{"id":25537,"date":"2022-09-20T06:53:03","date_gmt":"2022-09-20T06:53:03","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25537"},"modified":"2022-09-21T07:09:01","modified_gmt":"2022-09-21T07:09:01","slug":"trazimera","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/trazimera\/","title":{"rendered":"Trazimera &#8211; Trastuzumab uses, dose and side effects"},"content":{"rendered":"\n<p>Trazimera 150 mg powder for concentrate for solution for infusion&nbsp;Trazimera 420 mg powder for concentrate for&nbsp;solution for&nbsp;infusion<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Trazimera is and what it is used for<\/h2>\n\n\n\n<p>Trazimera contains the active ingredient trastuzumab, which is a monoclonal\u00a0antibody.\u00a0Monoclonal\u00a0antibodies\u00a0attach to specific\u00a0proteins\u00a0or\u00a0antigens.\u00a0Trastuzumab is designed to bind selectively to an\u00a0antigen\u00a0called\u00a0human\u00a0epidermal\u00a0growth factor receptor 2 (\u00a0HER2\u00a0).\u00a0HER2\u00a0is found in large quantities on the surface of certain cancer cells and then stimulates cell growth.\u00a0When Trazimera binds to\u00a0HER2, the growth of the cancer cells is stopped and this leads to their death.<\/p>\n\n\n\n<p>Your doctor may prescribe Trazimera to treat breast and stomach cancer if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have early breast cancer with high levels of\u00a0protein\u00a0et\u00a0HER2.<\/li><li>you have metastatic breast cancer (breast cancer that has spread beyond the original\u00a0tumor) with high levels of\u00a0HER2.\u00a0Trazimera can be prescribed in combination with the\u00a0chemotherapy\u00a0drugs paclitaxel or docetaxel as first-line treatment for metastatic breast cancer, or it can be prescribed as the only treatment if other treatments have failed.\u00a0It is also used in combination with medicines called aromatase inhibitors to treat patients with high levels of\u00a0HER2\u00a0and hormone receptor-positive metastatic (spread) breast cancer (cancer that is sensitive to the presence of female sex hormones).<\/li><li>you have metastatic gastric cancer with high levels of\u00a0HER2\u00a0when it is used in combination with capecitabine or 5-fluorouracil and cisplatin.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you receive Trazimera<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Trazimera if<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>you are allergic to trastuzumab, murine (mouse)\u00a0protein, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>you have severe breathing problems at rest due to your cancer or if you need oxygen therapy.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Your doctor will closely monitor your treatment.<\/p>\n\n\n\n<p><strong>Control of&nbsp;<\/strong><strong>the heart<\/strong><\/p>\n\n\n\n<p>Treatment with Trazimera alone or in combination with a taxane may affect the heart, especially if you have previously been treated with an&nbsp;anthracycline&nbsp;(taxanes and&nbsp;anthracyclines&nbsp;are two other types of medicine used to treat cancer).&nbsp;Effects can be moderate to severe and some patients have died.&nbsp;Your heart function will therefore be checked before and during treatment (every three months) and after (up to two to five years) treatment with Trazimera.&nbsp;If you develop signs of&nbsp;heart failure&nbsp;(insufficient pumping of blood from the heart), your heart function may be checked more frequently (every six to eight weeks).&nbsp;You may then receive treatment for&nbsp;heart failure&nbsp;or possibly need to stop treatment with Trazimera.<\/p>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before you are given Trazimera if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have had\u00a0heart failure, coronary artery disease, valvular heart disease (heart\u00a0murmur\u00a0), or high\u00a0blood pressure\u00a0if you have taken or are currently taking medicines for high\u00a0blood pressure.<\/li><li>you have previously received or are currently receiving a medicine called doxorubicin or epirubicin (medicines used to treat cancer).\u00a0These medicines (or other\u00a0anthracyclines\u00a0) can damage the heart muscle and increase the risk of heart problems with Trazimera.<\/li><li>you suffer from shortness of breath, especially if you are also being treated with taxidermy.\u00a0Trazimera can cause breathing difficulties, especially when it is given for the first time.\u00a0This can be more serious if you are already short of breath.