{"id":25431,"date":"2022-09-17T07:42:24","date_gmt":"2022-09-17T07:42:24","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25431"},"modified":"2022-09-19T06:59:21","modified_gmt":"2022-09-19T06:59:21","slug":"tramadol-krka","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tramadol-krka\/","title":{"rendered":"Tramadol Krka &#8211; Tramadol hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg hard capsules<br>tramadol hydrochloride<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tramadol Krka is and what it is used for<\/h2>\n\n\n\n<p>Tramadol &#8211; the active substance in Tramadol Krka &#8211; is an analgesic that belongs to the class of\u00a0opioids\u00a0that act on the\u00a0central nervous system.\u00a0Tramadol acts as a pain reliever by affecting specific nerve cells in the spinal cord and brain.<\/p>\n\n\n\n<p>Tramadol Krka is used to treat moderate to severe pain in adults and children over 12 years of age.<\/p>\n\n\n\n<p>Tramadol hydrochloride contained in Tramadol Krka may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Tramadol Krka<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Tramadol Krka<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to tramadol or any of the other ingredients of this medicine (listed in section 6);<\/li><li>In case of\u00a0acute\u00a0intoxication with alcohol, sleeping pills, painkillers, or other drugs that affect mood\/mood and emotional life;<\/li><li>If you are simultaneously using\u00a0MAO inhibitors\u00a0(some medicines for the treatment of depression) or have taken such medicines in the last 14 days before treatment with Tramadol Krka (see &#8220;Other medicines and Tramadol Krka&#8221;);<\/li><li>If you suffer from\u00a0epilepsy\u00a0that is not well controlled with treatment;<\/li><li>As a substitute for drug withdrawal.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Tramadol Krka:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you suspect that you are addicted to other painkillers (opioids\u00a0er);<\/li><li>If you suffer from a reduced level of consciousness (if you feel blacked out);<\/li><li>If you are in a state of shock (<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">cold<\/a> sweating can be a sign of this);<\/li><li>If you have increased pressure in your head (after a skull or brain injury);<\/li><li>If you have breathing difficulties;<\/li><li>If you are prone to epileptic seizures or convulsions as the risk of seizures may increase;<\/li><li>If you suffer from liver or kidney disease;<\/li><li>If you suffer from depression and take antidepressants because some of them can interact with tramadol (see &#8220;Other medicines and Tramadol Krka&#8221;).<\/li><\/ul>\n\n\n\n<p><strong>Serotonergic syndrome<\/strong><\/p>\n\n\n\n<p>There is a small risk that you may get a so-called serotonin syndrome, which can occur after taking tramadol in combination with certain antidepressants or tramadol alone.&nbsp;Seek immediate medical attention if you experience any of the symptoms of this serious syndrome (see section 4, \u201cPossible side effects\u201d).<\/p>\n\n\n\n<p><strong>Sleep-related breathing disorders<\/strong><\/p>\n\n\n\n<p>Tramadol Krka can cause sleep-related breathing disorders such as\u00a0sleep apnea\u00a0(breathing pauses during sleep) and sleep-related\u00a0hypoxemia\u00a0(low oxygen content in the blood).\u00a0The symptoms can be breathing pauses during sleep, awakenings during the night due to shortness of breath, difficulty maintaining sleep, or severe drowsiness during the day.\u00a0Contact a doctor if you or someone else notices these symptoms.\u00a0The doctor may consider lowering your\u00a0dose.<\/p>\n\n\n\n<p>Epileptic seizures have occurred in patients taking the recommended&nbsp;dose of&nbsp;tramadol.&nbsp;The risk may increase if the&nbsp;dose&nbsp;of tramadol exceeds the recommended upper daily dose (400 mg).<\/p>\n\n\n\n<p>Please note that Tramadol Krka can cause physical and psychological dependence.\u00a0When Tramadol Krka is taken for a longer period, the effect may decrease and higher\u00a0doses\u00a0may become necessary (\u00a0tolerance development\u00a0).