{"id":24617,"date":"2022-08-26T10:54:36","date_gmt":"2022-08-26T10:54:36","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24617"},"modified":"2022-08-29T11:45:37","modified_gmt":"2022-08-29T11:45:37","slug":"temodal","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/temodal\/","title":{"rendered":"Temodal &#8211; Temozolomide uses, dose and side effects"},"content":{"rendered":"\n<p>5 mg, 2 &#8211; temozolomide0 mg, 100 mg, 140 mg, 180 mg and 250 mg\u00a0hard capsules<br>temozolomide (temozolomidum)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Temodal is and what it is used for<\/h2>\n\n\n\n<p>Temodal contains the medicine temozolomide.\u00a0This medicine is used to treat\u00a0tumors.<\/p>\n\n\n\n<p>Temodal is used to treat patients with specific forms of brain tumors:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>in adults with newly diagnosed\u00a0glioblastoma multiforme.\u00a0Temodal is first used together with radiation (simultaneous treatment phase) and then alone (monotherapy phase of the treatment).<\/li><li>in children older than 3 years and adult patients with malignant\u00a0gliomas, such as\u00a0glioblastoma multiforme\u00a0or\u00a0anaplastic astrocytoma.\u00a0Temodal is used for these\u00a0tumors\u00a0if they return or continue to develop after standard treatment.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Temodal<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Temodal<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to temozolomide or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have had an\u00a0allergic reaction\u00a0to dacarbazine (an anti-cancer medicine, sometimes called DTIC).\u00a0Signs of\u00a0an allergic reaction\u00a0include feeling\u00a0itchy, shortness of breath or wheezing, and swelling of the face, lips, tongue, or throat.<\/li><li>if certain types of\u00a0blood cells\u00a0are greatly reduced (myelosuppression), such as the white\u00a0blood cells\u00a0or platelets.\u00a0These\u00a0blood cells\u00a0are important when it comes to fighting\u00a0infection\u00a0and for functioning blood coagulation.\u00a0Your doctor will check your blood to make sure you have enough of these\u00a0blood cells\u00a0before you start treatment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Temodal<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>because you must be closely monitored for the development of a serious form of\u00a0pneumonia\u00a0called\u00a0<em>Pneumocystis jirovecii<\/em>\u00a0&#8211;\u00a0pneumonia\u00a0(PCP).\u00a0If you have recently received your diagnosis (\u00a0glioblastoma multiforme\u00a0), you can receive Temodal for 42 days in combination with radiation.\u00a0If so, your doctor will also prescribe medication to help you prevent this type of\u00a0pneumonia\u00a0(PCP).<\/li><li>if you have ever had or possibly now have hepatitis B\u00a0infection.\u00a0Temodal can cause hepatitis B to become active again and in some cases, this can lead to death.\u00a0Patients will be carefully examined by their doctor for signs of this\u00a0infection\u00a0before starting treatment.<\/li><li>if you have low numbers of\u00a0red blood cells\u00a0(\u00a0anemia\u00a0),\u00a0white blood cells\u00a0and\u00a0platelets\u00a0(\u00a0thrombocytes\u00a0), or blood clotting problems before starting treatment, or if you develop them during treatment.\u00a0Your doctor may decide to lower the\u00a0dose, stop, stop or change the treatment.\u00a0You may also need other treatment.\u00a0In some cases, it may be necessary to stop treatment with Temodal.\u00a0Your blood will be tested regularly during treatment to monitor the\u00a0side effects\u00a0of Temodal on your\u00a0blood cells.<\/li><li>because you may have a small risk of other\u00a0blood cell\u00a0changes, including\u00a0leukemia.