{"id":24710,"date":"2022-08-30T07:48:53","date_gmt":"2022-08-30T07:48:53","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24710"},"modified":"2022-08-31T07:21:03","modified_gmt":"2022-08-31T07:21:03","slug":"tepmetko","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tepmetko\/","title":{"rendered":"TEPMETKO &#8211; Tepotinib uses, dose and side effects"},"content":{"rendered":"\n<p>225 mg&nbsp;film-coated tablets<br>tepotinib<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What TEPMETKO is and what it is used for<\/h2>\n\n\n\n<p>TEPMETKO contains the active substance tepotinib.&nbsp;It belongs to a group of medicines called protein kinase inhibitors, which are used to treat <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a>.<\/p>\n\n\n\n<p>TEPMETKO is used to treat adults with lung cancer that has spread to other parts of the body or cannot be removed with surgery.&nbsp;This medicine is given when the cancer cells have a change in a gene called&nbsp;<em>MET<\/em>&nbsp;(mesenchymal-epithelial transition factor) and previous treatment has not helped to stop the disease.<\/p>\n\n\n\n<p>A change in the\u00a0<em>MET<\/em>\u00a0gene can lead to the formation of an abnormal\u00a0protein, which can then lead to uncontrolled cell growth and cancer.\u00a0By blocking the effect of the abnormal\u00a0protein, TEPMETKO can delay or stop cancer growth.\u00a0It can also help shrink cancer.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take TEPMETKO<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take TEPMETKO<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to tepotinib or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking this medicine if you have any questions.<\/p>\n\n\n\n<p>Lung and breathing problems<\/p>\n\n\n\n<p>TEPMETKO can sometimes lead to sudden breathing problems which may be associated with <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a> and <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a>.&nbsp;Tell your doctor immediately if you develop new or worsening symptoms (see section 4) as these may be signs of a serious lung disease (interstitial lung disease) that needs to be treated immediately.&nbsp;The doctor may need to treat you with other medicines and interrupt the treatment with TEPMETKO.<\/p>\n\n\n\n<p>Control of liver function<\/p>\n\n\n\n<p>The doctor will take blood samples to check how well your liver is working before you receive treatment with TEPMETKO and, if necessary, during treatment.<\/p>\n\n\n\n<p>Control of heart function<\/p>\n\n\n\n<p>If necessary, the doctor will perform&nbsp;ECG&nbsp;examinations during treatment to check whether TEPMETKO affects your heart rhythm.<\/p>\n\n\n\n<p>Contraceptive<\/p>\n\n\n\n<p>This medicine should not be used during pregnancy as it may harm the unborn baby.\u00a0Men and women should use effective contraception during treatment with TEPMETKO and for at least 1 week after the last\u00a0dose.\u00a0The doctor will advise you on suitable contraceptives.\u00a0See &#8220;Pregnancy&#8221; below.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine has not been studied in patients under 18 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and TEPMETKO<\/h2>\n\n\n\n<p>Tell your doctor if you are using, have recently used, or might be using other medicines.<\/p>\n\n\n\n<p>The following medicines can affect how well TEPMETKO works:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>carbamazepine \u2013 used to treat epileptic seizures or nerve pain<\/li><li>phenytoin\u00a0\u2013 used to treat epileptic seizures<\/li><li>rifampicin \u2013 used to treat\u00a0tuberculosis\u00a0(TB)<\/li><li>St. John&#8217;s wort\u00a0&#8211; a natural remedy used to treat mild depression<\/li><li>itraconazole or\u00a0ketoconazole\u00a0\u2013 used to treat fungal infections<\/li><li>ritonavir, saquinavir or nelfinavir &#8211; used to\u00a0treat\u00a0HIV\u00a0infection<\/li><li>quinidine\u00a0or verapamil \u2013 is used to treat irregular heart rhythms.<\/li><\/ul>\n\n\n\n<p>TEPMETKO can affect how well the following medicines work and\/or increase the&nbsp;side effects&nbsp;of these medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dabigatran \u2013 used to prevent\u00a0stroke\u00a0or venous thrombosis\/pulmonary embolism<\/li><li>digoxin\u00a0\u2013 used to treat irregular heartbeats or other heart problems<\/li><li>aliskiren \u2013 used to treat high\u00a0blood pressure<\/li><li>everolimus \u2013 used to treat cancer<\/li><li>sirolimus \u2013 used to prevent organ rejection in transplant patients<\/li><li>rosuvastatin \u2013 used to treat high blood lipids<\/li><li>methotrexate \u2013 used to treat inflammatory diseases or cancer<\/li><li>topotecan \u2013 used to treat cancer<\/li><li>metformin\u00a0\u2013 is used to treat\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">diabetes<\/a>.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Pregnancy<\/p>\n\n\n\n<p>Do not take TEPMETKO if you are pregnant or think you may be pregnant unless your doctor has told you to.\u00a0This medicine may harm the unborn baby.\u00a0A pregnancy test is recommended before starting treatment with TEPMETKO.<\/p>\n\n\n\n<p>Contraceptives for men and women<\/p>\n\n\n\n<p>If you are a woman of childbearing potential, you must use effective contraception to avoid pregnancy during treatment with TEPMETKO and for at least 1 week after the last\u00a0dose.\u00a0Talk to your doctor if you are taking hormonal contraceptives (e.g.\u00a0birth control pills\u00a0) as you will need to use an additional contraceptive during this time.<\/p>\n\n\n\n<p>If you are a man, you should use a\u00a0barrier method\u00a0to prevent your partner from becoming pregnant during treatment with TEPMETKO and for at least 1 week after the last\u00a0dose.