{"id":25360,"date":"2022-09-15T07:27:53","date_gmt":"2022-09-15T07:27:53","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25360"},"modified":"2022-09-17T07:34:44","modified_gmt":"2022-09-17T07:34:44","slug":"tradil","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tradil\/","title":{"rendered":"Tradil &#8211; Dexibuprofen uses, dose and side effects"},"content":{"rendered":"\n<p>300 mg and 400 mg&nbsp;film-coated tablet<br>Dexibuprofen<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tradil is and what it is used for<\/h2>\n\n\n\n<p>Dexibuprofen, the active ingredient in Tradil, belongs to a group of medicines called non-steroidal anti-inflammatory\/anti-rheumatic agents (&nbsp;NSAIDs&nbsp;).&nbsp;NSAID&nbsp;preparations such as dexibuprofen are used to relieve pain and&nbsp;inflammation.&nbsp;They work by reducing the number of&nbsp;prostaglandins&nbsp;(substances that control&nbsp;inflammation&nbsp;and pain) produced in the body.<\/p>\n\n\n\n<p><strong>What is Tradil used for<\/strong><\/p>\n\n\n\n<p>Tradil is used in adults to relieve:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pain and&nbsp;inflammation&nbsp;caused by&nbsp;osteoarthritis&nbsp;(tissue-destroying joint disease)<\/li><li>menstrual pains<\/li><li>mild to moderate pain, such as muscle and joint pain and toothache.<\/li><\/ul>\n\n\n\n<p>The dexibuprofen found in Tradil may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Tradil<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Tradil<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to dexibuprofen or any of the other ingredients of this medicine (listed in section 6);<\/li><li>if you are allergic to\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/acetylsalicylic-acid-bluefish\/\">acetylsalicylic acid<\/a>\u00a0or other pain relievers (such\u00a0allergy\u00a0can cause breathing difficulties,\u00a0asthma, runny nose, skin rash, or facial swelling); if you previously had bleeding or\u00a0perforation\u00a0(hole) in the gastrointestinal tract caused by\u00a0NSAID\u00a0treatment;<\/li><li>if you have or have had recurrent stomach or\u00a0duodenal\u00a0ulcers (vomiting blood, black stools, or bloody diarrhea may be a sign of bleeding in the stomach or intestines);<\/li><li>if you have had brain bleeding (\u00a0cerebrovascular\u00a0bleeding) or another active bleeding;<\/li><li>if you have recently had a flare-up of symptoms of inflammatory\u00a0bowel disease (\u00a0ulcerative colitis,\u00a0Crohn&#8217;s disease\u00a0);<\/li><li>if you suffer from severe dehydration (e.g. caused by vomiting, diarrhea, or insufficient fluid intake);<\/li><li>if you have severe\u00a0heart failure\u00a0or severe liver or kidney disease;<\/li><li>if you are a woman who is pregnant in the last trimester of pregnancy;<\/li><li>if you suffer from a condition of unknown origin that results in the abnormal formation of blood cells.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Tradil:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have ever had a stomach or duodenal ulcer;<\/li><li>if you have had ulcerative colitis,\u00a0ulcerative colitis,\u00a0or Crohn&#8217;s disease;<\/li><li>if you have liver or kidney disease or if you are dependent on alcohol;<\/li><li>if you have a disease that affects the\u00a0clotting ability\u00a0of the blood (see also the section &#8220;Other medicines and Tradil&#8221;);<\/li><li>if you have\u00a0edema\u00a0(accumulation of fluid in the body&#8217;s\u00a0tissues\u00a0);<\/li><li>if you have heart disease or high blood pressure;<\/li><li>if you suffer from systemic lupus erythematosus,\u00a0SLE\u00a0(a disease that affects the joints, muscles, and skin) or from mixed collagenosis (a collagen disease that attacks the connective tissue) or<\/li><li>if you have problems getting pregnant;<\/li><li>if you have or have had\u00a0asthma\u00a0or allergic diseases, as shortness of breath may occur;<\/li><li>if you suffer from hay fever, nasal polyps, or\u00a0chronic\u00a0obstructive pulmonary disease, as there is an increased risk of allergic reactions.