\u00a0Patients with severe breathing difficulties have very rarely died in connection with treatment with Trazimera.<\/li><li>you have previously received any other cancer treatment.<\/li><\/ul>\n\n\n\n<p>If you receive Trazimera together with other medicines to treat cancer, such as paclitaxel, docetaxel, an aromatase inhibitor, capecitabine, 5-fluorouracil, or cisplatin, you should also carefully read the package leaflets for these products.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Tamera is not recommended for anyone under 18 years of age.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Trazimera<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>It can take up to 7 months for Trazimera to be removed from the body.\u00a0You should therefore tell the doctor, pharmacist, or nurse that you have been treated with Trazimera if you start any new medication within 7 months of finishing treatment.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and Breastfeeding<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor, pharmacist, or nurse for advice before using this medicine.<\/li><li>You must use effective contraception during treatment with Trazimera and for at least 7 months after treatment ends.<\/li><li>Your doctor will advise you about the disadvantages and advantages of taking Trazimera during pregnancy.\u00a0In rare cases, pregnant women treated with Trazimera have seen a reduction in the amount of (amniotic) fluid that surrounds the growing fetus in the womb.\u00a0This condition can be harmful to your baby in the womb and has been associated with the lungs not developing fully resulting in fetal death.<\/li><\/ul>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Do not breastfeed your child during treatment with Trazimera and within 7 months after the last\u00a0dose\u00a0of Trazimera because Trazimera can pass to your child through breast milk.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Trazimera may affect your ability to drive or use machines.\u00a0If you experience symptoms such as dizziness, sleepiness, chills, or <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a> during treatment, you should not drive or operate machinery until these symptoms have disappeared.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Trazimera contains trastuzumab<\/h2>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to get Trazimera<\/h2>\n\n\n\n<p>Before starting treatment, your doctor will determine whether your\u00a0tumor\u00a0is\u00a0HER2-positive.\u00a0Only patients with\u00a0HER2\u00a0-positive cancer (high amounts of\u00a0HER2\u00a0) will be treated with Trazimera.<\/p>\n\n\n\n<p>Trazimera should only be given by a doctor or nurse.\u00a0Your doctor will prescribe the right\u00a0dose\u00a0and treatment regimen for\u00a0<strong><em>you<\/em><\/strong>.\u00a0The dose of Trazimera\u00a0depends on your body weight.<\/p>\n\n\n\n<p>Trazimera for\u00a0intravenous\u00a0use is not intended for\u00a0subcutaneous\u00a0use (under the skin) and should only be given as an\u00a0intravenous\u00a0infusion.<\/p>\n\n\n\n<p>Trazimera for\u00a0intravenous\u00a0use is given as an\u00a0intravenous\u00a0infusion\u00a0(\u201cdrip\u201d) directly into a blood vessel.\u00a0The first\u00a0dose\u00a0is given over 90 minutes and you will be observed by healthcare professionals while you receive the\u00a0infusion\u00a0in case you experience any\u00a0side effects.\u00a0If the first\u00a0dose\u00a0is well tolerated, the subsequent\u00a0dose\u00a0can be given within 30 minutes (see section 2 under &#8220;Warnings and precautions&#8221;).\u00a0The number of\u00a0infusions\u00a0you receive depends on how you respond to treatment.\u00a0Your doctor will discuss this with you.<\/p>\n\n\n\n<p>To prevent medication errors, it is important to check the vial labeling to ensure that the drug being prepared and administered is Trazimera (trastuzumab) and not another product containing trastuzumab (eg, trastuzumab emtansine or trastuzumab deruxtecan).<\/p>\n\n\n\n<p>In early breast cancer, metastatic breast cancer, and metastatic stomach cancer, Trazimera is given every three weeks.\u00a0Trazimera can also be given once a week in metastatic breast cancer.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Trazimera<\/h2>\n\n\n\n<p>Do not stop using this medicine without talking to your doctor first.&nbsp;All&nbsp;doses&nbsp;should be taken at the correct time each week or every three weeks (depending on your dosing interval).&nbsp;This helps the medicine work as well as possible.