<\/li><li>if you experience nausea and\/or vomiting, which are very common\u00a0side effects\u00a0of Temodal (see section 4), your doctor may prescribe medicine (an\u00a0antiemetic\u00a0) to prevent vomiting.<br>If you vomit frequently before and during treatment, ask your doctor when it is best to take Temodal, until the vomiting is under control.\u00a0If you vomit after taking your\u00a0dose, do not take a second\u00a0dose\u00a0on the same day.<\/li><li>if you develop a fever or symptoms of an\u00a0infection, contact your doctor immediately.<\/li><li>if you are over 70, you may be more susceptible to infection, bruise, or bleeding more easily.<\/li><li>if you have liver or kidney problems, your Temodal\u00a0dose\u00a0may need to be adjusted.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this medicine to children younger than 3 years because there is no experience.\u00a0There is only limited information on patients older than 3 years who have taken Temodal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Temodal<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.\u00a0You should not be treated with Temodal if you are pregnant unless your doctor tells you so.<\/p>\n\n\n\n<p>Effective contraceptive methods must be used by female patients who may become pregnant during treatment with Temodal and for at least 6 months after stopping treatment.<\/p>\n\n\n\n<p>You must stop breastfeeding while receiving treatment with Temodal.<\/p>\n\n\n\n<p><strong>Male&nbsp;fertility<\/strong><\/p>\n\n\n\n<p>Temodal can cause permanent\u00a0infertility.\u00a0Male patients should use an effective method of contraception and not have children for at least 3 months after the end of treatment.\u00a0It is recommended to consult about sperm freezing before starting treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Temodal can make you feel tired or sleepy.\u00a0If this is the case, do not drive, use machinery, or cycle until you know how this medicine affects you (see section 4).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Temodal contains lactose<\/h2>\n\n\n\n<p>This medicine contains&nbsp;lactose&nbsp;(a type of sugar).&nbsp;If your doctor has told you that you are intolerant to any sugar, you should therefore contact your doctor before taking this medicine.<\/p>\n\n\n\n<p><strong>Temodal contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per capsule, i.e.&nbsp;is almost &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Temodal<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Dosage&nbsp;and duration of treatment<\/p>\n\n\n\n<p>Your doctor will determine the Temodal\u00a0dose.\u00a0It is based on your body size (height and weight) and whether you have a recurrent\u00a0tumor\u00a0and have previously received\u00a0chemotherapy.<\/p>\n\n\n\n<p>You may be prescribed other medicines (antiemetics) to be taken before and\/or after you take Temodal to prevent or control nausea and vomiting.<\/p>\n\n\n\n<p>Patients with newly diagnosed glioblastoma multiforme:<\/p>\n\n\n\n<p>If you are a newly diagnosed patient, the treatment will take place in two phases:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>treatment together with radiation (concurrent phase) first<\/li><li>followed by treatment with Temodal alone (monotherapy phase).<\/li><\/ul>\n\n\n\n<p>During the concurrent phase, your doctor will start Temodal at a&nbsp;dose&nbsp;of 75 mg\/m2 (usual&nbsp;dose&nbsp;).&nbsp;You will take this&nbsp;dose&nbsp;every day for 42 days (up to 49 days) in combination with radiotherapy.&nbsp;Temodal&nbsp;dose&nbsp;one can be postponed or interrupted depending on your blood values \u200b\u200band on how you tolerate the drug during the simultaneous phase.<\/p>\n\n\n\n<p>When the radiation treatment is finished, you will have a treatment break of 4 weeks.