{"id":24669,"date":"2022-08-29T11:54:15","date_gmt":"2022-08-29T11:54:15","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24669"},"modified":"2022-08-30T07:40:16","modified_gmt":"2022-08-30T07:40:16","slug":"tenofovir-disoproxil-sandoz","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tenofovir-disoproxil-sandoz\/","title":{"rendered":"Tenofovir disoproxil Sandoz &#8211; Tenofovir disoproxil uses, dose and side effects"},"content":{"rendered":"\n<p>245 mg&nbsp;film-coated tablets<br>tenofovir disoproxil<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tenofovir disoproxil Sandoz is and what it is used for<\/h2>\n\n\n\n<p>Tenofovir disoproxil Sandoz contains the active substance\u00a0<em>tenofovir disoproxil<\/em>.\u00a0This active substance is an\u00a0antiretroviral\u00a0or antiviral medicine used to treat\u00a0HIV\u00a0or HBV\u00a0infection\u00a0or both.\u00a0Tenofovir is a\u00a0reverse transcriptase inhibitor of the nucleotide type, generally called an NRTI, and works by affecting the normal function of\u00a0enzymes\u00a0(in the case of\u00a0HIV\u00a0reverse transcriptase; in the case of HBV\u00a0DNA polymerase\u00a0) that the\u00a0virus\u00a0needs for its reproduction (propagation).\u00a0In the case of\u00a0HIV\u00a0, Tenofovir disoproxil Sandoz should always be taken in combination with other medicines against HIV\u00a0.<\/p>\n\n\n\n<p><strong>Tenofovir disoproxil Sandoz\u00a0<\/strong><strong>is a treatment for\u00a0HIV\u00a0<\/strong>(human immunodeficiency virus)\u00a0infection.\u00a0The tablets are suitable for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>adults<\/strong><\/li><li><strong>young people aged 12 to younger than 18 who have already been treated<\/strong>\u00a0with other\u00a0HIV\u00a0drugs that no longer have a satisfactory effect due to the development of resistance or have caused\u00a0side\u00a0effects<strong>.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Tenofovir disoproxil Sandoz\u00a0<\/strong><strong>is also used as a treatment for\u00a0chronic\u00a0hepatitis\u00a0B, infection\u00a0with HBV<\/strong>\u00a0(\u00a0hepatitis\u00a0B\u00a0virus\u00a0).\u00a0The tablets are suitable for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>adults<\/strong><\/li><li><strong>young people aged 12 to younger than 18 years<\/strong>.<\/li><\/ul>\n\n\n\n<p>You do not need to have&nbsp;HIV&nbsp;to be treated with Tenofovir disoproxil Sandoz for HBV.<\/p>\n\n\n\n<p>This medicine does not\u00a0cure\u00a0HIV\u00a0infection.\u00a0While taking Tenofovir\u00a0disoproxil Sandoz, you may still develop\u00a0an infection\u00a0or other diseases associated with\u00a0HIV\u00a0infection.\u00a0You can also pass\u00a0HIV\u00a0or HBV on to others, so you must take precautions to avoid infecting other people.<\/p>\n\n\n\n<p>Tenofovir disoproxil contained in Tenofovir disoproxil Sandoz may also be approved to treat other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist or other healthcare professional if you have any further questions and always follow their instructions.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Tenofovir disoproxil Sandoz<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Tenofovir disoproxil Sandoz<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic<\/strong>\u00a0to tenofovir, tenofovir disoproxil, or any of the other ingredients of this medicine (listed in section 6).<br>If this applies to you, tell your doctor immediately and stop taking\u00a0Tenofovir disoproxil,<strong> Sandoz.<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Tenofovir disoproxil, Sandoz.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Be careful not to infect other people.\u00a0<\/strong>You can still transmit\u00a0HIV\u00a0when taking this medicine, although the risk is reduced with effective antiretroviral treatment.\u00a0Discuss with your doctor the necessary measures to avoid infecting others.\u00a0Tenofovir disoproxil Sandoz does not reduce the risk of transmitting HBV to others through sexual contact or blood infection.\u00a0You still need to take precautions to avoid this.<\/li><li><strong>Talk to your doctor or pharmacist if you have had kidney disease in the past or if tests have shown that you have problems with your kidneys.\u00a0<\/strong>Tenofovir disoproxil Sandoz should not be given to adolescents with kidney problems.\u00a0Before starting the treatment, your doctor may\u00a0order\u00a0some blood tests to assess that your kidneys are working normally.