{"id":25119,"date":"2022-09-07T07:59:06","date_gmt":"2022-09-07T07:59:06","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25119"},"modified":"2022-09-09T10:22:32","modified_gmt":"2022-09-09T10:22:32","slug":"tivicay","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tivicay\/","title":{"rendered":"Tivicay &#8211; Dolutegravir uses, dose and side effects"},"content":{"rendered":"\n<p>5 mg dispersible tablets<br>dolutegravir<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tivicay is and what it is used for<\/h2>\n\n\n\n<p>Tivicay contains the active substance dolutegravir.\u00a0Dolutegravir belongs to a group of antiretroviral drugs called\u00a0<em>integrase inhibitors<\/em>.<\/p>\n\n\n\n<p>Tivicay is used to treat\u00a0<strong>HIV\u00a0<\/strong><strong>infection\u00a0(\u00a0HIV\u00a0=\u00a0human immunodeficiency virus)<\/strong>\u00a0in adults, adolescents, and children from 4 weeks of age weighing at least 3 kg.<\/p>\n\n\n\n<p>Tivicay does not cure\u00a0HIV\u00a0&#8211;\u00a0infection\u00a0but it reduces the amount of\u00a0virus\u00a0in the body and keeps it at a low level.\u00a0A consequence of this is that it also increases the number of CD4 cells in your blood.\u00a0CD4 cells are a type of\u00a0white blood cell\u00a0that is important for the body&#8217;s ability to fight\u00a0infection.<\/p>\n\n\n\n<p>Not everyone reacts to treatment with Tivicay in the same way.&nbsp;Your doctor will check the effect of the treatment on you.<\/p>\n\n\n\n<p>Tivicay is always used in combination with other antiretroviral drugs (&nbsp;<em>combination therapy<\/em>&nbsp;).&nbsp;To keep your&nbsp;HIV&nbsp;infection under control and prevent the&nbsp;disease&nbsp;from getting worse, you must take all your medicines, unless your doctor tells you to stop taking any of them.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Tivicay<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Tivicay:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you (or your child, if the patient) are allergic (allergic) to dolutegravir or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you (or your child) are taking another medicine called fampridine (also called dalfampridine; used in&nbsp;multiple sclerosis&nbsp;).<\/li><li>If you think any of these apply to you (or your child), tell your doctor.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p><strong>Pay attention to important symptoms<\/strong><\/p>\n\n\n\n<p>Some people who take medicines for&nbsp;HIV&nbsp;infection&nbsp;develop&nbsp;other problems, which can be serious.&nbsp;These are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>symptoms\u00a0of\u00a0infection\u00a0and\u00a0inflammation<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/joint-pain\/\">joint pain<\/a>, stiffness, and bone problems.<\/li><\/ul>\n\n\n\n<p>You need to know the important signs and symptoms to look out for while you (or your child, if the patient) are taking Tivicay.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Read the information under section 4 of this leaflet.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Protect others<\/strong><\/p>\n\n\n\n<p>HIV&nbsp;&#8211;&nbsp;infection&nbsp;is spread through sexual contact with someone who is infected, or through transmission via infected blood (e.g. if you share the same injection needles).&nbsp;You can still transmit&nbsp;HIV&nbsp;when taking this medicine, although the risk is reduced with effective&nbsp;antiviral&nbsp;treatment.&nbsp;Discuss with your doctor the necessary measures to avoid infecting others.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Do not give this medicine to children under 4 weeks of age, with a body weight of less than 3 kg, or with\u00a0HIV\u00a0&#8211;\u00a0infection\u00a0that is resistant to other medicines of the same type as Tivicay.\u00a0The use of Tivicay dispersible tablets in children under 4 weeks of age or weighing less than 3 kg has not yet been studied.<\/p>\n\n\n\n<p>Children must come to&nbsp;<strong>scheduled medical appointments<\/strong>&nbsp;(&nbsp;<em>see \u201cChildren and young people\u201d in section 3 for more information<\/em>&nbsp;).