\u00a0It will allow your body to recover.<\/p>\n\n\n\n<p>You will then begin the monotherapy phase.<\/p>\n\n\n\n<p>During the monotherapy phase, the\u00a0dose\u00a0and the way you take Temodal will be different.\u00a0Your doctor will work out exactly what\u00a0amount\u00a0you should have.\u00a0You can have up to 6 treatment periods (cycles).\u00a0Each of these lasts for 28 days.\u00a0You will take only the new Temodal\u00a0dose\u00a0once a day for the first 5 days (\u201cdosing days\u201d) of each cycle.\u00a0The first\u00a0dose\u00a0will be 150 mg\/m\u00a02.\u00a0After that, you will have 23 days without Temodal.\u00a0In total, there will be a 28-day treatment cycle.<\/p>\n\n\n\n<p>After day 28, the next cycle begins.\u00a0You will again take Temodal once a day for 5 days followed by 23 days without Temodal.\u00a0The Temodal\u00a0dose\u00a0can be adjusted, postponed, or discontinued depending on your blood values \u200b\u200band how well you tolerate the medicine during each treatment cycle.<\/p>\n\n\n\n<p><em><u>Patients with\u00a0tumors\u00a0that have returned or worsened (malignant\u00a0glioma, such as\u00a0glioblastoma multiforme\u00a0or\u00a0anaplastic astrocytoma\u00a0) receiving Temodal alone:<\/u><\/em><\/p>\n\n\n\n<p>A treatment cycle with Temodal lasts 28 days.<\/p>\n\n\n\n<p>You will take only Temodal once daily for the first 5 days.&nbsp;The daily&nbsp;dose&nbsp;depends on whether you have previously received&nbsp;chemotherapy&nbsp;or not.<\/p>\n\n\n\n<p>If you have not previously been treated with\u00a0chemotherapy, the first\u00a0dose\u00a0of Temodal will be 200 mg\/m\u00a02\u00a0once daily for the first 5 days.\u00a0If you have previously been treated with\u00a0chemotherapy, the first\u00a0dose\u00a0of Temodal will be 150 mg\/m\u00a0<sup>2<\/sup>\u00a0once daily for the first 5 days.\u00a0After that, you will have 23 days without Temodal.\u00a0In total, there will be a treatment cycle of 28 days.<\/p>\n\n\n\n<p>After day 28, the next treatment cycle begins.&nbsp;You will again receive Temodal once daily for 5 days, followed by 23 days without Temodal.<\/p>\n\n\n\n<p>Before each new treatment cycle, your blood will be tested to see if the Temodal\u00a0dose\u00a0needs to be adjusted.\u00a0Depending on the results of your blood tests, your doctor may adjust the\u00a0dosage\u00a0from one to the next cycle.<\/p>\n\n\n\n<p>How to take Temodal<\/p>\n\n\n\n<p>Take the prescribed&nbsp;dose&nbsp;of Temodal once a day, preferably at the same time each day.<\/p>\n\n\n\n<p>Take the capsules on an empty stomach;\u00a0for example, at least one hour before you intend to eat breakfast.\u00a0Swallow the capsule(s) whole with a glass of water.\u00a0Do not open, crush or chew the capsules.\u00a0If a capsule is broken, avoid the powder coming into contact with the skin, eyes, or nose.\u00a0If you accidentally get something in your eyes or nose, rinse with water.<\/p>\n\n\n\n<p>Depending on the\u00a0dose\u00a0you have been prescribed, you may need to take several capsules at the same time, possibly in different strengths (the active substance in mg).\u00a0The color of the lid of the capsule is different for the different strengths (see the table below).<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Strength<\/td><td>The color of the outer half of the capsule<\/td><\/tr><tr><td>Temodal&nbsp;<strong>5 mg<\/strong>&nbsp;hard capsules<\/td><td>Green<\/td><\/tr><tr><td>Temodal&nbsp;<strong>20 mg<\/strong>&nbsp;hard capsules<\/td><td>yellow<\/td><\/tr><tr><td>Temodal&nbsp;<strong>100 mg<\/strong>&nbsp;hard capsules<\/td><td>pink<\/td><\/tr><tr><td>Temodal&nbsp;<strong>140 mg<\/strong>&nbsp;hard capsules<\/td><td>blue<\/td><\/tr><tr><td>Temodal&nbsp;<strong>180 mg<\/strong>&nbsp;hard capsules<\/td><td>orange<\/td><\/tr><tr><td>Temodal&nbsp;<strong>250 mg<\/strong>&nbsp;hard capsules<\/td><td>White<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Make sure you understand exactly and remember the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>how many capsules do you need to take each dosing day?