15 mg powder for concentrate for infusion solution, solution\u00a0100 mg powder for concentrate for\u00a0infusion solution, solution
tiotepa<\/p>\n\n\n\n
Thiotepa Riemser contains the active substance thiotepa, which belongs to a group of medicines called alkylating agents.<\/p>\n\n\n\n
Thiotepa Riemser is used to prepare patients for bone marrow transplantation.\u00a0It works by destroying bone marrow cells.\u00a0This makes it possible to transplant new bone marrow cells (hematopoietic\u00a0stem cells\u00a0), which in turn enable the body to form healthy\u00a0blood cells.<\/p>\n\n\n\n
Thiotepa Riemser can be used by adults and children and adolescents. – if you are allergic to thiotepa<\/p>\n\n\n\n – if you are pregnant or think you may be pregnant<\/p>\n\n\n\n – if you are breastfeeding<\/p>\n\n\n\n – if you receive vaccination against yellow fever, live viral and bacterial vaccines.<\/a><\/p>\n\n\n\n You should tell your doctor if you have:<\/p>\n\n\n\n – liver or kidney problems<\/p>\n\n\n\n – heart or lung problems<\/p>\n\n\n\n – seizures ( epilepsy ) or have had them in the past (if these are treated with phenytoin or fosphenytoin).<\/p>\n\n\n\n Because Thiotepa Riemser destroys bone marrow cells responsible for the production of\u00a0blood cells, you will regularly give blood samples during treatment to check the number of\u00a0blood cells.<\/p>\n\n\n\n To prevent and treat\u00a0infection, you will be given anti-infection medicine.<\/p>\n\n\n\n Thiotepa Riemser may induce another type of cancer in the future. Your doctor will discuss this risk with you.<\/a><\/p>\n\n\n\n Tell your doctor if you are taking or have recently taken or might take any other medicines.<\/a><\/p>\n\n\n\n You must tell your doctor if you are pregnant or think you may be pregnant before receiving Thiotepa Riemer.\u00a0You must not use Thiotepa Riemser during pregnancy.<\/p>\n\n\n\n Both women and men using Thiotepa Riemser must use effective contraception during treatment. Male patients should not father children while they are being treated and the year after treatment has ended.<\/p>\n\n\n\n It is unknown if this drug is excreted in breast milk.\u00a0As a precaution, women must not breastfeed during treatment with Thiotepa Riemer.<\/p>\n\n\n\n Thiotepa Riemser can impair fertility in men and women. Male patients should seek advice on saving sperm before starting treatment.<\/a><\/p>\n\n\n\n Likely, certain\u00a0side effects\u00a0of tiotepa such as dizziness, headache, and blurred vision can affect the ability to drive vehicles and use machines.\u00a0If you notice such\u00a0side effects, you should not drive or use machinery. Your doctor will calculate the dose according to your body surface area or weight and your disease.<\/p>\n\n\n\n How Thiotepa Riemser is given<\/strong><\/p>\n\n\n\n Thiotepa Riemser is given by qualified healthcare professionals as an intravenous infusion (drip into a vein) after diluting the solution for injection. Each infusion lasts 2-4 hours.<\/p>\n\n\n\n Frequency of administration<\/strong><\/p>\n\n\n\n You will receive your\u00a0infusions\u00a0every 12 or 24 hours.\u00a0The treatment can last up to 5 days.\u00a0How often the\u00a0infusions\u00a0are given and how long the treatment depends on your illness.<\/p>\n\n\n\n Like all medicines, Thiotepa Riemser can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n The most serious side effects of treatment with Thiotepa Riemser or of the transplant may include<\/p>\n\n\n\n Your doctor will regularly check your blood levels and liver enzymes to detect and treat these\u00a0side effects.<\/p>\n\n\n\n Other side effects of Thiotepa Riemser, which may occur in some frequencies, are listed below:<\/p>\n\n\n\n Very common side effects (may affect more than 1 in 10 users)<\/strong><\/p>\n\n\n\n Common side effects (may affect up to 1 in 10 users)<\/strong><\/p>\n\n\n\n Uncommon side effects (may affect up to 1 in 100 users)<\/strong><\/p>\n\n\n\n Frequency not known (frequency cannot be calculated from available data)<\/strong><\/p>\n\n\n\n Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n Do not use before the expiry date which is stated on the carton and the vial label after EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n Store and transport cold (2 \u00b0C-8 \u00b0C).<\/p>\n\n\n\n Do not freeze.<\/p>\n\n\n\n After\u00a0preparation, the solution is stable for 8 hours if stored at 2 \u00b0C-8 \u00b0C.<\/p>\n\n\n\n After dilution, the solution is stable for 24 hours if stored at 2 \u00b0C-8 \u00b0C and in<\/p>\n\n\n\n 4 hours if stored at 25 \u00b0C. From a microbiological point of view, the product should be used immediately.<\/p>\n\n\n\n
<\/a><\/p>\n\n\n\nWhat you need to know before you use Thiotepa Riemer<\/h2>\n\n\n\n
Do not use Thiotepa Riemser<\/h2>\n\n\n\n
Warnings and precautions<\/h2>\n\n\n\n
Other medicines and Thiotepa Riemer<\/h2>\n\n\n\n
Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n
Driving ability and use of machinery<\/h2>\n\n\n\n
<\/p>\n\n\n\nHow to use Thiotepa Riemser<\/h2>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
How to store Thiotepa Riemser<\/h2>\n\n\n\n