{"id":24663,"date":"2022-08-29T11:49:42","date_gmt":"2022-08-29T11:49:42","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24663"},"modified":"2022-08-30T07:39:51","modified_gmt":"2022-08-30T07:39:51","slug":"tenofovir-disoproxil-accordpharma","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tenofovir-disoproxil-accordpharma\/","title":{"rendered":"Tenofovir Disoproxil Accordpharma &#8211; Tenofovir disoproxil uses, dose and side effects"},"content":{"rendered":"\n<p>245 mg&nbsp;film-coated tablets<br>tenofovir disoproxil<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tenofovir disoproxil Accordpharma is and what it is used for<\/h2>\n\n\n\n<p>Tenofovir disoproxil Accordpharma contains the active substance\u00a0<em>tenofovir disoproxil<\/em>.\u00a0This active substance is an\u00a0antiretroviral\u00a0or antiviral medicine used to treat\u00a0HIV\u00a0or HBV\u00a0infection\u00a0or both.\u00a0Tenofovir is a\u00a0reverse transcriptase inhibitor of the nucleotide type, generally called an NRTI, and works by affecting the normal function of\u00a0enzymes\u00a0(in the case of\u00a0HIV\u00a0reverse transcriptase; in the case of HBV\u00a0DNA\u00a0polymerase\u00a0) that the\u00a0virus\u00a0needs for its reproduction (propagation).\u00a0In\u00a0HIV should Tenofovir disoproxil Accordpharma always be taken in combination with other medicines against\u00a0HIV?<\/p>\n\n\n\n<p>Tenofovir disoproxil Accordpharma 245 mg tablets is a treatment for\u00a0HIV\u00a0(human immunodeficiency virus)\u00a0infection.\u00a0The tablets are suitable for:<\/p>\n\n\n\n<p>adults<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>young people aged 12 to younger than 18 years who have already been treated with other\u00a0HIV\u00a0medicines that no longer have a satisfactory effect due to the development of resistance or have caused\u00a0side effects.<\/li><\/ul>\n\n\n\n<p><strong>Tenofovir disoproxil Accordpharma 245 mg tablets are also used as a treatment for\u00a0chronic\u00a0hepatitis\u00a0B, infection\u00a0with HBV<\/strong>\u00a0(\u00a0hepatitis\u00a0B\u00a0virus\u00a0).\u00a0The tablets are suitable for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>adults<\/li><li>young people aged 12 to younger than 18 years.<\/li><\/ul>\n\n\n\n<p>You do not need to have&nbsp;HIV&nbsp;to be treated with Tenofovir disoproxil Accordpharma for HBV.<\/p>\n\n\n\n<p>This medicine does not\u00a0cure\u00a0HIV\u00a0infection.\u00a0While taking Tenofovir disoproxil Accordpharma you may still develop\u00a0an infection\u00a0or\u00a0other diseases associated with\u00a0HIV\u00a0infection.\u00a0You can also pass\u00a0HIV\u00a0or HBV on to others, so you must take precautions to avoid infecting other people.<\/p>\n\n\n\n<p>Tenofovir disoproxil contained in Tenofovir disoproxil Accordpharma may also be approved to treat other diseases not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Tenofovir disoproxil Accordpharma<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Tenofovir disoproxil Accordpharma<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to tenofovir, tenofovir disoproxil, or any of the other ingredients of this medicine listed in section 6.<\/li><\/ul>\n\n\n\n<p>If this applies to you, tell your doctor immediately and stop taking Tenofovir disoproxil Accordpharma.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Tenofovir disoproxil Accordpharma.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Be careful not to infect other people.&nbsp;<\/strong>You can still transmit&nbsp;HIV&nbsp;when taking this medicine, although the risk is reduced with effective&nbsp;antiviral&nbsp;treatment.&nbsp;Discuss with your doctor the necessary measures to avoid infecting others.&nbsp;Tenofovir disoproxil Accordpharma does not reduce the risk of transmitting HBV to others through sexual contact or blood infection.&nbsp;You still need to take precautions to avoid this.<\/li><li><strong>Talk to your doctor or pharmacist if you have had kidney disease in the past or if tests have shown that you have problems with your kidneys.&nbsp;<\/strong>Tenofovir disoproxil Accordpharma should not be given to adolescents with kidney problems.&nbsp;Before starting the treatment, your doctor may&nbsp;order&nbsp;some blood tests to assess that your kidneys are working normally.&nbsp;Tenofovir disoproxil Accordpharma may affect your kidneys during treatment.