{"id":25280,"date":"2022-09-13T07:17:29","date_gmt":"2022-09-13T07:17:29","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25280"},"modified":"2022-09-14T07:22:57","modified_gmt":"2022-09-14T07:22:57","slug":"topotecan-hospira","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/topotecan-hospira\/","title":{"rendered":"Topotecan Hospira &#8211; Topoteca uses, dose and side effects"},"content":{"rendered":"\n<p>4 mg\/4 ml concentrate for infusion solution, solution<br>topotecan<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Topotecan Hospira is and what it is used for<\/h2>\n\n\n\n<p>Topotecan Hospira helps destroy\u00a0tumors.\u00a0A doctor or nurse will give you the medicine as an\u00a0infusion\u00a0into a vein in the hospital.<\/p>\n\n\n\n<p><strong>Topotecan Hospira is used to treat:<\/strong><\/p>\n\n\n\n<p>\u2022\u00a0<strong>ovarian <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a> or <\/strong>small cell lung cancer\u00a0that has recurred after\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/treatment-of-cancer-in-children\/\">chemotherapy<\/a>.<\/p>\n\n\n\n<p>\u2022&nbsp;<strong>advanced cervical cancer<\/strong>&nbsp;where treatment with&nbsp;surgery&nbsp;or radiotherapy is not possible.&nbsp;In the treatment of cervical cancer, Topotecan Hospira is given in combination with another medicine called&nbsp;<em>cisplatin.<\/em><\/p>\n\n\n\n<p>Your doctor will decide together with you whether treatment with Topotecan Hospira is better than continuing treatment with the&nbsp;chemotherapy&nbsp;you were initially treated with.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you receive Topotecan Hospira<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should not receive Topotecan Hospira:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to topotecan or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are breastfeeding.<\/li><li>if your blood cell count is too low.&nbsp;Your doctor will inform you if this is the case based on the test results of your last blood test.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if any of these apply to you.&nbsp;<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions&nbsp;<\/h2>\n\n\n\n<p>Before starting treatment, your doctor must know:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have kidney or liver problems.\u00a0Your\u00a0dose\u00a0of Topotecan Hospira may then need to be adjusted.<\/li><li>if you are pregnant or planning to become pregnant.\u00a0See the section &#8220;Pregnancy and breastfeeding&#8221; below.<\/li><li>if you are a man and planning to have children.\u00a0See the section &#8220;Pregnancy and breastfeeding&#8221; below.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if any of these apply to you.&nbsp;<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Topotecan Hospira<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or maybe taking other medicines, including over-the-counter and herbal medicines.<\/p>\n\n\n\n<p>Remember to tell your doctor if you start taking any other medicine while you are using Topotecan Hospira.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Topotecan is not recommended for pregnant women.\u00a0It can harm the fetus if it occurs before, during, or shortly after the treatment.\u00a0You must use effective contraception.\u00a0Ask your doctor for advice.\u00a0Do not try to get pregnant until your doctor says it is safe to do so.<\/p>\n\n\n\n<p>Male patients who wish to have a child should ask their doctor for family planning advice or treatment.&nbsp;If your partner becomes pregnant during treatment, you must tell your doctor immediately.<\/p>\n\n\n\n<p>Do\u00a0<strong>not<\/strong>\u00a0breastfeed if you are treated with topotecan.\u00a0Do not start breastfeeding again until your doctor tells you that it is safe to breastfeed.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Topotecan can make you feel tired.&nbsp;If you feel tired or weak, do not drive or use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Topotecan Hospira contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg) of&nbsp;sodium&nbsp;per dose unit, i.e. it is almost &#8216;sodium-free&#8217;.