{"id":24807,"date":"2022-09-01T07:40:11","date_gmt":"2022-09-01T07:40:11","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24807"},"modified":"2022-09-02T10:38:59","modified_gmt":"2022-09-02T10:38:59","slug":"tetmodis","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tetmodis\/","title":{"rendered":"Tetmodis &#8211; Tetrabenazine uses, dose and side effects"},"content":{"rendered":"\n<p>25 mg&nbsp;Tablet<br>Tetrabenazine<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tetmodis is and what it is used for<\/h2>\n\n\n\n<p>Tetmodis is a medicine that belongs to a group of medicines used to treat disorders of the nervous system.<\/p>\n\n\n\n<p>Tetmodis is used to treat disorders that cause jerky, irregular, uncontrollable movements (hyperkinetic movement disorders with Huntington&#8217;s chorea).<\/p>\n\n\n\n<p>The tetrabenazine contained in Tetmodis may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<br><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Tetmodis<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Tetmodis<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to tetrabenazine or any of the other ingredients in Tetmodis 25 mg tablets (listed in section 6).<\/li><li>if you are using reserpine (medicine to treat high\u00a0blood pressure\u00a0and psychotic conditions).<\/li><li>if you are using medicines belonging to a group of medicines called monoamine oxidase (MAO) inhibitors (medicines used to treat depression).<\/li><li>if you have impaired liver function<\/li><li>if you suffer from Parkinson&#8217;s-like symptoms.<\/li><li>if you have depression.<\/li><li>if you have thoughts of harming yourself.<\/li><li>if you are breastfeeding.<\/li><li>if you suffer from\u00a0pheochromocytoma\u00a0(tumor\u00a0of the adrenal gland).<\/li><li>if you suffer from prolactin-dependent tumors, e.g.\u00a0pituitary <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a> or breast cancer.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Tetmodis<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have ever had tremors in the hands and jerky movements of the arms and legs, known as\u00a0parkinsonism<\/li><li>if you suffer from a high concentration of\u00a0prolactin\u00a0in the blood (\u00a0hyperprolactinemia\u00a0)<\/li><li>if you are prone to a sudden drop in blood pressure when you stand up or stretch<\/li><li>if you know that you have a slow or\u00a0intermediate\u00a0metabolism\u00a0of an\u00a0enzyme\u00a0called CYP2D6, this may mean that a different\u00a0dose\u00a0is suitable for you.<\/li><li>if you have a heart condition called long\u00a0QT\u00a0syndrome, or if you have or have had heart rhythm problems.<\/li><li>if you start to have mental changes such as confusion or hallucinations or develop muscle stiffness and <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a>, you may be developing a condition called neuroleptic malignant syndrome.\u00a0If you experience these symptoms, contact your doctor immediately.<\/li><li>if you start to get an unpleasant feeling of inner restlessness, a compulsive need to be in constant movement, or disturbances in coordinating movements<\/li><li>note that Tetmodis binds to\u00a0tissue\u00a0containing melanin, which may affect your eyes<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Tetmodis is not recommended for the treatment of children.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tetmodis<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including those obtained without a prescription.<\/p>\n\n\n\n<p>Be especially careful if you use Tetmodis together with\u00a0levodopa\u00a0(a medicine used to treat\u00a0Parkinson&#8217;s disease\u00a0).\u00a0<\/p>\n\n\n\n<p>Do not use Tetmodis together with reserpine.&nbsp;<\/p>\n\n\n\n<p>Treatment with&nbsp;MAO inhibitors&nbsp;should be discontinued 14 days before starting treatment with tetrabenazine.<\/p>\n\n\n\n<p>The use of Tetmodis together with certain types of antidepressants, alcohol,\u00a0opioids, beta-blockers, antihypertensive drugs (drugs for the treatment of high\u00a0blood pressure\u00a0), sleeping pills, and\u00a0neuroleptics\u00a0(drugs for the treatment of mental disorders) is not recommended.<\/p>\n\n\n\n<p>Drugs that inhibit CYP2D6 (eg\u00a0fluoxetine,\u00a0paroxetine, terbinafine, moclobemide, and quinidine) may cause increased plasma concentrations of the active\u00a0metabolite\u00a0a dihydro-tetrabenazine.\u00a0If you are taking such medicines, you may need a lower\u00a0dose\u00a0of Tetmodis.