{"id":24773,"date":"2022-08-31T07:41:04","date_gmt":"2022-08-31T07:41:04","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24773"},"modified":"2022-09-01T07:34:13","modified_gmt":"2022-09-01T07:34:13","slug":"terrosa","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/terrosa\/","title":{"rendered":"Terrosa &#8211; Teriparatide uses, dose and side effects"},"content":{"rendered":"\n<p>20 micrograms\/80 microliters,&nbsp;solution&nbsp;<\/p>\n\n\n\n<p>for injection<br>teriparatide<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Terrosa is and what it is used for<\/h2>\n\n\n\n<p>Terrosa contains the active substance teriparatide, which is used to make the skeleton stronger and reduce the risk of bone fractures by stimulating bone formation.<\/p>\n\n\n\n<p>Terrosa is used to treat\u00a0osteoporosis\u00a0in adults.\u00a0Osteoporosis\u00a0is a disease that causes the bones in the body to become thin and fragile.\u00a0The disease is particularly common in postmenopausal women,\u00a0but can also occur in men.\u00a0Osteoporosis\u00a0is also common in patients receiving drugs called\u00a0corticosteroids.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Terrosa<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Terrosa<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to teriparatide or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have high levels of\u00a0calcium\u00a0in your blood (previously confirmed\u00a0hypercalcemia).<\/li><li>if you have severe kidney problems.<\/li><li>if you have had bone <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a> or if another cancer has spread (metastasized) to the bone.<\/li><li>if you have a certain type of bone disease.\u00a0Tell your doctor if you have a bone disease.<\/li><li>if you have unexplained high levels of\u00a0alkaline\u00a0phosphatase in your blood, which suggests that you may have Paget&#8217;s disease of bone (disease of abnormal breakdown and formation of bone).\u00a0Consult your doctor if you are unsure.<\/li><li>if you have received radiation therapy involving the bone structure.<\/li><li>if you are pregnant or breastfeeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Terrosa may increase the level of&nbsp;calcium&nbsp;in the blood or urine.<\/p>\n\n\n\n<p>Talk to your doctor before or while using Terrosa:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have persistent nausea, vomiting, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/constipation\/\">constipation<\/a>, low energy, or muscle weakness.\u00a0It could be a sign that you have too much\u00a0calcium\u00a0in your blood.<\/li><li>if you suffer from\u00a0kidney stones\u00a0or have had\u00a0kidney stones in\u00a0the past.<\/li><li>if you suffer from kidney problems (moderately impaired kidney function).<\/li><\/ul>\n\n\n\n<p>Some patients become dizzy or have a fast heart rate after the first&nbsp;doses&nbsp;of Terrosa.&nbsp;Inject Terrosa where you can quickly sit or lie down if you feel dizzy.<\/p>\n\n\n\n<p>The recommended treatment period of 24 months should not be exceeded.<\/p>\n\n\n\n<p>Before inserting a\u00a0cartridge\u00a0into the Terrosa Pen, write down the manufacturing batch (lot) number of the\u00a0cartridge\u00a0and the date of the first\u00a0injection\u00a0on the outer carton of the cartridge.\u00a0Leave this information if you need to report any\u00a0side effects.<\/p>\n\n\n\n<p>Terrosa should not be used in young adults who are still growing.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Terrosa should not be used in children or adolescents (under 18 years of age).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Terrosa<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are using, have recently used, or might be using other medicines.<\/p>\n\n\n\n<p>This is important because some medicines (eg digoxin\/digitalis, used to treat heart disease) can affect the effect of teriparatide.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Do not use Terrosa if you are pregnant or breastfeeding.&nbsp;If you are a&nbsp;fertile&nbsp;woman, you must use a safe method of contraception during treatment with Terrosa.&nbsp;If you become pregnant during treatment with Terrosa, treatment with Terrosa must be stopped.