{"id":25051,"date":"2022-09-06T07:28:06","date_gmt":"2022-09-06T07:28:06","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25051"},"modified":"2022-09-07T07:41:27","modified_gmt":"2022-09-07T07:41:27","slug":"tigecycline-mylan","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tigecycline-mylan\/","title":{"rendered":"Tigecycline Mylan &#8211; Tigecycline uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg\u00a0powder for\u00a0infusion, solution<br>tigecycline<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tigecycline Mylan is and what it is used for<\/h2>\n\n\n\n<p>Tigecycline Mylan is an\u00a0antibiotic\u00a0in the glycylcycline group that works by stopping the growth of bacteria that cause\u00a0infection.<\/p>\n\n\n\n<p>Your doctor has prescribed Tigecycline Mylan because you or your child over the age of 8 have one of the following serious infections:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Complicated\u00a0infections\u00a0in the skin and soft tissues (\u00a0tissues\u00a0under the skin), excluding foot infections in patients with\u00a0diabetes.<\/li><li>Complicated\u00a0infection\u00a0in the abdominal cavity.<\/li><\/ul>\n\n\n\n<p>Tigecycline Mylan is only used when your doctor considers other&nbsp;antibiotics&nbsp;unsuitable.<\/p>\n\n\n\n<p>The tigecycline contained in Tigecycline Mylan may also be approved to treat other conditions not mentioned in this leaflet.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you receive Tigecycline Mylan<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Tigecycline Mylan:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to tigecycline or any of the other ingredients of this medicine (listed in section 6).\u00a0If you are allergic to tetracycline antibiotics (eg,\u00a0minocycline,\u00a0doxycycline, etc.), you may be allergic to tigecycline.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to a doctor or nurse before receiving Tigecycline Mylan:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If the wound does not heal normally.<\/li><li>If you suffer from diarrhea before receiving Tigecycline Mylan.\u00a0If you get diarrhea during or after your treatment, tell your doctor right away.\u00a0Do not take any diarrhea medicine without first checking with your doctor.<\/li><li>If you have had any\u00a0side effects\u00a0in the past due to\u00a0antibiotics\u00a0belonging to the tetracycline class (eg skin sensitization to sunlight, discoloration of developing teeth, inflammation of the pancreas, and changes in certain laboratory values \u200b\u200bintended to measure how well your blood clots).<\/li><li>If you have or have previously had, liver problems.\u00a0Depending on the condition of your liver, your doctor may reduce the\u00a0dose\u00a0to avoid possible\u00a0side effects.<\/li><li>If you have a blockage of the bile ducts (cholestasis).<\/li><\/ul>\n\n\n\n<p><strong>During treatment with&nbsp;<\/strong><strong>Tigecycline Mylan:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor immediately if you experience symptoms of an\u00a0allergic reaction.<\/li><li>Tell your doctor immediately if you experience severe stomach pain, nausea, and vomiting.\u00a0These symptoms may be signs of inflammation of the pancreas (\u00a0acute\u00a0pancreatitis\u00a0).<\/li><li>For some severe\u00a0infections, your doctor may consider using Tigecycline Mylan together with other\u00a0antibiotics.<\/li><li>Your doctor will monitor you closely to make sure no other bacterial\u00a0infection\u00a0develops.\u00a0If you suffer from another bacterial\u00a0infection, the doctor may prescribe another\u00a0antibiotic\u00a0that is specific to that\u00a0infection.<\/li><li>Although\u00a0antibiotics\u00a0including Tigecycline Mylan work against some bacteria, other bacteria and fungi may continue to grow.\u00a0This is called overgrowth.\u00a0Your doctor will monitor you for possible\u00a0infection\u00a0and treat you if necessary.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Tigecycline Mylan should not be used in children under 8 years of age because there is a lack of data on safety and efficacy in this age group and because it can cause permanent\u00a0defects\u00a0in the teeth, such as discoloration of developing teeth.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tigecycline Mylan<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tigecycline may prolong certain tests that measure how well your blood clots.\u00a0You must tell your doctor if you are taking medicines to avoid excess blood clotting (so-called\u00a0anticoagulants\u00a0).\u00a0If so, your doctor will monitor you closely.