\u00a0The allergic reactions can manifest as asthma attacks (so-called\u00a0analgesic\u00a0asthma\u00a0),\u00a0Quincke&#8217;s edema\u00a0(swelling mainly in the face, lips, eyelids, or genitals), or hives;<\/li><li>if you have recently had major surgery;<\/li><li>if you have certain hereditary blood formation disorders (eg\u00a0acute\u00a0intermittent\u00a0porphyria\u00a0);<\/li><li>if you have an\u00a0infection\u00a0&#8211; see the heading &#8220;Infections&#8221; below.<\/li><\/ul>\n\n\n\n<p>Bleeding,\u00a0ulcers,\u00a0or holes (perforations) in the gastrointestinal tract, which can be life-threatening, have been reported with all\u00a0NSAIDs.\u00a0This has occurred at any time during treatment, with or without warning symptoms or previous occurrence of serious gastrointestinal side effects.\u00a0When bleeding or ulceration of the gastrointestinal tract occurs, treatment should be discontinued immediately.\u00a0The risk of bleeding, ulceration or perforation in the gastrointestinal tract increases with high\u00a0NSAID\u00a0doses,\u00a0in patients who have previously had\u00a0peptic ulcers, especially in more severe cases with bleeding or perforation (see section 2), and in the elderly.\u00a0These patients should start treatment with the lowest possible\u00a0dose.\u00a0Combination treatment with agents that have a protective effect (e.g. <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/angusta\/\">misoprostol<\/a> or\u00a0proton pump inhibitors\u00a0) should be considered for these patients, and also for patients who simultaneously need low-dose\u00a0aspirin\u00a0or other drugs that are likely to increase the risk of\u00a0side effects\u00a0in the gastrointestinal tract.<\/p>\n\n\n\n<p>If you have previously had&nbsp;side effects&nbsp;in the gastrointestinal tract, especially if you are older, you should report any unusual stomach symptoms to your doctor (especially bleeding in the gastrointestinal tract), especially if it occurs at the beginning of treatment.<\/p>\n\n\n\n<p>Anti-inflammatory\/pain-relieving drugs such as dexibuprofen may be associated with a small increased risk of heart attack or\u00a0stroke, especially when using high\u00a0doses.\u00a0Do not exceed the recommended\u00a0dose\u00a0or duration of treatment.<\/p>\n\n\n\n<p><em>You should discuss your treatment with a doctor or pharmacist before taking Tradil if you:<\/em><\/p>\n\n\n\n<p>&#8211; have heart problems including\u00a0heart failure, angina (chest pains) or if you have had a heart attack,\u00a0bypass\u00a0surgery,\u00a0peripheral\u00a0artery disease (poor circulation in the legs or feet due to narrowed or blocked blood vessels), or any type of\u00a0stroke\u00a0(including &#8220;mini-stroke&#8221; \u201d or\u00a0transient\u00a0ischemic attack (\u00a0TIA\u00a0)).<\/p>\n\n\n\n<p>&#8211; have high\u00a0blood pressure,\u00a0diabetes, high cholesterol, a history of heart disease or\u00a0stroke\u00a0in the family, or if you are a smoker.<\/p>\n\n\n\n<p>Severe acute\u00a0hypersensitivity reactions\u00a0(eg anaphylactic\u00a0shock\u00a0with symptoms such as shortness of breath, wheezing, and drop in blood pressure) have been observed very rarely.\u00a0Stop treatment immediately at the first signs of\u00a0a hypersensitivity reaction\u00a0after taking Tradil and talk to your doctor immediately.<\/p>\n\n\n\n<p>You may get a headache if you take high&nbsp;doses&nbsp;of pain relievers for a long time (beyond recommended use).