&nbsp;Your doctor may&nbsp;order&nbsp;blood tests during treatment to check how your kidneys are working.&nbsp;If you are an adult, your doctor may advise you to take the tablets less often.&nbsp;Do not reduce the prescribed&nbsp;dose by&nbsp;one unless your doctor has told you to do so.<br><br>Tenofovir disoproxil Accordpharma is usually not taken together with other medicines that can damage the kidneys (see&nbsp;<em>Other medicines and Tenofovir disoproxil Accordpharma<\/em>&nbsp;).&nbsp;If this cannot be avoided, your doctor will check your kidney function once a week.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Skeletal problems.\u00a0<\/strong>Some adult patients with\u00a0HIV\u00a0receiving\u00a0combination\u00a0antiretroviral\u00a0therapy may develop a bone disease called\u00a0osteonecrosis\u00a0(bone tissue dies due to loss of blood supply to the bone).\u00a0Some of the many risk factors for developing the disease are long-term\u00a0combination\u00a0antiretroviral\u00a0therapy, use of\u00a0corticosteroids, alcohol consumption, severe impairment of the immune system, and higher body mass index.\u00a0Signs of\u00a0osteonecrosis\u00a0are joint stiffness and <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a> (especially in the hip, knee, and shoulders) and difficulty moving.\u00a0Tell your doctor if you experience any of these symptoms.\u00a0For adult patients:<br><br><br><br>Bone problems (manifesting as persistent or worsening bone pain and sometimes leading to\u00a0fractures\u00a0) may also occur due to damage to renal tubule cells (see section 4,\u00a0Possible\u00a0side effects\u00a0).\u00a0Tell your doctor if you have bone pain or\u00a0a fracture.<br><br>Tenofovir disoproxil can also cause loss of bone mass.\u00a0The most pronounced loss of bone mass was seen in\u00a0clinical trials\u00a0when patients were treated with tenofovir disoproxil in combination with a boosted\u00a0protease inhibitor.<br><br>Overall, the effects of tenofovir disoproxil on long-term bone health and future fracture risk in adults and children are uncertain.<br><br>Tell your doctor if you know you have osteoporosis.\u00a0Patients with osteoporosis are at higher risk of\u00a0fracture.<br><br>Children and adolescents:<br><br>Bone problems (manifesting as persistent or worsening bone pain and sometimes leading to\u00a0fractures\u00a0) may also occur due to damage to renal tubule cells (see section 4,\u00a0Possible\u00a0side effects\u00a0).\u00a0Tell your child&#8217;s doctor if your child has bone pain or\u00a0a fracture.<br><br>Tenofovir disoproxil can also cause loss of bone mass.\u00a0The most pronounced loss of bone mass was seen in\u00a0clinical trials\u00a0when patients were treated with tenofovir disoproxil in combination with a boosted\u00a0protease inhibitor.<br><br>Overall, the effects of tenofovir disoproxil on long-term bone health and future fracture risk in adults and children are uncertain.<br><br>Tell your child&#8217;s doctor if your child has osteoporosis.\u00a0Patients with osteoporosis are at higher risk of\u00a0fracture.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Inform your doctor if you already have or have had liver disease, including\u00a0hepatitis.\u00a0<\/strong>Patients with liver disease, including\u00a0chronic\u00a0hepatitis\u00a0B or C, who are treated with antiretroviral agents are at increased risk of severe and potentially fatal liver complications.\u00a0If you have\u00a0hepatitis\u00a0B, your doctor will carefully choose the best treatment for you.\u00a0If you have or have had liver disease or\u00a0chronic\u00a0hepatitis\u00a0B, your doctor may take blood tests to check liver function.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Be observant about\u00a0infection<\/strong>.\u00a0If you have\u00a0advanced\u00a0HIV\u00a0infection\u00a0(\u00a0AIDS\u00a0) and have an\u00a0infection, you may develop symptoms of\u00a0infection\u00a0and\u00a0inflammation\u00a0or worsening of the symptoms of an existing\u00a0infection\u00a0when treatment with Tenofovir disoproxil Accordpharma is started.\u00a0These symptoms may indicate that your body&#8217;s improved immune system is fighting\u00a0infection.\u00a0Watch for signs of\u00a0inflammation\u00a0or\u00a0infection\u00a0during the first period after you start taking Tenofovir disoproxil Accordpharma.\u00a0If you discover signs of inflammation\u00a0or\u00a0infection,\u00a0you should immediately inform your doctor.