\u00a0Tenofovir disoproxil Sandoz may affect your kidneys during treatment.\u00a0Your doctor may\u00a0order\u00a0blood tests during treatment to check how your kidneys are working.\u00a0If you are an adult, your doctor may advise you to take the tablets less often.\u00a0Do not reduce the prescribed\u00a0dose by\u00a0one unless your doctor has told you to do so.<br>Tenofovir disoproxil Sandoz is usually not taken together with other medicines that can damage the kidneys (see\u00a0<em>Other medicines and Tenofovir disoproxil, Sandoz<\/em>\u00a0).\u00a0If this cannot be avoided, your doctor will check your kidney function once a week.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Skeletal problems.\u00a0<\/strong>Some adult patients with\u00a0HIV\u00a0receiving\u00a0combination\u00a0antiretroviral\u00a0therapy may develop a bone disease called\u00a0osteonecrosis\u00a0(bone tissue dies due to loss of blood supply to the bone).\u00a0Some of the many risk factors for developing the disease are long-term\u00a0combination\u00a0antiretroviral\u00a0therapy, use of\u00a0corticosteroids, alcohol consumption, severe impairment of the immune system, and higher body mass index.\u00a0Signs of\u00a0osteonecrosis\u00a0are joint stiffness and <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a> (especially in the hip, knee, and shoulders) and difficulty moving.\u00a0Tell your doctor if you experience any of these symptoms.<br>For adult and young patients: Bone problems (manifesting as persistent or worsening bone pain and sometimes leading to\u00a0fractures\u00a0) may also occur due to damage to renal tubule cells (see section 4,\u00a0Possible\u00a0side effects\u00a0).\u00a0Tell your doctor if you have bone pain or\u00a0a fracture. Tenofovir disoproxil can also cause loss of bone mass.\u00a0The most pronounced loss of bone mass was seen in\u00a0clinical trials\u00a0when patients were treated with tenofovir disoproxil in combination with a boosted\u00a0protease inhibitor. Overall, the effects of tenofovir disoproxil on long-term bone health and future fracture risk in adults and children are uncertain. Tell your doctor or your child&#8217;s doctor if you know you or your child has <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/osteoporosis\/\">osteoporosis<\/a>.\u00a0Patients with osteoporosis are at higher risk of\u00a0fracture\u00a0.<\/li><li>Inform your doctor if you already have or have had liver disease, including\u00a0hepatitis.\u00a0Patients with liver disease, including\u00a0chronic\u00a0hepatitis\u00a0B or C, who are treated with antiretroviral agents are at increased risk of severe and potentially fatal liver complications.\u00a0If you have\u00a0hepatitis\u00a0B, your doctor will carefully choose the best treatment for you.\u00a0If you have or have had liver disease or\u00a0chronic\u00a0hepatitis\u00a0B, your doctor may take blood tests to check liver function.<\/li><li>Be observant about\u00a0infection\u00a0.\u00a0If you have\u00a0advanced stage\u00a0HIV\u00a0infection (\u00a0AIDS\u00a0) and have an\u00a0infection, you may develop symptoms of\u00a0infection\u00a0and\u00a0inflammation\u00a0or worsening of symptoms of an existing\u00a0infection when\u00a0treatment\u00a0with Tenofovir disoproxil Sandoz is started.\u00a0These symptoms may indicate that your body&#8217;s improved immune system is fighting an\u00a0infection\u00a0.\u00a0Watch for signs of\u00a0inflammation\u00a0or\u00a0infection\u00a0during the first period after you start taking Tenofovir disoproxil Sandoz.\u00a0If you detect signs of\u00a0inflammationor\u00a0infection\u00a0,\u00a0<strong>you should immediately inform your doctor.<\/strong><br>In addition to opportunistic\u00a0infections\u00a0, autoimmune disorders (conditions where the immune system attacks healthy body tissue) can also occur after you start taking medicines to treat\u00a0your\u00a0HIV\u00a0infection\u00a0.\u00a0Autoimmune disorders may occur several months after starting treatment.\u00a0If you notice any symptoms of\u00a0infection\u00a0or other symptoms such as muscle weakness, weakness that starts in the hands or feet and moves to the trunk, palpitations, tremors or hyperactivity, inform your doctor immediately to get the necessary treatment.<\/li><li><strong>Talk to your doctor or pharmacist if you are over 65.\u00a0<\/strong>Tenofovir disoproxil Sandoz has not been studied in patients over 65 years of age.