<\/p>\n\n\n\n<p>It can take up to 7 months for Trazimera to disappear from the body.&nbsp;Therefore, your doctor may decide to continue to monitor your heart function even after treatment has ended.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Trazimera can cause\u00a0side effects, although not everybody gets them.\u00a0Some of these\u00a0side effects\u00a0can be serious and lead to hospitalization.<\/p>\n\n\n\n<p>During an\u00a0infusion\u00a0with Trazimera, chills, fever and other\u00a0flu-like symptoms\u00a0may occur.\u00a0These\u00a0side effects\u00a0are very common (may affect more than 1 in 10 patients).\u00a0Other symptoms caused by\u00a0infusion\u00a0one are nausea, vomiting, pain, increased muscle tension and tremors, headache, dizziness, difficulty breathing, high or low\u00a0blood pressure, altered heart rhythm (palpitations, fluttering or irregular heartbeat), swelling of the face and lips, skin rash and weakness.\u00a0Some of these symptoms can be serious and some patients have died (see section 2 under \u201cWarnings and precautions\u201d).<\/p>\n\n\n\n<p>These effects mainly occur in connection with the first intravenous\u00a0infusion\u00a0(the &#8220;drip&#8221;) and during the first hours after the start of the\u00a0infusion.\u00a0They are usually temporary.\u00a0You will be monitored by healthcare professionals during the\u00a0infusion\u00a0and for at least six hours after the start of the first\u00a0infusion\u00a0and one and two hours after the start of the other\u00a0infusions.\u00a0If you develop symptoms, the healthcare professional will slow down or stop the\u00a0infusion\u00a0and they may give you treatment to counteract the\u00a0side effects.\u00a0After the improvement of the symptoms, the\u00a0infusion\u00a0can be continued.<\/p>\n\n\n\n<p>Sometimes symptoms may occur later than six hours after the&nbsp;infusion&nbsp;is started.&nbsp;If this happens to you, contact your doctor immediately.&nbsp;Sometimes the symptoms may improve and later worsen.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Other\u00a0side effects\u00a0can occur at any time during treatment with Trazimera and are not related to the\u00a0infusion\u00a0itself.\u00a0<strong>Tell a doctor or nurse immediately if you notice any of the following side effects:<\/strong>\u00a0<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Heart problems can sometimes occur during treatment and sometimes after treatment has ended and can be serious.\u00a0They include weakening of the heart muscle which can eventually lead to\u00a0heart failure, inflammation around the heart, and altered heart rhythm.\u00a0This can lead to symptoms such as shortness of breath (including shortness of breath during the night), <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a>, fluid retention (swelling) in the legs or arms, and palpitations (fluttering or irregular heartbeats) (see section 2. Monitoring the heart).<\/li><\/ul>\n\n\n\n<p>Your doctor will regularly check your heart during and after treatment, but you should tell your doctor immediately if you experience any of the above symptoms.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tumor lysis syndrome (a group of metabolic complications that occur after cancer treatment and are characterized by high levels of\u00a0potassium\u00a0and\u00a0phosphate\u00a0in the blood and low levels of\u00a0calcium\u00a0in the blood).\u00a0Symptoms may include kidney problems (weakness, shortness of breath, tiredness, and confusion), heart problems (palpitations or a faster or slower heartbeat), seizures, vomiting or diarrhea, and tingling in the mouth, hands, or feet.<\/li><\/ul>\n\n\n\n<p>If you experience any of the above symptoms after stopping treatment with Trazimera, you should consult your doctor and tell the doctor that you have previously been treated with Trazimera.<\/p>\n\n\n\n<p>Very common: may affect more than 1 in 10 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection\u00a0_<\/li><li>diarrhea<\/li><li>constipation<\/li><li>heartburn (\u00a0dyspepsia\u00a0)<\/li><li>fatigue<\/li><li>rash<\/li><li>chest pain<\/li><li>abdominal pain<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/joint-pain\/\">joint pain<\/a><\/li><li>low levels of\u00a0red blood cells\u00a0and\u00a0white blood cells\u00a0(which help fight\u00a0infection\u00a0) sometimes with fever<\/li><li>muscle pain<\/li><li>conjunctivitis\u00a0(inflammation of the conjunctiva of the eye)<\/li><li>watery eyes<\/li><li>nosebleed<\/li><li>runny nose<\/li><li>hair loss<\/li><li>tremors<\/li><li>hot flashes<\/li><li>dizziness<\/li><li>nail changes<\/li><li>weight loss<\/li><li>loss of appetite<\/li><li>insomnia\u00a0_\u00a0_<\/li><li>taste changes<\/li><li>decreased number of\u00a0platelets<\/li><li>bruises<\/li><li>numbness or tingling in the fingers and toes, which can sometimes spread to the rest of the arm or leg<\/li><li>redness, swelling, or sores in the mouth and\/or throat<\/li><li>pain, swelling,\u00a0redness,\u00a0or tingling in the hands and\/or feet<\/li><li>shortness of breath<\/li><li>headache<\/li><li>cough<\/li><li>vomiting<\/li><li>nausea.