<br><br>In addition to opportunistic\u00a0infections, autoimmune disorders (conditions where the immune system attacks healthy body tissue) can also occur after you start taking medicines to treat\u00a0your\u00a0HIV\u00a0infection.\u00a0Autoimmune disorders may occur several months after starting treatment.\u00a0If you notice any symptoms of\u00a0infection\u00a0or other symptoms such as muscle weakness, a weakness that starts in the hands or feet and moves to the trunk, palpitations, tremors, or hyperactivity, inform your doctor immediately to get the necessary treatment.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor or pharmacist if you are over 65.&nbsp;<\/strong>Tenofovir disoproxil Accordpharma has not been studied in patients over 65 years of age.&nbsp;If you are older than that and have been prescribed Tenofovir disoproxil Accordpharma, your doctor will monitor you closely.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Tenofovir disoproxil Accordpharma 245 mg film-coated tablets are suitable for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>HIV\u00a0-1 -infected young people aged 12 to less than 18 years who weigh at least 35 kg and who have already been treated<\/strong>\u00a0with other\u00a0HIV\u00a0drugs that no longer have the full effect due to the development of resistance or have caused\u00a0side effects.<\/li><li><strong>HBV\u2011infected adolescents aged 12 years to younger than 18 years who weigh at least 35 kg.<\/strong><\/li><\/ul>\n\n\n\n<p>Tenofovir disoproxil Accordpharma 245 mg film-coated tablets are not suitable for the following groups:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Not for&nbsp;HIV&nbsp;-1-infected children<\/strong>&nbsp;under 12 years of age<\/li><li><strong>Not for HBV\u2011infected children<\/strong>&nbsp;under 12 years of age.<\/li><\/ul>\n\n\n\n<p>For\u00a0dosage, see section 3,\u00a0<em>How to take Tenofovir disoproxil Accordpharma.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tenofovir disoproxil Accordpharma<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Do not stop taking any anti-HIV<\/strong>\u00a0medicine prescribed by your doctor when you start taking Tenofovir disoproxil Accordpharma if you have both HBV and\u00a0HIV.<\/li><li><strong>Do not take Tenofovir disoproxil Accordpharma<\/strong>\u00a0if you are already taking other medicines containing tenofovir disoproxil or tenofovir alafenamide.\u00a0Do not take Tenofovir disoproxil Accordpharma together with medicines containing adefovir dipivoxil (a medicine used to treat\u00a0chronic\u00a0hepatitis\u00a0B).<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>You must tell<\/strong> your doctor if you are taking other medicines that can damage your kidneys.\u00a0Such drugs are:<ul><li>aminoglycosides, pentamidine, or vancomycin (against a bacterial\u00a0infection\u00a0)<\/li><li>amphotericin B (for fungal infection)<\/li><li>foscarnet, ganciclovir, or cidofovir (for viral infection)<\/li><li>interleukin\u00a0\u20112 (for the treatment of <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a>)<\/li><li>adefovir dipivoxil (for HBV)<\/li><li>tacrolimus (for\u00a0suppression\u00a0of the immune system)<\/li><li>non-steroidal anti-inflammatory drugs (\u00a0NSAIDs, to relieve bone or muscle pain).<\/li><\/ul><\/li><li><strong>Other medicines containing didanosine (for\u00a0HIV\u00a0infection\u00a0): If you take Tenofovir\u00a0disoproxil<\/strong>\u00a0Accordpharma together with other antiviral medicines containing didanosine, the blood levels of didanosine may increase and the CD4 cell count may decrease.\u00a0Rare cases of pancreatitis and lactic acidosis (excess\u00a0lactic acid\u00a0in the blood), in some cases with a fatal outcome, have been reported during concomitant treatment with medicines containing tenofovir disoproxil and didanosine.\u00a0Your doctor will carefully consider whether you can be treated with a combination of tenofovir and didanosine.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>It is also important that you tell your doctor<\/strong>&nbsp;if you are taking ledipasvir\/sofosbuvir, sofosbuvir\/velpatasvir or sofosbuvir\/velpatasvir\/voxilaprevir to treat&nbsp;hepatitis&nbsp;C&nbsp;infection&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Tenofovir disoproxil Accordpharma with food and drink<\/h2>\n\n\n\n<p>Take Tenofovir disoproxil Accordpharma with food (eg a meal or a snack).