{"id":25317,"date":"2022-09-14T07:33:46","date_gmt":"2022-09-14T07:33:46","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25317"},"modified":"2022-09-15T07:19:05","modified_gmt":"2022-09-15T07:19:05","slug":"tostrex","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tostrex\/","title":{"rendered":"Tostrex &#8211; Testosterone uses, dose and side effects"},"content":{"rendered":"\n<p>2%&nbsp;gel<br>Testosterone<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"> WHAT TOSTREX IS AND WHAT IT IS USED FOR<\/h2>\n\n\n\n<p>The active substance,\u00a0testosterone, is a\u00a0hormone\u00a0that is a type of\u00a0androgen.<\/p>\n\n\n\n<p>Tostrex is given to adult men as a testosterone replacement to treat various problems caused by testosterone deficiency (male&nbsp;hypogonadism&nbsp;).&nbsp;These complaints should be confirmed by two separate blood test testosterone measurements and also include clinical symptoms such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>impotence<\/li><li>infertility<\/li><li>low sex drive<\/li><li>fatigue<\/li><li>Depression<\/li><li>osteoporosis caused by low hormone levels<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">WHAT YOU NEED TO KNOW BEFORE YOU USE TOSTREX<\/h2>\n\n\n\n<p>Tostrex should only be used if&nbsp;hypogonadism&nbsp;has been confirmed by your doctor, based on your symptoms and laboratory tests.&nbsp;Other causes of your symptoms must have been ruled out by your doctor before starting treatment.<\/p>\n\n\n\n<p>Only men can use Tostrex.&nbsp;Tostrex has not been tested in men under the age of 18 and there is limited experience in treating men over the age of 65.<\/p>\n\n\n\n<p><strong>Do not use Tostrex<\/strong><\/p>\n\n\n\n<p>If you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>are allergic to\u00a0testosterone\u00a0or any of the other ingredients of this medicine (listed in section 6)<\/li><li>have or are suspected of having breast or\u00a0prostate cancer.<\/li><\/ul>\n\n\n\n<p>Consult a doctor or pharmacist if any of the above apply to you.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>It is necessary to have an examination before starting the treatment and then regularly during the treatment (usually once or twice a year).<\/p>\n\n\n\n<p>If you suffer from severe heart, liver, or\u00a0kidney failure, treatment with Tostrex can lead to severe complications in the form of fluid accumulation in the body which is sometimes accompanied by (\u00a0chronic\u00a0) heart failure.<\/p>\n\n\n\n<p>Your doctor will perform the following blood tests before and during treatment: testosterone levels in the blood, and complete blood cell count.<\/p>\n\n\n\n<p>Tell the doctor if you have high&nbsp;blood pressure&nbsp;or are being treated for high&nbsp;blood pressure&nbsp;because&nbsp;testosterone&nbsp;can cause an increase in&nbsp;blood pressure&nbsp;et.<\/p>\n\n\n\n<p>Testosterone treatment may increase the risk of developing an enlarged prostate gland (benign prostatic\u00a0hyperplasia\u00a0) or prostate cancer.\u00a0Testosterone treatment can also affect the number of\u00a0red blood cells\u00a0you have, your blood fat profile, and your liver function.<\/p>\n\n\n\n<p>Tell your doctor before treatment if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have swollen hands and feet<\/li><li>are overweight or suffer from a\u00a0chronic\u00a0lung disease, as testosterone treatment may worsen\u00a0sleep apnea\u00a0(temporary cessation of breathing during sleep)<\/li><li>have\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">diabetes<\/a>\u00a0and use\u00a0insulin\u00a0to control <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar levels<\/a>, as testosterone treatment can affect your insulin response<\/li><li>have or get\u00a0epilepsy\u00a0or\u00a0migraines, as these conditions may worsen during treatment<\/li><li>have bone cancer, as your doctor will need to check your blood calcium levels during treatment.<\/li><li>have or have ever had blood clotting problems<ul><li>thrombophilia (an abnormality in blood coagulation that increases the risk of\u00a0thrombosis\u00a0\u2013 blood clots in the blood vessels)<\/li><li>factors that increase your risk of blood clots in veins: previous blood clots in a vein;\u00a0smoking, being overweight, cancer, immobility (immobility), if someone in your immediate family has had blood clots in the legs, lungs, or other organs at a young age (eg under about 50 years of age) or with increasing age. This is how you recognize a blood clot: painful swelling in a leg or sudden color change of the skin, e.g.\u00a0pale, red or blue, sudden shortness of breath, sudden unexplained <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a> that may lead to you coughing up blood, sudden chest pain, feeling very unsteady or dizzy, severe stomach pain, sudden loss of vision.