\u00a0Patients with a tendency to drug abuse or with drug dependence should only be treated with Tramadol Krka for short periods and under strict medical supervision.<\/p>\n\n\n\n<p>Inform your doctor if one or more of these problems occur during treatment with Tramadol Krka or if they have affected you in the past.<\/p>\n\n\n\n<p>Extreme fatigue, loss of appetite, severe abdominal pain, nausea, vomiting, or low\u00a0blood pressure.\u00a0This can be a sign of adrenal cortex failure (low levels of\u00a0cortisol\u00a0).\u00a0Contact a doctor if you experience these symptoms.\u00a0The doctor will decide if you need to take hormone replacement.<\/p>\n\n\n\n<p>Tramadol is converted into the liver by an\u00a0enzyme.\u00a0Some people have a variation of this\u00a0enzyme\u00a0and it can affect different people in different ways.\u00a0Some people may not get enough pain relief, while others are at greater risk of serious\u00a0side effects.\u00a0If you experience any of the following\u00a0side effects, stop taking this medicine and see a doctor immediately: slow or shallow breathing, confusion, sleepiness, small\u00a0pupils, nausea or vomiting, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/constipation\/\">constipation<\/a>, and poor appetite.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p><em>Use in children with breathing problems<\/em><\/p>\n\n\n\n<p>Tramadol is not recommended for children with respiratory problems as the symptoms of tramadol poisoning may be worse in these children.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tramadol Krka<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tramadol Krka should not be taken together with&nbsp;MAO inhibitors&nbsp;(certain medicines for the treatment of depression).<\/p>\n\n\n\n<p>The pain-relieving effect of Tramadol Krka can be reduced and the duration of action can be shortened, if you simultaneously take other medicines that contain:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Carbamazepine (for&nbsp;epilepsy&nbsp;);<\/li><li>Ondansetron (for nausea).<\/li><\/ul>\n\n\n\n<p>Your doctor will tell you if you should take Tramadol Krka and in what\u00a0dose.<\/p>\n\n\n\n<p>Concomitant use of Tramadol Krka and sedative drugs or drugs for sleep disorders such as\u00a0benzodiazepines\u00a0or similar drugs increases the risk of drowsiness, breathing difficulties (\u00a0respiratory depression\u00a0),\u00a0and coma,\u00a0and can be life-threatening.\u00a0Because of this, concomitant use should only be considered when other treatment options are not possible.<\/p>\n\n\n\n<p>If your doctor prescribes Tramadol Krka at the same time as sedative drugs, the&nbsp;dose&nbsp;and duration of treatment should be limited by the doctor.<\/p>\n\n\n\n<p>Tell the doctor if you are taking any sedative medication and follow the doctor&#8217;s dosage recommendations carefully.&nbsp;It may be helpful to inform friends or relatives to be aware of the signs and symptoms described above.&nbsp;Contact a doctor if you experience any of these symptoms.<\/p>\n\n\n\n<p>The risk of&nbsp;side effects&nbsp;increases:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you take sleeping pills, other pain relievers such as morphine and\u00a0codeine\u00a0(also as <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a> medicine), and alcohol while taking Tramadol Krka.\u00a0You may then feel drowsy and faint.\u00a0In such a case, talk to your doctor.<\/li><li>If you are taking medicines that can cause convulsions (seizures), such as some antidepressants and antipsychotic medicines.\u00a0The risk of having a seizure may increase if you take Tramadol Krka at the same time.\u00a0Your doctor will tell you if Tramadol Krka is right for you<\/li><li>If you are taking certain antidepressants, then Tramadol Krka may interact with these medicines and you may develop serotonin syndrome (see section 4, &#8220;Possible side effects&#8221;)<\/li><li>If you are taking\u00a0anticoagulants\u00a0of the coumarin type (blood-thinning drugs) such as\u00a0warfarin\u00a0together with Tramadol Krka.\u00a0The effect of these medicines on the\u00a0clotting ability\u00a0of the blood can be affected and bleeding can occur.