{"id":25149,"date":"2022-09-09T12:30:45","date_gmt":"2022-09-09T12:30:45","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25149"},"modified":"2022-09-12T07:29:36","modified_gmt":"2022-09-12T07:29:36","slug":"tobi-podhaler","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tobi-podhaler\/","title":{"rendered":"TOBI Podhaler &#8211; Tobramycin uses, dose and side effects"},"content":{"rendered":"\n<p>28 mg\u00a0inhalation powder, hard capsules<br>tobramycin<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What TOBI Podhaler is and what it is used for<\/h2>\n\n\n\n<p><strong>What TOBI Podhaler is<\/strong><\/p>\n\n\n\n<p>TOBI Podhaler contains the drug tobramycin, which is an\u00a0antibiotic.\u00a0This\u00a0antibiotic\u00a0belongs to a class called\u00a0aminoglycosides.<\/p>\n\n\n\n<p><strong>What TOBI Podhaler is used for<\/strong><\/p>\n\n\n\n<p>TOBI Podhaler is used to treat lung infections caused by the bacterium\u00a0<em>Pseudomonas aeruginosa<\/em>\u00a0in patients aged 6 and over with\u00a0cystic fibrosis.<\/p>\n\n\n\n<p>Follow the instructions in this leaflet to get the best possible treatment results.<\/p>\n\n\n\n<p><strong>How TOBI Podhaler works<\/strong><\/p>\n\n\n\n<p>TOBI Podhaler is capsules that are filled with\u00a0inhalation powder.\u00a0When you inhale TOBI Podhaler, the medicine goes directly into the lungs to fight the\u00a0bacteria\u00a0causing the\u00a0infection\u00a0and improve your breathing.<\/p>\n\n\n\n<p><strong>What is&nbsp;<em>Pseumdomonas aeruginosa<\/em><\/strong><\/p>\n\n\n\n<p>It is a very common\u00a0bacterium\u00a0that at some point in life infects the lungs of almost everyone who has\u00a0cystic fibrosis.\u00a0Some people don&#8217;t get this\u00a0infection\u00a0until later in life, while others get it very early.\u00a0This\u00a0bacteria\u00a0is one of the most harmful to people with\u00a0cystic fibrosis.\u00a0If an\u00a0infection\u00a0is not treated properly, it will continue to damage your lungs and cause you further breathing problems.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take TOBI Podhaler<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take TOBI Podhaler<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic<\/strong>\u00a0to tobramycin, any type of aminoglycoside antibiotic, or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If this applies to you,&nbsp;<strong>do not take TOBI Podhaler and tell your doctor.<\/strong><\/p>\n\n\n\n<p>Consult a doctor if you think you may be allergic.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Tell your doctor if you have ever had any of the following problems:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hearing problems (including ringing in the ears and dizziness)<\/li><li>kidney problems<\/li><li>unusual difficulty breathing with wheezing, coughing, or tightness in the chest<\/li><li>bloody expectoration<\/li><li>muscle weakness that persists or worsens over time, a symptom mainly linked to diseases such as\u00a0myasthenia gravis\u00a0or\u00a0Parkinson&#8217;s disease.<\/li><\/ul>\n\n\n\n<p>If this applies to you,&nbsp;<strong>tell your doctor before taking TOBI Podhaler.<\/strong><\/p>\n\n\n\n<p>If you are 65 years of age or older, your doctor may do some additional tests to determine if TOBI Podhaler is suitable for you.<\/p>\n\n\n\n<p>Inhalation\u00a0of medicines may cause chest tightness and wheeze, and these symptoms may occur immediately after\u00a0inhalation\u00a0of the TOBI Podhaler.\u00a0Your doctor will be with you when you inhale the first\u00a0dose\u00a0of TOBI Podhaler and will check your lung function before and after\u00a0dosing.\u00a0The doctor may\u00a0prescribe\u00a0other suitable medicines for you to take before TOBI Podhaler.<\/p>\n\n\n\n<p>Inhalation&nbsp;of medicines can also cause coughing and this also applies to TOBI Podhaler.&nbsp;Contact your doctor if the <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a> persists and is bothersome to you.<\/p>\n\n\n\n<p>Strains of\u00a0<em>Pseudomonas<\/em>\u00a0can become resistant to treatment with\u00a0antibiotics\u00a0over time.