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tivicay<\/h2>\n\n\n\n<p>Tell your doctor if you (or your child) are taking, have recently taken, or plan to take any other medicines.<\/p>\n\n\n\n<p><strong>Do not take Tivicay<\/strong>&nbsp;together with the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fampridine (also called dalfampridine), is used to treat\u00a0multiple sclerosis<strong>.<\/strong><\/li><\/ul>\n\n\n\n<p>Some medicines can affect how Tivicay works, or increase the risk of\u00a0side effects.\u00a0Tivicay can also affect how some other medicines work.<\/p>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if you (or your child) are taking any of the medicines listed below:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>metformin, for the treatment of\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">diabetes<\/a><\/li><li>antacids, medicines to treat\u00a0indigestion\u00a0and\u00a0heartburn.\u00a0Do not take antacids\u00a0for 6 hours before taking Tivicay, or for the next 2 hours after taking Tivicay (\u00a0see also section 3\u00a0).<\/li><li>calcium supplements, iron supplements, and multivitamins.\u00a0Do not take calcium supplements, iron supplements, or multivitamins\u00a0for 6 hours before taking Tivicay, or for the next 2 hours after taking Tivicay\u00a0(see also section 3).<\/li><li>etravirine, efavirenz, fosamprenavir\/ritonavir, nevirapine or tipranavir\/ritonavir, to\u00a0treat\u00a0HIV\u00a0infection<\/li><li>rifampicin, for the treatment of\u00a0tuberculosis\u00a0and other\u00a0bacterial infections<\/li><li>phenytoin\u00a0and phenobarbital, for the treatment of\u00a0epilepsy<\/li><li>oxcarbazepine and carbamazepine, for the treatment of\u00a0epilepsy\u00a0or\u00a0bipolar disorder<\/li><li>St. John&#8217;s wort\u00a0(\u00a0Hypericum perforatum\u00a0) is, traditional herbal medicine used for\u00a0mild depression\u00a0and\u00a0mild anxiety.<\/li><li><strong>Tell your doctor or pharmacist<\/strong>\u00a0if you (or your child) are taking any of these medicines.\u00a0The doctor may decide that the\u00a0dose\u00a0needs to be changed or that you need to go for more checks.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor<\/strong>&nbsp;about the risks and benefits of Tivicay.<\/li><\/ul>\n\n\n\n<p>Taking Tivicay at the time of conception or during the first six weeks of pregnancy may increase the risk of a type of malformation called a neural tube defect, e.g.&nbsp;spina bifida (deformed spinal cord).<\/p>\n\n\n\n<p>If you could become pregnant while receiving Tivicay:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor<\/strong>\u00a0and discuss whether you need to use contraception, such as condoms or\u00a0birth control pills.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you become pregnant or plan to become pregnant.&nbsp;Your doctor will review your treatment.&nbsp;Do not stop taking Tivicay without talking to your doctor as this may harm you and your unborn baby.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p><strong>Women who are\u00a0HIV\u00a0positive should not breastfeed<\/strong>\u00a0because\u00a0HIV\u00a0infection\u00a0can be transmitted to the child through breast milk.<\/p>\n\n\n\n<p>A small amount of the ingredients in Tivicay can pass into breast milk.<\/p>\n\n\n\n<p>If you are breastfeeding or thinking about starting to breastfeed:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor immediately<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Tivicay can make you dizzy and have other&nbsp;side effects&nbsp;that reduce your attention.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Do not drive vehicles or use machines<\/strong>\u00a0if you are not sure that the medicine does not affect you.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Tivicay contains sodium<\/h2>\n\n\n\n<p><strong>Tivicay contains less than 1 mmol (23 mg)\u00a0of sodium\u00a0per tablet<\/strong>, i.e. it is almost &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Tivicay<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>The usual adult dose<\/strong>\u00a0is 30 mg (taken as six 5 mg dispersible tablets)\u00a0<strong>once daily.