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Tramadol Krka with food, drink, and alcohol<\/h2>\n\n\n\n<p>Do not drink alcohol during treatment with this medicine because alcohol can increase the effect of Tramadol Krka.&nbsp;The effect of Tramadol Krka is not affected by food.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p>There is very little information regarding the safety of tramadol during pregnancy.&nbsp;Tramadol Krka should therefore not be used during pregnancy.<\/p>\n\n\n\n<p>Long-term treatment during pregnancy can lead to habituation in the unborn child, which can result in the child experiencing withdrawal symptoms after birth.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>Tramadol is excreted in breast milk.\u00a0You should therefore not take Tramadol Krka more than once during breastfeeding.\u00a0Alternatively, if you take Tramadol Krka more than once, you should stop breastfeeding.<\/p>\n\n\n\n<p><em>Fertility<\/em><\/p>\n\n\n\n<p>Experience based on humans does not indicate that tramadol affects female or male\u00a0fertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Tramadol Krka can cause drowsiness, dizziness, and blurred vision and can therefore impair your ability to react.\u00a0Do not drive a car or other vehicle, and do not use electric tools or machines if you feel that your ability to react is affected.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tramadol Krka contains excipients<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per capsule, i.e.&nbsp;is next to &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Tramadol Krka<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Does\u00a0one should be adjusted to the severity of your pain and your sensitivity to pain.\u00a0Usually, you should take the lowest\u00a0dose\u00a0that provides pain relief.\u00a0Do not take more than 8 hard capsules of Tramadol Krka (equivalent to 400 mg tramadol hydrochloride) per day without a doctor&#8217;s\u00a0prescription.<\/p>\n\n\n\n<p><em>If the doctor has not prescribed anything else, the recommended dose is:<\/em><\/p>\n\n\n\n<p><em>Adults and adolescents from 12 years of age<\/em><em>:<\/em>\u00a0The usual\u00a0dose\u00a0is 1 or 2 capsules every 4-6 hours.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0for moderate pain is 1 hard capsule of Tramadol Krka (equivalent to 50 mg tramadol hydrochloride).\u00a0If pain relief is not achieved within 30 to 60 minutes, a second capsule may be taken.<\/p>\n\n\n\n<p>A higher need for pain relief can be expected in severe pain.&nbsp;In this case, 2 hard capsules can be taken as a single&nbsp;dose&nbsp;of Tramadol Krka (equivalent to 100 mg tramadol hydrochloride).<\/p>\n\n\n\n<p><em>Children<\/em><\/p>\n\n\n\n<p>Tramadol Krka capsules are not suitable for children under 12 years of age.<\/p>\n\n\n\n<p><em>Elderly<\/em><\/p>\n\n\n\n<p>For older people (over 75 years), it may take longer for tramadol to disappear from the body.\u00a0If this concerns you, your doctor may advise you to extend the time between\u00a0doses.<\/p>\n\n\n\n<p><em>Patients with severe liver or kidney disease (&nbsp;insufficiency&nbsp;)\/dialysis<\/em><\/p>\n\n\n\n<p>Patients with severe hepatic and\/or\u00a0renal insufficiency\u00a0should not take Tramadol Krka.\u00a0If you have mild or moderate\u00a0insufficiency, your doctor may recommend an extended dosing interval.<\/p>\n\n\n\n<p><em>How and when should you take Tramadol Krka?<\/em><\/p>\n\n\n\n<p>For&nbsp;oral&nbsp;use.<\/p>\n\n\n\n<p>The capsules should be swallowed whole, not split or chewed, together with sufficient liquid.<\/p>\n\n\n\n<p>You can take Tramadol Krka both on an empty stomach and in connection with a meal.<\/p>\n\n\n\n<p><em>How long should you take Tramadol Krka?<\/em><\/p>\n\n\n\n<p>You should not take Tramadol Krka for longer than necessary.\u00a0If you need to be treated for a longer period, your doctor will carefully check at regular, short intervals (interrupting the treatment if necessary) whether you should continue to take Tramadol Krka and at what\u00a0dose.<\/p>\n\n\n\n<p>If you feel that the effect of Tramadol Krka is too strong or too weak, contact your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Tramadol Krka&nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>After very high\u00a0doses, pupil dilation, vomiting, drop in blood pressure, palpitations, collapse, loss of consciousness,\u00a0coma\u00a0(deep unconsciousness), epileptic seizures, difficulty breathing, and respiratory arrest may occur.