{"id":25047,"date":"2022-09-06T07:24:08","date_gmt":"2022-09-06T07:24:08","guid":{"rendered":"https:\/\/zeepedia.com\/?p=25047"},"modified":"2022-09-07T07:41:46","modified_gmt":"2022-09-07T07:41:46","slug":"tenam","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tenam\/","title":{"rendered":"Tenam &#8211; Imipenem\/cilastatin uses, dose and side effects"},"content":{"rendered":"\n<p>500 mg\/500 mg&nbsp;powder for&nbsp;infusion&nbsp;solution<br>imipenem\/cilastatin<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tienam is and what it is used for<\/h2>\n\n\n\n<p>Tienam belongs to a group of medicines called carbapenem antibiotics.\u00a0It kills a large number of different bacteria that cause\u00a0infection\u00a0in different parts of the body in adults and children 1 year and older.<\/p>\n\n\n\n<p><strong>Treatment<\/strong><\/p>\n\n\n\n<p>Your doctor has prescribed Tienam because you have one (or more) of the following types of infection:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Complicated abdominal infections<\/li><li>Infection&nbsp;affecting the lungs (&nbsp;pneumonia&nbsp;)<\/li><li>Infections&nbsp;you can get during or after childbirth<\/li><li>Complicated urinary tract infections<\/li><li>Complicated skin and soft tissue infections<\/li><\/ul>\n\n\n\n<p>Tienam can be used to treat patients with low&nbsp;white blood cell counts&nbsp;who have a fever suspected to be caused by a bacterial infection.<\/p>\n\n\n\n<p>Tienam can be used to treat bacterial infections in the blood that may be a result of any of the&nbsp;infections&nbsp;mentioned above.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Tienam<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Tienam<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to imipenem, cilastatin, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are allergic to other\u00a0antibiotics\u00a0such as\u00a0penicillins,\u00a0cephalosporins,\u00a0or carbapenems<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Tell your doctor about any medical conditions you have or have had including:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergy&nbsp;to other medicines, even&nbsp;antibiotics&nbsp;(sudden life-threatening&nbsp;allergic reaction&nbsp;requires immediate medical attention)<\/li><li>colitis&nbsp;(&nbsp;inflammation&nbsp;of the colon) or other diseases of the gastrointestinal tract<\/li><li>kidney or urinary tract problems, including impaired kidney function (the levels of Tienam in the blood increase in patients with impaired kidney function).&nbsp;Side effects&nbsp;in the&nbsp;central nervous system&nbsp;may occur if the&nbsp;dose&nbsp;is not adjusted according to kidney function)<\/li><li>any disease of the&nbsp;central nervous system&nbsp;such as localized&nbsp;tremor&nbsp;or epileptic seizures<\/li><li>liver problems<\/li><\/ul>\n\n\n\n<p>You may get a positive test result on the Coombs test, which indicates that you have\u00a0antibodies\u00a0that can destroy\u00a0red blood cells.\u00a0Your doctor will discuss this with you.<\/p>\n\n\n\n<p><em>Children<\/em><\/p>\n\n\n\n<p>Tienam is not recommended for children younger than one year or children with kidney problems.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tienam<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tell your doctor if you are taking <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/cymevene\/\">ganciclovir<\/a>, which is used to treat certain viral infections.<\/p>\n\n\n\n<p>Also tell your doctor if you are taking\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/absenor\/\">valproic acid<\/a>\u00a0or sodium valproate (used to treat\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/epilepsy\/\">epilepsy<\/a>,\u00a0bipolar disorder,\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/migraine\/\">migraine<\/a>,\u00a0or schizophrenia) or any blood thinners such as\u00a0warfarin.<\/p>\n\n\n\n<p>Your doctor will decide whether you should use Tienam together with these medicines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>You must tell your doctor if you are pregnant or plan to become pregnant before receiving Tienam.\u00a0Tienam has not been studied in pregnant women.\u00a0Tienam should only be given during pregnancy if the potential benefit of treatment to the mother outweighs the possible risk to the fetus.<\/p>\n\n\n\n<p>You must tell your doctor if you are breastfeeding or if you intend to breastfeed before receiving Tienam.\u00a0Small amounts of this medicine may pass into breast milk and may affect the baby.\u00a0Your doctor will therefore decide whether you should use Tienam while you are breastfeeding.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>There are some\u00a0side effects\u00a0associated with this product (such as seeing, hearing, or feeling something that is not there (hallucinations), dizziness, tiredness, and a spinning sensation) which may affect some patients&#8217; ability to drive or use machines (see section 4 ).