&nbsp;Consult your doctor or pharmacist before using this medicine.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Some people may feel dizzy after\u00a0injection\u00a0with Terrosa.\u00a0If you feel dizzy, do not drive or use tools or machines until you feel better.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Terrosa contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg) of\u00a0sodium\u00a0per\u00a0dose, i.e. it is almost &#8220;sodium-free&#8221;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Terrosa<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 20 micrograms (equivalent to 80 microliters), which is injected under the skin in the thigh or abdomen, once a day.<\/p>\n\n\n\n<p>Take your medicine at the same time each day to make it easier to remember to take it.&nbsp;Terrosa can be injected with meals.&nbsp;Inject Terrosa every day for as long as the doctor prescribes.&nbsp;The total duration of treatment with Terrosa should not exceed 24 months.&nbsp;You should not receive more than one 24-month course of treatment in your lifetime.<\/p>\n\n\n\n<p>Your doctor may recommend that you take Terrosa with&nbsp;calcium&nbsp;and&nbsp;vitamin&nbsp;D. The doctor will tell you how much to take each day.<\/p>\n\n\n\n<p>Terrosa can be taken with or without food.<\/p>\n\n\n\n<p>Terrosa cartridges&nbsp;are&nbsp;designed to be used only with the reusable drug delivery system.&nbsp;Terrosa Pen for multiple&nbsp;doses&nbsp;and compatible pen needles.&nbsp;The pen and injection needles are not included in the package with Terrosa.&nbsp;To start treatment, however, an&nbsp;ampoule&nbsp;and pen package must be used, containing an inner package with a Terrosa&nbsp;cylinder&nbsp;ampoule and an inner package with a Terrosa Pen.<\/p>\n\n\n\n<p>The pen can be used with ISO standard needles with a thickness of 29-31 gauge (diameter 0.25-0.33 mm) and length 5-12.7 mm for\u00a0subcutaneous\u00a0injection\u00a0only.<\/p>\n\n\n\n<p>Insert&nbsp;cartridge&nbsp;one into the pen before first use.&nbsp;It is very important to carefully follow the instructions for use that come with the pen for the correct use of this medicine.<\/p>\n\n\n\n<p>Use a new injection needle for each&nbsp;injection&nbsp;to prevent contamination and dispose of the needle safely after use.<\/p>\n\n\n\n<p>Never store the pen with the needle attached.<\/p>\n\n\n\n<p>Never share a pen with other people.<\/p>\n\n\n\n<p>Do not use your Terrosa Pen to inject other medicines (eg&nbsp;insulin&nbsp;).<\/p>\n\n\n\n<p>The pen is adapted to be used only with Terrosa.<\/p>\n\n\n\n<p>Do not&nbsp;refill&nbsp;a cartridge.<\/p>\n\n\n\n<p>Do not transfer the medicine to a\u00a0syringe.<\/p>\n\n\n\n<p>Inject Terrosa immediately after removing the pen with the cartridge inserted&nbsp;from&nbsp;the refrigerator, as described in the instructions for use.&nbsp;Place the pen with the cartridge inserted back&nbsp;into the&nbsp;refrigerator immediately after use.&nbsp;Do not remove the&nbsp;cartridge&nbsp;from the pen after each use.&nbsp;Keep it in the cartridge holder for the entire 28-day treatment period.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Prepare the pen for use<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Always read the instructions for use of the Terrosa Pen included in the box with the pen to ensure proper\u00a0administration\u00a0of Terrosa.<\/li><li>Wash your hands before handling the\u00a0cartridge\u00a0or the pen.<\/li><li>The expiry date on the cartridge label must always be checked before inserting the cartridge\u00a0into\u00a0the pen.\u00a0Make sure the date when a new\u00a0cartridge\u00a0starts to be used is at least 28 days before the expiry date.\u00a0Insert\u00a0cartridge\u00a0one into the pen before the first use according to the instructions for use of the pen.\u00a0Enter the manufacturing batch (lot) number of each\u00a0cartridge\u00a0and the date of the first\u00a0injection\u00a0in a calendar.\u00a0The date of the first\u00a0injection\u00a0should also be indicated on the outer carton of Terrosa (see the designated space on the carton: {First day of use:}).