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you have taken Tenofovir disoproxil Accordpharma<\/strong>\u00a0during your pregnancy, the doctor may request that the baby regularly give blood samples and undergo other examinations to check the baby&#8217;s development.\u00a0For children whose\u00a0mothers\u00a0took NRTIs during pregnancy, the benefit of protection against\u00a0HIV\u00a0is greater than the risk of\u00a0side effects.<\/li><\/ul>\n\n\n\n<p><em>For adult patients:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are a mother and you have HBV and your baby has received treatment to prevent the transmission of&nbsp;hepatitis&nbsp;B at birth, you may be able to breastfeed your baby, but talk to your doctor first for more information<\/li><li>If you are an&nbsp;HIV&nbsp;-infected mother, you should not breastfeed your baby to avoid transmission of the&nbsp;virus&nbsp;to the baby through breast milk.<\/li><\/ul>\n\n\n\n<p><em>Children and young people:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If your baby has HBV, and her baby has received treatment to prevent the transmission of\u00a0hepatitis\u00a0B at birth, your baby may be able to breastfeed her baby but talk to your baby&#8217;s doctor first for more information<\/li><li>If your child has\u00a0HIV, she should not breastfeed her infant to avoid transmission of the\u00a0virus\u00a0et to the baby through breast milk.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Tenofovir disoproxil Accordpharma may cause dizziness.&nbsp;Do not drive or cycle or use tools or machines if you feel dizzy while taking Tenofovir disoproxil Accordpharma.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tenofovir disoproxil Accordpharma contains lactose and sodium<\/h2>\n\n\n\n<p>Talk to your doctor before taking Tenofovir disoproxil Accordpharma.&nbsp;If you have an intolerance to certain sugars, you should consult your doctor before taking this medicine.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Tenofovir disoproxil Accordpharma<\/h2>\n\n\n\n<p><strong>Always take this medicine as directed by your doctor or pharmacist.&nbsp;<\/strong>Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Adults:<\/strong>&nbsp;1 tablet a day with food (e.g. a meal or a snack).<\/li><li><strong>Adolescents aged 12 to less than 18 years weighing at least 35 kg:<\/strong>&nbsp;1 tablet a day with food (eg a meal or a snack).<\/li><\/ul>\n\n\n\n<p>If you have particular difficulty swallowing, you can crush the tablet with the tip of a spoon.\u00a0Then mix the powder with about 100 ml (half a glass) of water, orange juice, or grape juice and drink immediately.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Always take the\u00a0dose\u00a0prescribed by the doctor<\/strong>\u00a0to ensure that the medicine is effective and to reduce the development of\u00a0resistance\u00a0to the treatment.\u00a0Do not change the\u00a0dose\u00a0unless your doctor tells you to.<\/li><li><strong>If you are an adult and have kidney problems,<\/strong>\u00a0your doctor may advise you to take Tenofovir disoproxil Accordpharma less often.<\/li><li>If you have HBV, your doctor may offer you an\u00a0HIV\u00a0test to see if you have both HBV and\u00a0HIV.<\/li><\/ul>\n\n\n\n<p>Read the package leaflets of the other antiretroviral medicines for information on how to take these medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Tenofovir disoproxil Accordpharma<\/h2>\n\n\n\n<p>If you accidentally take too many Tenofovir disoproxil Accordpharma tablets, you may be at risk of possible\u00a0side effects\u00a0from this medicine (see section 4,\u00a0<em>Possible\u00a0side effects\u00a0)<\/em>.\u00a0If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.\u00a0Save the blister so you can easily describe what you have taken.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Tenofovir disoproxil Accordpharma<\/h2>\n\n\n\n<p>You mustn&#8217;t miss a\u00a0dose\u00a0of Tenofovir disoproxil Accordpharma.\u00a0If you miss a\u00a0dose, work out when you should have taken it.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If it is less than 12 hours<\/strong>\u00a0after the time it is usually taken, take it as soon as possible, then take the next\u00a0dose\u00a0at its regular time.<\/li><li><strong>If it has been more than 12 hours<\/strong>\u00a0since you should have taken it, do not take the missed\u00a0dose.\u00a0Wait and take the next\u00a0dose\u00a0at its regular time.