{"id":25319,"date":"2022-09-14T07:36:40","date_gmt":"2022-09-14T07:36:40","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25319"},"modified":"2022-09-15T07:18:59","modified_gmt":"2022-09-15T07:18:59","slug":"toujeo","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/toujeo\/","title":{"rendered":"Toujeo &#8211; Insulin\u00a0glargine uses, dose and side effects"},"content":{"rendered":"\n<p>300 units\/ml&nbsp;DoubleStar&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;pen<br>Insulin&nbsp;glargine.&nbsp;Each DoubleStar pen provides 2-160 units in dose increments of 2 units<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Toujeo is and what it is used for<\/h2>\n\n\n\n<p>Toujeo contains insulin\u00a0called &#8220;insulin glargine&#8221;.\u00a0This is a modified\u00a0insulin, very similar to human insulin.<\/p>\n\n\n\n<p>Toujeo contains 3 times more\u00a0insulin\u00a0in 1 ml than regular\u00a0insulin, which contains 100 units\/ml.<\/p>\n\n\n\n<p>Toujeo is used to treat&nbsp;diabetes mellitus&nbsp;in adults, adolescents and children from 6 years of age.&nbsp;Diabetes mellitus&nbsp;is a disease in which the body does not produce enough&nbsp;insulin&nbsp;to keep your <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar<\/a> level under control.<\/p>\n\n\n\n<p>Toujeo lowers your blood sugar steadily over a longer period.\u00a0It is given once daily.\u00a0You can change the time of your\u00a0injection\u00a0if you need it.\u00a0This is because this medicine lowers your blood sugar over a longer period (for more information, see section 3).<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Toujeo<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Toujeo<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to&nbsp;insulin&nbsp;glargine or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist or nurse before using Toujeo.<\/p>\n\n\n\n<p>Be sure to follow the dosage instructions and instructions for monitoring (of blood and urine), diet, physical activities (physical work and exercise) and injection technique as discussed with your doctor.<\/p>\n\n\n\n<p>Pay particular attention to the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Too low blood sugar (\u00a0hypoglycaemia\u00a0).\u00a0If your blood sugar is too low, follow the advice on treating\u00a0hypoglycaemia\u00a0(see information in the box at the end of this leaflet).<\/li><li>If you switch from another type of\u00a0insulin, another brand or another manufacturer, your insulin dose may need to be changed.<\/li><li>Pioglitazone.\u00a0See &#8220;Use of pioglitazone with insulin&#8221;.<\/li><li>Make sure you use the right\u00a0insulin.\u00a0Medication errors due to confusion between\u00a0insulins, especially between long-acting\u00a0insulins\u00a0and rapid-acting\u00a0insulins, have been reported.\u00a0You must always check the insulin label before each\u00a0injection, to avoid mixing Toujeo with other\u00a0insulins.<\/li><li>Never use a\u00a0syringe\u00a0to remove Toujeo from your pre-filled DoubleStar pen.\u00a0This is to avoid dosing errors and possible overdose, which can lead to low blood sugar.\u00a0See also section 3.<\/li><li>To avoid insulin underdosing,\u00a0a safety test must be performed before the first use of a new pen and also before each use of the pen (see step 3 in the instructions for use).\u00a0See also section 3.<\/li><li>If you are blind or have poor vision, do not use the pre-filled syringe without assistance, as you will not be able to read the dosing window on the pen.\u00a0Be sure to get the help of a person with good vision who is trained in using this pen.<\/li><\/ul>\n\n\n\n<p><strong>Skin changes at the injection site<\/strong><\/p>\n\n\n\n<p>To prevent skin changes, e.g.\u00a0knots under the skin, you should constantly change the injection site.\u00a0Insulin\u00a0it may\u00a0not work as well if you inject it into an area with nodules (see How to use Toujeo).\u00a0Contact the doctor before changing the injection site if you are currently injecting into an area with nodules.