\u00a0If you are older than this and have been prescribed Tenofovir disoproxil Sandoz, your doctor will monitor you closely.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Tenofovir disoproxil Sandoz is&nbsp;<strong>suitable<\/strong>&nbsp;for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>HIV&nbsp;-1-infected young people aged 12 to less than 18 years who weigh at least 35 kg and who have already been treated<\/strong>&nbsp;with other&nbsp;HIV&nbsp;medicines that no longer have a satisfactory effect due to the development of resistance or have caused&nbsp;side effects&nbsp;.<\/li><li><strong>HBV-infected adolescents aged 12 years to younger than 18 years who weigh at least 35 kg<\/strong>&nbsp;.<\/li><\/ul>\n\n\n\n<p>Tenofovir disoproxil Sandoz is&nbsp;<strong>not<\/strong>&nbsp;suitable for the following groups:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Not for&nbsp;HIV&nbsp;-1-infected children<\/strong>&nbsp;under 12 years of age<\/li><li><strong>Not for HBV-infected children<\/strong>&nbsp;under 12 years of age.<\/li><\/ul>\n\n\n\n<p>For&nbsp;dosage&nbsp;, see section 3,&nbsp;<em>How to take Tenofovir disoproxil Sandoz.<\/em><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tenofovir disoproxil Sandoz&nbsp;<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Do not stop taking any anti-&nbsp;HIV&nbsp;<\/strong>medicine prescribed by your doctor when you start taking Tenofovir disoproxil Sandoz, if you have both HBV and&nbsp;HIV&nbsp;.<\/li><li><strong>Do not&nbsp;<\/strong><strong>take Tenofovir disoproxil Sandoz<\/strong>&nbsp;if you are already taking other medicines containing tenofovir disoproxil or tenofovir alafenamide.&nbsp;Do not take Tenofovir disoproxil Sandoz together with medicines containing adefovir dipivoxil (a medicine used to treat&nbsp;chronic&nbsp;hepatitis&nbsp;B).<\/li><li><strong>It is very important that you tell your doctor if you are taking other medicines that can damage your kidneys.<\/strong><\/li><\/ul>\n\n\n\n<p>Such drugs are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>aminoglycosides&nbsp;, pentamidine or vancomycin (against bacterial&nbsp;infection&nbsp;)<\/li><li>amphotericin B (for fungal infection)<\/li><li>foscarnet, ganciclovir or cidofovir (for viral infection)<\/li><li>interleukin-2&nbsp;(for treating <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a>)<\/li><li>adefovir dipivoxil (for HBV)<\/li><li>tacrolimus (for&nbsp;suppression&nbsp;of the immune system)<\/li><li>non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs&nbsp;, to relieve bone or muscle pain).<\/li><li><strong>Other medicines containing didanosine (for&nbsp;HIV&nbsp;infection&nbsp;): If you take Tenofovir&nbsp;disoproxil<\/strong>&nbsp;Sandoz together with other antiviral medicines containing didanosine, the blood levels of didanosine may increase and the CD4 cell count may decrease.&nbsp;Rare cases of pancreatitis and lactic acidosis (excess&nbsp;lactic acid&nbsp;in the blood), in some cases with a fatal outcome, have been reported during concomitant treatment with medicines containing tenofovir disoproxil and didanosine.&nbsp;Your doctor will carefully consider whether you can be treated with a combination of tenofovir and didanosine.<\/li><li><strong>It is also important that you tell your doctor<\/strong>&nbsp;if you are taking ledipasvir\/sofosbuvir, sofosbuvir\/velpatasvir or sofosbuvir\/velpatasvir\/voxilaprevir to treat&nbsp;hepatitis&nbsp;C&nbsp;infection&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Tenofovir disoproxil Sandoz with food and drink<\/h2>\n\n\n\n<p><strong>Take&nbsp;<\/strong><strong>Tenofovir disoproxil Sandoz&nbsp;<\/strong><strong>with food<\/strong>&nbsp;(eg a meal or a snack).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are pregnant, you must not take&nbsp;<\/strong><strong>Tenofovir disoproxil Sandoz&nbsp;<\/strong>&nbsp;until you have specifically discussed this with your doctor.&nbsp;Although there are limited clinical data on the use of Tenofovir disoproxil Sandoz during pregnancy, it is usually not used unless absolutely necessary.<\/li><li><strong>If you become<\/strong>&nbsp;or are planning to become&nbsp;<strong>pregnant<\/strong>&nbsp;, you must contact your doctor to discuss the potential benefits and risks of your antiretroviral treatment for you and your baby.<\/li><li><strong>If you have taken&nbsp;<\/strong><strong>Tenofovir disoproxil Sandoz<\/strong>&nbsp;during your pregnancy, the doctor may request that you regularly submit blood samples and undergo other diagnostic tests to check the baby&#8217;s development.