&nbsp;However, if your doctor uses normal saline when diluting Topotecan Hospira, the sodium dose will be higher.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Topotecan Hospira is used<\/h2>\n\n\n\n<p>The topotecan&nbsp;dose&nbsp;you receive is determined by your doctor and is based on:<\/p>\n\n\n\n<p><strong>\u2022<\/strong>&nbsp;your body surface area (measured as square meters (m&nbsp;<sup>2<\/sup>&nbsp;))<\/p>\n\n\n\n<p><strong>\u2022<\/strong>&nbsp;the results of the blood samples taken before the treatment.<\/p>\n\n\n\n<p><strong>\u2022<\/strong>&nbsp;which&nbsp;<strong><\/strong>disease is being treated.<\/p>\n\n\n\n<p><strong>Usual&nbsp;dosage<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>For ovarian cancer and small cell lung cancer:<\/strong>\u00a01.5 mg per square meter of body surface per day.\u00a0You will be treated once a day for 5 days.\u00a0Usually, this treatment schedule is repeated every three weeks.<\/li><li>For cervical cancer:\u00a00.75 mg per square meter of body surface per day.\u00a0You will be treated once a day for 3 days.\u00a0Usually, this treatment schedule is repeated every three weeks. In the treatment of cervical cancer, Topotecan Hospira is combined with another drug called cisplatin.\u00a0Your doctor will decide which\u00a0dose\u00a0of cisplatin you will receive.<\/li><\/ul>\n\n\n\n<p>The treatment schedule may vary depending on the results of your regular blood tests.<\/p>\n\n\n\n<p><strong>How topotecan is given<\/strong><\/p>\n\n\n\n<p>A doctor or nurse will give you Topotecan Hospira as an&nbsp;infusion&nbsp;into your arm, over about 30 minutes.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor or pharmacist<strong>.<\/strong><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Topotecan Hospira can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious side effects: tell your doctor<\/strong><\/p>\n\n\n\n<p>These very common&nbsp;side effects&nbsp;may affect more than 1 in 10 people treated with Topotecan Hospira.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Signs of\u00a0infection<\/strong>.\u00a0Topotecan can reduce the number of\u00a0white blood cells\u00a0and reduce your resistance to\u00a0infection.\u00a0This can lead to life-threatening conditions.\u00a0Symptoms include:<ul><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a><\/li><li>severe deterioration of your general condition\/health<\/li><li>local symptoms such as a <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sore-throat\/\">sore throat<\/a> or difficulty urinating (for example, a burning sensation when you urinate, which may be due to a urinary tract infection)<\/li><\/ul><\/li><li>Sometimes severe abdominal pain, fever, and possible diarrhea (in rare cases bloody) can be signs of\u00a0inflammation\u00a0of the intestines (\u00a0<em>colitis<\/em>\u00a0).<\/li><\/ul>\n\n\n\n<p>This&nbsp;<strong>rare&nbsp;<\/strong>side effect&nbsp;may occur in up to 1 in 1,000 people treated with Topotecan Hospira.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Pneumonia\u00a0(\u00a0<\/strong><em>interstitial lung disease\u00a0<\/em><strong>).\u00a0<\/strong>You are most at risk if you have an existing lung disease, have had radiation treatment of your lungs, or have previously taken medications that caused lung damage.\u00a0Signs of this can be:<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>breathing difficulties<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a><\/li><li>fever<\/li><\/ul>\n\n\n\n<p>Contact your doctor immediately if you develop symptoms of any of these conditions as hospitalization may be necessary.<\/p>\n\n\n\n<p><strong><u>Very common&nbsp;side effects&nbsp;are<\/u><\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>more than 1 in 10 people<\/strong>&nbsp;treated with Topotecan Hospira:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Feeling of general weakness and fatigue (temporary\u00a0<em>anemia<\/em>\u00a0).\u00a0In some cases, you may need a\u00a0blood transfusion.<\/li><li>Easier to bruise and bleed, due to a reduction in the number of clotting cells in the blood.\u00a0This can lead to more bleeding from relatively small wounds such as small cuts.