n\n<p>Trecondi is used as\u00a0<strong>treatment before blood stem cell transplantation<\/strong>\u00a0in adults with cancer and other diseases (non-malignant diseases) and adolescents and children over one month of age with cancer<strong>.<\/strong><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you are given Trecondi<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Trecondi<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to treosulfan<\/li><li>if you have an active uncontrolled\u00a0infection<\/li><li>if you have severe heart, lung, liver, or kidney disease<\/li><li>if you have hereditary\u00a0DNA\u00a0repair deficiency, which is a condition that reduces the ability to repair\u00a0DNA\u00a0(which contains your genetic information)<\/li><li>if you are pregnant or think you may be pregnant.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Trecondi is a cell-killing (cytotoxic) medicine used to reduce the number of\u00a0blood cells.\u00a0At the recommended\u00a0dose, this is the desired effect.\u00a0Blood samples will be taken regularly during the treatment to check that the\u00a0blood cell count\u00a0does not become too low.<\/p>\n\n\n\n<p>To prevent and treat\u00a0infection, you will receive medicines, such as\u00a0antibiotics, antifungal medicines, and antiviral medicines.<\/p>\n\n\n\n<p>Trecondi can increase the risk of getting another form of cancer in the future.<\/p>\n\n\n\n<p>Since&nbsp;inflammation&nbsp;of the oral mucosa is a common&nbsp;side effect&nbsp;of this medicine, you must be careful with your oral hygiene.&nbsp;For preventive purposes, the use of mouth rinses (e.g. with barrier-protecting or bactericidal effect) or ice in the oral cavity (reduces blood flow to the oral mucosa and reduces the amount of treosulfan reaching the cells) is recommended.<\/p>\n\n\n\n<p>You must not be vaccinated with live vaccines (certain types of vaccines) during treatment with treosulfan.<\/p>\n\n\n\n<p>Trecondi can cause menopause-like symptoms (missing periods).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>In very rare cases, seizures may occur in infants under 4 months of age.&nbsp;Children under 1 year of age can have more serious&nbsp;side effects&nbsp;that affect breathing, compared to older children.&nbsp;Your child will be monitored for signs of&nbsp;side effects&nbsp;affecting the nerves and breathing problems.<\/p>\n\n\n\n<p>Diaper rash with ulcers in the area around the rectal opening can occur in infants, young children, and infants because treosulfan excreted in the urine can damage the skin.\u00a0Therefore, the child&#8217;s nappy should be changed frequently for 6\u20138 hours after each\u00a0dose\u00a0of this medicine.<\/p>\n\n\n\n<p>There is not enough information on the use of treosulfan in children younger than 1 month.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Trecondi<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might be taking any other medicines, even those without a prescription.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>You must not become pregnant during treatment with this medicine and up to 6 months after treatment.&nbsp;Use effective contraception when either you or your partner receives this medicine.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.<\/p>\n\n\n\n<p>You should stop breastfeeding before starting treatment with this medicine.<\/p>\n\n\n\n<p>If you are a man and are treated with this medicine, you must not make a woman pregnant during treatment and up to 6 months after treatment.<\/p>\n\n\n\n<p>This medicine can make you infertile and it is not certain that you can get pregnant after treatment with it.&nbsp;If you are concerned about your ability to have children, you should discuss this with the doctor before treatment.&nbsp;Men should ask if there is an option to save sperm before starting the treatment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>This medicine may cause nausea, vomiting, and dizziness, which may impair the ability to drive and use machines.\u00a0If you suffer from these symptoms, you should not drive a motor vehicle or use machinery.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Trecondi is used<\/h2>\n\n\n\n<p><strong>Use for adults<\/strong><\/p>\n\n\n\n<p>This medicine is used in combination with the medicine fludarabine.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 10\u201314 g\/m\u00b2 body surface (calculated based on height and body weight).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>This medicine is used in combination with the medicine fludarabine and most cases also with the medicine thiotepa.\u00a0The recommended\u00a0dose\u00a0is 10\u201314 g\/m\u00b2 body surface.<\/p>\n\n\n\n<p><strong>How Trecondi is given<\/strong><\/p>\n\n\n\n<p>You will be given this medicine by your doctor.\u00a0It is given by drip (\u00a0infusion\u00a0) into a vein over 2 hours for 3 days before the blood stem cell infusion.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have been given too much Trecondi<\/h2>\n\n\n\n<p>As this medicine is given by a doctor, you will receive the correct\u00a0dose.\u00a0If you still think you have been given more of this medicine than you should, tell your doctor or nurse as soon as possible.