<\/p>\n\n\n\n<p>Tigecycline can affect the effectiveness of\u00a0birth control pills.\u00a0Talk to your doctor about the need for additional birth control while using tigecycline.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Tigecycline can be harmful to the fetus.\u00a0If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before receiving Tigecycline Mylan.<\/p>\n\n\n\n<p>It is not known whether tigecycline passes into breast milk.&nbsp;Consult a doctor before breastfeeding your baby.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Tigecycline can cause&nbsp;side effects&nbsp;such as <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/dizziness\/\">dizziness<\/a>.&nbsp;This may impair the ability to drive and operate machinery.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tigecycline Mylan contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0per\u00a0dose, i.e. it is almost &#8220;sodium-free&#8221;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Tigecycline Mylan is used<\/h2>\n\n\n\n<p>Tigecycline Mylan will be administered to you by a doctor or nurse.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0for adults is 100 mg as an initial dose followed by 50 mg every 12 hours.\u00a0This\u00a0dose\u00a0is given\u00a0intravenously\u00a0(directly into the blood) over 30 to 60 minutes.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for children aged 8 to &lt; 12 years is 1.2 mg\/kg given every 12 hours&nbsp;intravenously&nbsp;up to a maximum dose of 50 mg every 12 hours.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for adolescents aged 12 to &lt; 18 years is 50 mg given every 12 hours.<\/p>\n\n\n\n<p>Usually, the treatment lasts for 5 to 14 days.\u00a0Your doctor will decide how long you will be treated.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have received too much Tigecycline Mylan<\/h2>\n\n\n\n<p>If you are concerned that you may have received too much Tigecycline Mylan, talk to your doctor or nurse immediately.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have forgotten a dose of Tigecycline Mylan<\/h2>\n\n\n\n<p>If you are concerned that you may have missed a\u00a0dose, talk to your doctor or nurse straight away.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Pseudomembranous\u00a0colitis\u00a0can occur during treatment with most\u00a0antibiotics, including Tigecycline Mylan.\u00a0It presents as severe, persistent, or bloody diarrhea associated with abdominal pain or fever.\u00a0This may be a sign of serious intestinal inflammation, which may occur during or after your treatment.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(&nbsp;<\/strong>&nbsp;<strong>may affect more than 1 in 10 users)<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea, vomiting, diarrhea.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 users)<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>An abscess\u00a0(accumulation),\u00a0infection,\u00a0etc<\/li><li>Laboratory measurements show that the blood has a reduced ability to clot (coagulate)<\/li><li>Dizziness<\/li><li>Blood vessel irritation from\u00a0injection\u00a0includes pain,\u00a0inflammation, swelling, and\u00a0coagulation<\/li><li>Stomach pain, digestive problems, loss of appetite<\/li><li>Increased liver enzymes, hyperbilirubinemia (excess bile pigment in the blood)<\/li><li>Itching, rash<\/li><li>Poor or slow wound healing<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/headache\/\">Headache<\/a><\/li><li>Increased levels of amylase, which is an\u00a0enzyme\u00a0found in the salivary glands and pancreas, increased levels of blood\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/calmuril\/\">urea<\/a>\u00a0nitrogen (BUN)<\/li><li>Pneumonia<\/li><li>Low blood sugar<\/li><li>Sepsis\/septic\u00a0shock\u00a0(a serious medical condition that can lead to multiple organ failures and death due to sepsis)<\/li><li>Injection site reaction (pain,\u00a0redness,\u00a0inflammation\u00a0)<\/li><li>Low levels of\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/curosurf\/\">protein<\/a>\u00a0in the blood.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 users)<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Acute\u00a0pancreatitis\u00a0(inflammation of the pancreas, which can result in severe stomach pain, nausea, and vomiting)<\/li><li>Jaundice (yellowing of the skin), inflammation of the liver<\/li><li>Low levels of\u00a0platelets\u00a0in the blood (which can lead to an increased tendency to bleed and bruise\/hematoma).