\u00a0In rare cases, this can lead to serious bleeding\u00a0(\u00a0hemorrhage\u00a0).\u00a0Talk to your doctor for advice on how to minimize the risk of bleeding.<\/li><li>Weight loss and loss of appetite (\u00a0anorexia\u00a0), fatigue, and weakness.<\/li><li>Nausea, vomiting, diarrhea, stomach ache, constipation.<\/li><li>Inflammation\u00a0and sores in the mouth, tongue, or gums.<\/li><li>High body temperature (\u00a0<em>fever<\/em>\u00a0).<\/li><li>Hair loss.<\/li><\/ul>\n\n\n\n<p><strong><u>Common&nbsp;side effects&nbsp;are<\/u><\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>up to 1 in 10 people<\/strong>&nbsp;treated with Topotecan Hospira:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic or\u00a0hypersensitivity reaction\u00a0(including skin rash).<\/li><li>Yellowish skin (jaundice)<\/li><li>A general feeling of discomfort<\/li><li>Itching<\/li><\/ul>\n\n\n\n<p><strong><u>Rare\u00a0side effects\u00a0ar<\/u><\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>up to 1 in 1,000 people<\/strong>&nbsp;treated with Topotecan Hospira:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe allergic or anaphylactic reactions.<\/li><li>Swelling is caused by fluid retention (\u00a0angioedema\u00a0).<\/li><li><strong>\u2022<\/strong>\u00a0Mild pain and\u00a0inflammation\u00a0at the injection site.<\/li><li>Itchy rash (or\u00a0<em>hives<\/em>\u00a0)<\/li><\/ul>\n\n\n\n<p><strong>Side effects&nbsp;are without known frequency<\/strong><\/p>\n\n\n\n<p>The frequency of some&nbsp;side effects&nbsp;is not known (derived from spontaneous reports and the frequency cannot be calculated from the available data):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe stomach pain, nausea, vomiting blood, black or bloody stools (possible symptoms of a hole in the gastrointestinal tract [gastrointestinal perforation]).<\/li><li>Mouth ulcers, difficulty swallowing, abdominal pain, nausea, vomiting, diarrhea, and bloody stools (possible signs and symptoms of\u00a0inflammation\u00a0of the lining of the mouth, stomach, and\/or intestine [mucositis]).<\/li><\/ul>\n\n\n\n<p><strong>If you are being treated for cervical cancer:<\/strong>&nbsp;you may have&nbsp;side effects&nbsp;from the other medicine (cisplatin) that you receive together with Topotecan Hospira.&nbsp;These&nbsp;side effects&nbsp;are described in the package insert for cisplatin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Topotecan Hospira<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use before the expiry date which is stated on the vial label and the carton after EXP.<\/p>\n\n\n\n<p>Store in a refrigerator (2\u00baC\u20138\u00baC).&nbsp;Do not freeze.<\/p>\n\n\n\n<p>Store the vial in the outer carton.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>This medicine is for single use only.&nbsp;After opening, the product must be used immediately.&nbsp;If the medicine is not used immediately, Topotecan Hospira can be used for up to 24 hours if stored in a refrigerator (protected from light) or at room temperature (under normal light conditions).<\/p>\n\n\n\n<p>If visible particles are observed, the product should not be given.<\/p>\n\n\n\n<p>The medicine should not be thrown down the drain.&nbsp;Ask the pharmacist how to dispose of medicines that are no longer used.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance in Topotecan Hospira is topotecan (as hydrochloride).\u00a01 ml concentrate for\u00a0infusion, the solution contains 1 mg topotecan (as hydrochloride) Each\u00a0vial\u00a0of 4 ml concentrate contains 4 mg topotecan (as hydrochloride).<\/li><li>The other ingredients are tartaric acid (E334), water for injections, and\u00a0hydrochloric acid\u00a0(E507) or sodium hydroxide (to adjust the\u00a0pH\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Topotecan Hospira is a clear yellow to yellow-green concentrate for\u00a0infusion, a solution supplied in clear glass vials containing 4 ml of concentrate.\u00a0Topotecan Hospira is available in two pack sizes, 1 or 5 vials.