&nbsp;If so, ask your doctor for advice;&nbsp;you should not take more Tradil for the headache.<\/p>\n\n\n\n<p>In general, the habitual use of pain-relieving drugs, especially in combinations of more than one pain-relieving active substance, can lead to permanent kidney damage with the risk of&nbsp;kidney failure&nbsp;(&nbsp;analgesic&nbsp;nephropathy&nbsp;).<\/p>\n\n\n\n<p><em>Skin reactions<\/em><\/p>\n\n\n\n<p>Serious skin reactions have been reported in connection with Tradil treatment.\u00a0You should stop taking Tradil and contact your doctor immediately if you develop a rash, sores on the mucous membranes, blisters, or other signs of\u00a0allergy\u00a0as these may be the first signs of a very serious skin reaction (see section 4).<\/p>\n\n\n\n<p><em>Infection&nbsp;you<\/em><\/p>\n\n\n\n<p>Tradil can mask signs of\u00a0infection\u00a0such as fever and pain.\u00a0Therefore, Tradil can cause the appropriate treatment of\u00a0infection\u00a0to be delayed and the risk of complications to increase.\u00a0This has been seen in\u00a0pneumonia\u00a0caused by bacteria and in bacterial skin infections associated with chickenpox.\u00a0If you take this medicine while you have an\u00a0infection\u00a0and the symptoms of infection\u00a0persist or worsen, contact your doctor immediately.<\/p>\n\n\n\n<p>You should avoid taking Tradil if you have chickenpox or\u00a0shingles.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tradil<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tradil can affect or be affected by certain other medicines.&nbsp;For example:<\/p>\n\n\n\n<p>&#8211;\u00a0anticoagulant\u00a0medicines (ie blood thinners, eg\u00a0aspirin,\u00a0warfarin, ticlopidine, rivaroxaban, apixaban, or dabigatran) may prolong bleeding time.<\/p>\n\n\n\n<p>&#8211; medicines that lower high\u00a0blood pressure\u00a0(\u00a0ACE inhibitors\u00a0eg\u00a0captopril,\u00a0beta-blockers\u00a0eg atenolol,\u00a0angiotensin\u00a0-II receptor antagonists eg\u00a0losartan\u00a0).<\/p>\n\n\n\n<p>&#8211; voriconazole and\u00a0fluconazole\u00a0(CYP2C9 inhibitors), are used in fungal infections, as the effect of dexibuprofen may be increased.<\/p>\n\n\n\n<p>Certain other medicines can also affect or be affected by treatment with Tradil.\u00a0You should therefore always consult a doctor or pharmacist before using Tradil with other medicines.\u00a0You must tell your doctor or pharmacist if, in addition to the medicines mentioned above, you also use any of the following medicines:<\/p>\n\n\n\n<p>You should\u00a0<strong>not<\/strong>\u00a0take the following medicines together with Tradil unless you are under close medical supervision:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Non-steroidal anti-inflammatory\/anti-rheumatic agents,&nbsp;NSAIDs&nbsp;(agents for pain, fever and&nbsp;inflammation&nbsp;).&nbsp;There is an increased risk of ulcers and bleeding in the gastrointestinal tract if you take Tradil together with other&nbsp;NSAIDs&nbsp;or&nbsp;acetylsalicylic acid&nbsp;as pain-relieving treatment.<\/li><\/ul>\n\n\n\n<p>You\u00a0<strong>can<\/strong>\u00a0take the following medicines, but for safety reasons, you must inform your doctor about them:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lithium is used to treat certain mental conditions where the mood is affected.\u00a0Tradil may increase the effect of lithium.<\/li><li>Methotrexate (a medicine for cancer or rheumatism).\u00a0Tradil can increase the\u00a0side effects\u00a0of methotrexate.\u00a0Diuretics\u00a0(\u00a0diuretics\u00a0) because dexibuprofen can reduce the effect of these drugs.<\/li><li>Corticosteroids: The risk of ulcers and bleeding in the gastrointestinal tract may increase.<\/li><li>Some antidepressants (selective serotonin reuptake inhibitors) can increase the risk of bleeding in the gastrointestinal tract.