\u00a0In these cases, a doctor must be called immediately!<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Tramadol Krka<\/h2>\n\n\n\n<p>If you forget to take the Tramadol Krka capsules, the pain is likely to return.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose, simply continue taking the capsules as before.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Tramadol Krka<\/h2>\n\n\n\n<p>If you interrupt or stop treatment with Tramadol Krka too soon, the pain is likely to return.<\/p>\n\n\n\n<p>Contact your doctor if you wish to discontinue treatment due to&nbsp;unwanted effects.<\/p>\n\n\n\n<p>You should not suddenly stop taking this medicine unless your doctor tells you to.&nbsp;If you want to stop taking your medicine, you should first discuss it with your doctor, especially if you have been taking it for a long time.&nbsp;The doctor will tell you when and how to stop, which can be done by gradually lowering the&nbsp;dose&nbsp;to reduce the risk of developing unnecessary&nbsp;side effects&nbsp;(withdrawal symptoms).<\/p>\n\n\n\n<p>Generally, no side effects occur when treatment with Tramadol Krka is terminated.\u00a0In rare cases, however, patients who have been treated with Tramadol Krka for a long time may feel unwell if they suddenly stop treatment.\u00a0They may feel worried, anxiety, nervousness, or become shaky.\u00a0They may be hyperactive, suffer from sleeping difficulties, or have stomach and intestinal disorders.\u00a0Very rarely, panic attacks, hallucinations, and unusual sensations such as\u00a0itching, tingling, numbness, and ringing in the ears (\u00a0tinnitus\u00a0) can occur.\u00a0Unusual\u00a0central nervous system symptoms have been observed in very rare cases, such as mental confusion, delusion, change in the perception of one&#8217;s personality (depersonalization), change in the perception of reality (derealization), and persecution mania (\u00a0paranoia\u00a0).\u00a0If you experience any of these side effects after you have finished your treatment with Tramadol Krka, you should contact your doctor.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>You should see a doctor immediately if you develop symptoms of an\u00a0allergic reaction\u00a0such as the swollen face, tongue, and\/or throat and\/or difficulty swallowing or if you develop hives along with difficulty breathing.<\/p>\n\n\n\n<p><em>Very common (may affect more than 1 in 10 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dizziness<\/li><li>Nausea<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache, drowsiness<\/li><li>Fatigue<\/li><li>Constipation,\u00a0dry mouth, vomiting<\/li><li>Sweating (hyperhidrosis)<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Effects on the heart and blood circulation (fast strong heartbeats, fast\u00a0pulse, feeling faint or collapse).\u00a0These\u00a0side effects\u00a0occur preferentially in patients who quickly get up or sit up or who are under physical exertion.<\/li><li>Nausea, stomach discomfort (feeling of pressure in the stomach, bloating), diarrhea<\/li><li>Skin reactions (e.g.\u00a0itching, rash)<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reactions (difficulty breathing, wheezing, swelling of the skin) and\u00a0shock\u00a0(sudden circulatory collapse) have occurred in very rare cases<\/li><li>Slow\u00a0pulse<\/li><li>Increased\u00a0blood pressure<\/li><li>Abnormal sensations (eg\u00a0itching, tingling, numbness), tremors, muscle twitching, uncoordinated movements, transient loss of consciousness (syncope), and speech difficulties.<\/li><li>Epileptic seizures have occurred mainly with high\u00a0doses of\u00a0tramadol or when tramadol was taken at the same time as other drugs that can induce seizures.<\/li><li>Appetite changes<\/li><li>Hallucinations, confusion, sleep disturbances, anxiety, and nightmares<\/li><li>Psychological problems can occur during treatment with Tramadol Krka.\u00a0Their\u00a0intensity\u00a0and nature vary individually (depending on the patient&#8217;s personality and treatment time).