{"id":25122,"date":"2022-09-07T08:00:22","date_gmt":"2022-09-07T08:00:22","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25122"},"modified":"2022-09-09T10:22:19","modified_gmt":"2022-09-09T10:22:19","slug":"tobi","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tobi\/","title":{"rendered":"Tobi &#8211; Tobramycin uses, dose and side effects"},"content":{"rendered":"\n<p>300 mg\/5 ml&nbsp;solution for&nbsp;nebulizer<br>tobramycin<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tobi is and what it is used for<\/h2>\n\n\n\n<p><strong>What is Tobi?<\/strong><\/p>\n\n\n\n<p>Tobi contains tobramycin.\u00a0It is an\u00a0antibiotic\u00a0that belongs to the group of\u00a0aminoglycosides.<\/p>\n\n\n\n<p>Tobi is used in patients from the age of six with\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cystic-fibrosis\/\">cystic fibrosis<\/a>\u00a0to treat lung infections caused by a\u00a0bacterium\u00a0called\u00a0<em>Pseudomonas aeruginosa<\/em>.<\/p>\n\n\n\n<p>Tobi treats&nbsp;infection&nbsp;in the lungs caused by the&nbsp;<em>Pseudomonas<\/em>&nbsp;bacteria and helps to facilitate breathing.<\/p>\n\n\n\n<p>When you inhale Tobi, the medicine goes directly into the lungs where it kills the bacteria that caused the\u00a0infection.\u00a0For the best effect of the medicine, follow the instructions in this information.<\/p>\n\n\n\n<p><strong>What is&nbsp;<em>Pseudomonas aeruginosa<\/em>&nbsp;?<\/strong><\/p>\n\n\n\n<p>This is a very common&nbsp;bacteria&nbsp;that affects almost everyone with&nbsp;cystic fibrosis&nbsp;at some point in their lives.&nbsp;Some get an&nbsp;infection&nbsp;later in life, while others get it at a very young age.<\/p>\n\n\n\n<p>It is one of the most harmful bacteria for people with\u00a0cystic fibrosis.\u00a0If an\u00a0infection\u00a0is not treated properly, it can continue to damage the lungs, leading to further breathing problems.<\/p>\n\n\n\n<p>Tobi kills the bacteria that caused the lung infection.&nbsp;If treatment is started at an early stage, the&nbsp;infection&nbsp;can be treated with good results.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Tobi<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Tobi:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to tobramycin, any aminoglycoside\u00a0antibiotic,\u00a0or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If any of the above applies to you, do not take this medicine without consulting your doctor.&nbsp;Consult your doctor if you think you are allergic.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Consult a doctor before using Tobi if you have or have ever had any of the following problems:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hearing problems (including ringing in the ears and dizziness).<\/li><li>Kidney problems.<\/li><li>Unusual difficulty breathing with wheezing or coughing, chest tightness.<\/li><li>Bloody mucus (when expectorated).<\/li><li>Muscle weakness that is persistent or worsens over time, symptoms mainly associated with&nbsp;myasthenia&nbsp;(muscle weakness) or&nbsp;Parkinson&#8217;s disease<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you, tell your doctor before using Tobi.<\/p>\n\n\n\n<p>Inhalation\u00a0of medications can cause spasms in the trachea and wheezing, which can also occur with Tobi.\u00a0The doctor will be with you when you take the first\u00a0dose\u00a0and examine the lung function before and after\u00a0dosing.\u00a0If you are not already using an airway dilator, the doctor may\u00a0prescribe\u00a0one (eg\u00a0salbutamol\u00a0) before you take Tobi.<\/p>\n\n\n\n<p>When using Tobi,&nbsp;<em>Pseudomonas<\/em>&nbsp;strains may become resistant to the treatment over time.&nbsp;This means that the medicine no longer works as well as it should.&nbsp;Talk to your doctor if this is something that worries you.<\/p>\n\n\n\n<p>If you receive tobramycin by\u00a0injection, it can cause <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sudden-hearing-loss-sudden-deafness\/\">deafness<\/a>, dizziness, kidney damage, and lead to birth defects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Tobi can be taken by children and young people aged 6 and over.&nbsp;Tobi should not be given to children under 6 years of age.<\/p>\n\n\n\n<p><strong>Older<\/strong><\/p>\n\n\n\n<p>If you are 65 years of age or older, your doctor may perform additional tests to determine if Tobi is the right treatment for you.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tobi<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including those obtained without a prescription.<\/p>\n\n\n\n<p>You should not take the following medicines during treatment with Tobi:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>furosemide\u00a0or ethacrynic acid\u00a0,\u00a0diuretics<\/li><li>mannitol is given\u00a0intravenously\u00a0or\u00a0urea<\/li><li>other medicines that can damage the nervous system, kidneys, or hearing.