\u00a0Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Pfizer Europe MA EEIG<\/p>\n\n\n\n<p>Boulevard de la Plaine 17<\/p>\n\n\n\n<p>1050 Brussels<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Pfizer Service Company BV<\/p>\n\n\n\n<p>Hoge Wei 10<\/p>\n\n\n\n<p>1930 Zaventem<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong><strong>Luxembourg\/Luxembourg<\/strong>Pfizer NV\/SATel\/Tel: +32 (0)2 554 62 11<\/td><td><strong>Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaTel.&nbsp;+370 5 251 4000<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Pfizer Luxembourg \u0421\u0410\u0420\u041b, \u041a\u043b\u043e\u043d \u0411\u0443\u043b\u0433\u0430\u0440\u0438\u044fTel.: +359 2 970 4333<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Pfizer Kft.Tel.: + 36 1 488 37 00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Pfizer, coil.\u00a0s iPhone: +420 283 004 111<\/td><td><strong>Malta<\/strong>Drugsales LtdPhone: +356 21419070\/1\/2<\/td><\/tr><tr><td><strong>Denmark<\/strong>Pfizer ApSPhone: +45 44 20 11 00<\/td><td><strong>The Netherlands<\/strong>Pfizer by phone: +31 (0)800 63 34 636<\/td><\/tr><tr><td><strong>Deutschland<\/strong>PFIZER PHARMA GmbHPhone: +49 (0)30 550055-51000<\/td><td><strong>Norway<\/strong>Pfizer iPhone: +47 67 52 61 00<\/td><\/tr><tr><td><strong>Estonia<\/strong>Pfizer Luxembourg SARL Eesti branch phone: +372 666 7500<\/td><td><strong>Austria<\/strong>Pfizer Corporation Austria Ges.mbHPhone: +43 (0)1 521 15-0<\/td><\/tr><tr><td><strong>Greece<\/strong>Pfizer Hellas iPhone: +30 210 6785800<\/td><td><strong>Polish<\/strong>Pfizer Polska Sp.&nbsp;z o. oTel.: +48 22 335 61 00<\/td><\/tr><tr><td><strong>Spain<\/strong>Pfizer, SLPhone: +34 91 490 99 00<\/td><td><strong>Portugal<\/strong>Laborat\u00f3rios Pfizer, Lda.Phone: +351 21 423 5500<\/td><\/tr><tr><td><strong>France<\/strong>PfizerTel: +33 (0)1 58 07 34 40<\/td><td><strong>Romania<\/strong>Pfizer Romania SRLPhone: +40 (0) 21 207 28 00<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Pfizer Croatia dooPhone: +385 1 3908 777<\/td><td><strong>Slovenija<\/strong>Pfizer Luxembourg SARLPfizer, a branch of marketing, LjubljanaPhone: +386 (0)1 52 11 400<\/td><\/tr><tr><td><strong>Ireland<\/strong>Pfizer Healthcare IrelandTel: +1800 633 363 (toll free)Phone: +44 (0)1304 616161<\/td><td><strong>Slovenian Republic<\/strong>Pfizer Luxembourg SARL, organiza\u010dn\u00e1 zlo\u017ekaPhone: +421 2 3355 5500<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hf.Telephone: +354 540 8000<\/td><td><strong>Finland\/Finland<\/strong>Pfizer OyPhone\/Tel: +358 (0)9 430 040<\/td><\/tr><tr><td><strong>Italy<\/strong>Pfizer SrlPhone: +39 06 33 18 21<\/td><td><strong>Sweden<\/strong>Pfizer phone: +46 (0)8 550 520 00<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Pfizer \u0395\u03bb\u03bb\u03ac\u03c2 \u0391.\u0395.&nbsp;(Cyprus Branch)Tel.: +357 22817690<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Pfizer LimitedPhone: +44 (0) 1304 616161<\/td><\/tr><tr><td><strong>Latvia<\/strong>Pfizer Luxembourg SARL branch in LatviaTel.: +371 670 35 775<\/td><td>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Topotecan Hospira helps destroy\u00a0tumors\u00a0.\u00a0A doctor or nurse will give you the medicine as an\u00a0infusion\u00a0into a vein in the hospital.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[26086,26092,26085,26087,26091,26093,26084,26090,26088,26089],"class_list":["post-25280","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-topoteca","tag-benefits-of-topotecan-hospira","tag-topoteca","tag-topoteca-side-effects","tag-topotecan-hospira","tag-topotecan-hospira-side-effects","tag-what-is-topoteca","tag-what-is-topotecan-hospira","tag-what-topoteca-is-used-for","tag-what-topotecan-hospira-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25280","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25280"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25280\/revisions"}],"predecessor-version":[{"id":25297,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25280\/revisions\/25297"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25280"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25280"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25280"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}