<\/p>\n\n\n\n<p>The doctor will advise you on suitable contraceptives.<\/p>\n\n\n\n<p>Breast-feeding<\/p>\n\n\n\n<p>It is not known whether TEPMETKO is passed to the baby through breast milk.\u00a0Stop breastfeeding your child during treatment with this medicine and for at least 1 week after the last\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>TEPMETKO does not influence the ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">TEPMETKO contains lactose<\/h2>\n\n\n\n<p>TEPMETKO contains 4.4 mg&nbsp;lactose monohydrate&nbsp;per tablet.&nbsp;If you have an intolerance to certain sugars, you should consult your doctor before taking this medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take TEPMETKO<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Consult a doctor if you are unsure.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0is 2 tablets of TEPMETKO taken by mouth once a day.\u00a0You can continue to take this medicine daily as long as you benefit from it and do not experience\u00a0side effects\u00a0that you do not tolerate.\u00a0In case of severe\u00a0side effects, the doctor may advise you to reduce the\u00a0dose\u00a0by one to 1 tablet daily or to interrupt the treatment for a few days.<\/p>\n\n\n\n<p>Take the tablets with food or shortly after a meal, and swallow them whole without chewing.\u00a0This ensures that the entire\u00a0dose\u00a0reaches your system.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much TEPMETKO<\/h2>\n\n\n\n<p>The experience of overdose with TEPMETKO is limited.&nbsp;The symptoms of overdose are expected to be similar to the&nbsp;side effects&nbsp;listed under &#8220;Possible side effects&#8221; (see section 4).&nbsp;Talk to your doctor if you have taken too much TEPMETKO.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take TEPMETKO<\/h2>\n\n\n\n<p>If you have forgotten a\u00a0dose\u00a0of TEPMETKO, take it as soon as you remember.\u00a0If you are due to take the next\u00a0dose\u00a0within 8 hours, skip the missed\u00a0dose\u00a0and take the next\u00a0dose\u00a0at your usual time.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Lung and breathing problems<\/p>\n\n\n\n<p>Tell your doctor immediately if you develop new or worsening symptoms such as sudden difficulty breathing, cough, or fever.\u00a0These may be signs of a serious lung disease (interstitial lung disease) that needs to be treated immediately.\u00a0This\u00a0side effect\u00a0is common (may affect up to 1 in 10 users).<\/p>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>Talk to your doctor if you get other\u00a0side effects.\u00a0These may include:<\/p>\n\n\n\n<p>Very common&nbsp;side effects&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling is caused by the accumulation of fluid in the body (\u00a0edema\u00a0)<\/li><li>Nausea or vomiting<\/li><li>Diarrhea<\/li><li>Increased levels of\u00a0creatinine\u00a0in the blood (a sign of possible kidney problems)<\/li><li>Elevated levels of\u00a0alanine aminotransferase,\u00a0aspartate aminotransferase,\u00a0or alkaline phosphatase in the blood (a sign of possible liver problems)<\/li><li>Increased levels of amylase or\u00a0lipase\u00a0in the blood (a sign of possible digestive problems)<\/li><li>Decreased levels of\u00a0protein\u00a0and albumin in the blood<\/li><\/ul>\n\n\n\n<p>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Change in the electrical activity of the heart as seen on the&nbsp;ECG&nbsp;(&nbsp;QT&nbsp;prolongation)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How TEPMETKO should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tepotinib.\u00a0Each film-coated tablet contains 225 mg of tepotinib (as a hydrochloride hydrate).<\/li><li>Other ingredients are mannitol,\u00a0colloidal\u00a0anhydrous silica, crospovidone, magnesium stearate and microcrystalline cellulose in the tablet core and hypromellose,\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/lactose-intolerance\/\">lactose<\/a> monohydrate\u00a0(see section 2, &#8220;TEPMETKO contains lactose&#8221;), macrogol, triacetin, red iron oxide (E172) and titanium dioxide (E171) in the film coating.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>TEPMETKO film-coated tablets are white-pink, oval, biconvex, approximately 18&#215;9 mm in size and debossed with \u201cM\u201d on one side and plain on the other side.&nbsp;Each package contains 60 tablets in a&nbsp;transparent&nbsp;blister consisting of a multi-layered foil and an aluminum lid.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Merck Europe BV<\/p>\n\n\n\n<p>Gustav Mahlerplein 102<\/p>\n\n\n\n<p>1082 MA Amsterdam<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Merck Healthcare KGaA<\/p>\n\n\n\n<p>Frankfurter Strasse 250<\/p>\n\n\n\n<p>64293 Darmstadt<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>TEPMETKO contains the active substance tepotinib.\u00a0It belongs to a group of medicines called protein kinase inhibitors, which are used to treat cancer.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200],"tags":[25635,25643,25641,25634,25637,25638,25640,25636,25642,25639],"class_list":["post-24710","post","type-post","status-publish","format-standard","hentry","category-medicines","tag-tepmetko","tag-tepmetko-side-effects","tag-tepmetko-tablet","tag-tepotinib","tag-tepotinib-side-effects","tag-tepotinib-tablet","tag-what-is-tepmetko","tag-what-is-tepotinib","tag-what-tepmetko-is-used-for","tag-what-tepotinib-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24710"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24710\/revisions"}],"predecessor-version":[{"id":24754,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24710\/revisions\/24754"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}