{"id":24627,"date":"2022-08-26T10:59:54","date_gmt":"2022-08-26T10:59:54","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24627"},"modified":"2022-08-29T11:45:07","modified_gmt":"2022-08-29T11:45:07","slug":"temozolomide-sun","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/temozolomide-sun\/","title":{"rendered":"Temozolomide SUN &#8211; Temozolomide uses, dose and side effects"},"content":{"rendered":"\n<p>5 mg, 20 mg, 100 mg, 140 mg, 180 mg, 250 mg&nbsp;hard capsules<br>temozolomide<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Temozolomide SUN is and what it is used for<\/h2>\n\n\n\n<p>Temozolomide SUN contains the medicine temozolomide.\u00a0This medicine is used to treat\u00a0tumors.<\/p>\n\n\n\n<p>Temozolomide SUN is used to treat certain types of brain tumors:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>in adults with newly diagnosed\u00a0glioblastoma multiforme.\u00a0Temozolomide SUN is first used together with radiotherapy (concomitant treatment phase) and then alone (monotherapy phase).<\/li><li>in children older than 3 years and adult patients with malignant\u00a0glioma, e.g.\u00a0glioblastoma multiforme\u00a0or\u00a0anaplastic astrocytoma.\u00a0Temozolomide SUN is used for these\u00a0tumors\u00a0if they recur or worsen after standard treatment.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Temozolomide SUN<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Temozolomide SUN<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to temozolomide or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have had an&nbsp;allergic reaction&nbsp;to dacarbazine (an anticancer medicine sometimes called DTIC).&nbsp;Signs of an&nbsp;allergic reaction&nbsp;may include&nbsp;itching&nbsp;, shortness of breath or wheezing, or swelling of the face, lips, tongue or throat.<\/li><li>about the number of certain types of blood cells, e.g.&nbsp;white blood cells&nbsp;, or&nbsp;platelets&nbsp;, drop drastically (called myelosuppression).&nbsp;These blood cells are important as protection against&nbsp;infection&nbsp;and for functioning blood coagulation.&nbsp;The doctor will check your blood to make sure you have enough of these cells before you start treatment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist or nurse before taking Temozolomide SUN<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>because you should be closely monitored for the development of a serious form of&nbsp;pneumonia&nbsp;called&nbsp;<em>Pneumocystis jirovecii&nbsp;<\/em>pneumonia&nbsp;(PCP).&nbsp;If you have recently been diagnosed with&nbsp;glioblastoma multiforme&nbsp;, you can receive Temozolomide SUN for 42 days in combination with radiotherapy.&nbsp;In this case, your doctor also prescribes medication to help prevent this type of&nbsp;pneumonia&nbsp;(PCP).<\/li><li>if you have ever had or possibly now have&nbsp;hepatitis&nbsp;B&nbsp;infection&nbsp;.&nbsp;Temozolomide SUN can cause&nbsp;hepatitis&nbsp;B to become active again and in some cases this can lead to death.&nbsp;Patients will be carefully examined by their doctor for signs of this&nbsp;infection&nbsp;before starting treatment.<\/li><li>if you have a low number of red&nbsp;blood cells&nbsp;(&nbsp;anaemia&nbsp;),&nbsp;white blood cells&nbsp;and&nbsp;platelets&nbsp;, or have problems with blood clotting before starting treatment or if you develop this problem during treatment.&nbsp;Your blood will be tested frequently during treatment to monitor&nbsp;side effects&nbsp;of Temozolomide SUN on your blood cells.&nbsp;Your doctor may reduce the&nbsp;dose&nbsp;, interrupt, stop or change the treatment.&nbsp;You may also need some other treatment.&nbsp;In some cases, it may be necessary to stop treatment with Temozolomide SUN.<\/li><li>because you may have a small risk of getting other blood cell changes, including&nbsp;leukemia&nbsp;.