&nbsp;For children of a&nbsp;mother&nbsp;who took NRTIs during pregnancy, the benefit of protection against&nbsp;HIV&nbsp;is greater than the risk of&nbsp;side effects&nbsp;.<\/li><\/ul>\n\n\n\n<p><em>For adult patients:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are a&nbsp;mother&nbsp;and you have HBV and your baby has received treatment to prevent the transmission of&nbsp;hepatitis&nbsp;B at birth, you may be able to breastfeed your baby, but talk to your doctor first for more information.<\/li><li>If you are an&nbsp;HIV&nbsp;-infected&nbsp;mother&nbsp;, you should not breastfeed your baby to avoid transmission of the&nbsp;virus&nbsp;et to the baby through the breast milk.<\/li><\/ul>\n\n\n\n<p><em>For young patients:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If your baby has HBV and her baby has received treatment to prevent transmission of&nbsp;hepatitis&nbsp;B at birth, your baby may be able to breastfeed, but talk to your baby&#8217;s doctor first for more information.<\/li><li>If your child has&nbsp;HIV&nbsp;, she should not breastfeed to avoid transmission of the&nbsp;virus&nbsp;to the child through breast milk.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Tenofovir disoproxil Sandoz may cause dizziness.&nbsp;<strong>Do not drive or cycle or<\/strong>&nbsp;use tools or machines if you feel dizzy while taking Tenofovir disoproxil Sandoz.<\/p>\n\n\n\n<p>You yourself are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects&nbsp;.&nbsp;Description of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;Discuss with your doctor or pharmacist if you are unsure.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tenofovir disoproxil Sandoz contains lactose<\/h2>\n\n\n\n<p>If you have an intolerance to certain sugars, you should consult your doctor before taking this medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Tenofovir disoproxil Sandoz<\/h2>\n\n\n\n<p><strong>Always take this medicine as directed by your doctor or pharmacist<\/strong>&nbsp;.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;is:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Adults:<\/strong>&nbsp;1 tablet a day with food (e.g. a meal or a snack).<\/li><li><strong>Adolescents aged 12 to less than 18 years weighing at least 35 kg:<\/strong>&nbsp;1 tablet a day with food (eg a meal or a snack).<\/li><\/ul>\n\n\n\n<p>If you have particular difficulty swallowing, you can crush the tablet with the tip of a spoon.&nbsp;Then mix the powder with about 100 ml (half a glass) of water, orange juice or grape juice and drink immediately.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Always take the&nbsp;dose&nbsp;prescribed by the doctor<\/strong>&nbsp;to ensure that the treatment is effective and to reduce the development of&nbsp;resistance&nbsp;to the treatment.&nbsp;Do not change the&nbsp;dose&nbsp;unless your doctor tells you to.<\/li><li><strong>If you are an adult and have kidney problems,<\/strong>&nbsp;your doctor may advise you to take Tenofovir disoproxil Sandoz less often.<\/li><li>If you have HBV, your doctor may offer you an&nbsp;HIV&nbsp;test to see if you have both HBV and&nbsp;HIV&nbsp;.<\/li><\/ul>\n\n\n\n<p>Read the package leaflets of the other antiretroviral medicines for information on how to take these medicines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Tenofovir disoproxil Sandoz<\/h2>\n\n\n\n<p>If you accidentally take too many Tenofovir disoproxil Sandoz tablets, you may have a higher risk of possible&nbsp;side effects&nbsp;from this medicine (see section 4,&nbsp;<em>Possible&nbsp;side effects&nbsp;)<\/em>&nbsp;.<\/p>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.\u00a0Take the medicine packaging with you to be able to more easily describe what you have taken.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Tenofovir disoproxil Sandoz<\/h2>\n\n\n\n<p>It is important that you do not miss a&nbsp;dose&nbsp;of Tenofovir disoproxil Sandoz.&nbsp;If you miss a&nbsp;dose&nbsp;, work out when you should have taken it.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If it is less than 12 hours<\/strong>&nbsp;after the time it is usually taken, take it as soon as possible, then take the next&nbsp;dose&nbsp;at its regular time.<\/li><li><strong>If it has been more than 12 hours<\/strong>&nbsp;since you should have taken it, do not take the missed&nbsp;dose&nbsp;.