\u00a0Ask your doctor or pharmacist to write it down (including the color).<\/li><li>which days are your dosing days?<\/li><\/ul>\n\n\n\n<p>Be sure to review the&nbsp;dosage&nbsp;with your doctor each time you start a new treatment period, as it may differ from the previous period.<\/p>\n\n\n\n<p>Always take Temodal as directed by your doctor.\u00a0Ask your doctor or pharmacist if you are unsure.\u00a0Mistakes in how you take your medication can have serious consequences on your health.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Temodal<\/h2>\n\n\n\n<p>If you accidentally take more Temodal capsules than you were prescribed, contact your doctor, pharmacist or nurse immediately.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Temodal<\/h2>\n\n\n\n<p>Take the missed\u00a0dose\u00a0as soon as possible on the same day.\u00a0If a day has already passed, contact your doctor.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose, unless your doctor has told you to do so.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Contact your doctor&nbsp;<strong>immediately<\/strong>&nbsp;if you experience any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a severe allergic (hypersensitivity) reaction (\u00a0hives, wheezing, or other breathing difficulties)<\/li><li>uncontrolled bleeding<\/li><li>seizures (convulsions)<\/li><li>fever<\/li><li>chills<\/li><li>severe headache that does not go away<\/li><\/ul>\n\n\n\n<p>Treatment with Temodal can cause a reduction in certain types of\u00a0blood cells.\u00a0This can mean that you bruise or bleed more easily,\u00a0anemia\u00a0(lack of\u00a0red blood cells\u00a0), fever, and reduced resistance to\u00a0infection.\u00a0The reduced number of\u00a0blood cells\u00a0is usually transient.\u00a0In some cases, it can be more prolonged and lead to a very severe form of\u00a0anemia\u00a0(\u00a0aplastic anemia\u00a0).\u00a0Your doctor will measure your blood levels regularly to detect any changes and determine if any special treatment is required.\u00a0In some cases, your\u00a0dose\u00a0of Temodal can be reduced or the treatment stopped.<\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;that have been reported are listed below:<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 in 10 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>loss of appetite, difficulty speaking, headache<\/li><li>vomiting, nausea, diarrhea, constipation<\/li><li>rash, hair loss<\/li><li>fatigue<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection,\u00a0infection\u00a0in the oral cavity<\/li><li>reduced number of\u00a0blood cells\u00a0(\u00a0neutropenia, lymphopenia,\u00a0thrombocytopenia\u00a0)<\/li><li>allergic reaction<\/li><li>elevated blood sugar<\/li><li>impaired memory, depression, anxiety, confusion, inability to fall asleep or stay asleep<\/li><li>impaired coordination and balance<\/li><li>difficulty concentrating, changes in mood or attention, forgetfulness<\/li><li>dizziness, impaired sensation, tingling, tremors, changes in taste<\/li><li>partial\u00a0vision loss, abnormal vision, double vision, painful eyes<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sudden-hearing-loss-sudden-deafness\/\">deafness<\/a>, ringing in the ears, earache<\/li><li>blood clots in the lungs or legs, high\u00a0blood pressure<\/li><li>pneumonia, shortness of breath,\u00a0bronchitis, cough, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sinusitis\/\">sinusitis<\/a><\/li><li>stomach or abdominal pain, upset