<\/li><li>if you have nausea and vomiting, which are common&nbsp;side effects&nbsp;of Temozolomide SUN (see section 4), your doctor may prescribe a medicine (&nbsp;antiemetic&nbsp;) to prevent vomiting.&nbsp;If you often vomit before or during treatment, ask your doctor when it is best to take Temozolomide SUN until the vomiting is under control.&nbsp;If you vomit after taking your&nbsp;dose&nbsp;, do not take a second&nbsp;dose&nbsp;on the same day.<\/li><li>if you develop a fever or symptoms of an&nbsp;infection&nbsp;, contact your doctor immediately.<\/li><li>if you are older than 70, you may be more susceptible to infection and bruise or bleed more easily.<\/li><li>if you have liver or kidney problems, the&nbsp;dose&nbsp;of Temozolomide SUN may need to be adjusted.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this medicine to children younger than 3 years because there is no experience.&nbsp;There is only limited information in patients older than 3 years who have taken Temozolomide SUN.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Temozolomide SUN<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.&nbsp;You should not be treated with Temozolomide SUN if you are pregnant unless your doctor clearly tells you so.<\/p>\n\n\n\n<p>Effective contraceptive methods must be used by&nbsp;<strong>both male and female patients<\/strong>&nbsp;taking Temozolomide SUN (see also below &#8220;Male Fertility&#8221;).<\/p>\n\n\n\n<p>Breast-feeding should be discontinued during treatment with Temozolomide SUN.<\/p>\n\n\n\n<p><strong>Male&nbsp;fertility<\/strong><\/p>\n\n\n\n<p>Temozolomide SUN can cause permanent&nbsp;infertility&nbsp;.&nbsp;Male patients should use an effective method of contraception and not have children up to 6 months after finishing treatment.&nbsp;It is recommended to consult about sperm freezing before starting treatment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Temozolomide SUN may make you feel tired or sleepy.&nbsp;If this is the case, do not drive or use tools or machines or cycle until you know how this medicine affects you (see section 4).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Temozolomide SUN contains lactose<\/h2>\n\n\n\n<p>Temozolomide SUN contains&nbsp;lactose&nbsp;(a type of sugar).&nbsp;If you have an intolerance to certain sugars, you should consult a doctor before taking this medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Temozolomide SUN<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Dosage&nbsp;and duration of treatment<\/strong><\/p>\n\n\n\n<p>Your doctor will determine the appropriate&nbsp;dose&nbsp;of Temozolomide SUN.&nbsp;It is based on your body size (height and weight) and whether you have a recurrent&nbsp;tumor&nbsp;and have previously received chemotherapy (&nbsp;chemotherapy&nbsp;).<\/p>\n\n\n\n<p>You may be given other medicines (antiemetics) to take before and\/or after taking Temozolomide SUN to prevent or control nausea and vomiting.<\/p>\n\n\n\n<p><strong><em>Patients with newly diagnosed&nbsp;glioblastoma multiforme<\/em><\/strong><\/p>\n\n\n\n<p>If you have recently received your diagnosis, treatment takes place in two phases:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>first treatment together with radiotherapy (concomitant treatment phase)<\/li><li>followed by treatment with Temozolomide SUN alone (monotherapy phase).<\/li><\/ul>\n\n\n\n<p>During the concomitant treatment phase, your doctor starts with a&nbsp;dose&nbsp;of 75 mg\/m&nbsp;<sup>2<\/sup>&nbsp;of Temozolomide SUN (usual&nbsp;dose&nbsp;).&nbsp;You take this&nbsp;dose&nbsp;every day for 42 to 49 days in combination with radiation therapy.&nbsp;Dose&nbsp;one of Temozolomide SUN may be delayed or interrupted, depending on your blood levels and how well you tolerate the medicine during the concomitant treatment phase.