\u00a0Seek medical attention immediately if you notice any of these symptoms.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Contact your doctor if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have frequent\u00a0erections<\/li><li>feel irritable, nervous, or notice that you are gaining weight<\/li><li>feel sick, vomit, notice a change in skin color, or if you get swollen ankles<\/li><li>have breathing disorders, including breathing disorders during sleep.<\/li><\/ul>\n\n\n\n<p>These symptoms may mean that the\u00a0dose\u00a0of Tostrex is too high and your doctor may need to adjust the\u00a0dose.<\/p>\n\n\n\n<p>Contact your doctor if you notice any skin reactions at the application site, such as a burning or stinging sensation, dryness, rash,\u00a0redness,\u00a0or\u00a0itching.\u00a0If the reaction is severe, your doctor should reassess the treatment and, if necessary, discontinue it.<\/p>\n\n\n\n<p>If you are an athlete, keep in mind that Tostrex contains the active substance\u00a0testosterone, which can give a positive result in a doping test.<\/p>\n\n\n\n<p>Tostrex should not be used to treat male sterility or\u00a0impotence.<\/p>\n\n\n\n<p>Tostrex should not be used by women because of the possible virilizing effect (such as facial and body hair, darker voice, or altered menstrual cycle).<\/p>\n\n\n\n<p><strong>How to avoid transferring Tostrex to other people:<\/strong><\/p>\n\n\n\n<p>It is important not to transfer the product to other people, especially women and children.\u00a0Transmission occurs through close skin contact, which causes elevated testosterone levels in the other person.\u00a0If the contact is repeated or takes place over a longer period, it can cause\u00a0side effects\u00a0such as facial or body hair, a darker voice, or a change in the menstrual cycle in women.<\/p>\n\n\n\n<p>This transmission can be avoided by covering the application site with loose clothing, or by showering or bathing before contact.<\/p>\n\n\n\n<p>The following precautions are therefore recommended:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>wash your hands thoroughly with soap and water after applying the gel;<\/li><li>cover the application site with loose clothing when the&nbsp;gel&nbsp;has dried;<\/li><li>shower or bathe before situations that involve close skin contact with someone else.<\/li><\/ul>\n\n\n\n<p>To ensure your partner&#8217;s safety, you should wait at least four hours after applying Tostrex before having sexual intercourse and wear clothing that covers the application site at the time of contact or wash the application site with soap and water before sexual intercourse.<\/p>\n\n\n\n<p>You should wear clothing that covers the application site when in contact with children to avoid the risk of transferring the&nbsp;gel&nbsp;to the child&#8217;s skin.<\/p>\n\n\n\n<p>If you transfer testosterone gel to another person through skin contact or if someone else comes into direct contact with the\u00a0gel\u00a0itself, wash the contact area of \u200b\u200bthe other person with soap and water as soon as possible.<\/p>\n\n\n\n<p>If Tostrex is applied to a patient by a health care provider or home care provider, they should wear appropriate disposable gloves.&nbsp;The gloves must be resistant to alcohol because the&nbsp;gel&nbsp;contains&nbsp;ethanol&nbsp;and isopropyl alcohol.<\/p>\n\n\n\n<p>Contact your doctor if you notice changes in body hair, markedly increased\u00a0acne,\u00a0or other signs of developing male features in\u00a0<strong>people not treated with Tostrex (ie female partner or children).<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tostrex<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, especially any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood thinners<\/li><li>corticosteroids&nbsp;_<\/li><\/ul>\n\n\n\n<p>Also, tell your doctor or pharmacist if you are taking or have recently taken over-the-counter medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tostrex with food and drink<\/h2>\n\n\n\n<p>Tostrex is not affected by your intake of food or drink.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Tostrex is intended for use by men only.<\/li><li>Tostrex must not be used by pregnant and breastfeeding women.<\/li><li>Pregnant women should avoid all contact with skin treated with Tostrex.&nbsp;Tostrex can cause damage or abnormalities in the unborn child.&nbsp;If your partner becomes pregnant, you must follow the advice on avoiding the transfer of testosterone gel given in this section.&nbsp;(In the event of contact with treated skin, wash the area immediately with soap and water.)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>It is unlikely that Tostrex will affect your ability to drive or use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tostrex contains butyl hydroxytoluene and propylene glycol<\/h2>\n\n\n\n<p>Butylhydroxytoluene can cause local skin reactions (e.g.