{"id":24709,"date":"2022-08-30T07:45:38","date_gmt":"2022-08-30T07:45:38","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24709"},"modified":"2022-08-31T07:21:17","modified_gmt":"2022-08-31T07:21:17","slug":"tepadina","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tepadina\/","title":{"rendered":"TEPADINA &#8211; Thiotepa uses, dose and side effects"},"content":{"rendered":"\n<p>400 mg\u00a0powder and liquid for\u00a0infusion, solution<br>thiotepa<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What TEPADINA is and what it is used for<\/h2>\n\n\n\n<p>TEPADINA contains the active substance thiotepa, which belongs to a group of medicines called alkylating agents.<\/p>\n\n\n\n<p>TEPADINA is used to prepare patients for bone marrow transplantation.\u00a0It works by destroying bone marrow cells.\u00a0This makes it possible to transplant new bone marrow cells (hematopoietic\u00a0stem cells\u00a0), which in turn enable the body to form healthy\u00a0blood cells.<\/p>\n\n\n\n<p>TEPADINA can be used by adults and children and adolescents.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use TEPADINA<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use TEPADINA<\/h2>\n\n\n\n<p>&#8211; if you are allergic to thiotepa<\/p>\n\n\n\n<p>&#8211; if you are pregnant or think you may be pregnant<\/p>\n\n\n\n<p>&#8211; if you are breastfeeding<\/p>\n\n\n\n<p>&#8211; if you receive vaccination against yellow fever, live viral and bacterial vaccines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>You should tell your doctor if you have<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver or kidney problems<\/li><li>heart or lung problems<\/li><li>seizures (&nbsp;epilepsy&nbsp;) or have had them in the past (if these are treated with&nbsp;phenytoin&nbsp;or fosphenytoin).<\/li><\/ul>\n\n\n\n<p>As TEPADINA destroys bone marrow cells responsible for the production of\u00a0blood cells, you will regularly give blood samples during treatment to check the number of\u00a0blood cells.<\/p>\n\n\n\n<p>To prevent and treat\u00a0infection, you will be given anti-infection medicine.<\/p>\n\n\n\n<p>TEPADINA may induce another type of cancer in the future.&nbsp;Your doctor will discuss this risk with you.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and TEPADINA<\/h2>\n\n\n\n<p>Tell your doctor if you are taking or have recently taken any other medicines, including those obtained without a prescription.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>You must tell your doctor if you are pregnant or think you may be pregnant before receiving TEPADINA.&nbsp;You must not use TEPADINA during pregnancy.<\/p>\n\n\n\n<p>Both women and men using TEPADINA must use effective contraception during treatment.&nbsp;Men should not father children during treatment with TEPADINA and for one year after stopping treatment.<\/p>\n\n\n\n<p>It is unknown if this drug is excreted in breast milk.\u00a0As a precaution, women should not breastfeed during treatment with TEPADINA.<\/p>\n\n\n\n<p>TEPADINA can impair fertility in men and women.&nbsp;Male patients should seek advice on sperm conservation before starting treatment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Likely, certain\u00a0side effects\u00a0of thiotepa such as dizziness, headache, and blurred vision can affect the ability to drive vehicles and use machines.\u00a0If you experience any\u00a0side effects, do not drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">TEPADINA contains sodium<\/h2>\n\n\n\n<p>This medicine contains 1418 mg (61.6 mmol) of&nbsp;sodium&nbsp;(the main ingredient in common\/table salt) in each sachet.&nbsp;This corresponds to 70.9% of the recommended maximum daily intake of&nbsp;sodium&nbsp;for adults.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use TEPADINA<\/h2>\n\n\n\n<p>Your doctor will calculate the&nbsp;dose&nbsp;according to your body surface area or weight and your disease.