<\/strong><\/li><li>If you are taking\u00a0<strong>certain\u00a0<\/strong><strong>other medicines<\/strong>, the\u00a0dose\u00a0is 30 mg (taken as six 5 mg dispersible tablets)\u00a0twice daily.<\/li><li>When treating\u00a0HIV\u00a0that is\u00a0resistant\u00a0to other medicines of the same type as Tivicay, the usual\u00a0dose\u00a0is one Tivicay 30 mg (taken as six 5 mg dispersible tablets)\u00a0twice daily.<\/li><\/ul>\n\n\n\n<p>The doctor will decide which&nbsp;dose&nbsp;of Tivicay is suitable for you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>The children&#8217;s dose<\/strong>\u00a0of Tivicay must be adjusted as the child gets older or gains weight.<ul><li>It is therefore important that children\u00a0<strong>attend scheduled doctor&#8217;s appointments<\/strong>.<\/li><\/ul><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Children and adolescents weighing at least 20 kg can take the adult dose, 30 mg, once daily or 15 mg twice daily.\u00a0Your doctor will decide how Tivicay should be taken.<\/li><li>For children from the age of 4 weeks who weigh between 3 and 20 kg, the doctor determines the correct\u00a0dose\u00a0of Tivicay based on the child&#8217;s weight and age.<\/li><li>If the tablets are swallowed whole, children\u00a0<strong>must not swallow more than one tablet at a time<\/strong>.\u00a0This is to reduce the risk of choking.<\/li><li>Tivicay should\u00a0<strong>not<\/strong>\u00a0be given to children and adolescents with\u00a0<strong>HIV\u00a0&#8211;\u00a0infection\u00a0that is\u00a0resistant\u00a0<\/strong>to other medicines of the same type as Tivicay.<\/li><\/ul>\n\n\n\n<p><strong>How to take the dispersible tablets<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The dispersible tablets can be dispersed in drinking water or swallowed whole with drinking water.\u00a0When the tablets are dispersed, the volume of water depends on the number of tablets prescribed.\u00a0The tablet(s) must be completely dissolved before being swallowed. See the separate instructions\u00a0for use on how to dissolve and administer tablets using the dosing cup and oral syringe provided in the package<\/li><li>The tablets should\u00a0not be\u00a0chewed, crushed, or split.<\/li><li>Tivicay can be taken\u00a0with or without food.\u00a0When Tivicay is taken twice daily, the doctor may advise you to take the tablets with food.<\/li><\/ul>\n\n\n\n<p>Tivicay is also available as&nbsp;<strong>film-coated tablets.&nbsp;<\/strong>Film-coated tablets and dispersible tablets are not interchangeable.&nbsp;<strong>Therefore, do not<\/strong>&nbsp;switch between film-coated tablets and dispersible tablets without first talking to the doctor.<\/p>\n\n\n\n<p><strong>Antacid drugs<\/strong><\/p>\n\n\n\n<p>Antacids, which are used for\u00a0<strong>indigestion<\/strong>\u00a0and\u00a0<strong>heartburn<\/strong>, can make Tivicay not absorbed by the body and therefore have a worse effect.<\/p>\n\n\n\n<p><strong>Do not take antacids<\/strong>&nbsp;for 6 hours before taking Tivicay, or for the next 2 hours after taking Tivicay.&nbsp;Other antacids such as ranitidine and omeprazole can be taken at the same time as Tivicay.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Talk to your doctor to get more information about antacids with Tivicay.<\/li><\/ul>\n\n\n\n<p><strong>Calcium supplements, iron supplements, or multivitamins<\/strong><\/p>\n\n\n\n<p>Calcium supplements, iron supplements, or multivitamins can mean that Tivicay is not absorbed by the body and therefore has a worse effect.<\/p>\n\n\n\n<p><strong>Do not take\u00a0<\/strong>calcium, iron supplements, or multivitamins for 6 hours before taking Tivicay, or for the next 2 hours after taking it.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Talk to your doctor for more information about calcium supplements, iron supplements, or multivitamins along with Tivicay.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Tivicay<\/h2>\n\n\n\n<p>If you (or your child) take too many Tivicay tablets,&nbsp;<strong>contact your doctor or pharmacist for advice.&nbsp;<\/strong>If possible, show them the Tivicay packaging.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Tivicay<\/h2>\n\n\n\n<p>If you (or your child) have missed a\u00a0dose, take it as soon as you remember.