{"id":25277,"date":"2022-09-13T07:15:45","date_gmt":"2022-09-13T07:15:45","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25277"},"modified":"2022-09-14T07:23:09","modified_gmt":"2022-09-14T07:23:09","slug":"topotecan-ebewe","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/topotecan-ebewe\/","title":{"rendered":"Topotecan Ebewe &#8211; Topotecan uses, dose and side effects"},"content":{"rendered":"\n<p>1 mg\/ml&nbsp;concentrate for&nbsp;infusion&nbsp;solution<br>topotecan<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Topotecan Ebewe is and what it is used for<\/h2>\n\n\n\n<p>Topotecan Ebewe helps destroy\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/tumors-and-other-growths\/\">tumors<\/a>.\u00a0A doctor or nurse will give you the medicine as an\u00a0infusion\u00a0into a vein in the hospital.<\/p>\n\n\n\n<p><strong>Topotecan Ebewe is used to treat<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>ovarian cancer or\u00a0small cell lung cancer<\/strong>\u00a0that has come back after\u00a0chemotherapy.<\/li><li><strong>advanced cervical cancer<\/strong>\u00a0where treatment with\u00a0surgery\u00a0or <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/radiotherapy\/\">radiotherapy<\/a> is not possible.\u00a0In the treatment of cervical cancer, Topotecan Ebewe is given in combination with another medicine called cisplatin.<\/li><\/ul>\n\n\n\n<p>Your doctor will decide together with you whether Topotecan Ebewe treatment is better than continuing treatment with the&nbsp;chemotherapy&nbsp;you were treated with initially.<\/p>\n\n\n\n<p>The topotecan contained in Topotecan Ebewe may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you receive Topotecan Ebewe<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should not receive Topotecan Ebewe<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to topotecan or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are breastfeeding.<\/li><li>if your blood levels are too low.&nbsp;Your doctor will tell you if this is the case, based on the results of your last blood test.<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if any of these apply to you.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Before starting treatment, your doctor must know:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have problems with your kidneys or liver.\u00a0The dose of Topotecan\u00a0Ebewe may need to be adjusted.<\/li><li>if you are pregnant or planning to become pregnant.\u00a0See the section &#8220;Pregnancy and breastfeeding&#8221; below.<\/li><li>if you are a man and planning to have children.\u00a0See the section &#8220;Pregnancy and breastfeeding&#8221; below.<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if any of these apply to you.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Topotecan Ebewe<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or may be taking other medicines, including over-the-counter and herbal medicines.<\/p>\n\n\n\n<p>Remember to tell your doctor if you start taking any other medicine while you are using Topotecan Ebewe.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Topotecan Ebewe is not recommended for pregnant women.\u00a0It can harm the fetus if conception occurs before, during, or shortly after treatment.\u00a0You must use an effective contraceptive method.\u00a0Consult your doctor.\u00a0Do not try to get pregnant until your doctor says it is safe to do so.<\/p>\n\n\n\n<p>Male patients who wish to have children should ask their doctor for family planning advice or treatment.&nbsp;If your partner becomes pregnant during treatment, tell the doctor immediately.<\/p>\n\n\n\n<p>Do not breastfeed if you are treated with Topotecan Ebewe.\u00a0Do not start breastfeeding again until your doctor tells you it is safe to do so.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Topotecan Ebewe makes you feel tired.\u00a0If you feel tired or weak, do not drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Topotecan Ebewe is used<\/h2>\n\n\n\n<p>The dose of Topotecan Ebewedo&nbsp;you&nbsp;receive is determined by your doctor and is based on:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>your body surface area (measured as square meters)<\/li><li>results from blood tests taken before treatment<\/li><li>what disease you are being treated for<\/li><\/ul>\n\n\n\n<p><strong>Usual&nbsp;dose<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Ovarian cancer and small cell lung cancer:<\/strong>\u00a01.5 mg per square meter of body surface per day.