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed tablet.<\/li><\/ul>\n\n\n\n<p><strong>If you vomit less than 1 hour after a&nbsp;dose&nbsp;of Tenofovir disoproxil Accordpharma,<\/strong>&nbsp;take another tablet.&nbsp;You do not need to take another tablet if you vomit more than 1 hour after taking Tenofovir disoproxil Accordpharma.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Tenofovir disoproxil Accordpharma<\/h2>\n\n\n\n<p>Do not stop taking Tenofovir disoproxil Accordpharma without consulting your doctor.&nbsp;Discontinuing treatment with Tenofovir disoproxil Accordpharma may result in a reduced effect of the treatment recommended by your doctor.<\/p>\n\n\n\n<p><strong>If you have\u00a0hepatitis\u00a0B or\u00a0HIV\u00a0infection\u00a0and\u00a0hepatitis\u00a0B\u00a0infection\u00a0at the same time,\u00a0you mustn&#8217;t<\/strong> stop Tenofovir disoproxil Accordpharma treatment without first talking to your doctor.\u00a0Some patients&#8217; blood tests or symptoms have shown that their\u00a0hepatitis\u00a0has worsened after stopping treatment with Tenofovir disoproxil Accordpharma.\u00a0You may need to provide blood samples for several months after the end of treatment.\u00a0In patients with advanced liver disease or\u00a0cirrhosis, discontinuation of treatment is not recommended as this may lead to a worsening of the hepatitis infection in some patients.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Talk to your doctor before you stop taking Tenofovir disoproxil Accordpharma for any reason, especially if you experience any\u00a0side effects\u00a0or have another illness.<\/li><li>Inform your doctor immediately of any new and unexpected symptoms that appear after stopping treatment, especially symptoms that you usually associate with your\u00a0hepatitis\u00a0B\u00a0infection.<\/li><li>Contact your doctor before you start taking Tenofovir disoproxil Accordpharma again.<\/li><\/ul>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>During\u00a0HIV\u00a0treatment, weight gain and increased levels of\u00a0lipids\u00a0and\u00a0glucose\u00a0in the blood may occur.\u00a0This is partly related to restored health and lifestyle, but in the case of blood lipids, there can sometimes be a connection with HIV\u00a0drugs.\u00a0The doctor will do tests to find such changes.<\/p>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Any serious side effects: inform your doctor immediately<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Lactic acidosis<\/strong>\u00a0(excess lactic acid in the blood) is a\u00a0<strong>rare<\/strong>\u00a0(may affect up to 1 in 1,000 users) but serious\u00a0side effect\u00a0that can be fatal.\u00a0The following\u00a0side effects\u00a0can be signs of lactic acidosis:<ul><li>deep, rapid breathing<\/li><li>drowsiness<\/li><li>nausea, vomiting, and abdominal pain<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>If you think you may have&nbsp;<strong>lactic acidosis, contact your doctor immediately.<\/strong><\/p>\n\n\n\n<p><strong>Other possible serious\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>less common<\/strong>&nbsp;(may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>pain in the stomach<\/strong>&nbsp;(abdomen) caused by&nbsp;inflammation&nbsp;of the pancreas<\/li><li>damage to the kidney (renal tubule cells)<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>rare<\/strong>&nbsp;(may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>kidney inflammation, that you\u00a0<strong>urinate a lot, and that you feel thirsty<\/strong><\/li><li><strong>changes in urine<\/strong>\u00a0and\u00a0<strong><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/back-hurts\/\">back pain<\/a><\/strong>\u00a0caused by kidney problems, including\u00a0kidney failure<\/li><li>decreased bone hardness (which causes\u00a0<strong>bone pain<\/strong>\u00a0and sometimes leads to\u00a0fractures\u00a0), which can occur due to damage to kidney tubule cells.<\/li><li>fatty liver<\/li><\/ul>\n\n\n\n<p><strong>If you think you may have any of these serious\u00a0side effects, talk to your doctor.