<\/li><li>Digoxin\u00a0(a heart medicine).\u00a0Tradil can increase the\u00a0side effects\u00a0of\u00a0digoxin.<\/li><li>Immunosuppressants (such as cyclosporin, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/adport\/\">tacrolimus<\/a>, sirolimus) sulphonylureas (type of oral anti-diabetic medicine), and antibiotic\u00a0aminoglycosides\u00a0(medicines to treat\u00a0infection\u00a0) \u2013 kidney damage may occur.<\/li><li>Quinolone antibiotics, as the risk of convulsions, may increase.<\/li><li>Potassium-sparing\u00a0diuretics, as can lead to high potassium levels in the blood.<\/li><li>Phenytoin is used to treat\u00a0epilepsy.\u00a0Tradil can increase the\u00a0side effects\u00a0of\u00a0phenytoin.<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/alimta\/\">Pemetrexed<\/a> (used to treat certain cancers)<\/li><li>Zidovudine (agent for treating HIV\/AIDS);\u00a0Dexibuprofen can lead to an increased risk of bleeding in a joint or bleeding that leads to swelling.<\/li><li>Baclofen (muscle relaxant):\u00a0side effects\u00a0of baclofen can develop after taking dexibuprofen.<\/li><li>Sulfinpyrazone, probenecid (medicine against\u00a0gout\u00a0), as excretion of dexibuprofen may be delayed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Tradil with food, drink, and alcohol<\/h2>\n\n\n\n<p>Tradil can be taken without food, but taking it with a meal is better because it can help avoid stomach upset.&nbsp;This applies especially if the treatment continues for a long time.<\/p>\n\n\n\n<p>You should avoid or limit your alcohol intake while using Tradil as this could worsen gastrointestinal problems.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.\u00a0You should not use Tradil during the last three months of pregnancy, as it may harm your unborn baby, even at very low\u00a0doses.\u00a0During the first 6 months of pregnancy, you should use Tradil only after consulting your doctor.<\/p>\n\n\n\n<p>You should also not use Tradil if you are planning to become pregnant, as this medicine can make it more difficult to get pregnant.<\/p>\n\n\n\n<p>In rare cases, drugs such as Tradil can affect a woman&#8217;s\u00a0fertility.\u00a0Your\u00a0fertility\u00a0will return to normal when you stop taking Tradil.<\/p>\n\n\n\n<p>Only small amounts of Tradil pass into breast milk.\u00a0If you are breastfeeding, however, you should not use Tradil for a long time or in high\u00a0doses.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>If you experience&nbsp;side effects&nbsp;such as dizziness, fatigue, vertigo or if you experience visual disturbances after taking Tradil, you should avoid driving a car or using machines that may pose a danger (see section 4 &#8220;Possible side effects&#8221;).<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Tradil<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>You should take Tradil with a glass of water or another liquid.&nbsp;Tradil has a faster effect if you take it without food.&nbsp;However, it is recommended to take the medicine with food, as it can help to avoid stomach upsets, especially if the treatment lasts for a long time.<\/p>\n\n\n\n<p><em>300 mg<\/em><\/p>\n\n\n\n<p>Do not take more than&nbsp;<strong>1 tablet<\/strong>&nbsp;of Tradil 300 mg as a&nbsp;<strong>single dose.<\/strong><\/p>\n\n\n\n<p>Do not take more than&nbsp;<strong>4 tablets<\/strong>&nbsp;of Tradil 300 mg&nbsp;<strong>per day.<\/strong><\/p>\n\n\n\n<p><em>400 mg<\/em><\/p>\n\n\n\n<p>Do not take more than&nbsp;<strong>1 tablet<\/strong>&nbsp;of Tradil 400 mg as a&nbsp;<strong>single dose.<\/strong><\/p>\n\n\n\n<p>Do not take more than&nbsp;<strong>3 tablets<\/strong>&nbsp;of Tradil 400 mg&nbsp;<strong>per day.