{"id":25439,"date":"2022-09-17T07:47:42","date_gmt":"2022-09-17T07:47:42","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25439"},"modified":"2022-09-19T06:58:48","modified_gmt":"2022-09-19T06:58:48","slug":"tramadol-retard-krka","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tramadol-retard-krka\/","title":{"rendered":"Tramadol Retard Krka &#8211; Tramadol uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg, 150 mg, 200 mg&nbsp;prolonged-release&nbsp;tablets<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tramadol Retard Krka is and what it is used for<\/h2>\n\n\n\n<p>Tramadol &#8211; the active substance in Tramadol\u00a0Retard\u00a0Krka &#8211; is a painkiller that belongs to the class of\u00a0opioids\u00a0that act on the\u00a0central nervous system.\u00a0Tramadol acts as a pain reliever by affecting specific nerve cells in the spinal cord and brain.<\/p>\n\n\n\n<p>Tramadol&nbsp;Retard&nbsp;Krka is used to treat moderate to severe pain.<\/p>\n\n\n\n<p>Tramadol hydrochloride contained in Tramadol\u00a0Retard\u00a0Krka may also be approved to treat other diseases not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Tramadol Retard Krka<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Tramadol Retard Krka<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to tramadol or any of the other ingredients of this medicine (listed in section 6);<\/li><li>in case of\u00a0acute\u00a0intoxication with alcohol, sleeping pills, painkillers, or other drugs that affect mood\/mood and emotional life;<\/li><li>if you are simultaneously using\u00a0MAO inhibitors\u00a0(some medicines for the treatment of depression) or have taken such medicines in the last 14 days before treatment with Tramadol\u00a0Retard\u00a0Krka (see &#8220;Other medicines and Tramadol\u00a0Retard\u00a0Krka&#8221;);<\/li><li>if you suffer from\u00a0epilepsy\u00a0that is not well controlled with treatment;<\/li><li>as a substitute for drug withdrawal.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to a doctor or pharmacist before taking Tramadol&nbsp;Retard&nbsp;Krka:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you suspect that you are dependent on other painkillers (opioids\u00a0er);<\/li><li>if you suffer from a reduced level of consciousness (if you feel faint);<\/li><li>if you are in a state of shock (<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">cold<\/a> sweating may be a sign of this);<\/li><li>if you have increased pressure in your head (after a skull or brain injury);<\/li><li>if you have breathing difficulties;<\/li><li>if you are prone to epileptic fits or convulsions as the risk of seizures may increase;<\/li><li>if you suffer from liver or kidney disease;<\/li><li>if you suffer from depression and take antidepressants because some of them can interact with tramadol (see &#8220;Other medicines and Tramadol\u00a0Retard\u00a0Krka&#8221;).<\/li><\/ul>\n\n\n\n<p>Serotonergic syndrome<\/p>\n\n\n\n<p>There is a small risk that you may get a so-called serotonin syndrome, which can occur after taking tramadol in combination with certain antidepressants or tramadol alone.&nbsp;Seek immediate medical attention if you experience any of the symptoms of this serious syndrome (see section 4, \u201cPossible side effects\u201d).<\/p>\n\n\n\n<p>Sleep-related breathing disorders<\/p>\n\n\n\n<p>Tramadol Krka can cause sleep-related breathing disorders such as\u00a0sleep apnea\u00a0(breathing pauses during sleep) and sleep-related\u00a0hypoxemia\u00a0(low oxygen content in the blood).\u00a0The symptoms can be breathing pauses during sleep, awakenings during the night due to shortness of breath, difficulty maintaining sleep, or severe drowsiness during the day.\u00a0Contact a doctor if you or someone else notices these symptoms.\u00a0The doctor may consider lowering your\u00a0dose.<\/p>\n\n\n\n<p>Epileptic seizures have occurred in patients taking the recommended&nbsp;dose of&nbsp;tramadol.