\u00a0The doctor may advise you to check your blood sugar more often and to adjust your insulin dose or the\u00a0dose\u00a0of other <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">diabetes<\/a> medicines.<\/p>\n\n\n\n<p><strong>Diseases and injuries<\/strong><\/p>\n\n\n\n<p>In the following situations, the management of your&nbsp;diabetes&nbsp;may require extra care (for example, blood and urine samples):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are ill or have had a serious accident.\u00a0Your blood sugar level may increase (\u00a0hyperglycaemia\u00a0).<\/li><li>If you don&#8217;t eat enough.\u00a0Your blood sugar level may become too low (\u00a0hypoglycaemia\u00a0).<\/li><\/ul>\n\n\n\n<p>In most cases, you will need to speak to a doctor.&nbsp;Contact a doctor as soon as you feel sick or injured.<\/p>\n\n\n\n<p>If you have type 1&nbsp;diabetes&nbsp;and have an illness or injury<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not stop&nbsp;insulin&nbsp;et.<\/li><li>Continue to eat enough carbohydrates.<\/li><\/ul>\n\n\n\n<p>Always tell those who look after you or treat you that you have\u00a0diabetes.<\/p>\n\n\n\n<p>Insulin treatment can cause the body to form&nbsp;antibodies&nbsp;against&nbsp;insulin&nbsp;(substances that react against&nbsp;insulin&nbsp;).&nbsp;Only in very rare cases is a change in the insulin dose required.<\/p>\n\n\n\n<p><strong>Travels<\/strong><\/p>\n\n\n\n<p>Talk to your doctor before you travel.&nbsp;You may need to address issues such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If your\u00a0insulin\u00a0is available in the country you are visiting.<\/li><li>How the supply of\u00a0insulin, syringes and other items should be arranged?<\/li><li>How your\u00a0insulin\u00a0can be stored correctly during the trip.<\/li><li>Times for meals and insulin use.<\/li><li>Possible consequences of travelling to other time zones.<\/li><li>Any health risks in the countries you are going to visit?<\/li><li>What to do in an emergency, if you feel unwell or become ill.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine should not be used in children younger than 6 years.&nbsp;There is no experience with the use of Toujeo in this age group.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Toujeo<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take any other medicines.<\/p>\n\n\n\n<p>Some medicines can change <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar levels<\/a>.\u00a0This may mean that your insulin dose needs to be changed.\u00a0Before taking a medicine, ask your doctor if it can affect your blood sugar level and what to do if so.\u00a0You also need to be careful when you stop taking medicine.<\/p>\n\n\n\n<p><strong>Your blood sugar level may drop (&nbsp;hypoglycaemia&nbsp;) if you take:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>All other medicines for the treatment of diabetes.<\/li><li>Disopyramide\u00a0&#8211; in certain heart conditions.<\/li><li>Fluoxetine\u00a0&#8211; for depression.<\/li><li>Sulfonamide antibiotics.<\/li><li>Fibrates &#8211; to lower high levels of blood fats.<\/li><li>MAO inhibitors\u00a0&#8211; in depression.<\/li><li>ACE inhibitors\u00a0&#8211; in case of heart disease or high\u00a0blood pressure.<\/li><li>Pain-relieving and antipyretic medicines such as pentoxifylline, propoxyphene and salicylates (eg\u00a0aspirin\u00a0).<\/li><li>Pentamidine \u2013 in certain\u00a0infections\u00a0caused by parasites.\u00a0This can cause low blood sugar, which is sometimes followed by high blood sugar.<\/li><\/ul>\n\n\n\n<p><strong>Your blood sugar level may increase (&nbsp;hyperglycaemia&nbsp;) if you take:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Corticosteroid, e.g.\u00a0cortisone\u00a0&#8211; in case of\u00a0inflammation.<\/li><li>Danazol \u2013 for\u00a0endometriosis\u00a0.<\/li><li>Diazoxide \u2013 in case of high\u00a0blood pressure.<\/li><li>Protease inhibitors\u00a0&#8211; in\u00a0HIV.<\/li><li>Diuretics\u00a0&#8211; in case of high\u00a0blood pressure\u00a0or if you have accumulated fluid.<\/li><li>Glucagon \u2013 in case of very low blood sugar.<\/li><li>Isoniazid\u00a0&#8211; in\u00a0tuberculosis\u00a0.<\/li><li>Somatropin &#8211; a\u00a0growth hormone.