<\/strong><\/p>\n\n\n\n<p><strong>In the case of\u00a0osteoarthritis<\/strong><\/p>\n\n\n\n<p><em>300 mg<\/em><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 1 tablet of Tradil 300 mg 2 to 3 times per day.&nbsp;In case of acute symptoms, your doctor can increase the&nbsp;dose&nbsp;by one to 4 tablets of Tradil 300 mg per day.<\/p>\n\n\n\n<p><em>400 mg<\/em><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 1 tablet of Tradil 400 mg 2 times a day (1 in the morning and 1 in the evening).&nbsp;In case of acute symptoms, your doctor can increase the&nbsp;dose&nbsp;by one to 3 tablets of Tradil 400 mg per day.<\/p>\n\n\n\n<p><strong>In case of menstrual pains<\/strong><\/p>\n\n\n\n<p><em>300 mg<\/em><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 1 tablet of Tradil 300 mg 2 to 3 times per day.<\/p>\n\n\n\n<p><em>400 mg<\/em><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 1 tablet of Tradil 400 mg 2 times a day.<\/p>\n\n\n\n<p><strong>For mild to moderate pain<\/strong><\/p>\n\n\n\n<p><em>300 mg<\/em><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 1 tablet of Tradil 300 mg 2 times per day.&nbsp;If a higher&nbsp;dose&nbsp;is needed, your doctor can&nbsp;prescribe&nbsp;up to 4 tablets of Tradil 300 mg per day.<\/p>\n\n\n\n<p><em>400 mg<\/em><\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0is 200 mg Tradil (half a 400 mg tablet) 3 times a day.\u00a0If a higher\u00a0dose\u00a0is needed, your doctor can\u00a0prescribe\u00a0up to 3 tablets of Tradil 400 mg per day.\u00a0Depending on your symptoms, your doctor may also prescribe lower-strength Tradil tablets (300 mg).\u00a0The break on the tablets (see the section &#8220;Appearance of the medicine&#8221;) allows them to be divided into two equal\u00a0doses.<\/p>\n\n\n\n<p>The lowest effective&nbsp;dose&nbsp;should be used for the shortest possible time to relieve symptoms.&nbsp;Contact your doctor immediately if you have an&nbsp;infection&nbsp;and symptoms (such as fever and pain) persist or worsen (see section 2).<\/p>\n\n\n\n<p>The 400 mg tablet can be divided into two equal\u00a0doses.\u00a0To split the tablet, place it on a hard surface and press down with your index fingers or thumbs.<\/p>\n\n\n\n<p><em>Patients with liver or kidney disease:<\/em>&nbsp;Your doctor may have prescribed Tradil at a lower&nbsp;dose&nbsp;than normal.&nbsp;You should not increase the&nbsp;dose&nbsp;prescribed by your doctor.<\/p>\n\n\n\n<p><em>Elderly patients:<\/em>&nbsp;If you are over 60 years of age, your doctor may have prescribed a lower&nbsp;dose&nbsp;than normal.&nbsp;If you do not have any problems using Tradil, your doctor may increase the&nbsp;dose&nbsp;for you.<\/p>\n\n\n\n<p><em>Children and adolescents:<\/em>\u00a0As there is not enough experience in the treatment of children and adolescents, Tradil should not be used in people younger than 18 years.<\/p>\n\n\n\n<p>If you think the effect of Tradil is too strong or too weak, consult a doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Tradil<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,&nbsp;a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>Symptoms may include nausea, stomach pain, vomiting (may contain some blood), headache, ringing in the ears, lack of coordination, confusion, and jerky eye movements.\u00a0At high\u00a0doses, drowsiness, chest pain, palpitations, unconsciousness, convulsions (mainly in children), weakness and dizziness, blood in the urine, low\u00a0blood pressure, freezing, and breathing problems have been reported.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Tradil<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a missed tablet.&nbsp;Take the next tablet as usual.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Side effects\u00a0can be minimized by taking the lowest\u00a0dose\u00a0for the shortest possible time to relieve symptoms.