<\/p>\n\n\n\n<p>You will have a treatment break for 4 weeks when the radiation treatment is finished.&nbsp;This break gives your body the opportunity to recover.<\/p>\n\n\n\n<p>Then the monotherapy phase begins.<\/p>\n\n\n\n<p>During the monotherapy phase, the&nbsp;dose&nbsp;and the way you take Temozolomide SUN may vary.&nbsp;Your doctor will calculate exactly what&nbsp;dose&nbsp;you should have.&nbsp;There can be up to 6 treatment periods (cycles).&nbsp;Each of these lasts for 28 days.&nbsp;The first&nbsp;dose&nbsp;will be 150 mg\/m&nbsp;<sup>2<\/sup>&nbsp;.&nbsp;You will take your new&nbsp;dose&nbsp;of Temozolomide SUN once daily for the first 5 days (&#8220;dosing days&#8221;) of each cycle.&nbsp;Then you will have 23 days without Temozolomide SUN.&nbsp;This gives a treatment cycle of 28 days.<\/p>\n\n\n\n<p>After day 28, the next treatment cycle begins.&nbsp;You take Temozolomide SUN again once daily for 5 days followed by 23 days without Temozolomide SUN.&nbsp;Dose&nbsp;one of Temozolomide SUN may be adjusted, delayed or discontinued, depending on your blood levels and how well you tolerate the medicine during each treatment cycle.<\/p>\n\n\n\n<p><strong><em>Patients with recurrent&nbsp;tumors&nbsp;or&nbsp;tumors&nbsp;that have worsened (malignant&nbsp;glioma&nbsp;, eg&nbsp;glioblastoma multiforme&nbsp;or&nbsp;anaplastic astrocytoma&nbsp;) taking only Temozolomide SUN<\/em><\/strong><\/p>\n\n\n\n<p>A treatment cycle with Temozolomide SUN lasts 28 days.<\/p>\n\n\n\n<p>You will only take Temozolomide SUN once a day for the first 5 days.&nbsp;The daily&nbsp;dose&nbsp;depends on whether you have received&nbsp;chemotherapy&nbsp;before.<\/p>\n\n\n\n<p>If you have not previously been treated with&nbsp;chemotherapy&nbsp;, your first&nbsp;dose&nbsp;of Temozolomide SUN will be 200 mg\/m2&nbsp;<sup>once<\/sup>&nbsp;daily for the first 5 days.&nbsp;If you have previously been treated with&nbsp;chemotherapy&nbsp;, your first&nbsp;dose&nbsp;of Temozolomide SUN will be 150 mg\/m&nbsp;<sup>2<\/sup>&nbsp;once daily for the first 5 days.&nbsp;Then you will have 23 days without Temozolomide SUN.&nbsp;This gives a treatment cycle of 28 days.<\/p>\n\n\n\n<p>After day 28, the next treatment cycle begins.&nbsp;You take Temozolomide SUN again once daily for 5 days followed by 23 days without Temozolomide SUN.<\/p>\n\n\n\n<p>Before each treatment cycle, your blood is tested to see if the&nbsp;dose&nbsp;of Temozolomide SUN needs to be adjusted.&nbsp;Your doctor may adjust your&nbsp;dose&nbsp;for the next treatment cycle, depending on your blood test results.<\/p>\n\n\n\n<p><strong>How to take Temozolomide SUN<\/strong><\/p>\n\n\n\n<p>Take your&nbsp;dose&nbsp;of Temozolomide SUN once a day, preferably at the same time each day.<\/p>\n\n\n\n<p>Take the capsules on an empty stomach, for example at least one hour before eating breakfast.&nbsp;Swallow the capsules whole with a glass of water.&nbsp;Do not open, crush or chew the capsules.&nbsp;If a capsule is broken, avoid the powder coming into contact with the skin, eyes or nose.&nbsp;If you accidentally get something in your eyes or nose, rinse with water.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100701000126#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/e399e17b-1e40-44a3-97f6-364386f8ba64\" alt=\"Blister map\" title=\"Blister map\"\/><\/a><\/figure>\n\n\n\n<p>You may need to take more than one capsule at a time, depending on the\u00a0dose\u00a0you have been prescribed.\u00a0You may need to take different strengths of the medicine to get the right\u00a0dose\u00a0.\u00a0The labeling on the capsule indicates the strength of the medicine (see the table below).