<\/li><li>Thyroid hormones &#8211; in thyroid diseases.<\/li><li>Estrogens\u00a0and progestogens \u2013 e.g.\u00a0birth control pills\u00a0used for birth control.<\/li><li>Clozapine, olanzapine and phenothiazine derivatives &#8211; in mental illnesses.<\/li><li>Sympathomimetics\u00a0e.g.\u00a0adrenaline\u00a0(\u00a0epinephrine\u00a0),\u00a0salbutamol\u00a0and\u00a0terbutaline\u00a0&#8211; in\u00a0asthma.<\/li><\/ul>\n\n\n\n<p><strong>Blood sugar levels may sometimes increase and sometimes decrease if you take:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Beta-blockers\u00a0or\u00a0clonidine\u00a0&#8211; in case of high\u00a0blood pressure.<\/li><li>Lithium salts &#8211; in mental illnesses.<\/li><\/ul>\n\n\n\n<p><strong>Beta-blockers<\/strong><\/p>\n\n\n\n<p>Beta-blockers\u00a0as well as other sympatholytic drugs (such as\u00a0clonidine, guanethidine and reserpine \u2013 in high\u00a0blood pressure\u00a0) can make it harder to recognize warning signs if your blood sugar is too low (\u00a0hypoglycaemia\u00a0).\u00a0It can also hide or stop the first signs that your blood sugar is too low.<\/p>\n\n\n\n<p><strong>Use of pioglitazone together with&nbsp;insulin<\/strong><\/p>\n\n\n\n<p>Some patients with long-standing type-2\u00a0diabetes mellitus\u00a0and heart disease or previous\u00a0stroke, who were treated with pioglitazone and\u00a0insulin, developed\u00a0heart failure.\u00a0If you develop signs of\u00a0heart failure\u00a0such as increased shortness of breath, rapid weight gain or local swelling (\u00a0oedema\u00a0), inform your doctor as soon as possible.<\/p>\n\n\n\n<p>If any of the above applies to you (or you are not sure), talk to your doctor, pharmacist or nurse before using Toujeo.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Toujeo with alcohol<\/h2>\n\n\n\n<p>Your blood sugar can either rise or fall if you drink alcohol.&nbsp;Check your blood sugar more often than usual.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, consult your doctor before using this medicine.&nbsp;The insulin dose may need to be adjusted during pregnancy and after delivery.&nbsp;For the sake of the baby, it is especially important that your&nbsp;diabetes&nbsp;is kept under control and that&nbsp;hypoglycaemia&nbsp;is prevented.<\/p>\n\n\n\n<p>Talk to your doctor if you are breastfeeding as your insulin dose and diet may need to be adjusted.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Too low or too high blood sugar or vision problems can affect the ability to drive or use tools or machines.&nbsp;Your ability to concentrate may be affected.&nbsp;It can be dangerous to yourself and others.<\/p>\n\n\n\n<p>Ask your doctor if you can drive over:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your blood sugar is often too low.<\/li><li>You have difficulty recognizing when your blood sugar is too low.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Important information about any excipient in Toujeo<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose.\u00a0This means that it is almost &#8220;sodium-free&#8221;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Toujeo<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor.&nbsp;Consult a doctor, pharmacist or nurse if you are unsure.<\/p>\n\n\n\n<p>Although Toujeo contains the same active substance as\u00a0insulin\u00a0glargine at 100 units\/ml, these medicines are not interchangeable.\u00a0The transition from one insulin treatment to another requires a prescription, medical monitoring and blood sugar control.\u00a0Consult a doctor for further information.<\/p>\n\n\n\n<p><strong>How much to take<\/strong><\/p>\n\n\n\n<p>Toujeo DoubleStar pre-filled pen can deliver a\u00a0dose\u00a0of 2 to 160 units for each\u00a0injection, in 2 unit dose steps.\u00a0The pen is recommended for patients who need at least 20 units of\u00a0insulin\u00a0per day (see also section 2).<\/p>\n\n\n\n<p>The dosage window on the DoubleStar pen shows the number of units of Toujeo to be injected.&nbsp;Do not recalculate&nbsp;dose&nbsp;one.