\u00a0Elderly people who use this medicine have an increased risk of\u00a0side effects.\u00a0Side effects\u00a0are mostly dose dependent and vary from patient to patient.\u00a0The risk of\u00a0side effects\u00a0in the gastrointestinal tract is particularly dependent on the\u00a0dose\u00a0and duration of treatment.<\/p>\n\n\n\n<p><strong>Stop using Tradil and seek immediate medical attention<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you get severe stomach pain, especially when you start taking Tradil.<\/li><li>if you have black stools, bloody diarrhea, or vomit blood.<\/li><li>if you get a rash, severe blistering or peeling of the skin, mucosal lesions, or any signs of hypersensitivity.<\/li><li>if you get symptoms such as fever, sore throat, and mouth,\u00a0flu-like symptoms, feeling tired, and nose and skin bleeding.\u00a0These symptoms can be caused by a decrease in\u00a0white blood cells\u00a0(\u00a0agranulocytosis\u00a0).<\/li><li>if you get severe or persistent <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/headache\/\">headaches<\/a>.<\/li><li>if you develop yellowing of the skin and whites of the eyes (jaundice).<\/li><li>if you develop swelling of the face, tongue, or throat, difficulty swallowing or breathing (\u00a0angioedema\u00a0), or a worsening\u00a0of asthma.<\/li><li>if you urinate less than normal, have swelling, cloudy urine, or generally feel unwell these may be the first signs of kidney damage or\u00a0kidney failure.<\/li><\/ul>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect more than 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Problems in the gastrointestinal tract, such as stomach pain, nausea, indigestion, diarrhea, gas formation (\u00a0flatulence\u00a0), constipation, heartburn, vomiting, and small blood losses in the stomach and\/or intestine which in exceptional cases can cause anemia.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;<\/strong>&nbsp;<strong>side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ulcers of the gastrointestinal tract, sometimes with bleeding and\u00a0perforation\u00a0(see section 2), black stools (melena), blood-stained vomit (hematemesis), mouth ulcers and\u00a0inflammation\u00a0(ulcerative\u00a0stomatitis\u00a0),\u00a0inflammation\u00a0of the large intestine (\u00a0colitis\u00a0), worsening of\u00a0inflammatory\u00a0bowel disease, complications associated with bulges of the large intestine (hole in the intestinal wall or\u00a0fistula\u00a0).<\/li><li>Central nervous system disorders\u00a0such\u00a0as headache, dizziness, insomnia, restlessness, irritability or sleepiness (drowsiness), dizziness, and fatigue.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Gastric catarrh<\/li><li>Visual disturbances<\/li><li>Hypersensitivity reactions, such as\u00a0hives\u00a0(\u00a0urticaria\u00a0),\u00a0itching, purple bruises (purpura), and\u00a0eczema\u00a0as well as asthma attacks (possibly with a drop in blood pressure)<\/li><li>Swelling of the face or neck (\u00a0angioedema\u00a0)<\/li><li>Anxiety<\/li><li>Ringing in the ears (\u00a0tinnitus\u00a0)<\/li><li>Rhinitis (\u00a0rhinitis\u00a0)<\/li><li>Rash<\/li><li>Development of\u00a0edema, especially in patients with high\u00a0blood pressure\u00a0or with kidney problems including nephritis and\u00a0kidney failure.