<\/p>\n\n\n\n<p><strong>How TEPADINA is given<\/strong><\/p>\n\n\n\n<p>TEPADINA is given by qualified healthcare professionals as an&nbsp;intravenous&nbsp;infusion&nbsp;(drip into a vein) after diluting the solution for injection.&nbsp;Each&nbsp;infusion&nbsp;lasts 2\u20134 hours.<\/p>\n\n\n\n<p><strong>Frequency of administration<\/strong><\/p>\n\n\n\n<p>You will receive your\u00a0infusions\u00a0every 12 or 24 hours.\u00a0The treatment can last up to 5 days.\u00a0How often the\u00a0infusions\u00a0are given and how long the treatment depends on your illness.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, TEPADINA can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The most serious&nbsp;side effects&nbsp;of treatment with TEPADINA or of the transplant may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of circulating&nbsp;blood cells&nbsp;(intended effect of the drug to prepare you for your transplant infusion)<\/li><li>infection<\/li><li>liver dysfunction including blockage of a vein in the liver<\/li><li>the graft&nbsp;attacks your body (&nbsp;graft&nbsp;-versus-host reaction)<\/li><li>respiratory complications.<\/li><\/ul>\n\n\n\n<p>Your doctor will regularly check your blood levels and liver enzymes to detect and treat these\u00a0side effects.<\/p>\n\n\n\n<p>Side effects&nbsp;of TEPADINA may occur in certain frequencies, which are defined as follows:<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(may affect more than 1 in 10 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased susceptibility to infection<\/li><li>blood poisoning (inflammatory condition throughout the body;\u00a0sepsis\u00a0)<\/li><li>reduced number of\u00a0white blood cells,\u00a0platelets,\u00a0and\u00a0red blood cells\u00a0(\u00a0anemia\u00a0)<\/li><li>the transplanted cells attack your body (\u00a0graft\u00a0-versus-host reaction)<\/li><li>dizziness, headache, blurred vision<\/li><li>uncontrolled shaking of the body (seizures)<\/li><li>a tingling, tingling, or numbness sensation (\u00a0paresthesia\u00a0)<\/li><li>partial\u00a0loss of mobility<\/li><li>cardiac arrest<\/li><li>nausea, vomiting, diarrhea<\/li><li>inflammation\u00a0of the oral mucosa (\u00a0mucositis\u00a0)<\/li><li>irritated stomach, esophagus, intestine<\/li><li>inflammation\u00a0of the colon<\/li><li>anorexia\u00a0decreased appetite<\/li><li>high blood sugar level<\/li><li>skin rash,\u00a0itching, scaling of the skin<\/li><li>changed skin color (not to be confused with jaundice \u2013 see below)<\/li><li>skin redness (\u00a0erythema\u00a0)<\/li><li>hair loss<\/li><li>back and abdominal pain, pain<\/li><li>muscle and <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/joint-pain\/\">joint pain<\/a><\/li><li>abnormal electrical activity in the heart (\u00a0arrhythmia\u00a0)<\/li><li>inflammation\u00a0of the lung tissue<\/li><li>enlarged liver<\/li><li>altered organ function<\/li><li>blockage of a vein in the liver (hepatic venous occlusive disease, VOD)<\/li><li>yellowing of the skin and eyes (jaundice)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/impaired-hearing\/\">impaired hearing<\/a><\/li><li>clogging of lymphatic vessels<\/li><li>high\u00a0blood pressure<\/li><li>elevated levels of liver, kidney, and digestive enzymes<\/li><li>abnormal amounts of\u00a0electrolytes\u00a0in the blood<\/li><li>weight gain<\/li><li>fever, general weakness, chills<\/li><li>bleeding<\/li><li>nosebleeds<\/li><li>general swelling due to fluid retention (\u00a0edema\u00a0)<\/li><li>pain or\u00a0inflammation\u00a0at the injection site<\/li><li>eye infection\u00a0(\u00a0conjunctivitis\u00a0)<\/li><li>decreased sperm count<\/li><li>bleeding from the vagina<\/li><li>missed periods (\u00a0amenorrhea\u00a0)<\/li><li>memory loss<\/li><li>delayed weight gain and height growth<\/li><li>bladder dysfunction<\/li><li>too low production of\u00a0testosterone<\/li><li>insufficient production of thyroid hormone<\/li><li>insufficient activity of the\u00a0pituitary\u00a0gland<\/li><li>state of confusion.