stomach\/heartburn, difficulty swallowing<\/li><li>dry skin,\u00a0itching<\/li><li>muscle damage, muscle weakness, muscle aches, and pains<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/joint-pain\/\">joint pain<\/a>, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/back-hurts\/\">back pain<\/a><\/li><li>frequent urges to urinate, difficulty holding tight<\/li><li>fever,\u00a0flu-like symptoms, aches, malaise, cold, or\u00a0flu<\/li><li>fluid retention, leg swelling<\/li><li>elevated levels of liver enzymes<\/li><li>weight loss, weight gain<\/li><li>radiation damage<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection\u00a0in the brain (meningoencephalitis caused by the herpes virus) which can be fatal<\/li><li>wound infections<\/li><li>new or reactivated (recurrent)\u00a0infection\u00a0with\u00a0cytomegalovirus<\/li><li>reactivated\u00a0hepatitis\u00a0B virus infections<\/li><li>secondary cancer including\u00a0leukemia<\/li><li>reduced number of\u00a0blood cells\u00a0(pancytopenia,\u00a0anemia,\u00a0leukopenia\u00a0)<\/li><li>red dots under the skin<\/li><li>diabetes insipidus\u00a0(symptoms include increased urine output and thirst), low blood potassium levels<\/li><li>mood swings, hallucinations<\/li><li>partial\u00a0paralysis, changes in the sense of smell<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/impaired-hearing\/\">impaired hearing<\/a>,\u00a0infection\u00a0in the middle ear<\/li><li>palpitations (you can feel the heartbeat), hot flushes<\/li><li>bloated stomach, difficulty controlling bowel movements,\u00a0hemorrhoids,\u00a0dry mouth<\/li><li>liver inflammation and liver damage (including fatal liver failure), cholestasis, increased level of\u00a0bilirubin<\/li><li>blisters on the body or in the mouth, scaly skin, skin reactions, painful reddening of the skin, a severe rash with skin swelling (on the palms of the hands and soles of the feet)<\/li><li>increased sensitivity to sunlight,\u00a0urticaria\u00a0(hives), increased sweating, change in skin color<\/li><li>difficulty urinating<\/li><li>vaginal bleeding, vaginal irritation, missed or heavy periods, breast pain, sexual\u00a0impotence<\/li><li>tremors, swelling of the face, discoloration of the tongue, thirst, toothache<\/li><li>dry eyes<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How Temodal should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children, preferably in a locked cabinet.&nbsp;Accidental ingestion can be fatal for children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the label and carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Glass jars<\/p>\n\n\n\n<p>Store at a maximum of 30\u00b0C.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Close the package well.<\/p>\n\n\n\n<p>Dose bags<\/p>\n\n\n\n<p>Store at a maximum of 30\u00b0C<\/p>\n\n\n\n<p>Tell the pharmacist if you notice any change in the appearance of the capsules.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is temozolomide.<\/p>\n\n\n\n<p><em>Temodal 5 mg hard capsules:<\/em>&nbsp;One capsule contains 5 mg temozolomide.<\/p>\n\n\n\n<p><em>Temodal 20 mg hard capsules:<\/em>&nbsp;One capsule contains 20 mg temozolomide.<\/p>\n\n\n\n<p><em>Temodal 100 mg hard capsules:<\/em>&nbsp;One capsule contains 100 mg temozolomide.<\/p>\n\n\n\n<p><em>Temodal 140 mg hard capsules:<\/em>&nbsp;One capsule contains 140 mg temozolomide.<\/p>\n\n\n\n<p><em>Temodal 180 mg hard capsules:<\/em>&nbsp;One capsule contains 180 mg temozolomide.<\/p>\n\n\n\n<p><em>Temodal 250 mg hard capsules:<\/em>&nbsp;One capsule contains 250 mg temozolomide.<\/p>\n\n\n\n<p>Other ingredients are<\/p>\n\n\n\n<p><strong>the contents of the capsule:<\/strong><\/p>\n\n\n\n<p>anhydrous\u00a0lactose,\u00a0colloidal\u00a0anhydrous silica, sodium starch glycolate type A, tartaric acid, and stearic acid (see section 2 &#8220;Temodal contains lactose&#8221;).