<\/li><\/ul>\n\n\n\n<p>The following medicines may increase the risk of&nbsp;side effects&nbsp;occurring if they are given when you are receiving tobramycin&nbsp;<strong>injection<\/strong>&nbsp;at the same time :<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>amphotericin B, cephalothin, cyclosporine, tacrolimus, and polymyxins: these medicines can damage the kidneys.<\/li><li>medicines containing platinum (eg carboplatin and cisplatin): these medicines can damage the kidneys and hearing.<\/li><li>cholinesterase inhibitors (eg neostigmine and pyridostigmine) or botulinum toxins: these medicines can cause or worsen muscle weakness.<\/li><\/ul>\n\n\n\n<p>If you are using one or more of the above medicines, consult your doctor before using Tobi.<\/p>\n\n\n\n<p>Tobi must not be mixed or diluted with any other medicine in the nebulizer.<\/p>\n\n\n\n<p>If you have several different medicines for\u00a0cystic fibrosis, you should take them in the following order:<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>bronchodilators eg&nbsp;salbutamol<\/li><li>breathing exercises<\/li><li>other inhaled medicines<\/li><li>then Tobi.<\/li><\/ol>\n\n\n\n<p>Also, check the order with the doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are trying to become pregnant or are pregnant, you should consult the doctor about the possible risk that this medicine could harm you or the fetus.<\/p>\n\n\n\n<p>It is not known whether&nbsp;inhalation&nbsp;of the drug causes birth defects during pregnancy.<\/p>\n\n\n\n<p>When given by\u00a0injection, tobramycin and other aminoglycoside antibiotics can cause birth defects such as deafness.<\/p>\n\n\n\n<p>If you are breastfeeding, you should talk to your doctor before taking the medicine.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Tobi should not affect your ability to drive or use machines.<a><\/a><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Tobi<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor.&nbsp;Consult a doctor if you are unsure.<\/p>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended\u00a0dose\u00a0is the same for everyone from the age of 6.<\/li><li>Use\u00a0<strong>two\u00a0<\/strong>ampoules\u00a0daily for 28 days.\u00a0Inhale the entire contents of one\u00a0ampoule\u00a0in the morning and one in the evening.\u00a0The doses\u00a0should preferably be taken 12 hours apart.<\/li><li><strong>At least 6 hours<\/strong>\u00a0must pass between two Tobi\u00a0inhalations.<\/li><li>After you have taken the medicine for 28 days, 28 treatment-free days follow when you do not take the medicine, before you start a treatment period again.<\/li><li>It is important that you take the medicine twice a day during the treatment period and that you follow the\u00a028-day interval with or without treatment.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><br><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20001229000028#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td><strong>WITH TOBY<\/strong><\/td><td><strong>WITHOUT TOBY<\/strong><\/td><\/tr><tr><td>Take Tobi twice daily for 28 days<\/td><td>Do not take Tobi for the next 28 days<\/td><\/tr><tr><td><br><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20001229000028#\" rel=\"noopener\"><\/a><br><strong>Repeated<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>If you have taken too much Tobi<\/strong><\/p>\n\n\n\n<p>If you have inhaled too much Tobi, you may become hoarse.&nbsp;Tell the doctor about this as soon as possible.&nbsp;If you accidentally swallow Tobi, tell your doctor as soon as possible.<\/p>\n\n\n\n<p><strong>If you forget to take Tobi<\/strong><\/p>\n\n\n\n<p>If you forget to take Tobi and it is at least 6 hours until the next\u00a0dose, take\u00a0dose\u00a0one as soon as you can, otherwise, you will skip\u00a0dose\u00a0one.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<p><strong>Instructions for using Tobi<\/strong><\/p>\n\n\n\n<p>This section of the leaflet explains how Tobi should be used and handled.&nbsp;Read through and follow these instructions carefully.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<\/p>\n\n\n\n<p><strong>Equipment for&nbsp;inhalation&nbsp;of Tobi<\/strong><\/p>\n\n\n\n<p>Tobi should be used with a clean and dry reusable\u00a0nebulizer.<\/p>\n\n\n\n<p>The LC PLUS nebulizer (manufactured by PARI GmbH) is suitable for use with Tobi.<\/p>\n\n\n\n<p>A doctor or physiotherapist can advise you on how to use Tobi correctly and on the equipment you need.\u00a0You may need different\u00a0nebulizers\u00a0for your other inhaled medicines for cystic\u00a0fibrosis.<\/p>\n\n\n\n<p><strong>Preparation for&nbsp;inhalation&nbsp;of Tobi<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Wash hands thoroughly with soap and water.<\/li><li>Each foil bag contains a tray with 14\u00a0ampoules.\u00a0Cut or tear open the bag.