<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;<\/strong>&nbsp;<strong>side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Psychotic reaction<\/li><li>Vision loss (toxic amblyopia)<\/li><li>Impaired hearing<\/li><li>Kidney damage (papillary\u00a0necrosis\u00a0), elevated urea concentration, and uric acid concentration in the blood<\/li><li>Liver function problems (usually\u00a0reversible\u00a0)<\/li><li>Depression, confusion, hallucination<\/li><\/ul>\n\n\n\n<p><strong>Very rare&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Difficulty breathing (mainly in patients with\u00a0bronchial asthma\u00a0)<\/li><li>Inflammation\u00a0of the esophagus or pancreas, formation of membrane-like strictures in the small and large intestine (membrane-like\u00a0strictures\u00a0in the intestine)<\/li><li>Swelling (\u00a0edema\u00a0), high\u00a0blood pressure,\u00a0inflammation\u00a0of the blood vessels, palpitations,\u00a0heart failure<\/li><li>Impaired liver function, liver damage, especially during long-term treatment, liver failure,\u00a0acute\u00a0liver inflammation (\u00a0hepatitis\u00a0), and jaundice<\/li><li>Photosensitivity reactions<\/li><li>Disorders in the production of blood cells (\u00a0anemia,\u00a0leukopenia,\u00a0thrombocytopenia, pancytopenia,\u00a0agranulocytosis\u00a0) \u2013 the first signs are: fever, sore throat, superficial mouth ulcers,\u00a0flu-like symptoms, severe exhaustion, nose, and skin bleeding.\u00a0In these cases, you must immediately stop treatment and consult a doctor.\u00a0You must not treat these symptoms with painkillers or antipyretic drugs<\/li><li>Exacerbation of infection-related inflammation\u00a0(eg,\u00a0necrotizing\u00a0fasciitis) associated with the use of certain analgesics (\u00a0NSAIDs\u00a0) has been described.\u00a0If signs of infection\u00a0appear or worsen while using dexibuprofen, see a doctor without delay to determine if there is a need for anti-infective\/\u00a0antibiotic treatment<\/li><li>In exceptional cases, serious skin infections and soft tissue complications in the case as chicken pox infection (varicella)<\/li><li>Symptoms of\u00a0meningitis\u00a0(aseptic\u00a0meningitis\u00a0) with neck stiffness, headache, malaise, nausea, fever, or clouded consciousness have been observed with the use of dexibuprofen.\u00a0Patients with autoimmune diseases (\u00a0SLE, mixed connective tissue disease) may be more likely to be affected.\u00a0Contact a doctor immediately if this occurs<\/li><li>Serious types of skin reactions such as skin rash with\u00a0redness\u00a0and blisters (e.g.\u00a0Stevens-Johnson syndrome, erythema multiforme,\u00a0toxic epidermal necrolysis\u00a0\/\u00a0Lyell&#8217;s syndrome\u00a0), hair loss (\u00a0alopecia\u00a0)<\/li><li>Severe generalized\u00a0hypersensitivity reaction\u00a0(swelling of the face, tongue, and larynx, shortness of breath, rapid heartbeat, low\u00a0blood pressure, severe\u00a0shock\u00a0), worsening of\u00a0asthma<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurring in an unknown number of users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A serious skin reaction called DRESS may occur.\u00a0Symptoms of DRESS include skin rash, fever, swollen\u00a0lymph nodes,\u00a0and an increase in\u00a0eosinophils\u00a0(a type of\u00a0white blood cell\u00a0).<\/li><li>Red, widespread, scaly rash with bumps under the skin and blisters mainly in skin folds, on the upper body and arms, accompanied by fever at the beginning of treatment (\u00a0acute\u00a0generalized exanthematous\u00a0pustulosis\u00a0).\u00a0If you develop these symptoms, stop taking Tradil and contact your doctor immediately (See section 2).<\/li><\/ul>\n\n\n\n<p>Medicines such as Tradil may be associated with a slightly increased risk of heart attack or\u00a0stroke.<\/p>\n\n\n\n<p>If you experience\u00a0side effects, talk to your doctor or pharmacist.\u00a0This also applies to any\u00a0side effects\u00a0that are not mentioned in this information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Tradil should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store at a maximum of 25 \u00b0C.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and blister after &#8220;EXP:&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is dexibuprofen.