\u00a0If it is time for the next\u00a0dose\u00a0within 4 hours, however, you should skip the\u00a0dose\u00a0you have missed and take the next\u00a0dose\u00a0at the usual time.\u00a0Then continue with your treatment as before.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Do not take a double\u00a0dose<\/strong>\u00a0to make up for a missed\u00a0dose.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Do not stop taking Tivicay without talking to your doctor<\/h2>\n\n\n\n<p>Take Tivicay for as long as your doctor recommends.&nbsp;Do not stop unless your doctor tells you to.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Allergic reactions<\/strong><\/p>\n\n\n\n<p>This is uncommon in people taking Tivicay.&nbsp;Signs of&nbsp;an allergic reaction&nbsp;are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash<\/li><li>high temperature (\u00a0<em><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a><\/em>\u00a0)<\/li><li>lack of energy (\u00a0<em>powerlessness<\/em>\u00a0)<\/li><li>swelling, sometimes of the face and mouth (\u00a0<em>angioedema<\/em>\u00a0), which can cause breathing difficulties<\/li><li>muscle or joint pain.<\/li><li><strong>Seek medical attention immediately.\u00a0<\/strong>Your doctor may decide to take liver, kidney, or blood tests and you may have to stop taking Tivicay.<\/li><\/ul>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong>&nbsp;<\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>more than 1 in 10&nbsp;<\/strong><strong>users<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>diarrhea<\/li><li>nausea.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>up to 1 in 10&nbsp;<\/strong><strong>users<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash<\/li><li>itching<\/li><li>vomiting<\/li><li>stomach pains (\u00a0<em>abdominal\u00a0<\/em><em>pains<\/em>\u00a0)<\/li><li>discomfort from the stomach (\u00a0<em>abdomen<\/em>\u00a0)<\/li><li>sleep difficulties<\/li><li>dizziness<\/li><li>abnormal dreams<\/li><li>depression (feelings of deep sadness and worthlessness)<\/li><li>concern<\/li><li>lack of energy (\u00a0<em>powerlessness<\/em>\u00a0)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/flatulence\/\">flatulence<\/a> (\u00a0<em>flatulence<\/em>\u00a0)<\/li><li>elevated liver enzyme levels<\/li><li>the increased amount of\u00a0enzymes\u00a0produced in the muscles (\u00a0<em>creatine phosphokinase<\/em>\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>Less common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>up to 1 in 100&nbsp;<\/strong><strong>users<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation of the liver (&nbsp;<em>hepatitis<\/em>&nbsp;)<\/li><li>suicide attempt*<\/li><li>suicidal thoughts*<\/li><li>panic attack<\/li><li>joint pain<\/li><li>muscle pain.<\/li><\/ul>\n\n\n\n<p>*&nbsp;<em>especially in patients who previously had depression or mental problems.<\/em><\/p>\n\n\n\n<p><strong>Rare\u00a0side effects\u00a0ar<\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>up to 1 in 1,000 users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver failure (signs of this may be yellowing of the skin and whites of the eyes or unusually dark urine)<\/li><li>increased levels of&nbsp;bilirubin&nbsp;(a test of liver function) in your blood<\/li><li>suicide (especially in patients who previously had depression or mental problems).<\/li><\/ul>\n\n\n\n<p><strong>\u2192 Talk to your doctor immediately<\/strong>&nbsp;if you experience mental health problems (see also other mental health problems above).<\/p>\n\n\n\n<p><strong>Symptoms&nbsp;of&nbsp;infection&nbsp;and&nbsp;inflammation<\/strong><\/p>\n\n\n\n<p>People with advanced\u00a0HIV\u00a0infection\u00a0(\u00a0AIDS ) have a weak immune system and the risk\u00a0<em>is<\/em>\u00a0greater that they will get serious\u00a0infections\u00a0(\u00a0<em>opportunistic\u00a0<\/em>infections\u00a0<em>)<\/em>.\u00a0Such\u00a0infections\u00a0may have been &#8220;silent&#8221; and not detected by the weak immune system before treatment began.\u00a0Once treatment has started, the immune system becomes stronger and can fight\u00a0infections, which can cause symptoms of infection or inflammation.