<\/p>\n\n\n\n<p>Depending on your lifestyle, the results of your blood sugar test and previous insulin treatment, the doctor will tell you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>How much Toujeo you will need each day and at what time of day?<\/li><li>When to check your blood sugar level and if you need to do a urine test.<\/li><li>When you may have to increase or decrease the\u00a0dose\u00a0a.<\/li><\/ul>\n\n\n\n<p>Toujeo is a long-acting\u00a0insulin.\u00a0The doctor may\u00a0prescribe\u00a0it in combination with fast-acting\u00a0insulin\u00a0or other medicines for high blood sugar.<\/p>\n\n\n\n<p>If you use more than one\u00a0insulin, make sure you are taking the correct\u00a0insulin\u00a0by checking the insulin label before each\u00a0injection.\u00a0Medication errors due to confusion between insulins, especially between long-acting\u00a0insulin\u00a0er and rapid-acting\u00a0insulin\u00a0er, have been reported.\u00a0The strength is marked in honey yellow on the label of your pre-filled Toujeo DoubleStar pen.\u00a0Ask your doctor or pharmacy staff if you are unsure.<\/p>\n\n\n\n<p>Many factors can affect blood sugar levels.\u00a0You need to know these factors to react correctly when the blood sugar level changes and to prevent the level from becoming too high or too low.\u00a0See the box at the end of this leaflet for more information.<\/p>\n\n\n\n<p><strong>Flexible timing of&nbsp;administration<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Use Toujeo once daily, preferably at the same time each day.<\/li><li>If necessary, you can inject Toujeo up to 3 hours before or after the usual dosing time.<\/li><\/ul>\n\n\n\n<p><strong>Use in elderly patients (65 years and older)<\/strong><\/p>\n\n\n\n<p>Talk to your doctor if you are 65 or older, as you may need a lower\u00a0dose.<\/p>\n\n\n\n<p><strong>If you have kidney or liver problems<\/strong><\/p>\n\n\n\n<p>Talk to your doctor if you have kidney or liver problems, as you may need a lower\u00a0dose.<\/p>\n\n\n\n<p><strong>Before injecting Toujeo<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Read the instructions for use that come with the package insert.<\/li><li>If you do not follow all instructions, you may receive too much or too little\u00a0insulin.<\/li><li>Perform a safety test as described in step 3 of the instructions for use.\u00a0If you do not do this, your full\u00a0dose\u00a0will not be delivered.\u00a0If this happens, you should check your blood glucose levels more often and you may also need to\u00a0administer\u00a0additional\u00a0insulin.\u00a0See also section 2.<\/li><\/ul>\n\n\n\n<p><strong>How to inject<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Toujeo is injected under the skin (\u00a0subcutaneous\u00a0use, sc).<\/li><li>Give an\u00a0injection\u00a0in the front of the thighs, in the upper arms or the front of the waist (abdomen).<\/li><li>Vary the injection site within the area of \u200b\u200bskin you use for\u00a0injection\u00a0each day.\u00a0It reduces the risk of the skin shrinking or thickening (for more information, see \u201cOther side effects\u201d in section 4).<\/li><\/ul>\n\n\n\n<p>To prevent the possible transmission of disease, injection pens should never be used for more than one person, even if the injection needle is changed.<\/p>\n\n\n\n<p>Always attach a new\u00a0sterile\u00a0needle before each\u00a0injection.\u00a0Never reuse needles.\u00a0Reusing a needle increases the risk of it becoming clogged and giving you too much or too little\u00a0insulin.<\/p>\n\n\n\n<p>Dispose of the used needle in a puncture-proof container or according to current procedures.<\/p>\n\n\n\n<p><strong>Do not use Toujeo<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>In a vein.\u00a0That would change the way it works and cause low blood sugar.<\/li><li>In an insulin infusion pump.<\/li><li>If there are particles in\u00a0insulin\u00a0et.\u00a0The solution should be clear, colourless and water-like.<\/li><\/ul>\n\n\n\n<p>Never use a\u00a0syringe\u00a0to remove Toujeo from a DoubleStar pen.\u00a0It can lead to serious overdoses.\u00a0See also section 2.<\/p>\n\n\n\n<p>If the DoubleStar pen is damaged or has not been stored properly, if you are not sure if it is working properly, or if you notice that your blood glucose control has unexpectedly worsened:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Discard the pen and use a new one.