<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Strength<\/td><td>Marking<\/td><\/tr><tr><td>Temozolomide SUN&nbsp;<strong>5 mg<\/strong>&nbsp;hard capsules<\/td><td>890 &amp; 5 mg<\/td><\/tr><tr><td>Temozolomide SUN&nbsp;<strong>20 mg<\/strong>&nbsp;hard capsules<\/td><td>891 &amp; 20 mg<\/td><\/tr><tr><td>Temozolomide SUN&nbsp;<strong>100 mg<\/strong>&nbsp;hard capsules<\/td><td>892 &amp; 100 mg<\/td><\/tr><tr><td>Temozolomide SUN&nbsp;<strong>140 mg<\/strong>&nbsp;hard capsules<\/td><td>929 &amp; 140 mg<\/td><\/tr><tr><td>Temozolomide SUN&nbsp;<strong>180 mg<\/strong>&nbsp;hard capsules<\/td><td>930 &amp; 180 mg<\/td><\/tr><tr><td>Temozolomide SUN&nbsp;<strong>250 mg<\/strong>&nbsp;hard capsules<\/td><td>893 &amp; 250 mg<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Make sure you understand exactly how to do it and remember the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the number of capsules you must take each dosing day.&nbsp;Ask the doctor or pharmacist to write down the&nbsp;dosage&nbsp;(including the label)<\/li><li>which days are dosing days.<\/li><\/ul>\n\n\n\n<p>Review&nbsp;dose&nbsp;one with your doctor each time you start a new treatment cycle, as it may differ from the previous cycle.<\/p>\n\n\n\n<p>Always take Temozolomide SUN exactly as your doctor has told you.&nbsp;It is very important to ask your doctor or pharmacist if you are unsure.&nbsp;Incorrect&nbsp;dosage&nbsp;of the medicine can have serious consequences for your health.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Temozolomide SUN<\/h2>\n\n\n\n<p>If you accidentally take more Temozolomide SUN capsules than prescribed by your doctor, contact your doctor, pharmacist or nurse immediately.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Temozolomide SUN<\/h2>\n\n\n\n<p>Take the missed&nbsp;dose&nbsp;as soon as possible on the same day.&nbsp;If a full day has passed, contact a doctor.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a missed&nbsp;dose&nbsp;, unless your doctor has instructed you to do so.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor, pharmacist or nurse.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<\/p>\n\n\n\n<p>Contact your doctor&nbsp;<strong>immediately<\/strong>&nbsp;if you experience any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe allergic (hypersensitivity) reaction (hives, wheezing or other breathing difficulties)<\/li><li>uncontrolled bleeding<\/li><li>seizures (convulsions)<\/li><li>fever<\/li><li>chills<\/li><li>severe headache that does not go away.<\/li><\/ul>\n\n\n\n<p>Treatment with Temozolomide SUN may cause a decrease in the number of certain types of&nbsp;blood cells&nbsp;.&nbsp;This can mean that you get bruises or bleeding,&nbsp;anemia&nbsp;(lack of&nbsp;red blood cells&nbsp;), fever and reduced resistance to&nbsp;infection&nbsp;.&nbsp;The decrease in the number of&nbsp;blood cells&nbsp;is usually short-lived.&nbsp;In some cases, it can be longer and lead to a very severe form of&nbsp;anemia&nbsp;(&nbsp;aplastic anemia&nbsp;).&nbsp;Your doctor will check your blood regularly for signs of any changes and decide if you need any special treatment.&nbsp;In some cases, the&nbsp;dose&nbsp;of Temozolomide SUN can be reduced or the treatment stopped.<\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;that have been reported are listed below:<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 in 10 users)<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>loss of appetite, difficulty speaking, headache<\/li><li>vomiting, nausea, diarrhoea, constipation<\/li><li>rash, hair loss<\/li><li>fatigue.