\u00a0Remove an\u00a0ampoule\u00a0from the tray by gently pulling it apart from the other attached\u00a0ampoule\u00a0by the tabs on the outer edge.\u00a0Put the tray back in the foil bag and put it in the fridge.<\/li><li>Place the nebulizer parts on a clean, dry piece of paper or a towel.<\/li><li>Make sure you have a\u00a0compressor\u00a0that fits and hoses to connect the nebulizer to the compressor.<\/li><li>Follow the instructions for the nebulizer carefully.\u00a0You must read the information provided by the manufacturer of the nebulizer.\u00a0Check that the nebulizer and compressor are working according to the manufacturer&#8217;s instructions before you start taking the medicine.<\/li><\/ul>\n\n\n\n<p><strong>Use of Tobi with LC PLUS (PARI GmbH)<\/strong><\/p>\n\n\n\n<p>For more detailed instructions on the use of the nebulizer, read the instructions that come with PARI LC PLUS.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>1.<\/td><td>Remove the upper part of the nebulizer from the lower part by turning the upper part counterclockwise and then lifting it off.&nbsp;Place the upper part on a towel and stand the lower part upright on the towel.<\/td><\/tr><tr><td>2.<\/td><td>Connect one end of the hose to the compressor outlet.&nbsp;Make sure the hose closes tightly.&nbsp;Connect the compressor to the wall outlet.<\/td><\/tr><tr><td>3.<\/td><td>Open&nbsp;ampoule&nbsp;one with TOBI by holding the bottom tab with one hand and twisting off the top with the other.&nbsp;Squeeze the entire contents into the lower part of the nebulizer.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20001229000028#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>&nbsp;<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20001229000028#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>&nbsp;<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20001229000028#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>4.<\/td><td>Replace the nebulizer top, attach the mouthpiece, and replace the inhalation valve cap on the nebulizer.&nbsp;Then connect the compressor according to the instructions for the PARI LC PLUS nebulizer.<\/td><\/tr><tr><td>5.<\/td><td>Turn on the compressor.&nbsp;Check that an even shower of spray comes from the nozzle.&nbsp;If there is no shower, check the hose connections and that the compressor is working properly.<\/td><\/tr><tr><td>6.<\/td><td>Sit or stand straight so you can breathe normally.<\/td><\/tr><tr><td>7.<\/td><td>Place the mouthpiece between the teeth on the top of the tongue.&nbsp;Breathe normally but only through the mouth (a nose clip may help).&nbsp;Try not to block the airflow with your tongue.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20001229000028#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>8.<\/td><td>Continue until all TOBI is used up and there is no more spray shower.&nbsp;The entire treatment should take about 15 minutes.&nbsp;A hissing sound can be heard when the nebulizer is empty.<\/td><\/tr><tr><td>9.<\/td><td><strong>Remember to clean and\u00a0disinfect\u00a0the nebulizer after use according to the manufacturer&#8217;s instructions.\u00a0Never use a dirty or clogged\u00a0nebulizer.\u00a0Do not share the\u00a0nebulizer\u00a0with anyone else.<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>If you are interrupted or need to <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a> or rest during treatment, turn off the compressor to save the medicine.\u00a0Turn the compressor back on as soon as you are ready to continue.\u00a0If it is less than 6 hours until your next regular\u00a0dose, skip this\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;can be serious<\/strong><\/p>\n\n\n\n<p>If you experience any of the following, stop taking Tobi and&nbsp;<strong>contact your doctor immediately:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Unusually difficult breathing with wheezing or coughing and chest tightness.<\/li><li>Allergic reactions include\u00a0hives\u00a0and\u00a0itching.<\/li><\/ul>\n\n\n\n<p>If you get any of the following,&nbsp;<strong>see a doctor immediately:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hearing loss (ringing in the ears is a potential warning sign of hearing loss), noises (eg hissing) in the ears.<\/li><\/ul>\n\n\n\n<p>The underlying lung disease may worsen while taking Tobi.&nbsp;This may be due to a lack of power.&nbsp;Talk to your doctor immediately if this happens.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;are very common<\/strong><\/p>\n\n\n\n<p><em>These&nbsp;side effects&nbsp;occur in more than 1 in 10 people.<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Runny or stuffy nose, sneezing<\/li><li>Voice changes (hoarseness)<\/li><li>Discoloration of the expectorated mucus<\/li><li>Impaired pulmonary function tests<\/li><\/ul>\n\n\n\n<p>If any of these\u00a0side effects\u00a0affect you seriously,\u00a0<strong>contact a doctor<\/strong>.