<\/p>\n\n\n\n<p>Be especially careful if you use Tetmodis with medicines known to prolong\u00a0the QTc interval\u00a0et in the\u00a0EKG, including some medicines used to treat mental health conditions (\u00a0neuroleptics\u00a0), some\u00a0antibiotics\u00a0(eg gatifloxacin, moxifloxacin), and some medicines used to treat heart rhythm problems (eg quinidine,\u00a0procainamide,\u00a0amiodarone, sotalol).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tetmodis with food and alcohol<\/h2>\n\n\n\n<p>Drinking alcohol while taking Tetmodis may make you feel abnormally tired.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Tetmodis should not be used during pregnancy or breastfeeding.\u00a0If you are pregnant, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Tetmodis can cause drowsiness and thus alter your ability to drive and use machines, to varying degrees depending on the&nbsp;dose&nbsp;and individual susceptibility.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tetmodis contains lactose<\/h2>\n\n\n\n<p>These tablets contain\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/lactose-intolerance\/\">lactose<\/a>.\u00a0If you have been told by your doctor that you have an intolerance to certain types of sugar, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Tetmodis<\/h2>\n\n\n\n<p>Always take Tetmodis as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.&nbsp;Swallow the tablet(s) with water or other non-alcoholic beverage.<\/p>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<p><em>Huntington&#8217;s chorea<\/em><\/p>\n\n\n\n<p>The recommended starting dose is half a tablet (12.5 mg) one to three times a day.\u00a0The dose can be increased by half a tablet every three or four days until the optimal effect is achieved or until symptoms of intolerance appear (drowsiness,\u00a0Parkinsonism, depression).<\/p>\n\n\n\n<p>The maximum daily&nbsp;dose&nbsp;is 8 tablets (200 mg) per day.<\/p>\n\n\n\n<p>If you have taken the maximum\u00a0dose\u00a0for seven days and your condition has not improved, it is possible that this medicine will not help you.<\/p>\n\n\n\n<p><strong>Older<\/strong><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;has been given to elderly patients without clear&nbsp;side effects&nbsp;occurring.&nbsp;However, Parkinson-like effects are common.<\/p>\n\n\n\n<p><strong>Children<\/strong><\/p>\n\n\n\n<p>The treatment is not recommended for children.<\/p>\n\n\n\n<p><strong>Patients with&nbsp;renal failure<\/strong><\/p>\n\n\n\n<p>Tetmodis is not recommended for use in this patient group.<\/p>\n\n\n\n<p>The tablet(s) should be swallowed with water or another non-alcoholic drink.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Tetmodis<\/h2>\n\n\n\n<p>If you take too much Tetmodis, you may develop drowsiness, sweating, low\u00a0blood pressure,\u00a0and extremely low body temperature (\u00a0hypothermia\u00a0).\u00a0Your doctor can treat these symptoms.\u00a0If you have ingested too much medicine or if, for example,\u00a0If a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Tetmodis<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.\u00a0Instead, you should simply continue with the next\u00a0dose\u00a0when it is due.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Tetmodis<\/h2>\n\n\n\n<p>Do not stop taking Tetmodis unless your doctor tells you to.\u00a0Neuroleptic malignant syndrome (state of high fever, sweating, blood pressure fluctuations, muscle rigidity, and disturbances of consciousness) has been described after the abrupt discontinuation of tetrabenazine.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Tetmodis can cause\u00a0side effects, although not everybody gets them.\u00a0<\/p>\n\n\n\n<p><strong>Side effects&nbsp;are divided by frequency as follows:<\/strong><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 in 10 users):<\/em><\/p>\n\n\n\n<p>Drowsiness (with higher\u00a0dose\u00a0er), depression, Parkinson-like syndrome (uncontrollable movements of hands, arms, legs, and head, with higher\u00a0dose\u00a0er)<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users):<\/em><\/p>\n\n\n\n<p>Confusion, restlessness, insomnia, low\u00a0blood pressure,\u00a0dysphagia\u00a0(difficulty swallowing), nausea, vomiting, diarrhea, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/constipation\/\">constipation<\/a><\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users):<\/em><\/p>\n\n\n\n<p>Mental changes such as confusion or hallucinations, muscle stiffness, fever<\/p>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 users):<\/em><\/p>\n\n\n\n<p>A condition called Neuroleptic Malignant Syndrome.