<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 users)<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection&nbsp;er,&nbsp;infection&nbsp;er in the oral cavity, wound infections<\/li><li>reduced number of&nbsp;blood cells&nbsp;(&nbsp;neutropenia&nbsp;, lymphopenia,&nbsp;thrombocytopenia&nbsp;)<\/li><li>allergic reaction<\/li><li>elevated blood sugar<\/li><li>impaired memory, depression, anxiety, confusion, inability to fall asleep or stay asleep<\/li><li>impaired coordination and balance<\/li><li>difficulty concentrating, changes in mood or attention, forgetfulness<\/li><li>dizziness, impaired sensation, tingling, tremors, changes in taste<\/li><li>partial&nbsp;vision loss, abnormal vision, double vision, dry or painful eyes<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sudden-hearing-loss-sudden-deafness\/\">deafness<\/a>, ringing in the ears, earache<\/li><li>blood clots in the lungs or legs, high&nbsp;blood pressure<\/li><li>pneumonia&nbsp;, shortness of breath,&nbsp;bronchitis&nbsp;, cough, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sinusitis\/\">sinusitis<\/a><\/li><li>stomach or abdominal pain, upset stomach\/heartburn, difficulty swallowing<\/li><li>dry skin,&nbsp;itching<\/li><li>muscle damage, muscle weakness, muscle aches and pains<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/joint-pain\/\">joint pain<\/a>, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/back-hurts\/\">back pain<\/a><\/li><li>frequent urges to urinate, difficulty holding tight<\/li><li>fever,&nbsp;flu-like symptoms&nbsp;, aches, malaise, cold or&nbsp;flu<\/li><li>fluid retention&nbsp;, leg swelling<\/li><li>elevated levels of liver enzymes<\/li><li>weight loss, weight gain<\/li><li>radiation damage.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 users)<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection&nbsp;in the brain (meningoencephalitis caused by herpes virus) which can be fatal<\/li><li>new or reactivated (recurrent)&nbsp;infection&nbsp;with&nbsp;cytomegalovirus<\/li><li>reactivated&nbsp;hepatitis&nbsp;B virus infections<\/li><li>secondary cancer including&nbsp;leukemia<\/li><li>reduced number of&nbsp;blood cells&nbsp;(pancytopenia,&nbsp;anemia&nbsp;,&nbsp;leukopenia&nbsp;)<\/li><li>red dots under the skin<\/li><li>diabetes insipidus&nbsp;(symptoms include increased urine output and thirst), low blood potassium levels<\/li><li>mood swings, hallucinations<\/li><li>partial&nbsp;paralysis, changes in the sense of smell<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/impaired-hearing\/\">impaired hearing<\/a>,&nbsp;infection&nbsp;in the middle ear<\/li><li>palpitations (you can feel the heartbeat), hot flushes<\/li><li>bloated stomach, difficulty controlling bowel movements,&nbsp;hemorrhoids&nbsp;,&nbsp;dry mouth<\/li><li>liver inflammation and liver damage (including fatal liver failure), cholestasis, increased level of&nbsp;bilirubin<\/li><li>blisters on the body or in the mouth, scaly skin, skin reactions, painful reddening of the skin, severe rash with skin swelling (on the palms of the hands and soles of the feet)<\/li><li>increased sensitivity to sunlight,&nbsp;urticaria&nbsp;(hives), increased sweating, change in skin color<\/li><li>difficulty urinating<\/li><li>vaginal bleeding, vaginal irritation, missed or heavy periods, pain in the breasts, sexual&nbsp;impotence<\/li><li>tremors, swelling of the face, discoloration of the tongue, thirst, toothache.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Temozolomide SUN<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children, preferably in a locked cabinet.&nbsp;Accidental ingestion can be life-threatening for children.<\/p>\n\n\n\n<p>Use this medicine before the expiry date which is stated on the label and carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store at a maximum of 25 \u00b0C.<\/p>\n\n\n\n<p>Tell the pharmacist if you notice any visible changes in the appearance of the capsules.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among household waste.&nbsp;Ask the pharmacist how to dispose of medicines that are no longer used.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is temozolomide.&nbsp;Each capsule contains 5 mg, 20 mg, 100 mg, 140 mg, 180 mg and 250 mg of temozolomide, respectively.