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;are common<\/strong><\/p>\n\n\n\n<p><em>These&nbsp;side effects&nbsp;occur in up to 1 in 10 people.<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>General malaise<\/li><li>Muscle <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a><\/li><li>Voice changes with a <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sore-throat\/\">sore throat<\/a> and difficulty swallowing (throat inflammation)<\/li><\/ul>\n\n\n\n<p>If any of these\u00a0side effects\u00a0affect you seriously,\u00a0<strong>contact a doctor<\/strong>.<\/p>\n\n\n\n<p><strong>Other side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Itching<\/li><li>Itchy rash<\/li><li>Rash<\/li><li>Loss of voice<\/li><li>Taste changes<\/li><li>Sore throat<\/li><\/ul>\n\n\n\n<p>If any of these symptoms affect you seriously,\u00a0<strong>consult a doctor<\/strong>.<\/p>\n\n\n\n<p>If you have received Tobi at the same time as\u00a0the injection\u00a0of tobramycin or another aminoglycoside antibiotic, or after repeated injection treatments, hearing loss has been reported as a\u00a0side effect.\u00a0Injection\u00a0with tobramycin or other aminoglycoside antibiotics can cause allergic reactions, hearing problems, and kidney problems.<\/p>\n\n\n\n<p>People with\u00a0cystic fibrosis\u00a0have several symptoms of the disease.\u00a0These may persist when Tobi is used, but should not occur more frequently or worsen compared to before.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Tobi should be stored<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Use before the expiry date stated on the packaging, bag, or\u00a0ampoule.<\/li><li>Do not use this medicine if the solution becomes cloudy or if there are particles in the solution.<\/li><li>Store at 2-8\u00b0C (\u00a0in a refrigerator\u00a0).\u00a0If a refrigerator is not available (e.g. when transporting the medicine), you can store the foil bags (opened or unopened) at room temperature (at a maximum of 25\u00b0C) for a maximum of 28 days.<\/li><li>Do not use Tobi\u00a0ampoules\u00a0that have been stored at room temperature for longer than 28 days.<\/li><li>Keep\u00a0the ampoules\u00a0in the original packaging as this medicine is sensitive to strong light.\u00a0This medicine is normally pale yellow, but the color can vary slightly and can sometimes be a darker yellow.\u00a0However, this does not affect the effectiveness of this medicine provided that the storage instructions have been followed.<\/li><\/ul>\n\n\n\n<p><strong>Never save an opened\u00a0ampoule.\u00a0Once an\u00a0ampoule\u00a0has been opened, it should be used immediately and any remaining amount should be discarded.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tobramycin.\u00a0One\u00a0ampoule\u00a0contains 300 mg tobramycin as a single dose.<\/li><li>Other ingredients are sodium chloride, water for injections, sodium hydroxide, and sulfuric acid (for\u00a0pH\u00a0adjustment ).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tobi is a clear, slightly yellow solution supplied in\u00a0ampoules.<\/p>\n\n\n\n<p>The ampoules\u00a0are packed in foil bags.\u00a0A foil bag contains 14\u00a0ampoules, which corresponds to 7 days of treatment.<\/p>\n\n\n\n<p>Tobi is supplied in packs of 56, 112, and 168\u00a0ampoules, which correspond to one, two, and three treatment periods respectively.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Viatris AB, Box 23033 104 35 Stockholm<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>McDermott Laboratories Ltd T\/A Mylan Dublin<\/p>\n\n\n\n<p>Respiratory<\/p>\n\n\n\n<p>Unit 25 Baldoyle Industrial Estate<\/p>\n\n\n\n<p>Grange Road, Baldoyle<\/p>\n\n\n\n<p>Dublin 13, D13 N5X2<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>alternatively<\/p>\n\n\n\n<p>Mylan Germany GmbH<\/p>\n\n\n\n<p>Zweigniederlassung Bad Homburg CEO Hoehe<\/p>\n\n\n\n<p>Benzstrasse 1<\/p>\n\n\n\n<p>61352 Bad Homburg CEO Hoehe<\/p>\n\n\n\n<p>German<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tobi contains tobramycin.\u00a0It is an\u00a0antibiotic\u00a0that belongs to the group of\u00a0aminoglycosides\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25952,18611,25948,25951,18607,18610,25949,18608,25950,18609],"class_list":["post-25122","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-tobi","tag-benefits-of-tobramycin","tag-tobi","tag-tobi-side-effects","tag-tobramycin","tag-tobramycin-side-effects","tag-what-is-tobi","tag-what-is-tobramycin","tag-what-tobi-is-used-for","tag-what-tobramycin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25122"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25122\/revisions"}],"predecessor-version":[{"id":25140,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25122\/revisions\/25140"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25122"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25122"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}