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>worry, confusion<\/li><li>abnormal bulging of one of the\u00a0arteries\u00a0in the brain (\u00a0intracranial\u00a0aneurysm\u00a0)<\/li><li>elevated creatinine level<\/li><li>allergic reactions<\/li><li>blood clot (clogging of a blood vessel; embolism)<\/li><li>disturbances in the heart rhythm<\/li><li>failure of the heart<\/li><li>dysfunction of the cardiovascular system<\/li><li>lack of oxygen<\/li><li>fluid accumulation in the lungs (\u00a0pulmonary edema)<\/li><li>pulmonary hemorrhages<\/li><li>respiratory arrest<\/li><li>blood in the urine (\u00a0hematuria\u00a0) and moderate deterioration of kidney function<\/li><li>inflammation\u00a0of the bladder<\/li><li>discomfort when urinating and decreased urine volume (\u00a0dysuria\u00a0and\u00a0oliguria\u00a0)<\/li><li>the increased amount of nitrogen components in the bloodstream (increased BUN)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cataracts\/\">cataracts<\/a>\u00a0_\u00a0_<\/li><li>liver failure<\/li><li>cerebral hemorrhage<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a><\/li><li>constipation and stomach upset<\/li><li>blockage of the intestine<\/li><li>perforation of the stomach<\/li><li>altered muscle tension<\/li><li>greatly reduced coordination of muscle movements<\/li><li>bruising due to low\u00a0platelet count<\/li><li>menopausal symptoms<\/li><li>cancer<\/li><li>abnormal brain function<\/li><li>male and female infertility.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>skin inflammation and scaling of the skin (erythrodermic\u00a0psoriasis\u00a0)<\/li><li>delirium, nervousness, hallucinations,\u00a0agitation<\/li><li>stomach\/intestinal ulcers<\/li><li>inflammation\u00a0of the muscle tissue of the heart (\u00a0myocarditis\u00a0)<\/li><li>heart disease (\u00a0cardiomyopathy\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>Frequency not known (frequency cannot be calculated from available data)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased\u00a0blood pressure\u00a0in the\u00a0arteries\u00a0(blood vessels) in the lungs (\u00a0pulmonary\u00a0arterial\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/hypertension\/\">hypertension<\/a>\u00a0)<\/li><li>serious skin damage (e.g. severe\u00a0lesions, large blisters, etc.) potentially covering the entire body surface which may be life-threatening<\/li><li>damage to a part of the brain (the so-called white brain matter) which can even be life-threatening (leukoencephalopathy).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store TEPADINA<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton, the label on the aluminum wrapper, and the bag after EXP.DAT.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store and transport cold (2 \u00b0C\u20138 \u00b0C).<\/p>\n\n\n\n<p>Do not freeze.<\/p>\n\n\n\n<p>Keep the bag in the aluminum wrapper to protect it from activation.<\/p>\n\n\n\n<p>After activation and\u00a0preparation, the product must be used immediately.<\/p>\n\n\n\n<p>Unused medicines and waste must be disposed of according to current instructions.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is thiotepa.&nbsp;One bag contains 400 mg of thiotepa.&nbsp;After&nbsp;reconstitution&nbsp;with the liquid, each ml of solution contains 1 mg of thiotepa&nbsp;<\/li><li>The other ingredients are sodium chloride and water for injections (see section 2 \u201cTEPADINA contains&nbsp;sodium&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>TEPADINA is supplied in a double chamber bag containing 400 mg thiotepa and 400 ml sodium chloride 9 mg\/ml (0.9%) solution for\u00a0injection.<\/p>\n\n\n\n<p>After\u00a0preparation, the bag contains a clear and colorless solution for\u00a0infusion.<\/p>\n\n\n\n<p>Each bag is packed in an aluminum wrapper.<\/p>\n\n\n\n<p>Each box contains 1 bag.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>ADRIENNE Srl<\/p>\n\n\n\n<p>Via Galileo Galilei, 19<\/p>\n\n\n\n<p>20867 Caponago (MB) Italy<\/p>\n\n\n\n<p>Tel.