<\/li><\/ul>\n\n\n\n<p>Common: may affect up to 1 in 10 people<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>allergic reaction throat infections infection\u00a0in the bladder and on the skin breast inflammation inflammation of the liver-kidney damage increased\u00a0muscle tone\u00a0or tension (hypertonus)pain in arms and\/or legs itchy rashsleepiness (\u00a0somnolence\u00a0)hemorrhoidsitchingdry mouth and skin<\/td><td>dry eyes\u00a0sweating feeling of weakness and malaiseconcernDepressionasthmapneumonialung impact <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/back-hurts\/\">back pain<\/a> neck pain bone painacneleg cramps<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Uncommon: may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sudden-hearing-loss-sudden-deafness\/\">deafness<\/a><\/li><li>bumpy skin rash<\/li><li>wheezing\/wheezing<\/li><li>inflammation&nbsp;or scarring of the lungs<\/li><\/ul>\n\n\n\n<p>Rare: may affect up to 1 in 1,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>jaundice<\/li><li>anaphylactic reactions<\/li><\/ul>\n\n\n\n<p>Has been reported: occurring in an unknown number of users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal or impaired blood clotting<\/li><li>high potassium levels<\/li><li>swelling or bleeding inside the eye<\/li><li>shock<\/li><li>abnormal heart rhythm<\/li><li>respiratory distress<\/li><li>breathing problems<\/li><li>acute\u00a0accumulation of fluid in the lungs<\/li><li>acute\u00a0narrowed airways<\/li><li>abnormally low oxygen content in the blood<\/li><li>difficulty breathing when lying down<\/li><li>liver damage<\/li><li>swelling of the face, lips, and throat<\/li><li>kidney failure<\/li><li>abnormally little amniotic fluid around the fetus in the womb<\/li><li>underdeveloped lungs of the fetus in the womb<\/li><li>abnormal development of the kidneys of the fetus in the womb.<\/li><\/ul>\n\n\n\n<p>Some of the\u00a0side effects\u00a0you experience may be due to your underlying disease cancer.\u00a0If you are treated with Trazimera together with\u00a0chemotherapy, some of the\u00a0side effects\u00a0may also be due to the\u00a0chemotherapy.<\/p>\n\n\n\n<p>If you get\u00a0side effects, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Trazimera<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the outer carton (EXP) and the vial label (EXP).\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C\u20138 \u00b0C).<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Unopened vials of Trazimera can be stored at up to 30&nbsp;<sup>o<\/sup>&nbsp;C for a single period of no more than 3 months.&nbsp;Once Trazimera has been removed from the refrigerator, Trazimera must not be put back.&nbsp;Discard the product after these 3 months or when the expiry date stated on the vial has been reached, whichever occurs first.&nbsp;Record the date &#8220;To be discarded&#8221; in the date field on the carton.<\/p>\n\n\n\n<p>Infusion solutions must be used immediately after\u00a0preparation.\u00a0Do not use Trazimera if you see particles or discoloration before\u00a0administration.<\/p>\n\n\n\n<p>The medicine must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to deal with medicines that are no longer used.\u00a0These measures will help to protect the environment.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is trastuzumab.&nbsp;A&nbsp;vial&nbsp;contains either:<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>150 mg of trastuzumab to be dissolved in 7.2 ml of sterile water for injections, or<\/li><li>420 mg of trastuzumab to be dissolved in 20 ml of sterile water for injections. The reconstituted solution contains approximately 21 mg\/ml of trastuzumab.<\/li><li>Other ingredients are L-histidine hydrochloride monohydrate, L-histidine, sucrose, and polysorbate 20 (E 432).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Trazimera is a powder for concentrate solution for infusion supplied in a glass\u00a0vial\u00a0with a rubber stopper and contains either 150 mg or 420 mg of trastuzumab.