\u00a0contact dermatitis\u00a0) or irritation of the eyes or mucous membranes.\u00a0This medicine contains up to 1400 mg of propylene glycol per dose unit, corresponding to 350 mg\/g.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">HOW TO USE TOSTREX<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor.&nbsp;Consult a doctor or pharmacist if you are unsure how and when to apply&nbsp;gel&nbsp;en.<\/p>\n\n\n\n<p>The usual starting dose is 3 g\u00a0gel\u00a0(contains 60 mg\u00a0of testosterone\u00a0) a day.\u00a0The dose\u00a0can be adjusted by your doctor and the maximum\u00a0dose\u00a0is 4 g\u00a0gel\u00a0(80 mg\u00a0testosterone\u00a0) per day.<\/p>\n\n\n\n<p>Tostrex is supplied in a multi-dose container with a dosing pump that delivers half a gram of&nbsp;gel&nbsp;(10 mg of&nbsp;testosterone&nbsp;) with each push of the pump (when the pump mechanism is fully depressed).<\/p>\n\n\n\n<p><strong>The first time the multi-dose container is used&nbsp;<\/strong><strong>:<\/strong><\/p>\n\n\n\n<p>Before using the dosing pump for the first time, it must be prepared.\u00a0You do this by holding the container upright and slowly pushing down the pump properly eight times.\u00a0At the first press, there may not be any\u00a0gel, but throw away any\u00a0gel\u00a0that is squeezed out.\u00a0The pump only needs to be prepared before the first\u00a0dose.<\/p>\n\n\n\n<p><strong>Administration&nbsp;of Tostrex:<\/strong><\/p>\n\n\n\n<p>Your doctor will inform you how many times you have to press down the pump to get the right\u00a0dose of\u00a0gel\u00a0when the pump is prepared.\u00a0The table below gives you more information about this.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><td><strong>Number of prints<\/strong><\/td><td><strong>Amount of&nbsp;gel&nbsp;(g)<\/strong><\/td><td><strong>Amount of&nbsp;testosterone&nbsp;applied to the skin (mg)<\/strong><\/td><\/tr><\/thead><tbody><tr><td>1<\/td><td>0.5<\/td><td>10<\/td><\/tr><tr><td>2<\/td><td>1<\/td><td>20<\/td><\/tr><tr><td>4<\/td><td>2<\/td><td>40<\/td><\/tr><tr><td>6<\/td><td>3<\/td><td>60<\/td><\/tr><tr><td>8<\/td><td>4<\/td><td>80<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Apply&nbsp;gel&nbsp;one to clean, dry and undamaged skin once a day, at the same time each day, e.g.&nbsp;in the morning after you shower.<\/p>\n\n\n\n<p>Gel\u00a0one should be smeared either on the abdomen (on an area of \u200b\u200bat least 10 x 30 cm) or divided in half and smeared on the inside of\u00a0<strong>each<\/strong>\u00a0thigh (on an area of \u200b\u200bat least 10 x 15 cm).\u00a0It is recommended that you apply Tostrex on the abdomen one day and the inside of\u00a0<strong>both<\/strong>\u00a0thighs the next day.<\/p>\n\n\n\n<p>Application in other places should be avoided.&nbsp;In particular, do not apply Tostrex to the genitals.<\/p>\n\n\n\n<p>Gently apply\u00a0gel\u00a0one with a finger until it has dried, then cover the area with loose-fitting clothing (eg T-shirt, shorts, pants).\u00a0Wash your hands thoroughly with soap and water when you are finished.<\/p>\n\n\n\n<p>If you intend to shower or bathe, you should do so either before applying Tostrex or wait at least two hours after application.<\/p>\n\n\n\n<p>Two weeks after you start your medication, the doctor will take a blood test to see if your&nbsp;dose&nbsp;needs to be changed.&nbsp;While you are taking Tostrex, your doctor will carry out regular medical checks.<\/p>\n\n\n\n<p>If you are responsible for having blood samples tested while using Tostrex, you must ensure that all testosterone measurements are performed by the same laboratory, due to varying assay values \u200b\u200bbetween different diagnostic laboratories.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Tostrex&nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Tostrex<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.\u00a0Apply the next\u00a0dose\u00a0at the usual time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Tostrex<\/h2>\n\n\n\n<p>Always talk to your doctor or pharmacist before you stop using Tostrex.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">POSSIBLE SIDE EFFECTS<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Very common\u00a0side effects\u00a0(\u00a0<em>occurring in more than 1 user in 10)<\/em>\u00a0are skin reactions at the application site such as\u00a0a burning or stinging sensation, dryness, rash,\u00a0redness,\u00a0or\u00a0itching.\u00a0These are usually mild temporary\u00a0side effects\u00a0of Tostrex but if they are bothersome or last more than a few days you should talk to your doctor or pharmacist as soon as possible.<\/p>\n\n\n\n<p>Common\u00a0side effects\u00a0(\u00a0<em>affects 1 to 10 users in 100)<\/em>\u00a0are: swelling of the hands or feet, high\u00a0blood pressure, prostate changes (including increased blood levels of a\u00a0protein\u00a0called a prostate-specific antigen, which is produced by the\u00a0prostate\u00a0), increased body hair, breast enlargement, increased number of\u00a0red blood cells\u00a0(measured in blood tests).