&nbsp;+39-02 40700445<\/p>\n\n\n\n<p>adienne@adienne.com<\/p>\n\n\n\n<p>For further information about this medicinal product, contact the representative of the marketing authorization holder:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Accord Healthcare bvT\u00e8l\/Tel: +32 51 79 40 12<\/td><td><strong>Lithuania<\/strong>Accord Healthcare phone: +46 8 624 00 25<\/td><\/tr><tr><td><br><strong>Bulgaria<\/strong>Accord Healthcare Polska Sp.\u00a0z o. iPhone: +48 22 577 28 00<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>Accord Healthcare bvT\u00e8l\/Tel: +32 51 79 40 12<\/td><\/tr><tr><td><br><strong>Czech Republic<\/strong>Accord Healthcare Polska Sp.\u00a0z o. iPhone: +48 22 577 28 00<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Accord Healthcare Polska Sp.&nbsp;z o. oTel.: +48 22 577 28 00<\/td><\/tr><tr><td><br><strong>Denmark<\/strong>Accord Healthcare ABTel: + 46 8 624 00 25<\/td><td><strong>Malta<\/strong>Accord Healthcare Ireland LtdPhone: +44 (0) 208 901 3370<\/td><\/tr><tr><td><br><strong>Deutschland<\/strong>Accord Healthcare GmbHPhone: +49 89 700 9951 0<\/td><td><strong>The Netherlands<\/strong>Accord Healthcare BVPhone: +31 30 850 6014<\/td><\/tr><tr><td><br><strong>Estonia<\/strong>Accord Healthcare ABPhone: +46 8 624 00 25<\/td><td><strong>Norway<\/strong>Accord Healthcare ABTel: + 46 8 624 00 25<\/td><\/tr><tr><td><br><strong>Greece<\/strong>Accord Healthcare Italia SrlTel: + 39 02 943 23 700<\/td><td><strong>Austria<\/strong>Accord Healthcare GmbHPhone: +43 (0)662 424899-0<\/td><\/tr><tr><td><strong>Spain<\/strong>Accord Healthcare SLUPhone: +34 93 301 00 64<\/td><td><strong>Polish<\/strong>Accord Healthcare Polska Sp.&nbsp;z o. oTel.: +48 22 577 28 00<\/td><\/tr><tr><td><strong>France<\/strong>Accord Healthcare France SASTel: +33 (0)320 401 770<\/td><td><strong>Portugal<\/strong>Accord Healthcare, Unipersonal LdaPhone: +351 214 697 835<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Accord Healthcare Polska Sp.\u00a0z o. iPhone: +48 22 577 28 00<\/td><td><strong>Romania<\/strong>Accord Healthcare Polska Sp.\u00a0z o. iPhone: +48 22 577 28 00<\/td><\/tr><tr><td><strong>Ireland<\/strong>Accord Healthcare Ireland LtdPhone: +44 (0)1271 385257<\/td><td><strong>Slovenija<\/strong>Accord Healthcare Polska Sp.\u00a0z o. iPhone: +48 22 577 28 00<\/td><\/tr><tr><td><strong>Iceland<\/strong>Accord Healthcare ABPhone: + 46 8 624 00 25<\/td><td><strong>Slovenian Republic<\/strong>Accord Healthcare Polska Sp.\u00a0z o. iPhone: +48 22 577 28 00<\/td><\/tr><tr><td><strong>Italy<\/strong>Accord Healthcare Italia SrlPhone: +39 02 943 23 700<\/td><td><strong>Finland\/Finland<\/strong>Accord Healthcare OyTel: + 358 10 231 4180<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Accord Healthcare SLUTel: + 34 93 301 00 64<\/td><td><strong>Sweden<\/strong>Accord Healthcare ABPhone: + 46 8 624 00 25<\/td><\/tr><tr><td><strong>Latvia<\/strong>Accord Healthcare phone: +46 8 624 00 25<\/td><td><strong>United Kingdom<\/strong>Accord-UK LtdPhone: +44 (0)1271 385257<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>TEPADINA contains the active substance thiotepa, which belongs to a group of medicines called alkylating agents.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25651,25646,25648,25653,25644,25647,25650,25645,25652,25649],"class_list":["post-24709","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-tepadina","tag-benefits-of-thiotepa","tag-tepadina","tag-tepadina-side-effects","tag-thiotepa","tag-thiotepa-side-effects","tag-what-is-tepadina","tag-what-is-thiotepa","tag-what-tepadina-is-used-for","tag-what-thiotepa-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24709","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24709"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24709\/revisions"}],"predecessor-version":[{"id":24756,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24709\/revisions\/24756"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24709"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24709"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24709"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}