<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tienam contains sodium<\/h2>\n\n\n\n<p>This medicine contains 37.6 mg of\u00a0sodium\u00a0(the main ingredient in common\/table salt) per\u00a0vial.\u00a0This corresponds to 1.9% of the maximum recommended daily intake of\u00a0sodium\u00a0for adults.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Tienam<\/h2>\n\n\n\n<p>Tienam will be prepared and given to you by a doctor or other healthcare professional.&nbsp;Your doctor will decide how much Tienam you need.<\/p>\n\n\n\n<p>Use for adults and adolescents<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0for adults and adolescents is 500 mg\/500 mg every 6 hours or 1000 mg\/1000 mg every 6 or 8 hours.\u00a0If you have kidney problems, your doctor may lower your\u00a0dose.<\/p>\n\n\n\n<p>Use for children<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0for children 1 year of age or older is 15\/15 or 25\/25 mg\/kg body weight and\u00a0the dose\u00a0every 6 hours.\u00a0Tienam is not recommended for children younger than one year and children with kidney problems.<\/p>\n\n\n\n<p>Mode of administration<\/p>\n\n\n\n<p>Tienam is given&nbsp;intravenously&nbsp;(into a vein) over 20-30 minutes for a&nbsp;dose&nbsp;of \u2264500 mg\/500 mg or 40-60 minutes for a&nbsp;dose&nbsp;of &gt;500 mg\/500 mg.&nbsp;In case of nausea, the infusion rate can be reduced.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Tienam&nbsp;<\/h2>\n\n\n\n<p>Symptoms of overdose may include seizures, confusion, tremors, nausea, vomiting, low\u00a0blood pressure,\u00a0and slow\u00a0pulse.<\/p>\n\n\n\n<p>If you are worried that you have ingested too much Tienam or if, for example, a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forgot to use Tienam<\/h2>\n\n\n\n<p>If you are concerned that you have missed a\u00a0dose, contact your doctor or another healthcare professional immediately.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Possible&nbsp;side effects&nbsp;are divided according to the following frequency groups:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>very common: affects more than 1 user in 10<\/li><li>common: affects 1 to 10 users in 100<\/li><li>less common: affects 1 to 10 users in 1,000<\/li><li>rare: affects 1 to 10 users in 10,000<\/li><li>very rare: affects less than 1 user in 10,000<\/li><li>frequency not known: cannot be estimated from available data<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;may occur in rare cases.&nbsp;If these&nbsp;side effects&nbsp;occur while you are taking or after taking Tienam, you should immediately stop using the medicine and contact your doctor immediately.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions including skin rash, swelling of the face, lips, tongue, and\/or throat (with difficulty breathing or swallowing), and\/or low\u00a0blood pressure<\/li><li>skin flaking (\u00a0toxic epidermal necrolysis\u00a0)<\/li><li>severe skin reactions (\u00a0Stevens-Johnson syndrome\u00a0and erythema multiforme)<\/li><li>severe skin rash with skin and hair loss (exfoliative\u00a0dermatitis\u00a0)<\/li><\/ul>\n\n\n\n<p>Other possible side effects:<\/p>\n\n\n\n<p><strong>Usual<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea, vomiting, diarrhea.\u00a0Nausea and vomiting occur more often in patients with low\u00a0white blood cell counts<\/li><li>swelling and\u00a0redness\u00a0along a vein that is extremely tender to the touch<\/li><li>rash<\/li><li>abnormal liver function detected by analysis of blood samples<\/li><li>increase in certain\u00a0white blood cells<\/li><\/ul>\n\n\n\n<p><strong>Less common<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>local skin redness<\/li><li>local pain and formation of hard swelling at the injection site<\/li><li>skin itching<\/li><li>hives<\/li><li>fever<\/li><li>blood diseases that affect the\u00a0blood cells.\u00a0This is usually detected by blood test analysis (symptoms can be fatigue, pale skin, and prolonged bruising after injuries)<\/li><li>abnormal kidney, liver, and blood function detected by blood test analysis<\/li><li>tremors\u00a0and uncontrolled muscle twitching<\/li><li>convulsions<\/li><li>mental disorders (such as mood swings and impaired judgment)<\/li><li>hallucinations (seeing, hearing, or feeling something that is not there)<\/li><li>confusion<\/li><li>dizziness, drowsiness<\/li><li>low\u00a0blood pressure<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fungal infection (candida infection)<\/li><li>discoloration of teeth and\/or tongue<\/li><li>inflammation&nbsp;of the colon with severe diarrhea<\/li><li>taste impact<\/li><li>impaired liver function<\/li><li>liver inflammation<\/li><li>impaired