&nbsp;The risk may increase if the&nbsp;dose&nbsp;of tramadol exceeds the highest recommended daily dose (400 mg).<\/p>\n\n\n\n<p>Please note that Tramadol&nbsp;Retard&nbsp;Krka can cause physical and psychological dependence.<\/p>\n\n\n\n<p>When Tramadol\u00a0Retard\u00a0Krka is taken for a longer period, the effect may decrease and higher\u00a0doses\u00a0may become necessary (\u00a0tolerance development\u00a0).\u00a0Patients with a tendency to drug abuse or drug dependence should only be treated with Tramadol\u00a0Retard\u00a0Krka for short periods and under strict medical supervision.<\/p>\n\n\n\n<p>Also, inform your doctor if one or more of these problems arise during treatment with Tramadol\u00a0Retard\u00a0Krka or if they affected you in the past.<\/p>\n\n\n\n<p>Extreme fatigue, loss of appetite, severe abdominal pain, nausea, vomiting, or low\u00a0blood pressure.\u00a0This can be a sign of adrenal cortex failure (low levels of\u00a0cortisol\u00a0).\u00a0Contact a doctor if you experience these symptoms.\u00a0The doctor will decide if you need to take hormone replacement.<\/p>\n\n\n\n<p>Tramadol is converted into the liver by an\u00a0enzyme.\u00a0Some people have a variation of this\u00a0enzyme\u00a0and it can affect different people in different ways.\u00a0Some people may not get enough pain relief, while others are at greater risk of serious\u00a0side effects.\u00a0If you experience any of the following\u00a0side effects, stop taking this medicine and see a doctor immediately: slow or shallow breathing, confusion, sleepiness, small\u00a0pupils, nausea or vomiting, constipation, and poor appetite.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine should not be given to children under 12 years of age.<\/p>\n\n\n\n<p>Tramadol is not recommended for children and adolescents with respiratory problems because the symptoms of tramadol poisoning may be worse in these children and adolescents.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tramadol Retard Krka<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tramadol&nbsp;Retard&nbsp;Krka should not be taken together with&nbsp;MAO inhibitors&nbsp;(certain medicines for the treatment of depression).<\/p>\n\n\n\n<p>The pain-relieving effect of Tramadol&nbsp;Retard&nbsp;Krka can be reduced and the duration of action can be shortened, if you simultaneously take other medicines that contain:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>carbamazepine (for&nbsp;epilepsy&nbsp;);<\/li><li>ondansetron (for nausea).<\/li><\/ul>\n\n\n\n<p>Simultaneous use of Tramadol\u00a0Retard\u00a0Krka and sedative drugs such as\u00a0benzodiazepines\u00a0or similar drugs increases the risk of drowsiness, breathing difficulties (\u00a0respiratory depression\u00a0),\u00a0and coma,\u00a0and can be life-threatening.\u00a0Because of this, concomitant use should only be considered when other treatment options are not possible.<\/p>\n\n\n\n<p>If the doctor prescribes Tramadol&nbsp;Retard&nbsp;Krka at the same time as sedative drugs, the&nbsp;dose&nbsp;and duration of treatment must be limited by the doctor.<\/p>\n\n\n\n<p>Tell the doctor if you are taking any sedative medication and follow the doctor&#8217;s dosage recommendations carefully.&nbsp;It may be helpful to inform friends or relatives to be aware of the signs and symptoms described above.&nbsp;Contact a doctor if you experience any of these symptoms.<\/p>\n\n\n\n<p>Your doctor will tell you if you should take Tramadol\u00a0Retard\u00a0Krka and in what\u00a0dose.<\/p>\n\n\n\n<p>The risk of&nbsp;side effects&nbsp;increases:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you take tranquilizers, sleeping pills, other pain relievers such as morphine and\u00a0codeine\u00a0(also as <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a> medicine), and alcohol while taking Tramadol\u00a0Retard\u00a0Krka.