<\/li><li>Each 5 mg hard&nbsp;<em>capsule contains<\/em>&nbsp;:&nbsp;lactose&nbsp;, sodium starch glycolate (type B), tartaric acid, stearic acid (see section 2 &#8220;Temozolomide SUN contains lactose&#8221;).<br><em>capsule shell:<\/em>&nbsp;gelatin, titanium dioxide (E171), sodium lauryl sulfate,<br><em>printing ink<\/em>&nbsp;: shellac, propylene glycol, yellow iron oxide (E172), blue #1\/Brilliant blue FCF Aluminum Lake (E133).<\/li><li>Each 20 mg hard&nbsp;<em>capsule contains<\/em>&nbsp;:&nbsp;lactose&nbsp;, sodium starch glycolate (type B), tartaric acid, stearic acid (see section 2 &#8220;Temozolomide SUN contains lactose&#8221;).<br><em>capsule shell:<\/em>&nbsp;gelatin, titanium dioxide (E171), sodium lauryl sulfate<br><em>printing ink:<\/em>&nbsp;shellac, propylene glycol, yellow iron oxide (E172).<\/li><li>Each 100 mg hard&nbsp;<em>capsule contains<\/em>&nbsp;:&nbsp;lactose&nbsp;, sodium starch glycolate (type B), tartaric acid, stearic acid (see section 2 &#8220;Temozolomide SUN contains lactose&#8221;).<br><em>capsule shell:<\/em>&nbsp;gelatin, titanium dioxide (E171), sodium lauryl sulfate,<em>printing ink<\/em>&nbsp;: shellac, propylene glycol, red iron oxide (E172), yellow iron oxide (E172).<\/li><li>Each 140 mg hard&nbsp;<em>capsule contains<\/em>&nbsp;:&nbsp;lactose&nbsp;, sodium starch glycolate (type B), tartaric acid, stearic acid (see section 2 &#8220;Temozolomide SUN contains lactose&#8221;).<em>capsule shell:<\/em>&nbsp;gelatin, titanium dioxide (E171), sodium lauryl sulfate,<em>printing ink:<\/em>&nbsp;shellac, propylene glycol, blue #1\/Brilliant blue FCF Aluminum Lake (E133).<\/li><li>Each 180 mg hard&nbsp;<em>capsule contains:&nbsp;<\/em>lactose&nbsp;, sodium starch glycolate (type B), tartaric acid, stearic acid (see section 2 &#8220;Temozolomide SUN contains lactose&#8221;).<em>capsule shell:<\/em>&nbsp;gelatin, titanium dioxide (E171), sodium lauryl sulfate,<em>ink:<\/em>&nbsp;shellac, propylene glycol, red iron oxide (E172).<\/li><li>Each 250 mg hard&nbsp;<em>capsule contains:&nbsp;<\/em>lactose&nbsp;, sodium starch glycolate (type B), tartaric acid, stearic acid (see section 2 &#8220;Temozolomide SUN contains lactose&#8221;).<em>capsule shell:<\/em>&nbsp;gelatin, titanium dioxide (E171), sodium lauryl sulfate,<em>ink:<\/em>&nbsp;shellac, propylene glycol, black iron oxide (E172).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Temozolomide SUN 5 mg hard gelatin capsules, with white opaque upper and lower capsule halves, printed in green ink.&nbsp;The upper half with print &#8216;890&#8217;.&nbsp;The lower half with print &#8216;5 mg&#8217; and 2 stripes.<\/p>\n\n\n\n<p>Temozolomide SUN 20 mg hard gelatin capsules, with white opaque upper and lower capsule halves, printed in yellow ink.&nbsp;The upper half with print &#8216;891&#8217;.&nbsp;The lower half with print &#8217;20 mg&#8217; and 2 stripes.<\/p>\n\n\n\n<p>Temozolomide SUN 100 mg hard gelatin capsules, with white opaque upper and lower capsule halves, printed in pink ink.&nbsp;The upper half with print &#8216;892&#8217;.&nbsp;The lower half with print &#8216;100 mg&#8217; and 2 stripes.<\/p>\n\n\n\n<p>Temozolomide SUN 140 mg hard gelatin capsules, with white opaque upper and lower capsule halves, printed in blue ink.&nbsp;The upper half with print &#8216;929&#8217;.&nbsp;The lower half with print &#8216;140 mg&#8217; and 2 stripes.<\/p>\n\n\n\n<p>Temozolomide SUN 180 mg hard gelatin capsules, with white opaque upper and lower capsule halves, printed in red ink.&nbsp;The upper half with print &#8216;930&#8217;.&nbsp;The lower half with print &#8216;180 mg&#8217; and 2 stripes.<\/p>\n\n\n\n<p>Temozolomide SUN 250 mg hard gelatin capsules, with white opaque upper and lower capsule halves, printed in black ink.&nbsp;The upper half with print &#8216;893&#8217;.&nbsp;The lower half with print &#8216;250 mg&#8217; and 2 stripes.