<\/li><li>After inserting a new\u00a0cartridge\u00a0and before the first\u00a0injection\u00a0from\u00a0cartridge\u00a0one, the pen should be filled according to the instructions provided.\u00a0Do not refill after the first\u00a0dose.<\/li><\/ul>\n\n\n\n<p><strong>Inject Terrosa<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Clean the skin where you will inject (thigh or abdomen) as directed by your doctor before injecting Terrosa.<\/li><li>Gently grasp and squeeze the cleaned skin and insert the needle straight into the skin.\u00a0Press and hold the button until the dose indicator has returned to the starting position.<\/li><li>Leave the needle in the skin for six seconds after\u00a0injection\u00a0to make sure you got the full\u00a0dose.<\/li><li>Attach the outer needle cap to the pen needle and twist the cap counterclockwise to remove the pen needle.\u00a0This keeps the remaining Terrosa sterile and does not leak from the pen.\u00a0It also means that air does not return to the\u00a0cartridge\u00a0and that the needle does not clog.<\/li><li>Put the cap on the pen.\u00a0Leave\u00a0cartridge\u00a0one in the pen.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Terrosa&nbsp;<\/h2>\n\n\n\n<p>If you have accidentally used more Terrosa than you should, contact your doctor or pharmacist.<\/p>\n\n\n\n<p>Expected effects of an overdose may include nausea, vomiting, dizziness, and headache.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Terrosa<\/h2>\n\n\n\n<p>If you forget an\u00a0injection\u00a0or cannot use the medicine at the usual time, inject as soon as possible on the same day.\u00a0Do not use a double\u00a0dose\u00a0to make up for the missed\u00a0dose.\u00a0Do not take more than one\u00a0injection\u00a0on the same day even if you have missed a\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Terrosa<\/h2>\n\n\n\n<p>If you are considering stopping Terrosa treatment, you should talk to your doctor.&nbsp;Your doctor will consult with you and decide how long you should continue with Terrosa.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The most common\u00a0side effects\u00a0are a <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a> in the arms and legs (very common, may affect more than 1 in 10 people).\u00a0Other common\u00a0side effects\u00a0(which may affect up to 1 in 10 people) include nausea, headache, and dizziness.\u00a0If you feel dizzy after\u00a0injection\u00a0one, sit or lie down until you feel better.\u00a0If you do not improve, a doctor should be called before continuing the treatment.\u00a0Cases of fainting have occurred following the use of teriparatide.<\/p>\n\n\n\n<p>If you feel discomfort around the injection site such as redness, pain, swelling,\u00a0itching, bruising or minor bleeding (which can be common), it should go away within a few days or weeks.\u00a0Otherwise, a doctor should be contacted.<\/p>\n\n\n\n<p>Patients have rarely (may affect up to 1 in 1,000 people) experienced allergic reactions, such as shortness of breath, facial swelling, rash, and chest pain.\u00a0These reactions usually occur right after\u00a0injection.\u00a0In rare cases, serious and potentially life-threatening allergic reactions including\u00a0anaphylaxis may\u00a0occur.<\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;are:<\/p>\n\n\n\n<p><em>Common<\/em>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased cholesterol levels in the blood<\/li><li>Depression<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">nerve pain<\/a> in the legs<\/li><li>feeling of weakness<\/li><li>feeling dizzy<\/li><li>irregular heartbeats<\/li><li>shortness of breath<\/li><li>increased sweating<\/li><li>muscle cramps<\/li><li>decreased energy<\/li><li>fatigue<\/li><li>chest pain<\/li><li>low&nbsp;blood pressure<\/li><li>heartburn (pain or burning sensation below the breastbone)<\/li><li>vomiting<\/li><li>hernia&nbsp;in the esophagus (&nbsp;hiatal hernia&nbsp;)<\/li><li>low&nbsp;hemoglobin&nbsp;or low&nbsp;red blood cell count&nbsp;(&nbsp;anemia&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>Uncommon<\/em>&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased heart rate<\/li><li>abnormal heart sound<\/li><li>shortness of breath<\/li><li>hemorrhoids<\/li><li>urine leakage<\/li><li>increased need to empty the bladder<\/li><li>weight gain<\/li><li>kidney stones\u00a0are<\/li><li>pains in muscles and pains in joints.