&nbsp;Wait and take the next&nbsp;dose&nbsp;at its regular time.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a missed tablet.<\/li><\/ul>\n\n\n\n<p><strong>If you vomit within less than 1 hour after a&nbsp;dose&nbsp;<\/strong><strong>of Tenofovir disoproxil Sandoz&nbsp;<\/strong><strong>,<\/strong>&nbsp;take another tablet.&nbsp;You do not need to take another tablet if you vomit more than 1 hour after taking Tenofovir disoproxil Sandoz.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Tenofovir disoproxil Sandoz<\/h2>\n\n\n\n<p>Do not stop taking Tenofovir disoproxil without consulting a doctor.&nbsp;Discontinuing treatment with Tenofovir disoproxil Sandoz may result in a reduced effect of the treatment recommended by your doctor.<\/p>\n\n\n\n<p><strong>If you have&nbsp;hepatitis&nbsp;B or&nbsp;HIV&nbsp;infection&nbsp;and&nbsp;hepatitis&nbsp;B&nbsp;infection&nbsp;at the same time,&nbsp;it<\/strong>&nbsp;is very important that you do not stop treatment with Tenofovir disoproxil Sandoz without first talking to your doctor.&nbsp;Some patients&#8217; blood tests or symptoms have shown that their&nbsp;hepatitis&nbsp;has worsened after stopping treatment with this medicine.&nbsp;You may need to provide blood samples for several months after the end of treatment.&nbsp;In patients with advanced liver disease or&nbsp;cirrhosis&nbsp;, discontinuation of treatment is not recommended as this may lead to a worsening of the hepatitis infection in some patients.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Talk to your doctor before you stop taking Tenofovir disoproxil Sandoz for any reason, especially if you experience any&nbsp;side effects&nbsp;or have another illness.<\/li><li>Tell your doctor immediately about any new and unexpected symptoms that appear after stopping treatment, especially symptoms that you usually associate with your&nbsp;hepatitis&nbsp;B&nbsp;infection&nbsp;.<\/li><li>Contact your doctor before you start taking Tenofovir disoproxil Sandoz again.<\/li><\/ul>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>During&nbsp;HIV&nbsp;treatment, weight gain and increased levels of&nbsp;lipids&nbsp;and&nbsp;glucose&nbsp;in the blood may occur.&nbsp;This is partly related to restored health and lifestyle, but in the case of blood lipids there can sometimes be a connection with the&nbsp;HIV&nbsp;drugs.&nbsp;The doctor will do tests to find such changes.<\/p>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Any serious side effects: inform your doctor immediately<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lactic acidosis (excess&nbsp;lactic acid&nbsp;in the blood) is a&nbsp;<strong>rare<\/strong>&nbsp;(may affect up to 1 in 1,000 users) but serious&nbsp;side effect&nbsp;that can be fatal.&nbsp;The following&nbsp;side effects&nbsp;can be signs of lactic acidosis:<\/li><li>deep, rapid breathing<\/li><li>drowsiness<\/li><li>nausea, vomiting and abdominal pain.<\/li><\/ul>\n\n\n\n<p>If you think you may have&nbsp;<strong>lactic acidosis, contact your doctor immediately.<\/strong><\/p>\n\n\n\n<p><strong>Other possible serious&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>less common<\/strong>&nbsp;(may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>pain in the stomach<\/strong>&nbsp;(abdomen) caused by&nbsp;inflammation&nbsp;of the pancreas<\/li><li>damage to the kidney (renal tubule cells).<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>rare<\/strong>&nbsp;(may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>kidney inflammation,&nbsp;<strong>that you urinate a lot and that you feel thirsty<\/strong><\/li><li><strong>changes in urine<\/strong>&nbsp;and&nbsp;<strong><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/back-hurts\/\">back pain<\/a><\/strong>&nbsp;caused by kidney problems, including&nbsp;kidney failure<\/li><li>decreased bone hardness (causing&nbsp;<strong>bone pain<\/strong>&nbsp;and sometimes leading to&nbsp;fractures&nbsp;), which may occur due to damage to renal tubule cells<\/li><li><strong>fatty liver&nbsp;.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>If you think you may have any of these serious&nbsp;side effects&nbsp;, talk to your doctor.<\/strong><\/p>\n\n\n\n<p><strong>The most common&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>very common<\/strong>&nbsp;(may affect more than 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhoea, vomiting, nausea, dizziness, skin rash, feeling weak.