kidney function<\/li><li>changes in the amount of urine, changes in the color of the urine<\/li><li>brain disorders, tingling sensation (numbness), limited tremors<\/li><li>hearing loss<\/li><\/ul>\n\n\n\n<p><strong>Very rare<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe liver dysfunction due to\u00a0inflammation\u00a0(\u00a0fulminant\u00a0hepatitis\u00a0)<\/li><li>inflammation\u00a0of the stomach or intestines (\u00a0gastroenteritis\u00a0)<\/li><li>inflammation\u00a0of the intestines with bloody diarrhea (\u00a0hemorrhagic\u00a0colitis\u00a0)<\/li><li>red swollen tongue, overgrowth on the surface of the tongue giving it a hairy appearance, heartburn, sore throat, increased salivation<\/li><li>stomach pain<\/li><li>spinning sensation (dizziness, vertigo), <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/headache\/\">headache<\/a><\/li><li>ringing in the ears (\u00a0tinnitus\u00a0)<\/li><li>pain in several joints, weakness<\/li><li>irregular heartbeat, the heart beats forcefully or rapidly<\/li><li>chest discomfort, difficulty breathing, abnormally fast and shallow breathing, pain in the upper part of the spine<\/li><li>redness, bluish discoloration of the face and lips, changes in the texture of the skin, excessive sweating<\/li><li>genital itching\u00a0in women<\/li><li>changes in the amount of\u00a0blood cells\u00a0are<\/li><li>worsening of a rare disease with muscle weakness (\u00a0myasthenia gravis\u00a0)<\/li><\/ul>\n\n\n\n<p><strong>No known frequency<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal movements<\/li><li>indignation<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tienam<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the vial.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 25 \u00baC.<\/p>\n\n\n\n<p>After preparation:<\/p>\n\n\n\n<p>A ready-made solutions should be used immediately.\u00a0The time interval between the start of\u00a0preparation\u00a0and the end of the intravenous\u00a0infusion\u00a0should not exceed two hours.<\/p>\n\n\n\n<p>Diluted solution must not be frozen.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are imipenem and cilastatin.\u00a0One\u00a0vial\u00a0contains imipenem monohydrate equivalent to 500 mg imipenem and cilastatin sodium equivalent to 500 mg cilastatin.<\/li><li>Another ingredient is sodium bicarbonate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tienam is a white to light yellow powder for\u00a0infusion, solution in a\u00a0glass\u00a0vial.\u00a0Pack sizes: 1, 10 or 25 vials.\u00a0Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Merck Sharp &amp; Dohme BV<\/p>\n\n\n\n<p>PO Box 581<\/p>\n\n\n\n<p>2031 BN, 2003 PC Haarlem<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>FAREVA Mirabel<\/p>\n\n\n\n<p>Route de Marsat &#8211; Riom<\/p>\n\n\n\n<p>63963 Clermont-Ferrand Cedex 9<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Information provided by<\/p>\n\n\n\n<p>Merck Sharp &amp; Dohme (Sweden) AB<\/p>\n\n\n\n<p>Box 45192<\/p>\n\n\n\n<p>104 30 Stockholm<\/p>\n\n\n\n<p>Phone: 077 570 04 88<\/p>\n\n\n\n<p><strong>This medicine is approved in the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p>Austria: Zienam<\/p>\n\n\n\n<p>Bulgaria: Tienam<\/p>\n\n\n\n<p>Cyprus: Tienam<\/p>\n\n\n\n<p>Czech Republic: Tienam<\/p>\n\n\n\n<p>France: TIENAM<\/p>\n\n\n\n<p>Germany: ZIENAM<\/p>\n\n\n\n<p>Greece: Primaxin<\/p>\n\n\n\n<p>Hungary: Tienam<\/p>\n\n\n\n<p>Ireland: Primaxin IV<\/p>\n\n\n\n<p>The Netherlands: TIENAM<\/p>\n\n\n\n<p>Norway: Tienam<\/p>\n\n\n\n<p>Portugal: Tienam IV<\/p>\n\n\n\n<p>Sweden: Tienam<\/p>\n\n\n\n<p>UK: Primaxin IV<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tienam belongs to a group of medicines called carbapenemantibiotics.\u00a0It kills a large number of different bacteria that cause\u00a0infection\u00a0in different parts of the body in adults and children 1 year and older.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[22556,25937,13060,13064,25931,25934,25936,13062,25935,13061,25932,25933],"class_list":["post-25047","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-cilastatin","tag-cilastatin-side-effects","tag-imipenem","tag-imipenem-side-effects","tag-tenam","tag-tenam-side-effects","tag-what-cilastatin-is-used-for","tag-what-imipenem-is-used-for","tag-what-is-cilastatin","tag-what-is-imipenem","tag-what-is-tenam","tag-what-tenam-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=25047"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25047\/revisions"}],"predecessor-version":[{"id":25103,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/25047\/revisions\/25103"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=25047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=25047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=25047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}