\u00a0This means that after a while TOBI Podhaler may not have as good an effect as it should.\u00a0Contact your doctor if this concerns you.<\/p>\n\n\n\n<p>When tobramycin or other aminoglycoside antibiotics are given by\u00a0injection, hearing loss, dizziness, and kidney damage can sometimes occur.<\/p>\n\n\n\n<p><strong>Children<\/strong><\/p>\n\n\n\n<p>TOBI Podhaler should not be given to children under 6 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and TOBI Podhaler<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>You should not take the following medicines while taking TOBI Podhaler:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>furosemide\u00a0or ethacrynic acid,\u00a0diuretics<\/li><li>other drugs with diuretic properties, eg\u00a0urea\u00a0or mannitol is given\u00a0intravenously<\/li><li>other medicines, which can damage the kidneys or hearing.<\/li><\/ul>\n\n\n\n<p>The following medicines may increase the risk of harmful effects if they are given to you while you are also receiving&nbsp;<strong>injections&nbsp;<\/strong><strong>of<\/strong>&nbsp;tobramycin or other aminoglycoside antibiotics:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>amphotericin B, cephalothin, polymyxins (used to treat microbial\u00a0infections\u00a0), cyclosporine, and tacrolimus (used to\u00a0suppress\u00a0the immune system).\u00a0These medicines can damage the kidneys.<\/li><li>platinum compounds such as carboplatin and cisplatin (used to treat certain forms of cancer).\u00a0These medicines can damage the kidneys or hearing.<\/li><li>anticholinesterases such as neostigmine and pyridostigmine (used to treat muscle weakness) or botulinum toxin.\u00a0These drugs can cause or worsen muscle weakness.<\/li><\/ul>\n\n\n\n<p>If you are taking one or more of the above medicines, you should contact your doctor before taking TOBI Podhaler.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p>It is not known whether&nbsp;inhalation&nbsp;of this medicine can cause&nbsp;side effects&nbsp;during pregnancy.<\/p>\n\n\n\n<p>If tobramycin and other aminoglycoside antibiotics are injected, they can cause birth defects, such as <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sudden-hearing-loss-sudden-deafness\/\">deafness<\/a>.<\/p>\n\n\n\n<p>If you are breastfeeding, talk to your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>TOBI Podhaler has a little or negligible effect on the ability to drive and use machines.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take TOBI Podhaler<\/h2>\n\n\n\n<p>Always take TOBI Podhaler as directed by your doctor.&nbsp;Consult a doctor if you are unsure.<\/p>\n\n\n\n<p>Caregivers must help children who start treatment with TOBI Podhaler, especially those who are 10 years of age or younger.&nbsp;This support should continue until they can use the Podhaler inhaler correctly without help.<\/p>\n\n\n\n<p><strong>How much TOBI Podhaler you should take<\/strong><\/p>\n\n\n\n<p>Inhale the contents of 4 capsules twice a day (4 capsules in the morning and 4 capsules in the evening) using the Podhaler inhaler.<\/p>\n\n\n\n<p>Dose\u00a0one is the same for everyone from the age of 6.\u00a0Do not take more than the recommended\u00a0dose.<\/p>\n\n\n\n<p><strong>When should you take TOBI Podhaler?<\/strong><\/p>\n\n\n\n<p>If you take the capsules at the same time every day, it will be easier to remember when to take them.&nbsp;Inhale the contents of 4 capsules twice a day as follows:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inhale 4 capsules in the morning with the Podhaler inhaler.<\/li><li>Inhale 4 capsules in the evening with the Podhaler inhaler.<\/li><li>It is best if 12 hours pass between\u00a0doses, but at least 6 hours must pass.<\/li><\/ul>\n\n\n\n<p>If you use several different medicines for\u00a0inhalation\u00a0or other treatment against\u00a0cystic fibrosis, you should take TOBI Podhaler when you have finished all other treatment measures.\u00a0Ask your doctor about the order of your medications.