{"id":24999,"date":"2022-09-05T08:20:25","date_gmt":"2022-09-05T08:20:25","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24999"},"modified":"2022-09-06T07:11:45","modified_gmt":"2022-09-06T07:11:45","slug":"tibinide","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tibinide\/","title":{"rendered":"Tibinide &#8211; Isoniazid uses, dose and side effects"},"content":{"rendered":"\n<p>300 mg&nbsp;tablets&nbsp;isoniazid<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tibinide is and what it is used for<\/h2>\n\n\n\n<p>Tibninide belongs to the group of antituberculosis drugs.\u00a0The active substance in Tibinide is\u00a0isoniazid, which is a bactericidal agent with an effect only on tubercle bacteria.\u00a0Tibinide is most often used in combination with other drugs against\u00a0tuberculosis.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Tibinide<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Tibinide<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to&nbsp;isoniazid&nbsp;or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have liver disease or liver damage.<\/li><li>if you have previously had a serious&nbsp;side effect&nbsp;in connection with treatment with&nbsp;isoniazid&nbsp;(<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a>, chills,&nbsp;arthritis&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Tibinide if you have or have had any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>impaired renal function, the\u00a0dose\u00a0of Tibinide may need to be reduced.<\/li><li>impaired liver function.<\/li><li>epilepsy, the risk of suffering\u00a0side effects\u00a0such as convulsions is higher.<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">diabetes<\/a> mellitus, it may become more difficult to control your\u00a0diabetes.<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/psychosis\/\">psychosis<\/a>, the risk of relapse increases with treatment with Tibinide.<\/li><\/ul>\n\n\n\n<p>Treatment with\u00a0isoniazid\u00a0can affect the liver.\u00a0Contact your doctor in case of suspected liver damage.\u00a0Early signs of liver damage are yellowing of the skin,\u00a0itching, abdominal pain, nausea, dark-colored urine, and loss of appetite.<\/p>\n\n\n\n<p>You should not consume alcohol while being treated with Tibinide.<\/p>\n\n\n\n<p>Tibinide should not be used in people who weigh less than 45 kilograms.<\/p>\n\n\n\n<p>If you are <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/peanut-allergy-and-nut-allergy\/\">hypersensitive<\/a> to ethionamide, pyrazinamide,\u00a0and niacin\u00a0(\u00a0nicotinic acid\u00a0), you may also be hypersensitive to\u00a0isoniazid\u00a0contained in Tibinide.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tibinide<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tell your doctor if you are using any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Alfentanil is used by\u00a0injection\u00a0as a pain reliever before and after surgery.<\/li><li>Antacids containing aluminum for heartburn and acid reflux, eg Novalucol, Novaluzid, Rennie.<\/li><li>Anticoagulants, for example,\u00a0warfarin.<\/li><li>Benzodiazepines, such as\u00a0diazepam\u00a0, flurazepam, triazolam and midazolam, which have a sleep-inducing and sedative effect.<\/li><li>Disulfiram\u00a0such as\u00a0included in Antabuse.<\/li><li>Medicines against\u00a0epilepsy\u00a0eg ethosuximide, phenobarbital,\u00a0phenytoin, carbamazepine.<\/li><li>Haloperidol\u00a0is used in\u00a0psychosis.<\/li><li>Ketoconazole, is used for fungal infections.<\/li><li>Levodopa\u00a0for\u00a0Parkinson&#8217;s disease.<\/li><li>Methotrexate, a cytotoxic drug.<\/li><li>Paracetamol\u00a0, for pain and fever.<\/li><li>Prednisolone, is a cortisone preparation.<\/li><li>Rifampicin, is an anti-tuberculosis\u00a0drug.<\/li><li>Sulfasalazine is used to treat rheumatism.<\/li><li>Theophylline is used for\u00a0asthma.<\/li><\/ul>\n\n\n\n<p>Other medicines can affect or be affected by the treatment with Tibinide.\u00a0Treating doctors, therefore, need to be aware of other concomitant medications.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tibinide with food, drink, and alcohol<\/h2>\n\n\n\n<p>Intake of alcohol should be avoided during treatment with Tibinide because the effect of&nbsp;isoniazid&nbsp;can be reduced and the risk of liver damage increased with simultaneous use.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>No known influence on the ability to drive and use machines.\u00a0You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Tibinide<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Consult a doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The dose&nbsp;must be determined by a doctor.<\/p>\n\n\n\n<p>Tibinide tablets should be swallowed whole with a glass of water or other drink.<\/p>\n\n\n\n<p>The tablets are taken on an empty stomach, ie at least 1 hour before or 2 hours after a meal.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Tibinide tablets should not be used by people weighing less than 45 kg as the necessary dose adjustment is not possible.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Tibinide<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has accidentally ingested the medicine, always contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Tibinide<\/h2>\n\n\n\n<p>If you forget to take a tablet, take it as soon as possible.\u00a0If it is less than 6 hours until the next\u00a0dose, skip the forgotten tablet and take the next tablet as planned.