<\/p>\n\n\n\n<p>The hard capsules are available in blister cards containing 5 capsules.&nbsp;Packages of 20 capsules consist of a carton with 4 blister cards of 5 capsules.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Sun Pharmaceutical Industries Europe BV<\/p>\n\n\n\n<p>87 Polaris Avenue<\/p>\n\n\n\n<p>2132 JH Hoofddorp<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<p><strong>Belgi\u00eb\/Belgique\/Belgien\/\u0411\u044a\u043b\u0433\u0430\u0440\u0438\u044f\/\u010cesk\u00e1 republika\/<\/strong><\/p>\n\n\n\n<p><strong>Denmark\/Eesti\/\u0395\u03bb\u03bb\u03ac\u03b4\u03b1\/Croatia\/Ireland\/\u00cdsland\/<\/strong><\/p>\n\n\n\n<p><strong>\u039aypros\/Latvija\/Lietuva\/Luxembourg\/Luxemburg\/Magyarorsz\u00e1g\/<\/strong><\/p>\n\n\n\n<p><strong>Malta\/Nederland\/Norway\/Austria\/Portugal\/<\/strong><\/p>\n\n\n\n<p><strong>Slovenija\/Slovensk\u00e1 republika\/Suomi\/Finland\/Sweden<\/strong><\/p>\n\n\n\n<p>Sun Pharmaceutical Industries Europe BV<\/p>\n\n\n\n<p>87 Polaris Avenue<\/p>\n\n\n\n<p>2132 JH Hoofddorp<\/p>\n\n\n\n<p>Nederland\/Pays-Bas\/Niederlande\/\u041d\u0438\u0434\u0435\u0440\u043b\u0430\u043d\u0434\u0438\u044f\/Holanda\/<\/p>\n\n\n\n<p>Nederlandene\/Holland\/\u039f\u03bb\u03bb\u03b1\u03bd\u03b4\u03af\u03b1\/Holanda\/The Netherlands\/Holland\/<\/p>\n\n\n\n<p>Holland\/Netherlands\/Nyderlandai\/Pays-Bas\/Niederlande\/Hollandia\/<\/p>\n\n\n\n<p>L-Olanda\/Nederland\/Nederland\/Niederlande\/Pa\u00edses Baixos\/<\/p>\n\n\n\n<p>Holland\/Holandsko\/Alankomaat\/Netherlands\/Netherlands<\/p>\n\n\n\n<p>Tel.\/\u0442\u0435\u043b.\/tel.\/\u03c4\u03b7\u03bb.\/S\u00edmi\/\u03c4\u03b7\u03bb.\/Tlf.\/Puh.\/<\/p>\n\n\n\n<p>+31 (0)23 568 5501<\/p>\n\n\n\n<p><strong>Deutschland<\/strong><\/p>\n\n\n\n<p>Sun Pharmaceuticals Germany GmbH<\/p>\n\n\n\n<p>Hemmelrather Weg 201<br>51377 Leverkusen<\/p>\n\n\n\n<p>Deutschland<\/p>\n\n\n\n<p>tel.&nbsp;+49 (0) 214 403 990<\/p>\n\n\n\n<p><strong>Spain<\/strong><\/p>\n\n\n\n<p>Sun Pharma Laboratorios, SL<\/p>\n\n\n\n<p>Rambla de Catalunya 53-55<br>08007 Barcelona<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p>tel.&nbsp;+34 93 342 78 90<\/p>\n\n\n\n<p><strong>France<\/strong><\/p>\n\n\n\n<p>Sun Pharma France<\/p>\n\n\n\n<p>11-15, Quai de Dion Bouton<\/p>\n\n\n\n<p>92800 Puteaux<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Tel.&nbsp;+33 1 41 44 44 50<\/p>\n\n\n\n<p><strong>Italy<\/strong><\/p>\n\n\n\n<p>Sun Pharma Italia Srl<\/p>\n\n\n\n<p>Viale Giulio Richard, 1<\/p>\n\n\n\n<p>20143 \u2013 Milan<\/p>\n\n\n\n<p>Italy<\/p>\n\n\n\n<p>tel.&nbsp;+39 02 33 49 07 93<\/p>\n\n\n\n<p><strong>Polish<\/strong><\/p>\n\n\n\n<p>Ranbaxy (Poland) Sp.&nbsp;Z oo<\/p>\n\n\n\n<p>ul.&nbsp;Kubickiego 11<\/p>\n\n\n\n<p>02-954 Warsaw<\/p>\n\n\n\n<p>Polish<\/p>\n\n\n\n<p>Tel.&nbsp;+48 22 642 07 75<\/p>\n\n\n\n<p><strong>Romania<\/strong><\/p>\n\n\n\n<p>Terapia SA<\/p>\n\n\n\n<p>Str. Fabricii No. 124<\/p>\n\n\n\n<p>Cluj-Napoca, Cluj Jude\u0163ul<\/p>\n\n\n\n<p>Romania<\/p>\n\n\n\n<p>Tel.&nbsp;+40 (264) 501 500<\/p>\n\n\n\n<p><strong>United Kingdom<\/strong><\/p>\n\n\n\n<p>Ranbaxy UK Ltd<br>a Sun Pharma Company<\/p>\n\n\n\n<p>11 Millington Road<\/p>\n\n\n\n<p>Hyde Park, Hayes 3<br>5th Floor<br>UB3 4AZ HAYES<\/p>\n\n\n\n<p>United Kingdom<br>Tel.&nbsp;+44 (0) 208 848 8688<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Temozolomide SUN contains the medicine temozolomide.\u00a0This medicine is used to treat\u00a0tumors.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[],"class_list":["post-24627","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24627"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24627\/revisions"}],"predecessor-version":[{"id":24657,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24627\/revisions\/24657"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24627"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24627"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}