<\/p>\n\n\n\n<p><strong>How to take TOBI Podhaler<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For inhalation\u00a0only.<\/li><li>Do not swallow the capsules.<\/li><li>Only use the capsules with the\u00a0inhaler\u00a0included in the package.\u00a0The capsules must remain in the blister card until you need to use them.<\/li><li>When you start a new pack, use the new inhaler included in that pack.\u00a0Each\u00a0inhaler\u00a0should only be used for 7 days.<\/li><li>Read the instructions at the end of this leaflet for more information on how to use the inhaler.<\/li><\/ul>\n\n\n\n<p><strong>How long to take TOBI Podhaler<\/strong><\/p>\n\n\n\n<p>When you have taken TOBI Podhaler for 28 days, you should make a 28-day break in the treatment when you should not use TOBI Podhaler.&nbsp;Then you start with the next treatment cycle.<\/p>\n\n\n\n<p>It is important that you continue to use the medicine twice a day during the 28 days of treatment and that you follow the cycle of 28 days of treatment followed by 28 days off.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100127000014#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td><strong>WITH TOBI Podhaler<\/strong><\/td><td><strong>WITHOUT TOBI Podhaler<\/strong><\/td><\/tr><tr><td>Take TOBI Podhaler twice daily for 28 days<\/td><td>Do not take TOBI Podhaler for the next 28 days<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100127000014#\" rel=\"noopener\"><\/a><br><strong>Repeat the cycle<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Continue to take TOBI Podhaler as directed by your doctor.<\/p>\n\n\n\n<p>Consult a doctor or pharmacist if you wonder how long you should continue treatment with TOBI Podhaler.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much TOBI Podhaler<\/h2>\n\n\n\n<p>If you inhale too much TOBI Podhaler, tell your doctor immediately.\u00a0There is no danger if you swallow TOBI Podhaler but tell your doctor as soon as possible.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take TOBI Podhaler<\/h2>\n\n\n\n<p>If you have forgotten to take TOBI Podhaler and it is at least 6 hours until the next\u00a0dose, you should take a\u00a0dose\u00a0as soon as possible.\u00a0Otherwise, you should wait until the next\u00a0dose.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>People with&nbsp;cystic fibrosis&nbsp;have many symptoms of the disease.&nbsp;You may still experience such symptoms while taking TOBI Podhaler, but they should not occur more often or be worse than before.<\/p>\n\n\n\n<p>If the underlying lung disease appears to worsen while taking TOBI Podhaler,&nbsp;<strong>contact your doctor immediately.<\/strong><\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;can be serious.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>unusual difficulty breathing with wheezing or coughing and chest tightness (common).<\/li><\/ul>\n\n\n\n<p>If you experience any of these symptoms:&nbsp;<strong>stop taking TOBI Podhaler and contact your doctor immediately.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>coughing up blood (very common)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/impaired-hearing\/\">impaired hearing<\/a> (ringing in the ears can be a warning sign of hearing loss), and disturbing noises in the ears such as tinnitus (common).<\/li><\/ul>\n\n\n\n<p>If you experience any of these symptoms,&nbsp;<strong>tell your doctor immediately.<\/strong><\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;can be:<\/strong><\/p>\n\n\n\n<p>Very common&nbsp;(may affect more than 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>respiratory distress<\/li><li>cough, coughing up phlegm, voice change (hoarseness)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sore-throat\/\">sore throat<\/a><\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a>.<\/li><\/ul>\n\n\n\n<p>Common&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>wheezing, rattling breathing<\/li><li>chest discomfort, chest pain originating in muscles or bones<\/li><li>nasal congestion<\/li><li>nosebleed<\/li><li>vomiting, nausea<\/li><li>diarrhea<\/li><li>rash<\/li><li>altered sense of taste<\/li><li>vote loss.