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Tibinide<\/h2>\n\n\n\n<p>Always take the tablets until the treatment is finished, even if you start to feel better.<\/p>\n\n\n\n<p>Always consult a doctor before you stop taking Tibinide.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Contact a doctor immediately if you experience any of the following symptoms:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation\u00a0of the pancreas, causes severe pain in the abdomen and back (\u00a0pancreatitis, has been reported &#8211; occurring in an unknown number of users).<\/li><li>Severe widespread skin damage (sloughing of the epidermis and superficial mucous membranes) (\u00a0toxic epidermal necrolysis, TEN, may affect up to 1 in 1,000 users).<\/li><li>Drug reactions causing skin rash, fever,\u00a0inflammation\u00a0of internal organs, altered blood count, and systemic disease (DRES&#8217;s syndrome, may affect up to 1 in 1,000 users).<\/li><li>Yellowing of the skin or the whites of the eyes, darker urine and paler stools, tiredness, weakness, feeling unwell, loss of appetite, nausea, or vomiting caused by liver problems (\u00a0hepatitis, may affect up to 1 in 100 people).<\/li><li>In rare cases, Tibinide can affect the white\u00a0blood cells\u00a0so that the defense against infection deteriorates.\u00a0If you get an\u00a0infection\u00a0with symptoms such as fever with a greatly worsened general condition or fever with local infection symptoms such as sore throat\/pharynx\/mouth or difficulty urinating, you should see a doctor as soon as possible so that a lack of\u00a0white blood cells\u00a0can be ruled out via a blood test (\u00a0agranulocytosis\u00a0).\u00a0It is important that you then information about your medication.\u00a0The frequency is not known for this side effect.<\/li><li>An extremely strong\u00a0allergic reaction\u00a0with a skin rash is usually in the form of blisters or sores in the mouth and eyes as well as other mucous membranes such as the genitals (Steven-Johnson syndrome).\u00a0The frequency is not known for this side effect.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;that may occur:<\/strong><\/p>\n\n\n\n<p><em>Very common (affects more than 1 in 10 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Numbness in the hands and feet, and nerve inflammation in the arms and legs which manifests itself as a burning sensation.\u00a0Simultaneous treatment with\u00a0pyridoxine\u00a0reduces the risk of this\u00a0side effect.<\/li><li>Elevated liver enzymes.<\/li><\/ul>\n\n\n\n<p><em>Uncommon (affects less than 1 in 100 but more than 1 in 1000 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Convulsions, brain disease.<\/li><li>Memory disorders,\u00a0psychosis.<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dizziness, headache, tremors, vertigo, increased reflexes.<\/li><li>Confusion, disorientation, hallucinations.<\/li><li>Nausea, vomiting, loss of appetite,\u00a0dry mouth, belching, abdominal pain, constipation.<\/li><li>Difficulty urinating, kidney damage.<\/li><li>Increased <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar<\/a>, disturbance of the acid\/base balance in the blood, pellagra (a condition characterized by gastrointestinal discomfort, skin redness, nervous and mental disturbance).<\/li><li>Allergic reactions in the form of severe skin reactions,\u00a0itching, fever, altered blood count, hypersensitivity, swollen\u00a0lymph nodes, rheumatic syndrome, and lupus-like syndrome.<\/li><li>Inflammation\u00a0in the blood vessels.<\/li><li>Various forms of\u00a0anemia\u00a0reduced amount of\u00a0blood platelets.<\/li><li>Allergic\u00a0pneumonia.<\/li><li>Arthritis\u00a0(joint inflammation).<\/li><li>Damage to\u00a0optic nerve\u00a0one.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tibinide<\/h2>\n\n\n\n<p>Store out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the packaging.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p><em>The active substance is&nbsp;<\/em>isoniazid&nbsp;300 mg.<\/p>\n\n\n\n<p><em>Other ingredients are<\/em>\u00a0microcrystalline cellulose, stearic acid, talc, and silicon dioxide.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>White, round, flat tablet with the score.<\/p>\n\n\n\n<p>Packaging: 100 tablets in a plastic jar.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder:<\/h2>\n\n\n\n<p>Meda AB<\/p>\n\n\n\n<p>Box 906<\/p>\n\n\n\n<p>170 09 Solna.<\/p>\n\n\n\n<p>Telephone 08-630 19 00<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tibninide belongs to the group of antituberculosis drugs.\u00a0The active substance in Tibinide is\u00a0isoniazid\u00a0, which is a bactericidal agent with an effect only on tubercle bacteria.\u00a0Tibinide is most often used in combination with other drugs against\u00a0tuberculosis\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[23059,25840,23074,25839,25844,25841,23060,25842,23061,25843],"class_list":["post-24999","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-isoniazid","tag-isoniazid-side-effects","tag-isoniazid-tablet","tag-tibinide","tag-tibinide-side-effects","tag-tibinide-tablet","tag-what-is-isoniazid","tag-what-is-tibinide","tag-what-isoniazid-is-used-for","tag-what-tibinide-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24999"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24999\/revisions"}],"predecessor-version":[{"id":25042,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24999\/revisions\/25042"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}