\u00a0Symptoms usually include <strong>fever<\/strong>\u00a0and any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>gripe<\/li><li>breathing difficulties<\/li><\/ul>\n\n\n\n<p>In rare cases, when the immune system becomes stronger, it can also attack healthy body tissue (\u00a0<em>autoimmune diseases<\/em>\u00a0).\u00a0The symptoms of autoimmune diseases can develop several months after you start taking medicines for\u00a0your\u00a0HIV\u00a0infection.\u00a0Symptoms may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>palpitations (fast or irregular heartbeats) or tremors<\/li><li>hyperactivity (excessive restlessness and excessive movements)<\/li><li>weakness that starts in the hands and feet and moves up the trunk.<\/li><\/ul>\n\n\n\n<p><strong>If you (or your child) develop symptoms of an&nbsp;infection&nbsp;<\/strong>and inflammation or if you notice any of the symptoms mentioned above:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor immediately.\u00a0<\/strong>Do not take other anti-infection\u00a0medicines unless the doctor has recommended them.<\/li><\/ul>\n\n\n\n<p><strong>Joint pain, stiffness, and bone problems<\/strong><\/p>\n\n\n\n<p>Some people taking combination anti-HIV\u00a0therapy\u00a0develop osteonecrosis<em>.\u00a0<\/em>This means that parts of the bone tissue die because the blood supply to the bone is reduced.\u00a0The risk of being affected by this increases if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have been taking the combination treatment for a long time<\/li><li>you&nbsp;also take anti-inflammatory drugs called&nbsp;corticosteroids<\/li><li>you drink alcohol<\/li><li>the immune system is very weak<\/li><li>you are overweight.<\/li><\/ul>\n\n\n\n<p><strong>Signs of&nbsp;osteonecrosis&nbsp;are:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>stiffness in the joints<\/li><li>aches and pains in the joints (especially in the hips, knees, or shoulders)<\/li><li>difficulty moving.<\/li><\/ul>\n\n\n\n<p>If you get any of these symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor about it<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Effects on weight, blood lipids, and <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar<\/a><\/strong><\/p>\n\n\n\n<p>During\u00a0HIV\u00a0treatment, weight gain and increased levels of blood fats and blood sugar may occur.\u00a0This is partly related to restored health and lifestyle, but in the case of blood lipids, there can sometimes be a connection with HIV\u00a0drugs.\u00a0The doctor will perform tests to find such changes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tivicay<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry dais stated on the carton and can after &#8220;EXP&#8221;.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Moisture sensitive.&nbsp;Close the jar well.&nbsp;Do not remove the desiccant.&nbsp;Do not swallow the desiccant.&nbsp;No special temperature instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispo ofse of medications that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is dolutegravir.\u00a0One tablet contains dolutegravir sodium equivalent to 5 mg of dolutegravir.<\/li><li>Other ingredients are mannitol (E421), microcrystalline cellulose, povidone, sodium starch glycolate,\u00a0colloidal\u00a0silicon dioxide, microcrystalline cellulose, crospovidone, sodium stearyl fumarate, calcium sulfate dihydrate, sucralose, strawberry cream flavor, titanium dioxide (E171), hypromellose and macrogol.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tivicay 5 mg dispersible tablets are white, round, biconvex tablets debossed with \u201cSV H7S\u201d on one side and \u201c5\u201d on the other side.&nbsp;The jar contains a desiccant to reduce moisture.&nbsp;Leave the desiccant in the can after opening, do not take it out.<\/p>\n\n\n\n<p>The dispersible tablets are available in cans containing 60 tablets.<\/p>\n\n\n\n<p>A dosing cup and&nbsp;oral&nbsp;syringe are&nbsp;included in the package.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>ViiV Healthcare BV<\/p>\n\n\n\n<p>Van Asch van Wijckstraat 55H<\/p>\n\n\n\n<p>3811 LP Amersfoort<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong>&nbsp;<\/p>\n\n\n\n<p>Glaxo Wellcome, SA, Avda.