\u00a0You will be treated once a day for 5 days.\u00a0Usually, this treatment schedule is repeated every three weeks.<\/li><li>Cervical cancer:\u00a00.75 mg per square meter of body surface per day.\u00a0You will be treated once a day for 3 days.\u00a0Usually, this treatment schedule is repeated every three weeks.<\/li><\/ul>\n\n\n\n<p><strong>In the treatment of\u00a0<\/strong><strong>cervical cancer<\/strong>, Topotecan Ebewe is combined with another medicine called cisplatin.\u00a0Your doctor will decide which\u00a0dose\u00a0of cisplatin you will receive.<\/p>\n\n\n\n<p>The treatment schedule may vary depending on the results of your regular blood tests.<\/p>\n\n\n\n<p><strong>How Topotecan Ebewe is given<\/strong><\/p>\n\n\n\n<p>A doctor or nurse will give you Topotecan Ebewe as an\u00a0infusion\u00a0into your arm for about 30 minutes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious side effects: tell&nbsp;<\/strong><strong>your doctor<\/strong><\/p>\n\n\n\n<p>These&nbsp;<strong>very common<\/strong>&nbsp;&nbsp;side effects may affect&nbsp;<strong>more than 1 in 10<\/strong>&nbsp;people treated with topotecan:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Signs of infections:<\/strong>\u00a0\u00a0topotecan can reduce the number of\u00a0white blood cells\u00a0and reduce your resistance to\u00a0infection.\u00a0This can lead to life-threatening conditions.\u00a0Symptoms include:<ul><li>fever<\/li><li>severe deterioration of your general condition<\/li><li>local symptoms such as a sore throat or difficulty urinating (for example, a burning sensation when you urinate, which may be due to a urinary tract infection)<\/li><\/ul><\/li><li>Sometimes severe abdominal pain, fever, and possible diarrhea (in rare cases bloody) can be signs of intestinal inflammation (\u00a0<em>colitis<\/em>\u00a0)<\/li><\/ul>\n\n\n\n<p>This&nbsp;<strong>rare<\/strong>&nbsp;&nbsp;side effect may affect&nbsp;<strong>up to 1&nbsp;<\/strong><strong>in&nbsp;<\/strong><strong>1,000 users<\/strong>&nbsp;treated with topotecan:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Pneumonia<\/strong>\u00a0(<em>\u00a0interstitial lung disease<\/em>\u00a0): You are most at risk if you have an existing lung disease, have had radiation treatment of your lungs, or have previously taken medications that caused damage to the lungs.\u00a0Signs of this can be:<ul><li>breathing difficulties<\/li><li>cough<\/li><li>fever<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Contact your doctor immediately<\/strong>&nbsp;if you develop symptoms of any of these conditions as hospitalization may be necessary.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong>&nbsp;<\/p>\n\n\n\n<p>These may affect&nbsp;<strong>more than 1 in 10 users<\/strong>&nbsp;treated with topotecan:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Feeling of general weakness and tiredness (temporary\u00a0<em><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/anemia\/\">anemia<\/a>\u00a0<\/em>[lack of blood]).\u00a0In some cases, you may need a\u00a0blood transfusion.<\/li><li>Unusual bruising or bleeding is caused by a reduced number of clotting cells in the blood.\u00a0This can lead to more bleeding from relatively small wounds such as small cuts.\u00a0In rare cases, this can lead to serious bleeding (\u00a0hemorrhage\u00a0).\u00a0Talk to your doctor for advice on how to minimize the risk of bleeding.<\/li><li>Weight loss and loss of appetite, fatigue, and weakness.<\/li><li>Nausea (nausea), vomiting, diarrhea, abdominal pain, constipation.<\/li><li>Inflammation\u00a0and sores in the mouth, tongue, or gums.<\/li><li>Fever.<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/hair-loss\/\">Hair loss<\/a>.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong>&nbsp;<\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>up to 1 in 10 users<\/strong>&nbsp;treated with topotecan:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic or\u00a0<em>hypersensitivity reactions\u00a0(<\/em>\u00a0including skin rash).<\/li><li>Yellow skin.<\/li><li>A general feeling of discomfort.<\/li><li>Itchy skin.