\u00a0If you start to experience disturbances of consciousness such as confusion or hallucinations or develop muscle stiffness or fever, you may have developed a condition called Neuroleptic Malignant Syndrome.<\/p>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 users):<\/em><\/p>\n\n\n\n<p>Muscle damage<\/p>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users):<\/em><\/p>\n\n\n\n<p>Disorientation, nervousness, inability to coordinate movements, inability to sit or stand still (akathisia), a movement disorder with involuntary\u00a0spasms\u00a0and abnormal posture (\u00a0dystonia\u00a0), dizziness, impaired memory, lower heart rate, dizziness when standing up quickly from lying or sitting posture, stomach <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a>,\u00a0dry mouth, low body temperature.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tetmodis<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the can and carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Store at a maximum of 25 \u00b0C.<\/p>\n\n\n\n<p>The medicine must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to deal with drugs that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tetrabenazine.<\/li><li>Each tablet contains 25 mg of tetrabenazine.<\/li><li>Other ingredients are pregelatinized corn starch,\u00a0lactose monohydrate, talc, iron oxide yellow E172, and magnesium stearate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Yellow, round tablets with a score on one side and engraved with \u201cTE25\u201d on the other side.<\/p>\n\n\n\n<p>Pack size: 112 tablets in a white jar with a screw cap.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorization Holder<\/strong>&nbsp;:<\/p>\n\n\n\n<p>AOP Orphan Pharmaceuticals GmbH<\/p>\n\n\n\n<p>Leopold-Ungar-Platz 2<\/p>\n\n\n\n<p>AT 1190 Vienna<\/p>\n\n\n\n<p>Austria<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong>&nbsp;:<\/p>\n\n\n\n<p>AOP Orphan Pharmaceuticals GmbH<\/p>\n\n\n\n<p>Leopold-Ungar-Platz 2<\/p>\n\n\n\n<p>AT 1190 Vienna<\/p>\n\n\n\n<p>Austria<\/p>\n\n\n\n<p>This medicine is approved in the European Economic Area under the names\u00a0<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Austria:<\/td><td>Tetmodis 25 mg Tablet<\/td><\/tr><tr><td>Belgium:<\/td><td>Tetrabenazine AOP Orphan Pharmaceuticals 25 mg tablet<\/td><\/tr><tr><td>Bulgaria:<\/td><td>Tetmodis 25 mg tablets<\/td><\/tr><tr><td>Czech Republic:<\/td><td>Tetmodis<\/td><\/tr><tr><td>Denmark:<\/td><td>Tetmodis 25 mg tablets<\/td><\/tr><tr><td>Estonia:<\/td><td>Tetmodis 25 mg tablet<\/td><\/tr><tr><td>Finland:<\/td><td>Tetmodis 25 mg tabletti<\/td><\/tr><tr><td>France:<\/td><td>Comprim\u00e9s Tetmodis 25 mg<\/td><\/tr><tr><td>Germany:<\/td><td>Tetmodis 25 mg Tablet<\/td><\/tr><tr><td>Greece:<\/td><td>Tetmodis 25 mg \u03b4\u03b9\u03c3\u03ba\u03af\u03b1<\/td><\/tr><tr><td>Hungary:<\/td><td>Motets 25 mg tablet<\/td><\/tr><tr><td>Ireland:<\/td><td>Tetrabenazine 25 mg tablets<\/td><\/tr><tr><td>Latvia:<\/td><td>Tetmodis 25 mg tablets<\/td><\/tr><tr><td>Lithuania:<\/td><td>Tetmodis 25 mg tablet\u0117s<\/td><\/tr><tr><td>Netherlands:<\/td><td>Tetmodis 25 mg tablet<\/td><\/tr><tr><td>Poland:<\/td><td>Tetmodis 25 mg tabletki<\/td><\/tr><tr><td>Portugal:<\/td><td>Comprimidos de Tetmodis 25 mg<\/td><\/tr><tr><td>Romania:<\/td><td>Tetmodis, tablete, 25 mg<\/td><\/tr><tr><td>Slovakia:<\/td><td>Tetmodis 25 mg tablet<\/td><\/tr><tr><td>Slovenia:<\/td><td>Tetmodis 25 mg tablete<\/td><\/tr><tr><td>Spain:<\/td><td>Tetmodis 25 mg comprimidos<\/td><\/tr><tr><td>Sweden:<\/td><td>Tetmodis 25 mg tablets<\/td><\/tr><tr><td>UK:<\/td><td>Tetrabenazine 25 mg tablets<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Tetmodis is a medicine that belongs to a group of medicines used to treat disorders of the nervous system.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200],"tags":[25736,25741,25743,25734,25739,25737,25740,25735,25742,25738],"class_list":["post-24807","post","type-post","status-publish","format-standard","hentry","category-medicines","tag-tetmodis","tag-tetmodis-side-effects","tag-tetmodis-tablet","tag-tetrabenazine","tag-tetrabenazine-side-effects","tag-tetrabenazine-tablet","tag-what-is-tetmodis","tag-what-is-tetrabenazine","tag-what-tetmodis-is-used-for","tag-what-tetrabenazine-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24807","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24807"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24807\/revisions"}],"predecessor-version":[{"id":24862,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24807\/revisions\/24862"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}