\u00a0An increase in the number of\u00a0red blood cells,\u00a0hematocrit\u00a0(the percentage of\u00a0red blood cells\u00a0in the blood), and\u00a0hemoglobin\u00a0(the component of\u00a0red blood cells that transport oxygen) are identified with regular blood tests.<\/p>\n\n\n\n<p>Other known\u00a0side effects\u00a0associated with testosterone treatment are hair loss, dandruff,\u00a0acne, jaundice (liver problems that can sometimes be accompanied by a yellowing of the skin and the whites of the eyes), abnormal liver function tests, nausea, altered sexual desire, more\u00a0frequent erections, difficulty urinating, depression, nervousness, hostility, weight gain, muscle cramps or muscle pain, fluid retention, swollen ankles,\u00a0sleep apnea\u00a0and, rarely, painful and persistent\u00a0erections.\u00a0Decreased sperm production and decreased testicular size may occur at high\u00a0doses.\u00a0Long-term testosterone administration can cause changes in salt levels (\u00a0electrolytes) in the body.<\/p>\n\n\n\n<p>There is no convincing evidence that testosterone replacement in hypogonadal men causes prostate cancer.&nbsp;However, testosterone treatment should be avoided in men who are known or suspected to have prostate cancer.<\/p>\n\n\n\n<p>Hyperglycaemia\u00a0(too high a <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar<\/a> level) has been reported in cases involving 2 people who had\u00a0diabetes mellitus.<\/p>\n\n\n\n<p>If any&nbsp;side effects&nbsp;get worse or if you notice any&nbsp;side effects&nbsp;not mentioned in this information, contact your doctor or pharmacist as soon as possible.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">HOW TOSTREX SHOULD BE STORED<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 25\u00baC.<br>Store protected from <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">cold<\/a>, do not freeze.<br>Store container upright after opening.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">PACKAGING CONTENTS AND OTHER INFORMATION<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is\u00a0testosterone.\u00a0One gram of\u00a0gel\u00a0contains 20 mg of\u00a0testosterone.<\/li><li>Other ingredients are propylene glycol, anhydrous\u00a0ethanol, isopropyl alcohol, oleic acid, carbomer 1382, trolamine, butylhydroxytoluene (E321), purified water, and\u00a0hydrochloric acid\u00a0(for\u00a0pH\u00a0adjustment).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tostrex is a clear\u00a0gel, which varies from colorless to pale yellow.<\/p>\n\n\n\n<p>Tostrex is delivered in containers of 60 grams of\u00a0gel\u00a0each.\u00a0The containers are equipped with a dosing pump that provides a set amount of\u00a0gel.<\/p>\n\n\n\n<p>A carton may contain one, two, or three multi-dose containers of\u00a0gel.\u00a0Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Kyowa Kirin Holdings BV<\/p>\n\n\n\n<p>Bloemlaan 2<\/p>\n\n\n\n<p>2132NP Hoofddorp<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Information provided by:<\/p>\n\n\n\n<p>Kyowa Kirin AB<\/p>\n\n\n\n<p>Coffin<\/p>\n\n\n\n<p>Tel.: 08-50 90 74 10<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>PHARBIL Waltrop GmbH<br>I&#8217;m Wirrigen 25<br>45731 Waltrop<br>Germany<\/p>\n\n\n\n<p><strong>This medicine is approved in the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p>Austria, Denmark, Finland, Germany, Greece, Hungary, Ireland, Netherlands, Norway, Poland, Portugal, United Kingdom: Tostran<\/p>\n\n\n\n<p>Italy, Sweden: Tostrex<\/p>\n\n\n\n<p>Belgium, Spain, Luxembourg: Itnogen<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The active substance,\u00a0testosterone\u00a0, is a\u00a0hormone\u00a0that is a type of\u00a0androgen\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25658,26145,25659,26146,26150,26149,25654,26147,25655,26148],"class_list":["post-25317","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-testosterone","tag-testosterone-gel","tag-testosterone-side-effects","tag-tostrex","tag-tostrex-gel","tag-tostrex-side-effects","tag-what-is-testosterone","tag-what-is-tostrex","tag-what-testosterone-is-used-for","tag-what-tostrex-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25317","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25317"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25317\/revisions"}],"predecessor-version":[{"id":25349,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25317\/revisions\/25349"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25317"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25317"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25317"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}