\u00a0You may then feel drowsy and faint.\u00a0In such a case, talk to a doctor.<\/li><li>if you are taking medicines that can cause convulsions (seizures), such as some antidepressants and antipsychotic medicines.\u00a0The risk of having a seizure may increase if you take Tramadol\u00a0Retard\u00a0Krka at the same time.\u00a0Your doctor will tell you if Tramadol\u00a0Retard\u00a0Krka is right for you.<\/li><li>if you take certain antidepressants, then Tramadol\u00a0Retard\u00a0Krka can interact with these medicines and you may develop serotonin syndrome (see section 4, \u201cPossible side effects\u201d).<\/li><li>if you take coumarin-type\u00a0anticoagulants\u00a0(blood-thinning drugs) e.g.\u00a0warfarin\u00a0together with Tramadol\u00a0Retard\u00a0Krka.\u00a0The effect of these medicines on the\u00a0clotting ability\u00a0of the blood can be affected and bleeding can occur.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Tramadol Retard Krka with food, drink, and alcohol<\/h2>\n\n\n\n<p>Do not drink alcohol during treatment with this medicine because alcohol can increase the effect of Tramadol&nbsp;Retard&nbsp;Krka.&nbsp;The effect of Tramadol&nbsp;Retard&nbsp;Krka is not affected by food.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.\u00a0There is very little information regarding the safety of tramadol during pregnancy.\u00a0Tramadol\u00a0Retard\u00a0Krka should therefore not be used during pregnancy.<\/p>\n\n\n\n<p>Long-term treatment during pregnancy may lead to the child experiencing withdrawal symptoms after birth.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Tramadol is excreted in breast milk.\u00a0You should therefore not take Tramadol\u00a0Retard\u00a0Krka more than once during breastfeeding.\u00a0Alternatively, if you take Tramadol\u00a0Retard\u00a0Krka more than once, you should stop breastfeeding.<\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>Experience based on humans does not indicate that tramadol affects female or male\u00a0fertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Tramadol\u00a0Retard\u00a0Krka can cause drowsiness, dizziness, and blurred vision and can therefore impair your ability to react.\u00a0Do not drive a car or other vehicle, and do not use electric tools or machines if you feel that your ability to react is affected.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tramadol Retard Krka contains lactose<\/h2>\n\n\n\n<p>If you have an intolerance to certain sugars, you should consult your doctor before taking this medication.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Tramadol Retard Krka<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Your doctor will adjust the\u00a0dosage\u00a0to the severity of your pain and your sensitivity to pain.\u00a0Usually, you should take the lowest\u00a0dose\u00a0that provides pain relief.\u00a0Do not take more than 400 mg tramadol hydrochloride daily without a doctor&#8217;s\u00a0prescription.<\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;is:<\/strong><\/p>\n\n\n\n<p><em>Adults and adolescents from the age of 12:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>One tablet of Tramadol\u00a0Retard\u00a0Krka 100 mg twice daily (equivalent to 200 mg tramadol hydrochloride per day) preferably in the morning and in the evening.<\/li><\/ul>\n\n\n\n<p>If necessary, the&nbsp;dose&nbsp;can be increased up to 150 mg or 200 mg twice daily (equivalent to 300 mg &#8211; 400 mg tramadol hydrochloride per day).<\/p>\n\n\n\n<p><em>Children<\/em><\/p>\n\n\n\n<p>Tramadol&nbsp;Retard&nbsp;Krka is not suitable for children under 12 years of age.<\/p>\n\n\n\n<p><em>Elderly<\/em><\/p>\n\n\n\n<p>For older people (over 75 years), it may take longer for tramadol to disappear from the body.\u00a0If this concerns you, your doctor may advise you to extend the time between\u00a0doses.