&nbsp;One film-coated tablet contains either 300 mg or 400 mg of dexibuprofen.<\/li><li>Other ingredients are<br>Tablet core: hypromellose, microcrystalline cellulose, carmellose calcium,&nbsp;colloidal&nbsp;anhydrous silica, talc.<br>Film coating: hypromellose, titanium dioxide (E 171), triacetin, talc, macrogol 6000.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p><em>300 mg<\/em><\/p>\n\n\n\n<p>The 300 mg tablets are white and round.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20001103000069#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/c7d56ff9-78c8-4e74-a7e0-c0374cdd85c3\" alt=\"300\" title=\"300\"\/><\/a><\/figure>\n\n\n\n<p>Diameter: approx.&nbsp;11.2 mm<\/p>\n\n\n\n<p>Height: approx. 5.2 mm<\/p>\n\n\n\n<p>Tradil 300 mg tablets are supplied in cartons of 10, 20, 30, 50, 60, 90, and 100 tablets in transparent, colorless PVC\/PVDC\/aluminum blisters.<\/p>\n\n\n\n<p><em>400 mg<\/em><\/p>\n\n\n\n<p>The 400 mg tablets are white with a score on both sides.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20001103000069#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/f598e1e2-b2a4-4ddc-ac89-b9a7c019954a\" alt=\"400\" title=\"400\"\/><\/a><\/figure>\n\n\n\n<p>Length: approx.&nbsp;18.2 mm&nbsp;<\/p>\n\n\n\n<p>Width: approx.&nbsp;8.2 mm<\/p>\n\n\n\n<p>Height: approx.&nbsp;5.9 mm<\/p>\n\n\n\n<p>Tradil 400 mg tablets are supplied in cartons of 4, 10, 20, 30, 50, 60, 90, and 100 tablets in transparent, colorless PVC\/PVDC\/aluminum blisters.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Nordic Drugs AB, Box 300 35, 200 61 Limhamn<\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>Gebro Pharma GmbH, 6391 Fieberbrunn, Austria<\/p>\n\n\n\n<p><strong>This medicine is approved in the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Austria:<\/td><td>Dexibuprofen &#8220;Gebro&#8221; 300, 400 mg Film tablet<\/td><\/tr><tr><td>Portugal:<\/td><td>Seractil 300, 400 mg comprimidos revestidos<\/td><\/tr><tr><td>Sweden:<\/td><td>Tradil 300, 400 mg film-coated tablets<\/td><\/tr><tr><td>Denmark:<\/td><td>Selective 300, 400 mg film-coated tablets<\/td><\/tr><tr><td>Spain:<\/td><td>Seractil 400 mg comprimidos recubiertos con pel\u00edcula<\/td><\/tr><tr><td>Greece:<\/td><td>Seractil 400 mg film-coated tablets<\/td><\/tr><tr><td>Germany:<\/td><td>Dolomagon 300, 400 mg Film tablet<\/td><\/tr><tr><td>Italy:<\/td><td>Seractil 300, 400 compresse rivestite con film<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Dexibuprofen, the active ingredient in Tradil, belongs to a group of medicines called non-steroidal anti-inflammatory\/anti-rheumatic agents (\u00a0NSAIDs\u00a0).\u00a0NSAID\u00a0preparations such as dexibuprofen are used to relieve pain and\u00a0inflammation\u00a0.\u00a0They work by reducing the amount of\u00a0prostaglandins\u00a0(substances that control\u00a0inflammation\u00a0and pain) produced in the body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[26208,26211,26210,26212,26217,26216,26213,26209,26214,26215],"class_list":["post-25360","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-dexibuprofen","tag-dexibuprofen-side-effects","tag-dexibuprofen-tablet","tag-tradil","tag-tradil-side-effects","tag-tradil-tablet","tag-what-dexibuprofen-is-used-for","tag-what-is-dexibuprofen","tag-what-is-tradil","tag-what-tradil-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25360"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25360\/revisions"}],"predecessor-version":[{"id":25428,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25360\/revisions\/25428"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25360"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25360"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}