<\/li><\/ul>\n\n\n\n<p><em>Samples may also show:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lowering of the phosphate level in the blood.<\/li><\/ul>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>common<\/strong>&nbsp;(may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache, stomach pain, feeling tired, feeling bloated, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/flatulence\/\">flatulence<\/a>.<\/li><\/ul>\n\n\n\n<p><em>Samples may also show:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver problems.<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>less common<\/strong>&nbsp;(may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>muscle breakdown, muscle pain or muscle weakness.<\/li><\/ul>\n\n\n\n<p><em>Samples may also show:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lowered potassium levels in the blood<\/li><li>increased creatinine level in the blood<\/li><li>pancreatic disorders.<\/li><\/ul>\n\n\n\n<p>The breakdown of muscles, decreased bone hardness (which causes bone pain and sometimes leads to&nbsp;fracture&nbsp;), muscle pain, muscle weakness and lowered&nbsp;potassium&nbsp;or phosphate levels in the blood can occur due to damage to kidney tubule cells.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>rare<\/strong>&nbsp;(may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pain in the stomach (abdomen) caused by&nbsp;inflammation&nbsp;of the liver<\/li><li>swelling of the face, lips, tongue or throat.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tenofovir disoproxil Sandoz<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the can, carton or blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Opened can must be used within 30 days.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among household waste.&nbsp;Ask the pharmacist how to dispose of medicines that are no longer used.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tenofovir disoproxil.&nbsp;Each film-coated tablet contains 245 mg tenofovir disoproxil.<\/li><li>Other ingredients are:<em>Tablet core:<\/em>&nbsp;microcrystalline cellulose,&nbsp;lactose monohydrate&nbsp;, pregelatinized corn starch, crospovidone (type B), magnesium stearate.<em>Film coating:<\/em>&nbsp;hypromellose, titanium dioxide (E171), macrogol 400, polysorbate 80.<br>See section 2 &#8220;Tenofovir disoproxil Sandoz contains lactose&#8221;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>White, almond-shaped, biconvex film-coated tablets with dimensions 16 mm x 10 mm, marked on one side with &#8220;H&#8221; and on the other side with &#8220;T11&#8221;.<\/p>\n\n\n\n<p>OPA-Al-PVC\/Al single-dose blister packs.<\/p>\n\n\n\n<p>Pack sizes: 30&#215;1, 60&#215;1 and 90&#215;1 film-coated tablets.<\/p>\n\n\n\n<p>White, opaque HDPE jar with white, opaque, child-resistant polypropylene screw cap.&nbsp;The jar contains desiccant (silica gel capsule) and purified rayon.<\/p>\n\n\n\n<p>Pack sizes: 30, 60 (2&#215;30) and 90 (3&#215;30) film-coated tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Sandoz A\/S, Edvard Thomsens Vej 14, 2300 Copenhagen S, Denmark<\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>Salutas Pharma GmbH, Otto-von-Guericke-Allee 1, 39179 Barleben, Germany<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Pharmadox Ltd., KW20A Kordin Industrial Park, Paola PLA 3000, Malta<\/p>\n","protected":false},"excerpt":{"rendered":"<p>245 mg\u00a0film-coated tablets<br \/>\ntenofovir disoproxil<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[3389,4336,4338,4339,4331,4332,4330,4337,13322,25588],"class_list":["post-24669","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-tenofovir-disoproxil","tag-tenofovir-disoproxil-sandoz","tag-tenofovir-disoproxil-sandoz-side-effects","tag-tenofovir-disoproxil-sandoz-tablet","tag-tenofovir-disoproxil-side-effects","tag-tenofovir-disoproxil-tablet","tag-what-is-tenofovir-disoproxil","tag-what-is-tenofovir-disoproxil-sandoz","tag-what-tenofovir-disoproxil-is-used-for","tag-what-tenofovir-disoproxil-sandoz-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24669"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24669\/revisions"}],"predecessor-version":[{"id":24708,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24669\/revisions\/24708"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24669"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24669"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}