&nbsp;Extremadura 3, 09400 Aranda De Duero, Burgos, Spain<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>ViiV Healthcare srl\/bv&nbsp;Tel\/Tel: + 32 (0) 10 85 65 00<\/td><td><strong>Lithuania<\/strong>ViiV Healthcare BVPhone: + 370 80000334<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>ViiV Healthcare BVTel.: + 359 80018205<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>ViiV Healthcare Srl\/bvBelgique\/BelgiumTel\/Tel: + 32 (0) 10 85 65 00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>GlaxoSmithKline, Serophene: + 420 222 001 111cz.info@gsk.com<\/td><td><strong>Magyarorsz\u00e1g<\/strong>ViiV Healthcare BVTel.: + 36 80088309<\/td><\/tr><tr><td><strong>Denmark<\/strong>GlaxoSmithKline Pharma A\/SPhone: + 45 36 35 91 00dk-info@gsk.com<\/td><td><strong>Malta<\/strong>ViiV Healthcare BVPhone: + 356 80065004<\/td><\/tr><tr><td><strong>Deutschland<\/strong>ViiV Healthcare GmbHTel.: + 49 (0)89 203 0038-10viiv.med.info@viivhealthcare.com<\/td><td><strong>The Netherlands<\/strong>ViiV Healthcare BVPhone: + 31 (0)33 2081199<\/td><\/tr><tr><td><strong>Estonia<\/strong>ViiV Healthcare BVPhone: + 372 8002640<\/td><td><strong>Norway<\/strong>GlaxoSmithKline iPhone: + 47 22 70 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>GlaxoSmithKline \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b7 AEBETel: + 30 210 68 82 100<\/td><td><strong>Austria<\/strong>GlaxoSmithKline Pharma GmbHTel: + 43 (0)1 97075 0at.info@gsk.com<\/td><\/tr><tr><td><strong>Spain<\/strong>Laboratorios ViiV Healthcare, SLPhone: + 34 900 923 501es-ci@viivhealthcare.com<\/td><td><strong>Polish<\/strong>GSK Services Sp.&nbsp;z o. oTel.: + 48 (0)22 576 9000<\/td><\/tr><tr><td><strong>France<\/strong>ViiV Healthcare SASTel.: + 33 (0)1 39 17 69 69Infomed@viivhealthcare.com<\/td><td><strong>Portugal<\/strong>VIIVHIV HEALTHCARE, UNIPESSOAL, LDAPhone: + 351 21 094 08 01viiv.fi.pt@viivhealthcare.com<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>ViiV Healthcare BVPhone: + 385 1 800787089<\/td><td><strong>Romania<\/strong>ViiV Healthcare BVPhone: + 40800672524<\/td><\/tr><tr><td><strong>Ireland<\/strong>GlaxoSmithKline (Ireland) LimitedPhone: + 353 (0)1 4955000<\/td><td><strong>Slovenija<\/strong>ViiV Healthcare BVPhone: + 386 80688869<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Telephone: + 354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>ViiV Healthcare BVPhone: + 421 800500589<\/td><\/tr><tr><td><strong>Italy<\/strong>ViiV Healthcare SrlPhone: + 39 (0)45 7741600<\/td><td><strong>Finland\/Finland<\/strong>GlaxoSmithKline OyPhone\/Tel: + 358 (0)10 30 30 30<\/td><\/tr><tr><td><strong>Cyprus<\/strong>ViiV Healthcare BVTel: + 357 80070017<\/td><td><strong>Sweden<\/strong>GlaxoSmithKline ABPhone: + 46 (0)8 638 93 00info.produkt@gsk.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>ViiV Healthcare BVPhone: + 371 80205045<\/td><td><strong>United Kingdom<\/strong><strong>(Northern Ireland)<\/strong>ViiV Healthcare BVPhone: + 44 (0)800 221441customercontactuk@gsk.com&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Tivicay contains the active substance dolutegravir.\u00a0Dolutegravir belongs to a group of antiretroviral drugs called\u00a0integrase inhibitors\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25958,5221,5223,5224,25953,25954,25957,14840,5222,25955,25956],"class_list":["post-25119","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-tivicay","tag-dolutegravir","tag-dolutegravir-side-effects","tag-dolutegravir-tablet","tag-tivicay","tag-tivicay-side-effects","tag-tivicay-tablet","tag-what-dolutegravir-is-used-for","tag-what-is-dolutegravir","tag-what-is-tivicay","tag-what-tivicay-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25119","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25119"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25119\/revisions"}],"predecessor-version":[{"id":25141,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25119\/revisions\/25141"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25119"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25119"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}