<\/li><\/ul>\n\n\n\n<p><strong>Side effects&nbsp;that have been reported (occurring in an unknown number of users)<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anaphylactic\/anaphylactoid&nbsp;hypersensitivity reaction&nbsp;(which can range from mild to severe, including sudden, generalized&nbsp;allergic reaction&nbsp;that can lead to life-threatening&nbsp;shock&nbsp;[eg, difficulty breathing, drop in blood pressure, rapid&nbsp;pulse&nbsp;]).<\/li><li>Liver failure<\/li><li>Skin rash that can lead to severe blistering of the skin and peeling of the skin (&nbsp;Stevens-Johnson syndrome&nbsp;)<\/li><li>Low levels of fibrinogen in the blood (a&nbsp;protein&nbsp;involved in blood clotting).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tigecycline Mylan<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store at a maximum of 25\u00b0C.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the vial and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><strong>Storage after&nbsp;preparation<\/strong><\/p>\n\n\n\n<p>Chemical and physical stability in use has been demonstrated for tigecycline in&nbsp;admixture&nbsp;with 0.9% sodium chloride&nbsp;solution for injection&nbsp;or&nbsp;glucose&nbsp;5%.&nbsp;The product can be stored in a refrigerator at 2\u00ba to 8\u00baC for a maximum of 48 hours after the reconstituted solution is immediately added to the&nbsp;intravenous&nbsp;bag.<\/p>\n\n\n\n<p>From a&nbsp;microbiological&nbsp;point of view, the product must be used immediately.<\/p>\n\n\n\n<p>If not used immediately, in-use storage times and conditions are the responsibility of the user.<\/p>\n\n\n\n<p>Tigecycline Mylan solution should be yellow to orange after the dissolution of the powder;\u00a0otherwise, the solution should be discarded.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tigecycline.\u00a0Each\u00a0vial\u00a0contains 50 mg of tigecycline.<\/li><li>Other ingredients are L-\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/clinimix\/\">arginine<\/a>,\u00a0hydrochloric acid,\u00a0and sodium hydroxide (for adjusting\u00a0pH\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tigecycline Mylan is supplied in a&nbsp;vial&nbsp;containing an orange to orange-red lyophilized cake or powder.&nbsp;These vials are distributed to hospitals in a pack of 10 or 1.&nbsp;Not all pack sizes may be marketed.<\/p>\n\n\n\n<p>The powder should be dissolved in the bottle with a small amount of solution.\u00a0The vial is gently rotated until the medicine has dissolved.\u00a0The solution from the vial should then be immediately added to a 100 ml\u00a0infusion bag\u00a0or another suitable infusion container at the hospital, for\u00a0intravenous\u00a0use.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Mylan Ireland Limited<\/p>\n\n\n\n<p>Unit 35\/36 Grange Parade,<\/p>\n\n\n\n<p>Baldoyle Industrial Estate, Dublin 13<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Galenicum Health SL<br>Avda.&nbsp;Diagonal, 123, 11\u00aa planta<br>08005 Barcelona<br>Spain<\/p>\n\n\n\n<p>Paradox Healthcare, Ltd<br>KW20A Kordin Industrial Park, Paola<br>PLA 3000<br>Malta<\/p>\n\n\n\n<p>SAG Manufacturing SLU<br>Crta.&nbsp;NI, Km 36, San Agustin de Guadalix<br>28750 Madrid<br>Spain<\/p>\n\n\n\n<p>Mylan Germany GmbH<\/p>\n\n\n\n<p>Zweigniederlassung Bad Homburg vd H\u00f6he, Benzstrasse 1<\/p>\n\n\n\n<p>Bad Homburg CEO Hohe<\/p>\n\n\n\n<p>Hesse, 61352<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Hikma Italia SpA<\/p>\n\n\n\n<p>Viale Certosa, 10<\/p>\n\n\n\n<p>27100, Pavia (PV)<\/p>\n\n\n\n<p>Italy<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tigecycline Mylan is an\u00a0antibiotic\u00a0in the glycylcycline group that works by stopping the growth of bacteria that cause\u00a0infection\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25919,25925,25916,25920,25924,25917,25918,25922,25921,25923],"class_list":["post-25051","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-tigecycline","tag-benefits-of-tigecycline-mylan","tag-tigecycline","tag-tigecycline-mylan","tag-tigecycline-mylan-side-effects","tag-tigecycline-side-effects","tag-what-is-tigecycline","tag-what-is-tigecycline-mylan","tag-what-tigecycline-is-used-for","tag-what-tigecycline-mylan-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25051","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25051"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25051\/revisions"}],"predecessor-version":[{"id":25101,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25051\/revisions\/25101"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25051"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25051"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}