<\/p>\n\n\n\n<p><em>Patients with severe liver or kidney disease (&nbsp;insufficiency&nbsp;)\/dialysis<\/em><\/p>\n\n\n\n<p>Patients with severe liver and\/or\u00a0kidney insufficiency\u00a0should not take Tramadol\u00a0Retard\u00a0Krka.\u00a0If you have mild or moderate\u00a0insufficiency, your doctor may recommend you extend the time between\u00a0doses.<\/p>\n\n\n\n<p><strong>Mode of administration<\/strong><\/p>\n\n\n\n<p>Tramadol&nbsp;Retard&nbsp;Krka&nbsp;prolonged-release tablets&nbsp;should always be swallowed whole, not divided or chewed, together with a sufficient amount of liquid.&nbsp;Preferably in the morning and in the evening.&nbsp;You can take the tablets on an empty stomach or with a meal.<\/p>\n\n\n\n<p><strong>How long should you take Tramadol&nbsp;Retard&nbsp;Krka?<\/strong><\/p>\n\n\n\n<p>You should not take Tramadol\u00a0Retard\u00a0Krka longer than necessary.\u00a0If you need to be treated for a longer period, your doctor will carefully check at regular, short intervals (interrupting the treatment if necessary) whether you should continue to take Tramadol\u00a0Retard\u00a0Krka and in what\u00a0dose.<\/p>\n\n\n\n<p>If you feel that the effect of Tramadol&nbsp;Retard&nbsp;Krka is too strong or too weak, contact your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Tramadol&nbsp;Retard&nbsp;Krka is not suitable for children under 12 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Tramadol Retard Krka&nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>If you have taken an extra&nbsp;dose&nbsp;by mistake, this method will generally not have any negative effects.&nbsp;You should take the next&nbsp;dose&nbsp;as directed.<\/p>\n\n\n\n<p>If you (or someone else) take many Tramadol\u00a0Retard\u00a0Krka tablets at the same time, you should go to the hospital or contact a doctor immediately.\u00a0Signs of overdose include dilated pupils, vomiting, drop in blood pressure, palpitations, collapse, unconsciousness, epileptic seizures, and difficulty breathing or shallow breathing.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Tramadol Retard Krka<\/h2>\n\n\n\n<p>If you forget to take the tablets, the pain is likely to return.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose, but simply continue taking the tablets as before.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Tramadol Retard Krka<\/h2>\n\n\n\n<p>If you interrupt or end the treatment with Tramadol\u00a0Retard\u00a0Krka too soon, the pain will likely return.<\/p>\n\n\n\n<p>You should not suddenly stop taking this medicine unless your doctor tells you to.&nbsp;If you want to stop taking your medicine, you should first discuss it with your doctor, especially if you have been taking it for a long time.&nbsp;Your doctor will tell you when and how to stop, which can be done by gradually reducing the&nbsp;dose&nbsp;to reduce the risk of developing unnecessary&nbsp;side effects&nbsp;(withdrawal symptoms).<\/p>\n\n\n\n<p>Contact your doctor if you wish to discontinue the treatment due to unwanted effects.<\/p>\n\n\n\n<p>As a rule, no side effects occur when treatment with Tramadol\u00a0Retard\u00a0Krka ends.\u00a0In rare cases, however, patients who have been treated with Tramadol\u00a0Retard\u00a0Krka for a long time may feel unwell if they suddenly stop the treatment.\u00a0They may feel worried, anxiety, nervousness, or become shaky.\u00a0They may be hyperactive, suffer from sleeping difficulties, or have stomach and intestinal disorders.\u00a0Very few patients may experience panic attacks, hallucinations, and unusual sensations such as\u00a0itching, tingling, numbness, and ringing in the ears (\u00a0tinnitus\u00a0).\u00a0Additional unusual\u00a0central nervous system symptoms have been observed in very rare cases, such as\u00a0confusion, delusion, change in the perception of one&#8217;s personality (depersonalization), change in the perception of reality (derealization), and persecution mania (\u00a0paranoia\u00a0).