\u00a0The complaints can appear in the form of mood swings (mostly elevated mood, occasionally irritated mood), change in activity (usually inhibited temporarily increased), and reduced perception (changes in mind and recognition, which can lead to altered decision-making behaviors).<\/li><li>Drug dependence may occur.\u00a0When treatment is stopped suddenly, withdrawal symptoms may occur (see &#8220;If you stop taking Tramadol Krka&#8221;).<\/li><li>Blurred vision, pupil dilation (\u00a0mydriasis\u00a0), pupil narrowing (\u00a0miosis\u00a0)<\/li><li>Slow breathing (\u00a0respiratory depression\u00a0), shortness of breath (\u00a0dyspnoea\u00a0)<\/li><li>Worsening of\u00a0asthma\u00a0has been reported, however, it is not clear if this is caused by tramadol.\u00a0If the recommended\u00a0dose\u00a0is significantly exceeded, or if any drug that lowers brain function is taken at the same time, the breathing rate may decrease (\u00a0respiratory depression\u00a0).<\/li><li>Muscle weakness<\/li><li>Bladder emptying problems (difficulty or painful passing water), decreased urine output (\u00a0dysuria\u00a0)<\/li><\/ul>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Elevated liver values<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lowering <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar<\/a> level<\/li><li>Hiccup<\/li><li>Serotonergic syndrome, may manifest as altered mental status (eg, restlessness, hallucinations,\u00a0coma\u00a0) and other symptoms such as <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a>, increased heart rate, unstable\u00a0blood pressure, involuntary twitching, muscle stiffness, lack of coordination of movements, and\/or gastrointestinal symptoms (eg nausea, vomiting, diarrhea) (see section 2 &#8220;What you need to know before you take Tramadol Krka&#8221;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tramadol Krka<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 30 \u00b0C.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tramadol hydrochloride.\u00a0One hard capsule contains 50 mg tramadol hydrochloride.<\/li><li>Other ingredients (excipients) are microcrystalline cellulose, sodium starch glycolate (type A), talc, and magnesium stearate (E 470b) in the capsule core and titanium dioxide (E 171), indigo carmine (E 132) and gelatin in the capsule shell.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>The body of the capsule is white and the cap is blue.&nbsp;The capsules are filled with white or almost white powder.&nbsp;The capsule size is no.&nbsp;4. The length of the filled capsules is 14-15 mm.<\/p>\n\n\n\n<p>Tramadol Krka is available in boxes containing 10, 20, 30, 50, 60, 90, and 100 hard capsules in blisters.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>KRKA, dd, Novo mesto, \u0160marje\u0161ka cesta 6, 8501 Novo mesto, Slovenia<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tramadol &#8211; the active substance in Tramadol Krka &#8211; is an analgesic that belongs to the class of\u00a0opioids\u00a0that act on the\u00a0central nervous system\u00a0.\u00a0Tramadol acts as a pain reliever by affecting specific nerve cells in the spinal cord and brain.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[5337,14540,5339,26276,26279,26280,5338,26277,14539,26278],"class_list":["post-25431","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-tramadol-hydrochloride","tag-tramadol-hydrochloride-capsule","tag-tramadol-hydrochloride-side-effects","tag-tramadol-krka","tag-tramadol-krka-capsule","tag-tramadol-krka-side-effects","tag-what-is-tramadol-hydrochloride","tag-what-is-tramadol-krka","tag-what-tramadol-hydrochloride-is-used-for","tag-what-tramadol-krka-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25431","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25431"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25431\/revisions"}],"predecessor-version":[{"id":25482,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25431\/revisions\/25482"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25431"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25431"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25431"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}