<\/li><li>Talk to your doctor, pharmacist or nurse if you think you have a problem with the pen.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use too much Toujeo&nbsp;<\/h2>\n\n\n\n<p>If you have injected too much of this medicine, your blood sugar level may become too low.&nbsp;Check your blood sugar and eat more food to prevent blood sugar from getting too low.&nbsp;If your blood sugar gets too low, read the advice in the box at the end of this leaflet.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Toujeo<\/h2>\n\n\n\n<p>If needed, Toujeo can be injected up to 3 hours before or after the time you usually inject it.<\/p>\n\n\n\n<p>If you have forgotten a\u00a0dose\u00a0of Toujeo or if you have not injected enough\u00a0insulin, your blood sugar level may become too high (\u00a0hyperglycaemia\u00a0).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not inject a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/li><li>Check the blood sugar and then inject the next\u00a0dose\u00a0at the usual time.<\/li><li>For information on the treatment of\u00a0hyperglycaemia, see the box at the end of this leaflet.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Toujeo<\/h2>\n\n\n\n<p>Do not stop taking this medicine without talking to your doctor.&nbsp;If you stop taking the medicine, it can lead to very high blood sugar and acid build-up in the blood (&nbsp;ketoacidosis&nbsp;).<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor, pharmacist or nurse.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>If you notice that your blood sugar is getting too low (&nbsp;hypoglycaemia&nbsp;),<\/strong>&nbsp;take immediate action to raise your blood sugar level (see the box at the end of this leaflet).<\/p>\n\n\n\n<p>Hypoglycaemia&nbsp;can be very serious and is very common with insulin treatment (may affect more than 1 in 10 people).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Low blood sugar means that there is not enough sugar in your blood.<\/li><li>If your blood sugar level gets too low, you may pass out (pass out).<\/li><li>Very low blood sugar can cause brain damage and can be life-threatening.<\/li><li>For more information, see the box at the end of this leaflet.<\/li><\/ul>\n\n\n\n<p><strong>Serious\u00a0allergic reaction<\/strong>\u00a0(rare, may affect up to 1 in 1,000 people).\u00a0Symptoms may include rash and\u00a0itching\u00a0all over the body, swelling of the skin and mouth, shortness of breath, feeling faint (drop in blood pressure) with rapid heartbeat and sweating.\u00a0Severe\u00a0allergic reactions\u00a0to\u00a0insulin\u00a0can be life-threatening.\u00a0Contact a doctor immediately if you notice signs of a severe\u00a0allergic reaction.<\/p>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>Tell your doctor, pharmacist or nurse if you notice any of the following side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Skin changes at the injection site: <\/strong>If you inject\u00a0insulin\u00a0too often in the same place, the skin may either shrink (lipoatrophy) (\u00a0<em>may affect up to 1 in 100 people<\/em>\u00a0) or thicken (lipohypertrophy) (\u00a0<em>may affect up to 1 in 10 people<\/em>\u00a0).\u00a0Nodules under the skin can also be caused by the accumulation of a\u00a0protein\u00a0called amyloid (\u00a0cutaneous\u00a0amyloidosis. How often this occurs is not known).\u00a0Insulin\u00a0it may\u00a0not work as well if you inject it into an area with nodules.\u00a0Change the injection site for each\u00a0injection\u00a0to prevent these skin changes.<\/li><\/ul>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;may affect up to 1 in 10 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Skin side effects and allergic reactions at the injection site: The reactions may include\u00a0redness, unusually intense <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a> at the\u00a0injection site,\u00a0itching,\u00a0hives, swelling and\u00a0inflammation.\u00a0These reactions may spread around the injection site.