\u00a0If you experience any of these side effects after you have finished your treatment with Tramadol\u00a0Retard\u00a0Krka, you should contact your doctor.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>You should see a doctor immediately if you develop symptoms of an\u00a0allergic reaction\u00a0such as a swollen face, tongue, and\/or throat and\/or difficulty swallowing or if you develop hives along with difficulty breathing.<\/p>\n\n\n\n<p><em>Very common: may affect more than 1 in 10 users<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness<\/li><li>nausea<\/li><\/ul>\n\n\n\n<p><em>Common: may affect up to 1 in 10 users<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache, drowsiness<\/li><li>fatigue<\/li><li>constipation,\u00a0dry mouth, vomiting<\/li><li>sweating (\u00a0hyperhidrosis\u00a0)<\/li><\/ul>\n\n\n\n<p><em>Uncommon: may affect up to 1 in 100 users<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>effects on the heart and blood circulation (fast strong heartbeats, fast\u00a0pulse, feeling faint or collapse).\u00a0These\u00a0side effects\u00a0occur preferentially in patients who quickly get up or sit up or who are under physical exertion.<\/li><li>nausea, stomach discomfort (feeling of pressure in the stomach, bloating), diarrhea<\/li><li>skin reactions (eg\u00a0itching, rash)<\/li><\/ul>\n\n\n\n<p><em>Rare: may affect up to 1 in 1,000 users<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions (difficulty breathing, wheezing, swelling of the skin) and\u00a0shock\u00a0(sudden circulatory collapse) have occurred in very rare cases.<\/li><li>slow\u00a0pulse<\/li><li>increased\u00a0blood pressure<\/li><li>abnormal sensations (eg\u00a0itching, tingling, numbness), tremors, epileptic seizures, muscle twitching, uncoordinated movements, transient loss of consciousness (syncope), and difficulty speaking.<\/li><li>epileptic seizures have occurred mainly with high\u00a0doses of\u00a0tramadol or when tramadol was taken at the same time as other drugs that can induce seizures.<\/li><li>appetite changes<\/li><li>hallucinations, confusion, sleep disturbances,\u00a0delirium, anxiety, and nightmares<\/li><li>Psychological problems can occur during treatment with Tramadol\u00a0Retard\u00a0Krka.\u00a0Their\u00a0intensity\u00a0and nature vary individually (depending on the patient&#8217;s personality and treatment time).\u00a0The complaints can appear in the form of mood swings (mostly elevated mood, occasionally irritated mood), change in activity (usually inhibited temporarily increased), and reduced perception (changes in mind and recognition, which can lead to altered decision-making behaviors).<\/li><li>drug dependence may occur.\u00a0If treatment is stopped suddenly, withdrawal symptoms may occur (see &#8220;If you stop taking Tramadol\u00a0Retard\u00a0Krka&#8221;).<\/li><li>blurred vision, pupil dilation (\u00a0mydriasis\u00a0), pupil narrowing (\u00a0miosis\u00a0)<\/li><li>slow breathing, shortness of breath (\u00a0dyspnoea\u00a0)<\/li><li>worsening of\u00a0asthma\u00a0has been reported, however, it is not clear whether this was caused by tramadol.\u00a0If the recommended\u00a0dose\u00a0is significantly exceeded, or if any drug that lowers brain function is taken at the same time, the breathing rate may decrease.<\/li><li>muscle weakness<\/li><li>bladder emptying problems (difficulty or painful passing water), decreased urine output (\u00a0dysuria\u00a0)<\/li><\/ul>\n\n\n\n<p><em>Very rare: may affect up to 1 in 10,000 users<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>with elevated liver values<\/li><\/ul>\n\n\n\n<p><em>Has been reported: frequency cannot be estimated from the available data<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lowering of <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar<\/a> level<\/li><li>hiccup<\/li><\/ul>\n\n\n\n<p>The serotonergic syndrome may manifest as altered mental status (eg, restlessness, hallucinations,\u00a0coma\u00a0) and other symptoms such as <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a>, increased heart rate, unstable\u00a0blood pressure, involuntary twitching, muscle stiffness, lack of coordination of movements, and\/or gastrointestinal symptoms (e.g. nausea, vomiting, diarrhea) (see section 2 &#8220;What you need to know before you take Tramadol\u00a0Retard\u00a0Krka&#8221;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tramadol Retard Krka<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tramadol hydrochloride. Each\u00a0prolonged-release tablet\u00a0contains 100 mg tramadol hydrochloride. Each\u00a0prolonged-release tablet\u00a0contains 150 mg of tramadol hydrochloride. Each\u00a0prolonged-release tablet\u00a0contains 200 mg tramadol hydrochloride.<\/li><li>Other ingredients are hypromellose, microcrystalline cellulose, colloidal anhydrous silica, magnesium stearate in the tablet core and hypromellose,\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/lactose-intolerance\/\">lactose<\/a> monohydrate, titanium dioxide (E171), macrogol, triacetin, red iron oxide (E172) \u2013 (only for 150 mg and 200 mg\u00a0prolonged-release tablets\u00a0), yellow iron oxide (E172) &#8211; (only for 150 mg and 200 mg\u00a0prolonged-release tablets\u00a0) in the film coating. See section 2 &#8220;Tramadol\u00a0Retard\u00a0Krka contains lactose&#8221;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p><em>Tramadol&nbsp;Retard&nbsp;Krka 100 mg&nbsp;prolonged-release tablet&nbsp;er<\/em><\/p>\n\n\n\n<p>White, round, biconvex, film-coated tablets debossed with T1 on one side of the tablet.&nbsp;Tablet diameter: approx. 10 mm.<\/p>\n\n\n\n<p><em>Tramadol&nbsp;Retard&nbsp;Krka 150 mg&nbsp;prolonged-release tablet&nbsp;er<\/em><\/p>\n\n\n\n<p>Light orange-pink, round, biconvex, film-coated tablets with imprint T2 on one side of the tablet.&nbsp;Tablet diameter: approx. 10 mm.<\/p>\n\n\n\n<p><em>Tramadol&nbsp;Retard&nbsp;Krka 200 mg&nbsp;prolonged-release tablet&nbsp;er<\/em><\/p>\n\n\n\n<p>Light pink, round, biconvex, film-coated tablets with imprint&nbsp;T3&nbsp;on one side of the tablet.&nbsp;Tablet diameter: approx. 10 mm.<\/p>\n\n\n\n<p>Tramadol&nbsp;Retard&nbsp;Krka is available in cartons containing:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>10, 20, 28, 30, 50, 60, 90, 100&nbsp;prolonged-release tablets&nbsp;in child-resistant blisters.<\/li><li>10 x 1, 20 x 1, 28 x 1, 30 x 1, 50 x 1, 60 x 1, 90 x 1, 100 x 1&nbsp;prolonged-release tablets&nbsp;in perforated child-resistant single-dose blisters.<\/li><\/ul>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>KRKA, dd, Novo mesto, \u0160marje\u0161ka cesta 6, 8501 Novo mesto, Slovenia<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tramadol &#8211; the active substance in Tramadol\u00a0Retard\u00a0Krka &#8211; is a painkiller that belongs to the class of\u00a0opioids\u00a0that act on the\u00a0central nervous system\u00a0.\u00a0Tramadol acts as a pain reliever by affecting specific nerve cells in the spinal cord and brain.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[26256,26261,26265,26263,26260,26257,26259,26262,26258,26264],"class_list":["post-25439","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-tramadol","tag-tramadol-retard-krka","tag-tramadol-retard-krka-side-effects","tag-tramadol-retard-krka-tablet","tag-tramadol-side-effects","tag-tramadol-tablet","tag-what-is-tramadol","tag-what-is-tramadol-retard-krka","tag-what-tramadol-is-used-for","tag-what-tramadol-retard-krka-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25439"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25439\/revisions"}],"predecessor-version":[{"id":25477,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25439\/revisions\/25477"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25439"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}