<\/li><\/ul>\n\n\n\n<p>Frequency not known&nbsp;(cannot be calculated from available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>general malaise<\/li><li>discolored sputum.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How TOBI Podhaler should be stored<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Store out of sight and reach of children.<\/li><li>Use before the expiry date stated on the carton or blister card.<\/li><li>Store in the original packaging.&nbsp;Moisture sensitive.<\/li><\/ul>\n\n\n\n<p><strong>Once the capsule has been removed from the blister card, it should be used immediately.<\/strong><\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tobramycin.\u00a0One capsule contains 28 mg of tobramycin.<\/li><li>Other ingredients are DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine), calcium chloride and sulfuric acid (for\u00a0pH\u00a0adjustment).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>TOBI Podhaler\u00a0inhalation powder, hard capsules consist of a white or almost white powder for\u00a0inhalation\u00a0in clear, colorless hard capsules with &#8220;MYL TPH&#8221; printed in blue on one side of the capsule and the Mylan logo printed in blue on the other side.<\/p>\n\n\n\n<p>TOBI Podhaler is supplied as monthly packs containing 4 weekly cartons and a spare Podhaler\u00a0inhaler\u00a0with a protective cap.<\/p>\n\n\n\n<p>Each weekly carton contains 7 blister cards with 8 capsules in each and a Podhaler\u00a0inhaler\u00a0with a protective cap.<\/p>\n\n\n\n<p>The package sizes are as follows:<\/p>\n\n\n\n<p>56\u00a0inhalation powders, hard capsules, and 1\u00a0inhaler\u00a0(weekly pack)<\/p>\n\n\n\n<p>224 (4 x 56)\u00a0inhalation powders, hard capsules, and 5\u00a0inhalers\u00a0(1-month pack)<\/p>\n\n\n\n<p>448 (8 x 56)\u00a0inhalation powders, hard capsules, and 10\u00a0inhalers\u00a0(2-month packaging in foil)<\/p>\n\n\n\n<p>Not all pack sizes may be available in your country.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Mylan IRE Healthcare Limited<\/p>\n\n\n\n<p>Unit 35\/36 Grange Parade,<\/p>\n\n\n\n<p>Baldoyle Industrial Estate, Dublin 13<\/p>\n\n\n\n<p>Ireland<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Manufacturer<\/h2>\n\n\n\n<p>McDermott Laboratories Ltd T\/A Mylan Dublin Respiratory<\/p>\n\n\n\n<p>Unit 25, Baldoyle Industrial Estate<\/p>\n\n\n\n<p>Grange Road, Baldoyle<\/p>\n\n\n\n<p>Dublin 13, D13 N5X2<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Mylan Germany GmbH<\/p>\n\n\n\n<p>Zweigniederlassung Bad Homburg CEO Hoehe<\/p>\n\n\n\n<p>Benzstrasse 1<\/p>\n\n\n\n<p>61352 Bad Homburg CEO Hoehe<\/p>\n\n\n\n<p>GermanyManufacturer<\/p>\n\n\n\n<p>McDermott Laboratories Ltd T\/A Mylan Dublin Respiratory<\/p>\n\n\n\n<p>Unit 25, Baldoyle Industrial Estate<\/p>\n\n\n\n<p>Grange Road, Baldoyle<\/p>\n\n\n\n<p>Dublin 13, D13 N5X2<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Mylan Germany GmbH<\/p>\n\n\n\n<p>Zweigniederlassung Bad Homburg CEO Hoehe<\/p>\n\n\n\n<p>Benzstrasse 1<\/p>\n\n\n\n<p>61352 Bad Homburg CEO Hoehe<\/p>\n\n\n\n<p>Germany13 May 2022<\/p>\n","protected":false},"excerpt":{"rendered":"<p>TOBI Podhaler contains the drug tobramycin, which is an\u00a0antibiotic\u00a0.\u00a0This\u00a0antibiotic\u00a0belongs to a class called\u00a0aminoglycosides\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[26040,18611,26036,26039,18607,18610,26037,18608,26038,18609],"class_list":["post-25149","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-tobi-podhaler","tag-benefits-of-tobramycin","tag-tobi-podhaler","tag-tobi-podhaler-side-effects","tag-tobramycin","tag-tobramycin-side-effects","tag-what-is-tobi-podhaler","tag-what-is-tobramycin","tag-what-tobi-podhaler-is-used-for","tag-what-tobramycin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25149"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25149\/revisions"}],"predecessor-version":[{"id":25197,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25149\/revisions\/25197"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}