<\/p>\n\n\n\n<p><strong>capsule shell:<\/strong><\/p>\n\n\n\n<p><em>Temodal 5 mg hard capsules:<\/em>&nbsp;gelatin, titanium dioxide (E 171), sodium lauryl sulfate, yellow iron oxide (E 172), indigo carmine (E 132),<\/p>\n\n\n\n<p><em>Temodal 20 mg hard capsules:<\/em>&nbsp;gelatin, titanium dioxide (E 171), sodium lauryl sulfate, yellow iron oxide (E 172),<\/p>\n\n\n\n<p><em>Temodal 100 mg hard capsules:<\/em>&nbsp;gelatin, titanium dioxide (E 171), sodium lauryl sulfate, red iron oxide (E 172),<\/p>\n\n\n\n<p><em>Temodal 140 mg hard capsules:<\/em>&nbsp;gelatin, titanium dioxide (E 171), sodium lauryl sulfate, indigo carmine (E 132),<\/p>\n\n\n\n<p><em>Temodal 180 mg hard capsules:<\/em>\u00a0gelatin, titanium dioxide (E 171), sodium lauryl sulfate, yellow iron oxide (E 172), and red iron oxide (E 172),<\/p>\n\n\n\n<p><em>Temodal 250 mg hard capsules:<\/em>&nbsp;gelatin, titanium dioxide (E 171), sodium lauryl sulfate.<\/p>\n\n\n\n<p><strong>ink for printing:<\/strong><\/p>\n\n\n\n<p>shellac, propylene glycol (E 1520), purified water, ammonium hydroxide, potassium hydroxide, and black iron oxide (E 172).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p><em>Temodal&nbsp;<\/em><em>5 mg hard capsules<\/em>&nbsp;have an opaque white inner half and an opaque green outer half and are marked with black ink<\/p>\n\n\n\n<p><em>Temodal&nbsp;<\/em><em>20 mg&nbsp;<\/em><em>hard capsules<\/em>&nbsp;have an opaque white inner half and an opaque yellow outer half and are marked with black ink.<\/p>\n\n\n\n<p><em>Temodal&nbsp;<\/em><em>100 mg&nbsp;<\/em><em>hard capsules<\/em>&nbsp;have an opaque white inner half and an opaque pink outer half and are marked with black ink.<\/p>\n\n\n\n<p><em>Temodal&nbsp;<\/em><em>140 mg&nbsp;<\/em><em>hard capsules<\/em>&nbsp;have an opaque white inner half and a blue outer half and are marked with black ink.<\/p>\n\n\n\n<p><em>Temodal&nbsp;<\/em><em>180 mg&nbsp;<\/em><em>hard capsules<\/em>&nbsp;have an opaque white inner half and an opaque orange outer half and are marked with black ink.<\/p>\n\n\n\n<p><em>Temodal&nbsp;<\/em><em>250 mg&nbsp;<\/em><em>hard capsules<\/em>&nbsp;have an opaque white inner half and an opaque white outer half and are marked with black ink.<\/p>\n\n\n\n<p>Glass jars<\/p>\n\n\n\n<p>The hard capsules for&nbsp;oral&nbsp;use are packaged in brown glass jars containing 5 or 20 capsules.<\/p>\n\n\n\n<p>The carton contains one jar.<\/p>\n\n\n\n<p>Dose bags<\/p>\n\n\n\n<p>The hard capsules (capsules) for\u00a0oral\u00a0use are packaged in cartons containing 5 or 20 hard capsules, each in a sealed\u00a0sachet.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Marketing Authorisation Holder:<\/p>\n\n\n\n<p>Merck Sharp &amp; Dohme BV<br>Waarderweg 39<br>2031 BN Haarlem<br>The Netherlands<\/p>\n\n\n\n<p>Manufacturer: SP Labo NV, Industriepark 30, B-2220<\/p>\n\n\n\n<p>Heist-op-den-Berg, Belgium<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgique\/Belgi\u00eb\/Belgien<\/strong>MSD BelgiumTel\/Tel: +32(0)27766211dpoc_belux@merck.com<\/td><td><strong>Lithuania<\/strong>UAB Merck Sharp &amp; DohmeTel.: +370 5 278 02 47msd_lietuva@merck.com<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>\u041c\u0435\u0440\u043a \u0428\u0430\u0440\u043f \u0438 \u0414\u043e\u043c \u0411\u0443\u043b\u0433\u0430\u0440\u0438\u044f \u0415\u041e\u041e\u0414Tel.: +359 2 819 3737info-msdbg@merck.com<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>MSD BelgiumTel\/Tel: +32(0)27766211dpoc_belux@merck.com<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Merck Sharp &amp; Dohme s.r.oPhone: +420 233 010 111dpoc_czechslovak@merck.com<\/td><td><strong>Magyarorsz\u00e1g<\/strong>MSD Pharma Hungary Kft.Tel.: +36 1 888 53 