<\/li><\/ul>\n\n\n\n<p><strong>Rare\u00a0side effects\u00a0ar<\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>up to 1 in 1,000 users<\/strong>&nbsp;treated with topotecan:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A severe allergic or\u00a0anaphylactic\u00a0reaction.<\/li><li>Swelling is caused by fluid retention (\u00a0angioedema\u00a0).<\/li><li>Mild pain and\u00a0inflammation\u00a0at the injection site.<\/li><li>Itchy rash (or\u00a0hives\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong><\/p>\n\n\n\n<p>The frequency of some&nbsp;side effects&nbsp;is not known (derived from spontaneous reports and occurring in an unknown number of users).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe stomach pain, nausea, vomiting blood, black or bloody stools (possible symptoms of a hole in the gastrointestinal tract [gastrointestinal perforation]).<\/li><li>Mouth ulcers, difficulty swallowing, abdominal pain, nausea, vomiting, diarrhea, and bloody stools (possible signs and symptoms of\u00a0inflammation\u00a0of the lining of the mouth, stomach, and\/or intestine [mucositis]).<\/li><\/ul>\n\n\n\n<p><strong>If you are being treated for cervical cancer<\/strong>, you may have\u00a0side effects\u00a0from the other medicine (cisplatin) that you receive together with Topotecan Ebewe.\u00a0These\u00a0side effects\u00a0are described in the package insert for cisplatin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Topotecan Ebewe<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and&nbsp;vial&nbsp;after the Issue date.&nbsp;or EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C\u20138 \u00b0C).<\/p>\n\n\n\n<p>Store the vial in the outer carton.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Do not freeze.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is topotecan.<\/p>\n\n\n\n<p>One milliliter of concentrate for&nbsp;infusion&nbsp;solution contains 1 mg of topotecan (as <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/cardizem-unotard\/\">hydrochloride<\/a>).<\/p>\n\n\n\n<p>Each 1 ml&nbsp;vial&nbsp;contains 1 mg of topotecan (as hydrochloride).<\/p>\n\n\n\n<p>Each 3 ml&nbsp;vial&nbsp;contains 3 mg of topotecan (as hydrochloride).<\/p>\n\n\n\n<p>Each 4 ml&nbsp;vial&nbsp;contains 4 mg topotecan (as hydrochloride).<\/p>\n\n\n\n<p>Other ingredients are: tartaric acid, dilute\u00a0hydrochloric acid,\u00a0and water for injections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>This medicine is supplied as a concentrate for\u00a0infusion, and solution.<\/p>\n\n\n\n<p>The concentrate is a clear, yellow solution, practically free of visible particles, in a colorless type 1 glass\u00a0vial\u00a0with a gray rubber stopper and an aluminum seal with a plastic snap cap with or without plastic protection (Onco-Safe or protective film).\u00a0Once-Safe and protective foil are not in contact with the drug and provide increased safety during transport, which increases the safety of pharmacy and healthcare personnel.\u00a0The vials are sealed with aluminum shrink caps.<\/p>\n\n\n\n<p>Package sizes:<\/p>\n\n\n\n<p>1 x 1 ml, 5 x 1 ml, 10 x 1 ml<\/p>\n\n\n\n<p>1 x 3 ml, 5 x 3 ml, 10 x 3 ml<\/p>\n\n\n\n<p>1 x 4 ml, 5 x 4 ml, 10 x 4 ml<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Ebewe Pharma Ges.mbH Nfg.&nbsp;KG, Mondseestra\u00dfe 11, A-4866 Unterach, Austria<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Topotecan Ebewe helps destroy\u00a0tumors\u00a0.\u00a0A doctor or nurse will give you the medicine as an\u00a0infusion\u00a0into a vein in hospital.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[13598,26097,13594,26094,26098,13599,13595,26095,26096,13596],"class_list":["post-25277","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-topotecan","tag-benefits-of-topotecan-ebewe","tag-topotecan","tag-topotecan-ebewe","tag-topotecan-ebewe-side-effects","tag-topotecan-side-effects","tag-what-is-topotecan","tag-what-is-topotecan-ebewe","tag-what-topotecan-ebewe-is-used-for","tag-what-topotecan-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25277"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25277\/revisions"}],"predecessor-version":[{"id":25299,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25277\/revisions\/25299"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25277"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25277"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}