\u00a0Some patients have had such severe cramps or <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/back-hurts\/\">back pain<\/a> that they have had to be treated in a hospital.<\/li><li>increase in the amount of calcium in the blood<\/li><li>increase in the amount of uric acid in the blood<\/li><li>increase in an\u00a0enzyme\u00a0called alkaline phosphatase<\/li><\/ul>\n\n\n\n<p><em>Rare<\/em>&nbsp;(may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>impaired renal function, including\u00a0renal failure<\/li><li>swelling, mainly in the hands, feet, and legs.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Terrosa<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and the\u00a0cartridge\u00a0one after EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C\u20138 \u00b0C).&nbsp;Do not freeze.<\/p>\n\n\n\n<p>Store&nbsp;cartridge&nbsp;one in the outer carton.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Terrosa can be used up to 28 days after the first\u00a0injection, as long as the cartridge\/pen with the cartridge inserted\u00a0is\u00a0stored in a refrigerator (2\u00b0C to 8\u00b0C).<\/p>\n\n\n\n<p>Avoid&nbsp;placing the&nbsp;cartridges near the freezer section of the refrigerator to prevent them from freezing.&nbsp;Do not use Terrosa if it is or has been frozen.<\/p>\n\n\n\n<p>Each\u00a0cartridge\u00a0should be discarded after 28 days from the first use, even if it is not empty.<\/p>\n\n\n\n<p>Terrosa contains a clear and colorless solution.&nbsp;Do not use Terrosa if solid particles are visible in the solution or if the solution is cloudy or colored.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is teriparatide.\u00a0Each 80-microliter\u00a0dose\u00a0contains 20 micrograms of teriparatide.\u00a0A 2.4 ml cartridge contains 600 micrograms of\u00a0teriparatide\u00a0(equivalent to 250 micrograms per ml).<\/li><li>Other ingredients are: concentrated acetic acid, mannitol, metacresol, sodium acetate trihydrate,\u00a0hydrochloric acid\u00a0(for\u00a0pH\u00a0adjustment), sodium hydroxide (for\u00a0pH\u00a0adjustment), and water for injections (see section 2 &#8220;Terrosa contains sodium&#8221;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Terrosa is a colorless and clear solution for\u00a0injection\u00a0(\u00a0injection\u00a0).\u00a0It is supplied in a\u00a0cartridge.\u00a0Each\u00a0cartridge\u00a0contains 2.4 ml of solution, which is enough for 28\u00a0doses.<\/p>\n\n\n\n<p>Pack sizes: 1&nbsp;cartridge&nbsp;or 3&nbsp;cartridges&nbsp;packed on a plastic tray sealed with a foil lid and packed in a carton.<\/p>\n\n\n\n<p>Terrosa&nbsp;ampoule&nbsp;and pen packaging: 1 Terrosa cartridge&nbsp;packed&nbsp;on a plastic tray sealed with a foil lid and packed in an inner pack, and 1 Terrosa Pen packed in an inner pack.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Gedeon Richter Plc.<\/p>\n\n\n\n<p>Gy\u00f6mr\u0151i \u00fat 19-21.<\/p>\n\n\n\n<p>1103 Budapest<\/p>\n\n\n\n<p>Hungary<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Terrosa contains the active substance teriparatide, which is used to make the skeleton stronger and reduce the risk of bone fractures by stimulating bone formation.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[18099,25667,2469,2472,25664,25666,18097,25665,18098,25668],"class_list":["post-24773","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-teriparatide","tag-benefits-of-terrosa","tag-teriparatide","tag-teriparatide-side-effects","tag-terrosa","tag-terrosa-side-effects","tag-what-is-teriparatide","tag-what-is-terrosa","tag-what-teriparatide-is-used-for","tag-what-terrosa-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24773","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24773"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24773\/revisions"}],"predecessor-version":[{"id":24797,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24773\/revisions\/24797"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24773"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24773"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24773"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}