00hungary_msd@merck.com<\/td><\/tr><tr><td><strong>Denmark<\/strong>MSD Danmark ApSPhone: + 45 4482 4000dkmail@merck.com<\/td><td><strong>Malta<\/strong>Merck Sharp &amp; Dohme Cyprus LimitedPhone: 8007 4433 (+356 99917558)malta_info@merck.com<\/td><\/tr><tr><td><strong>Deutschland<\/strong>MSD Sharp &amp; Dohme GmbHPhone: 0800 673 673 673 (+49 (0) 89 45610)e-mail@msd.de<\/td><td><strong>The Netherlands<\/strong>Merck Sharp &amp; Dohme BVPhone: 0800 9999000(+31 23 5153153)medicalinfo.nl@merck.com<\/td><\/tr><tr><td><strong>Estonia<\/strong>Merck Sharp &amp; Dohme O\u00dcTel.: +372 6144 200msdeesti@merck.com<\/td><td><strong>Norway<\/strong>MSD (Norway) iPhone: +47 32 20 73 00msdnorge@msd.no<\/td><\/tr><tr><td><strong>Greece<\/strong>MSD \u0391.\u03a6.\u0392.\u0395.\u0395.Tel: +30 210 98 97 300dpoc_greece@merck.com<\/td><td><strong>Austria<\/strong>Merck Sharp &amp; Dohme Ges.mbHPhone: +43 (0) 1 26 044msd-medizin@merck.com<\/td><\/tr><tr><td><strong>Spain<\/strong>Merck Sharp &amp; Dohme de Espa\u00f1a, SAPhone: +34 91 321 06 00msd_info@merck.com<\/td><td><strong>Polish<\/strong>MSD Polska Sp.&nbsp;z o. oTel. +48 22 549 51 00msdpolska@merck.com<\/td><\/tr><tr><td><strong>France<\/strong>MSD FranceTel: +33 (0) 1 80 46 40 40<\/td><td><strong>Portugal<\/strong>Merck Sharp &amp; Dohme, LdaPhone: +351 21 446 57 00inform_pt@merck.com<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Merck Sharp &amp; Dohme dooPhone: + 385 1 6611 333croatia_info@merck.com<\/td><td><strong>Romania<\/strong>Merck Sharp &amp; Dohme Romania SRLPhone: +4021 529 29 00msdromania@merck.com<\/td><\/tr><tr><td><b>Ireland Merck<\/b> Sharp and Dohme Ireland (\u00a0Human\u00a0Health) LimitedPhone: +353 (0)1 2998700medinfo_ireland@merck.com<\/td><td><strong>Slovenija<\/strong>Merck Sharp &amp; Dohme, inovativna svlad\u00edva dooPhone: +386 1 5204 201msd.slovenia@merck.com<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Simi: +354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>Merck Sharp &amp; Dohme, s.r.oPhone: +421 2 58282010dpoc_czechslovak@merck.com<\/td><\/tr><tr><td><strong>Italy<\/strong>MSD Italia SrlPhone: +39 06 361911medicalinformation.it@merck.com<\/td><td><strong>Finland\/Finland<\/strong>MSD Finland OyTel: + 358 (0)9 804650info@msd.fi<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Merck Sharp &amp; Dohme Cyprus Limited.Tel.: 800 00 673(+357 22866700)cyprus_info@merck.co<\/td><td><strong>Sweden<\/strong>Merck Sharp &amp; Dohme (Sweden) ABPhone: +46 (0) 77 5700488medicalinfo@merck.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Merck Sharp &amp; Dohme LatvijaPhone: +371 67364224msd_lv@merck.com<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Merck Sharp &amp; Dohme Ireland (&nbsp;Human&nbsp;Health) LimitedPhone: +353 (0)1 2998700medinfoNI@msd.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Temodal contains the medicine temozolomide.\u00a0This medicine is used to treat\u00a0tumors\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25556,25527,25552,25554,25531,25529,25555,25526,25553,25551,25530],"class_list":["post-24617","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-temodal","tag-benefits-of-temozolomide","tag-temodal","tag-temodal-side-effects","tag-temozolomide","tag-temozolomide-side-effects","tag-what-is-temodal","tag-what-is-temozolomide","tag-what-temodal-is-used-for","tag-what-temozolomide","tag-what-temozolomide-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24617","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24617"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24617\/revisions"}],"predecessor-version":[{"id":24660,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24617\/revisions\/24660"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24617"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}