\u00a0The powder is in the form of a white cake.\u00a0Each carton contains 1\u00a0vial\u00a0of powder.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Pfizer Europe MA EEIG<\/p>\n\n\n\n<p>Boulevard de la Plaine 17<\/p>\n\n\n\n<p>1050 Brussels<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Pfizer Manufacturing Belgium NV<\/p>\n\n\n\n<p>Rijksweg 12<\/p>\n\n\n\n<p>2870 Puurs<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong><strong>Luxembourg\/Luxembourg<\/strong>Pfizer NV\/SATel\/Tel: +32 (0)2 554 62 11<\/td><td><strong>Cyprus<\/strong>Pfizer \u0395\u03bb\u03bb\u03ac\u03c2 AE (Cyprus Branch)Phone: +357 22817690<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Pfizer, coil.\u00a0s iPhone: +420 283 004 111<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Pfizer Kft.Tel.: +36 1 488 37 00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Pfizer ApSPhone: +45 44 20 11 00<\/td><td><strong>Malta<\/strong>Drugsales LtdPhone: +356 21419070\/1\/2<\/td><\/tr><tr><td><strong>Deutschland<\/strong>PFIZER PHARMA GmbHPhone: +49 (0)30 550055-51000<\/td><td><strong>The Netherlands<\/strong>Pfizer by phone: +31 (0)10 406 43 01<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Pfizer Luxembourg \u0421\u0410\u0420\u041b, Clone Bulgaria phone: +359 2 970 4333<\/td><td><strong>Norway<\/strong>Pfizer iPhone: +47 67 52 61 00<\/td><\/tr><tr><td><strong>Estonia<\/strong>Pfizer Luxembourg SARL Eesti branch phone: +372 666 7500<\/td><td><strong>Austria<\/strong>Pfizer Corporation Austria Ges.mbHPhone: +43 (0)1 521 15-0<\/td><\/tr><tr><td><strong>Greece<\/strong>Pfizer Hellas iPhone: +30 210 6785800<\/td><td><strong>Polish<\/strong>Pfizer Polska Sp.&nbsp;z o. oTel.: +48 22 335 61 00<\/td><\/tr><tr><td><strong>Spain<\/strong>Pfizer, SLPhone: +34 91 490 99 00<\/td><td><strong>Portugal<\/strong>Laborat\u00f3rios Pfizer, Lda.Phone: +351 21 423 5500<\/td><\/tr><tr><td><strong>France<\/strong>PfizerTel: + 33 (0)1 58 07 34 40<\/td><td><strong>Romania<\/strong>Pfizer Romania SRLPhone: +40 (0) 21 207 28 00<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Pfizer Croatia dooPhone: +385 1 3908 777<\/td><td><strong>Slovenija<\/strong>Pfizer Luxembourg SARLPfizer, branch of the fieldpharmacistactivities, LjubljanaPhone: +386 (0)1 52 11 400<\/td><\/tr><tr><td><strong>Ireland<\/strong>Pfizer Healthcare IrelandTel: +1800 633 363 (toll free)Phone: +44 (0)1304 616161<\/td><td><strong>Slovenian Republic<\/strong>Pfizer Luxembourg SARL, organiza\u010dn\u00e1 zlo\u017ekaPhone: +421 2 3355 5500<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hf.Telephone: +354 540 8000<\/td><td><strong>Finland\/Finland<\/strong>Pfizer OyPhone\/Tel: +358 (0)9 430 040<\/td><\/tr><tr><td><strong>Italy<\/strong>Pfizer SrlPhone: +39 06 33 18 21<\/td><td><strong>Sweden<\/strong>Pfizer ABPhone: +46 (0)8 550 520 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>Pfizer Luxembourg SARL branch in LatviaPhone: +371 670 35 775<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Pfizer LimitedPhone: +44 (0)1304 616161<\/td><\/tr><tr><td><strong>Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaPhone: +370 5 251 4000<\/td><td>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Trazimera contains the active ingredient trastuzumab, which is a monoclonal\u00a0antibody\u00a0.\u00a0Monoclonal\u00a0antibodies\u00a0attach to specific\u00a0proteins\u00a0or\u00a0antigens\u00a0.\u00a0Trastuzumab is designed to bind selectively to an\u00a0antigen\u00a0called\u00a0human\u00a0epidermal\u00a0growth factor receptor 2 (\u00a0HER2\u00a0).\u00a0HER2\u00a0is found in large quantities on the surface of certain cancer cells and then stimulates cell growth.\u00a0When Trazimera binds to\u00a0HER2\u00a0, the growth of the cancer cells is stopped and this leads to their death.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[13803,26370,13800,13804,26366,26368,13801,26367,13802,26369],"class_list":["post-25537","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-trastuzumab","tag-benefits-of-trazimera","tag-trastuzumab","tag-trastuzumab-side-effects","tag-trazimera","tag-trazimera-side-effects","tag-what-is-trastuzumab","tag-what-is-trazimera","tag-what-trastuzumab-is-used-for","tag-what-trazimera-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25537"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25537\/revisions"}],"predecessor-version":[{"id":25577,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25537\/revisions\/25577"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}