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>The most serious&nbsp;side effects&nbsp;of treosulfan treatment or&nbsp;stem cell transplantation&nbsp;are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of\u00a0blood cells, which is the intended effect of the medicine to prepare you for the transplant infusion (all patients: very common)<\/li><li>infection\u00a0caused by bacteria,\u00a0viruses,\u00a0and fungi (all patients: very common)<\/li><li>blockage of a vein going to the liver (adults: less common; children and adolescents: have been reported)<\/li><li>pneumonia\u00a0(\u00a0pneumonitis\u00a0) (adults: less common)<\/li><\/ul>\n\n\n\n<p>The doctor will check your blood levels and liver enzymes to detect and treat these\u00a0side effects.<\/p>\n\n\n\n<p><strong><em>Adults<\/em><\/strong><\/p>\n\n\n\n<p>All other side effects&nbsp;are listed below&nbsp;according to how common they are.<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of\u00a0white blood cells\u00a0with fever (febrile\u00a0neutropenia\u00a0)<\/li><li>inflammation\u00a0of the mucous membrane in various parts of the body, especially in the mouth (which can cause ulcers), diarrhea, nausea, vomiting, stomach pain<\/li><li>fatigue<\/li><li>increased level of\u00a0bilirubin\u00a0(a pigment in the liver which is often a sign of liver problems) in the blood<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood poisoning (\u00a0sepsis\u00a0)<\/li><li>allergic reactions<\/li><li>decreased appetite<\/li><li>sleep problems (insomnia)<\/li><li>headache, dizziness<\/li><li>changes and abnormalities in heart rhythm (heartbeats are irregular, too fast or too slow)<\/li><li>high\u00a0blood pressure,\u00a0flushing<\/li><li>breathing difficulties, nosebleeds<\/li><li>pain in the mouth,\u00a0inflammation\u00a0of the stomach, upset stomach, constipation, difficulty swallowing<\/li><li>a type of rash with flat or raised red bumps on the skin (maculopapular rash), red dots on the skin (purpura), reddening of the skin (\u00a0erythema\u00a0), hand-foot syndrome (palms or soles of the feet tingling, numbness, swelling, and pain, or becoming red), itching, hair loss<\/li><li>pain in arms or legs, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/back-hurts\/\">back pain<\/a>, bone pain, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/joint-pain\/\">joint pain<\/a>, muscle pain<\/li><li>sudden deterioration of kidney function, blood in the urine<\/li><li>fluid accumulation in the body causing swelling (\u00a0edema\u00a0), fever, chills<\/li><li>increase in liver enzymes, increase in C-reactive\u00a0protein\u00a0(a marker of inflammation in the body), weight gain, weight loss<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar<\/a><\/li><li>confusion<\/li><li>problems in the nerves in the arms and legs with symptoms such as numbness decreased or increased sensitivity, tingling, burning pain (\u00a0peripheral\u00a0sensory\u00a0neuropathy\u00a0)<\/li><li>bruising, low\u00a0blood pressure<\/li><li>fluid around the lungs,\u00a0inflammation\u00a0of the throat,\u00a0inflammation\u00a0or pain in the larynx, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a>, hiccups<\/li><li>bleeding in the mouth, a feeling of bloating, pain in the esophagus or stomach,\u00a0dry mouth<\/li><li>liver damage<\/li><li>a type of rash with red dots and sometimes with areas that may be purple or have blisters in the center (erythema multiforme),\u00a0acne, rash, heavy sweating<\/li><li>chest pain, pain<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurring in an unknown number of users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a life-threatening condition associated with blood poisoning (\u00a0septic\u00a0shock\u00a0)<\/li><li>other cancer caused by\u00a0chemotherapy\u00a0(secondary\u00a0malignancy\u00a0)<\/li><li>increased acidity in the blood, abnormal blood sugar level, abnormal level of\u00a0electrolytes\u00a0in the blood (salts in the blood)<\/li><li>restlessness<\/li><li>abnormal brain function (\u00a0encephalopathy\u00a0);\u00a0cerebral hemorrhage;\u00a0restless, repetitive, or involuntary movements and rapid speech (extrapyramidal disorder);\u00a0fainting;\u00a0a crawling, tingling, or numbing sensation (\u00a0paresthesia\u00a0)<\/li><li>dry eyes<\/li><li>the heart does not pump enough blood for the body&#8217;s needs (\u00a0heart failure\u00a0), heart attack, fluid in the pericardium<\/li><li>blood clot, bleeding<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sore-throat\/\">sore throat<\/a>, reduced oxygen supply to a\u00a0tissue\u00a0(\u00a0hypoxia\u00a0), hoarseness<\/li><li>bleeding in the gastrointestinal tract,\u00a0inflammation\u00a0of the large intestine,\u00a0inflammation\u00a0of the esophagus,\u00a0inflammation\u00a0of the rectal opening, mouth ulcers<\/li><li>liver failure, enlarged liver, liver pain<\/li><li>skin redness (generalized\u00a0erythema\u00a0), skin inflammation (\u00a0dermatitis\u00a0), dead skin tissue, skin ulcers, bronze-colored skin, dry skin<\/li><li>muscle weakness<\/li><li>kidney failure,\u00a0inflammation\u00a0of the bladder (\u00a0cystitis\u00a0), pain when urinating<\/li><li>pain or\u00a0inflammation\u00a0at the injection site, feeling cold<\/li><li>increased level of\u00a0creatinine\u00a0(a substance normally removed by the kidneys and excreted in the urine) in the blood, increased level of\u00a0lactate dehydrogenase\u00a0(a substance that indicates tissue or cell damage) in the blood<\/li><\/ul>\n\n\n\n<p><strong><em>Children and young people<\/em><\/strong><\/p>\n\n\n\n<p>All other side effects&nbsp;are listed below&nbsp;according to how common they are.