\u00a0Most less serious insulin reactions usually go away within a few days to a few weeks.<\/li><\/ul>\n\n\n\n<p><strong>Rare:<\/strong>&nbsp;may affect up to 1 in 1,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Visual impact: A marked change (improvement or deterioration) in blood sugar control can impair your vision.\u00a0If you have an eye disease associated with\u00a0diabetes\u00a0called\u00a0proliferative\u00a0retinopathy, attacks of very low blood sugar can cause temporary loss of vision.<\/li><li>Swelling in the calves and ankles is caused by the temporary accumulation of water in the body.<\/li><\/ul>\n\n\n\n<p><strong>Very rare:<\/strong>&nbsp;may affect up to 1 in 10,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Taste changes (&nbsp;dysgeusia&nbsp;).<\/li><li>Muscle pain (&nbsp;myalgia&nbsp;).<\/li><\/ul>\n\n\n\n<p>Inform the doctor, pharmacist or nurse if you notice any of the above\u00a0side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Toujeo should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and the pen label after \u201cEXP\u201d.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><strong>Before first use<\/strong><\/p>\n\n\n\n<p>Store in a refrigerator (2\u00b0C-8\u00b0C).<\/p>\n\n\n\n<p>May not be frozen or stored in direct contact with freezer compartments or cooling clamps.<\/p>\n\n\n\n<p>Store the pre-filled pen in the outer carton.&nbsp;Light sensitive.<\/p>\n\n\n\n<p><strong>After first use or if it is taken as a spare<\/strong><\/p>\n\n\n\n<p>Do not store the injection pen in the refrigerator.\u00a0The pen can be stored for a maximum of 6 weeks below 30\u00b0C and protected from direct heat and direct light.\u00a0Discard the pen after this period.\u00a0Do not leave\u00a0insulin\u00a0in a car on an unusually hot or <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">cold<\/a> day.\u00a0Always keep the protective cap on the pen when not in use to protect it from light.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is\u00a0insulin\u00a0glargine.\u00a0Each ml of solution contains 300 units\u00a0of insulin\u00a0glargine (equivalent to 10.91 mg).\u00a0Each DoubleStar\u00a0injection\u00a0pen contains 3 ml of\u00a0injection fluid, corresponding to 900 units.<\/li><li>Other ingredients are zinc chloride, metacresol,\u00a0glycerol, water for injections and sodium hydroxide (see section 2 &#8220;Important information about any ingredient in Toujeo&#8221;) and\u00a0hydrochloric acid\u00a0(for\u00a0pH\u00a0adjustment).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Toujeo is a clear and colourless solution.<\/p>\n\n\n\n<p>Each DoubleStar&nbsp;injection&nbsp;pen contains 3 ml of&nbsp;injection solution&nbsp;(equivalent to 900 units).<\/p>\n\n\n\n<p>Packs of 1, 3, 6 (2 packs of 3), 9 (3 packs of 3) and 10 pre-filled pens are available.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Sanofi-Aventis Deutschland GmbH, D\u201165926 Frankfurt am Main, Germany.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Toujeo contains an\u00a0insulin\u00a0called &#8220;insulin glargine&#8221;.\u00a0This is a modified\u00a0insulin\u00a0, very similar to human insulin.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[12074,26143,12069,12080,26140,26144,12071,12070,26141,26142],"class_list":["post-25319","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-insulin-glargine","tag-benefits-of-toujeo","tag-insulin-glargine","tag-insulin-glargine-side-effects","tag-toujeo","tag-toujeo-side-effects","tag-what-insulin-glargine-is-used-for","tag-what-is-insulin-glargine","tag-what-is-toujeo","tag-what-toujeo-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25319","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25319"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25319\/revisions"}],"predecessor-version":[{"id":25347,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25319\/revisions\/25347"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25319"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25319"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25319"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}