<\/strong><\/p>\n\n\n\n<p><strong>The most common&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>very common&nbsp;(<\/strong>&nbsp;may affect more than 10 users in 100):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea, vomiting, nausea, dizziness, skin rash, feeling weak<\/li><\/ul>\n\n\n\n<p><em>Samples may also show:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lowering of the phosphate level in the blood<\/li><\/ul>\n\n\n\n<p><strong>Other possible\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>common<\/strong>&nbsp;(may affect up to 10 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache, stomach (abdominal) pain, feeling tired, feeling bloated, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/flatulence\/\">flatulence<\/a><\/li><\/ul>\n\n\n\n<p><em>Samples may also show:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver problems<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>less common<\/strong>&nbsp;(may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>muscle breakdown, muscle pain, or muscle weakness<\/li><\/ul>\n\n\n\n<p><em>Samples may also show:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lowered potassium levels in the blood<\/li><li>increased creatinine level in the blood<\/li><li>pancreatic disorders<\/li><\/ul>\n\n\n\n<p>The breakdown of muscles decreased bone hardness (which causes bone pain and sometimes leads to\u00a0fractures\u00a0), muscle pain, muscle weakness, and lowered\u00a0potassium\u00a0or phosphate levels in the blood can occur due to damage to kidney tubule cells.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>rare<\/strong>&nbsp;(may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pain in the stomach (abdomen) caused by\u00a0inflammation\u00a0of the liver<\/li><li>swelling of the face, lips, tongue, or throat.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tenofovir disoproxil Accordpharma<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 30 \u00b0C.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tenofovir.\u00a0Each Tenofovir disoproxil Accordpharma tablet contains 245 mg of tenofovir disoproxil (as fumarate).<\/li><li>Other ingredients are microcrystalline cellulose (E460),\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/lactose-intolerance\/\">lactose<\/a> monohydrate, pregelatinized\u00a0starch\u00a0(maize), croscarmellose sodium (E468), and magnesium stearate (E407b) which make up the tablet core and hypromellose (E464),\u00a0lactose monohydrate, titanium dioxide (E171) and triacetin (E1518) which make up the tablet coating.\u00a0See section 2 &#8220;Tenofovir disoproxil Accordpharma contains lactose&#8221;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tenofovir disoproxil Accordpharma 245 mg film-coated tablets are white, almond-shaped, film-coated tablets approximately 16.9 mm long and 10.4 mm wide, debossed with \u201cH\u201d on one side and \u201c123\u201d on the other side.<\/p>\n\n\n\n<p>Tenofovir disoproxil Accordpharma 245 mg film-coated tablets are supplied in Aluminium\/PVC\/Aluminium\/OPA (unit dose) blister packs containing 30 x 1 film-coated tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 VK Utrecht<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Paradox Healthcare Ltd<\/p>\n\n\n\n<p>KW20A Kordin Industrial Park<\/p>\n\n\n\n<p>Paola, PLA 3000<\/p>\n\n\n\n<p>Malta<\/p>\n\n\n\n<p>Accord Healthcare Limited,<\/p>\n\n\n\n<p>Sage House, 319 Pinner road, North Harrow,<\/p>\n\n\n\n<p>Middlesex, HA1 4HF, United Kingdom<\/p>\n\n\n\n<p>LABORATORIES FUNDACI\u00d3 DAU<\/p>\n\n\n\n<p>C\/ C, 12-14 Pol.&nbsp;Ind.&nbsp;Zona Franca,<\/p>\n\n\n\n<p>Barcelona, \u200b\u200b08040, Spain<\/p>\n","protected":false},"excerpt":{"rendered":"<p>245 mg\u00a0film-coated tablets<br \/>\ntenofovir disoproxil<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[3389,25597,25600,4331,4332,4330,25598,25599,13322],"class_list":["post-24663","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-tenofovir-disoproxil","tag-tenofovir-disoproxil-accordpharma","tag-tenofovir-disoproxil-accordpharma-side-effects","tag-tenofovir-disoproxil-side-effects","tag-tenofovir-disoproxil-tablet","tag-what-is-tenofovir-disoproxil","tag-what-is-tenofovir-disoproxil-accordpharma","tag-what-tenofovir-disoproxil-accordpharma-tablet","tag-what-tenofovir-disoproxil-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24663","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24663"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24663\/revisions"}],"predecessor-version":[{"id":24707,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24663\/revisions\/24707"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24663"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}