<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation\u00a0of the mucous membranes, especially in the mouth (with ulcers), diarrhea, nausea, vomiting, stomach pain<\/li><li>itching<\/li><li>fever<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sore throat, nosebleed<\/li><li>difficulty swallowing, pain in the mouth<\/li><li>reddening\u00a0and peeling of much of the skin on the body (exfoliative\u00a0dermatitis\u00a0), a type of rash with flat or raised red bumps on the skin (maculopapular rash), rash, skin redness, skin pain, bronzed skin, hair loss<\/li><li>increase in liver enzymes increased level of\u00a0bilirubin\u00a0(a pigment in the liver which is often a sign of liver problems) in the blood<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurring in an unknown number of users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>other cancer caused by\u00a0chemotherapy\u00a0(secondary\u00a0malignancy\u00a0)<\/li><li>decreased number of\u00a0white blood cells\u00a0with fever (febrile\u00a0neutropenia\u00a0)<\/li><li>less acid than normal in the blood (\u00a0alkalosis\u00a0), abnormal level of\u00a0electrolytes\u00a0in the blood, reduced level of\u00a0magnesium\u00a0in the blood<\/li><li>headache;\u00a0a crawling, tingling, or numbness sensation (\u00a0paresthesia\u00a0);\u00a0convulsions<\/li><li>eye bleeding, dry eyes<\/li><li>fluid leakage from the\u00a0capillaries\u00a0(small blood vessels), high\u00a0blood pressure, low\u00a0blood pressure<\/li><li>reduced oxygen supply to parts of the body (\u00a0hypoxia\u00a0)<\/li><li>inflammation\u00a0of the colon, inflammation of the rectal opening, stomach upset,\u00a0inflammation\u00a0of the rectal mucosa, pain in the gastrointestinal tract, constipation<\/li><li>enlarged liver, liver damage<\/li><li>skin sores, a type of rash with red dots and sometimes with areas that may be purple or have blisters in the center (erythema multiforme),\u00a0hives, a skin condition with fluid-filled blisters (\u00a0dermatitis\u00a0bullous ),\u00a0acne, hand-foot syndrome (the palms of the hands or soles of the feet get tingling, numbness, becomes swollen and painful, or becomes red), diaper rash with sores in the area around the anus<\/li><li>pain in arms or legs<\/li><li>impaired kidney function,\u00a0kidney failure,\u00a0inflammation\u00a0of the bladder (\u00a0cystitis\u00a0)<\/li><li>skin redness on the scrotum<\/li><li>chills, fatigue, pain<\/li><li>increased level of a liver enzyme (gamma-glutamyltransferase) in the blood<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How Trecondi should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p><br>Use before the expiry date stated on the label and carton after &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Storage instructions for the medicine after&nbsp;preparation&nbsp;can be found in the section below for healthcare professionals.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is treosulfan.&nbsp;This medicine has no other ingredients.<\/p>\n\n\n\n<p><strong><em>Trecondi 1 g powder for\u00a0infusion, solution<\/em><\/strong><\/p>\n\n\n\n<p>1&nbsp;vial&nbsp;contains 1 g of treosulfan.<\/p>\n\n\n\n<p><strong><em>Trecondi 5 g powder for\u00a0infusion, solution<\/em><\/strong><\/p>\n\n\n\n<p>1&nbsp;vial&nbsp;contains 5 g of treosulfan.<\/p>\n\n\n\n<p>After reconstitution, 1 ml of the solution contains 50 mg of treosulfan.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>White crystalline powder in a glass vial with a rubber stopper and an aluminum cap.<\/p>\n\n\n\n<p>Trecondi is available in packs containing 1 or 5 vials (type I glass).<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>medac<\/p>\n\n\n\n<p>Gesellschaft f\u00fcr klinische Spezialpr\u00e4parate mbH<\/p>\n\n\n\n<p>Theater.\u00a06<\/p>\n\n\n\n<p>22880 Wedel<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Tel.: +49 4103 8006-0<\/p>\n\n\n\n<p>Fax: +49 4103 8006-100<\/p>\n\n\n\n<p>Email: contact@medac.de<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Trecondi contains the active substance treosulfan, which belongs to a group of medicines called alkylating agents.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[26365,26360,26362,26363,26356,26357,26361,26358,26364,26359],"class_list":["post-25540","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-trecondi","tag-benefits-of-treosulfan","tag-trecondi","tag-trecondi-side-effects","tag-treosulfan","tag-treosulfan-side-effects","tag-what-is-trecondi","tag-what-is-treosulfan","tag-what-trecondi-is-used-for","tag-what-treosulfan-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25540","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25540"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25540\/revisions"}],"predecessor-version":[{"id":25576,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25540\/revisions\/25576"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25540"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25540"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25540"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}